Research Topics
| Cynthia Neill EppersonSummaryAffiliation: Yale University Country: USA Publications
Research Grants
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Detail Information
Publications
Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairsN Epperson
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
Am J Psychiatry 158:1631-7. 2001..This study determined the degree of transporter blockade in infants exposed to sertraline through maternal breast milk...
Luteal-phase accentuation of acoustic startle response in women with premenstrual dysphoric disorderCynthia Neill Epperson
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
Neuropsychopharmacology 32:2190-8. 2007..Physiologic response to affective stimuli appears to be intact in women with PMDD across the menstrual cycle...- The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findingsC Neill Epperson
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
J Psychopharmacol 21:414-20. 2007..While preliminary, the results suggest that serotonin may be less critical to the pathogenesis of depression during the menopause... - Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS studyC Neill Epperson
Department of Psychiatry, Yale University School of Medicine, and Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT 06519, USA
Psychopharmacology (Berl) 186:425-33. 2006..Childbirth is associated with rapid neuroendocrine fluctuations, which are thought to contribute to the phatogenesis of postpartum major depression (PPD)... - Sex, GABA, and nicotine: the impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopyC Neill Epperson
Department of Psychiatry, Yale University School of Medicine, University Towers Suite 2H, 100 York Street, New Haven, CT 06511, USA
Biol Psychiatry 57:44-8. 2005..Given that nicotine modulates amino acid neurotransmission, we sought to examine the impact of nicotine on cortical gamma-aminobutyric acid (GABA) levels in male and female smokers... - Randomized clinical trial of bright light therapy for antepartum depression: preliminary findingsC Neill Epperson
Department of Psychiatry, Yale University School of Medicine, University Towers Suite 2H, 100 York Street, New Haven, CT 06511, USA
J Clin Psychiatry 65:421-5. 2004..Bright light therapy was shown to be a promising treatment for depression during pregnancy in a recent open-label study. In an extension of this work, we report findings from a double-blind placebo-controlled pilot study... - Maternal fluoxetine treatment in the postpartum period: effects on platelet serotonin and plasma drug levels in breastfeeding mother-infant pairsC Neill Epperson
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
Pediatrics 112:e425. 2003..Thus, to extend our previous work in this area, we measured platelet 5-HT levels and plasma drug levels in breastfeeding mother-infant pairs before and during maternal treatment with fluoxetine... - Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy studyC Neill Epperson
Yale Behavioral Gynecology Program, Department of Psychiatry, Yale University School of Medicine University Towers, Suite 2H, 100 York St, New Haven, CT 06511, USA
Arch Gen Psychiatry 59:851-8. 2002.... - Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depressionGerard Sanacora
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Arch Gen Psychiatry 61:705-13. 2004..An initial report, using this technique, suggested that occipital cortex GABA concentrations are reduced in patients with major depressive disorder (MDD) relative to healthy comparison subjects... - 123I-5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual phaseKelly P Cosgrove
Yale University School of Medicine, New Haven, Connecticut, USA
J Nucl Med 48:1633-40. 2007..We examined the availability of nAChR containing the beta(2) subunit in healthy men and women and the influence of menstrual phase among women... 
Onset and exacerbation of obsessive-compulsive disorder in pregnancy and the postpartum periodAriadna Forray
Departments of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
J Clin Psychiatry 71:1061-8. 2010..The primary goal of this study was to examine the impact of pregnancy, childbirth, and menstruation on the onset of obsessive-compulsive disorder (OCD) and/or exacerbation of OCD symptoms...- Estradiol and tryptophan depletion interact to modulate cognition in menopausal womenZenab Amin
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
Neuropsychopharmacology 31:2489-97. 2006..These data support the interaction of estrogen and 5-HT in nonreproductive behavior in humans as well as highlight the role of ovarian steroids in cognition... - Increase in prefrontal cortex serotonin 2A receptors following estrogen treatment in postmenopausal womenAkira Kugaya
Department of Psychiatry, Yale University, New Haven, Conn 06516, USA
Am J Psychiatry 160:1522-4. 2003..This study investigated the effect of estrogen on brain serotonin 2A (5-HT(2A)) receptors in postmenopausal women and whether there was any correlation of receptor changes with cognition and mood... - Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smokingGraeme F Mason
NIAAA Center for the Translational Neuroscience of Alcoholism and Department of Psychiatry, Yale University, School of Medicine, New Haven, CT 06520, USA
Biol Psychiatry 59:85-93. 2006..This study's objective was to measure time-dependent cortical GABA levels with sobriety in ethanol-dependent patients with mild to moderate withdrawal severity, controlling for alcoholism-related neurotoxicity and smoking... - Platelet serotonin in newborns and infants: ontogeny, heritability, and effect of in utero exposure to selective serotonin reuptake inhibitorsGeorge M Anderson
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Pediatr Res 56:418-22. 2004..The observed mother-infant correlation agrees with a previous report of high heritability in a large adult population... - The role of sex steroids in catamenial epilepsy and premenstrual dysphoric disorder: implications for diagnosis and treatmentConstance Guille
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Epilepsy Behav 13:12-24. 2008..Through exploration of the phenomenological and neurobiological overlap between CE and PMDD, we aim to highlight areas for future research and development of treatments for menstrual cycle-linked neuropsychiatric disorders... - Increased peripheral blood expression of electron transport chain genes in bipolar depressionRobert D Beech
Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA
Bipolar Disord 12:813-24. 2010..To identify specific genetic pathways showing altered expression in peripheral blood of depressed subjects with bipolar disorder (BPD)... - An open trial of morning light therapy for treatment of antepartum depressionDan A Oren
Pychiatry Department, Yale University, New Haven, CT, USA
Am J Psychiatry 159:666-9. 2002..No pharmacotherapy is specifically approved for antepartum depression; novel treatment approaches may be welcome. The authors explored the use of morning bright light therapy for antepartum depression... - Prevalence of post-traumatic stress disorder in pregnant women with prior pregnancy complicationsAriadna Forray
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
J Matern Fetal Neonatal Med 22:522-7. 2009..To assess the prevalence of post-traumatic stress disorder (PTSD) in pregnant women with prior pregnancy complications... - Guidelines for the management of depression during pregnancyDeborah R Kim
Department of Psychiatry, University of Pennsylvania, 3535 Market Street, 2nd Floor, Philadelphia, PA 19104, USA
Curr Psychiatry Rep 12:279-81. 2010..Guidelines regarding the treatment of depression during pregnancy were recently published by the American Psychiatric Association and the American College of Obstetricians and Gynecologists. We provide a commentary on these guidelines... - A sequencing-based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controlsZenab Amin
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Am J Med Genet B Neuropsychiatr Genet 153:332-5. 2010..In addition, the E777K and N782T variants were found at low frequencies both in patients and population controls, suggesting that these variants have limited impact on risk for MDD...
Research Grants
- NEURONAL DYSFUNCTION IN PREMENSTRUAL DYSPHORIC DISORDERC Epperson; Fiscal Year: 2004..abstract_text> ..
- SSRI-INDUCED CHANGES IN CORTICAL GABA IN WOMEN WITH PMDDCYNTHIA EPPERSON; Fiscal Year: 2007..We anticipate that our findings will provide further support for the role of GABA and neurosteroids in the pathogenesis and treatment of PMDD. ..
- Neuroactive Steroids, GABA & Glutamate in PMDDC Epperson; Fiscal Year: 2007..abstract_text> ..
- Sex, GABA and Nicotine: A 1H-MRS StudyC Epperson; Fiscal Year: 2007....