Cynthia Neill Epperson

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairs
    N Epperson
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Am J Psychiatry 158:1631-7. 2001
  2. pmc Luteal-phase accentuation of acoustic startle response in women with premenstrual dysphoric disorder
    Cynthia Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 32:2190-8. 2007
  3. ncbi request reprint The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    J Psychopharmacol 21:414-20. 2007
  4. ncbi request reprint Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, and Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 186:425-33. 2006
  5. ncbi request reprint Sex, GABA, and nicotine: the impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, University Towers Suite 2H, 100 York Street, New Haven, CT 06511, USA
    Biol Psychiatry 57:44-8. 2005
  6. ncbi request reprint Randomized clinical trial of bright light therapy for antepartum depression: preliminary findings
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, University Towers Suite 2H, 100 York Street, New Haven, CT 06511, USA
    J Clin Psychiatry 65:421-5. 2004
  7. ncbi request reprint Maternal fluoxetine treatment in the postpartum period: effects on platelet serotonin and plasma drug levels in breastfeeding mother-infant pairs
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Pediatrics 112:e425. 2003
  8. ncbi request reprint Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study
    C Neill Epperson
    Yale Behavioral Gynecology Program, Department of Psychiatry, Yale University School of Medicine University Towers, Suite 2H, 100 York St, New Haven, CT 06511, USA
    Arch Gen Psychiatry 59:851-8. 2002
  9. ncbi request reprint Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Arch Gen Psychiatry 61:705-13. 2004
  10. ncbi request reprint 123I-5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual phase
    Kelly P Cosgrove
    Yale University School of Medicine, New Haven, Connecticut, USA
    J Nucl Med 48:1633-40. 2007

Research Grants

Detail Information

Publications21

  1. ncbi request reprint Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairs
    N Epperson
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Am J Psychiatry 158:1631-7. 2001
    ..This study determined the degree of transporter blockade in infants exposed to sertraline through maternal breast milk...
  2. pmc Luteal-phase accentuation of acoustic startle response in women with premenstrual dysphoric disorder
    Cynthia Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 32:2190-8. 2007
    ..Physiologic response to affective stimuli appears to be intact in women with PMDD across the menstrual cycle...
  3. ncbi request reprint The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    J Psychopharmacol 21:414-20. 2007
    ..While preliminary, the results suggest that serotonin may be less critical to the pathogenesis of depression during the menopause...
  4. ncbi request reprint Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, and Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 186:425-33. 2006
    ..Childbirth is associated with rapid neuroendocrine fluctuations, which are thought to contribute to the phatogenesis of postpartum major depression (PPD)...
  5. ncbi request reprint Sex, GABA, and nicotine: the impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, University Towers Suite 2H, 100 York Street, New Haven, CT 06511, USA
    Biol Psychiatry 57:44-8. 2005
    ..Given that nicotine modulates amino acid neurotransmission, we sought to examine the impact of nicotine on cortical gamma-aminobutyric acid (GABA) levels in male and female smokers...
  6. ncbi request reprint Randomized clinical trial of bright light therapy for antepartum depression: preliminary findings
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, University Towers Suite 2H, 100 York Street, New Haven, CT 06511, USA
    J Clin Psychiatry 65:421-5. 2004
    ..Bright light therapy was shown to be a promising treatment for depression during pregnancy in a recent open-label study. In an extension of this work, we report findings from a double-blind placebo-controlled pilot study...
  7. ncbi request reprint Maternal fluoxetine treatment in the postpartum period: effects on platelet serotonin and plasma drug levels in breastfeeding mother-infant pairs
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Pediatrics 112:e425. 2003
    ..Thus, to extend our previous work in this area, we measured platelet 5-HT levels and plasma drug levels in breastfeeding mother-infant pairs before and during maternal treatment with fluoxetine...
  8. ncbi request reprint Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study
    C Neill Epperson
    Yale Behavioral Gynecology Program, Department of Psychiatry, Yale University School of Medicine University Towers, Suite 2H, 100 York St, New Haven, CT 06511, USA
    Arch Gen Psychiatry 59:851-8. 2002
    ....
  9. ncbi request reprint Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Arch Gen Psychiatry 61:705-13. 2004
    ..An initial report, using this technique, suggested that occipital cortex GABA concentrations are reduced in patients with major depressive disorder (MDD) relative to healthy comparison subjects...
  10. ncbi request reprint 123I-5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual phase
    Kelly P Cosgrove
    Yale University School of Medicine, New Haven, Connecticut, USA
    J Nucl Med 48:1633-40. 2007
    ..We examined the availability of nAChR containing the beta(2) subunit in healthy men and women and the influence of menstrual phase among women...
  11. doi request reprint Onset and exacerbation of obsessive-compulsive disorder in pregnancy and the postpartum period
    Ariadna Forray
    Departments of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Psychiatry 71:1061-8. 2010
    ..The primary goal of this study was to examine the impact of pregnancy, childbirth, and menstruation on the onset of obsessive-compulsive disorder (OCD) and/or exacerbation of OCD symptoms...
  12. ncbi request reprint Estradiol and tryptophan depletion interact to modulate cognition in menopausal women
    Zenab Amin
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 31:2489-97. 2006
    ..These data support the interaction of estrogen and 5-HT in nonreproductive behavior in humans as well as highlight the role of ovarian steroids in cognition...
  13. ncbi request reprint Increase in prefrontal cortex serotonin 2A receptors following estrogen treatment in postmenopausal women
    Akira Kugaya
    Department of Psychiatry, Yale University, New Haven, Conn 06516, USA
    Am J Psychiatry 160:1522-4. 2003
    ..This study investigated the effect of estrogen on brain serotonin 2A (5-HT(2A)) receptors in postmenopausal women and whether there was any correlation of receptor changes with cognition and mood...
  14. ncbi request reprint Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smoking
    Graeme F Mason
    NIAAA Center for the Translational Neuroscience of Alcoholism and Department of Psychiatry, Yale University, School of Medicine, New Haven, CT 06520, USA
    Biol Psychiatry 59:85-93. 2006
    ..This study's objective was to measure time-dependent cortical GABA levels with sobriety in ethanol-dependent patients with mild to moderate withdrawal severity, controlling for alcoholism-related neurotoxicity and smoking...
  15. ncbi request reprint Platelet serotonin in newborns and infants: ontogeny, heritability, and effect of in utero exposure to selective serotonin reuptake inhibitors
    George M Anderson
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Pediatr Res 56:418-22. 2004
    ..The observed mother-infant correlation agrees with a previous report of high heritability in a large adult population...
  16. doi request reprint The role of sex steroids in catamenial epilepsy and premenstrual dysphoric disorder: implications for diagnosis and treatment
    Constance Guille
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Epilepsy Behav 13:12-24. 2008
    ..Through exploration of the phenomenological and neurobiological overlap between CE and PMDD, we aim to highlight areas for future research and development of treatments for menstrual cycle-linked neuropsychiatric disorders...
  17. pmc Increased peripheral blood expression of electron transport chain genes in bipolar depression
    Robert D Beech
    Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA
    Bipolar Disord 12:813-24. 2010
    ..To identify specific genetic pathways showing altered expression in peripheral blood of depressed subjects with bipolar disorder (BPD)...
  18. ncbi request reprint An open trial of morning light therapy for treatment of antepartum depression
    Dan A Oren
    Pychiatry Department, Yale University, New Haven, CT, USA
    Am J Psychiatry 159:666-9. 2002
    ..No pharmacotherapy is specifically approved for antepartum depression; novel treatment approaches may be welcome. The authors explored the use of morning bright light therapy for antepartum depression...
  19. doi request reprint Prevalence of post-traumatic stress disorder in pregnant women with prior pregnancy complications
    Ariadna Forray
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    J Matern Fetal Neonatal Med 22:522-7. 2009
    ..To assess the prevalence of post-traumatic stress disorder (PTSD) in pregnant women with prior pregnancy complications...
  20. doi request reprint Guidelines for the management of depression during pregnancy
    Deborah R Kim
    Department of Psychiatry, University of Pennsylvania, 3535 Market Street, 2nd Floor, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 12:279-81. 2010
    ..Guidelines regarding the treatment of depression during pregnancy were recently published by the American Psychiatric Association and the American College of Obstetricians and Gynecologists. We provide a commentary on these guidelines...
  21. pmc A sequencing-based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controls
    Zenab Amin
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 153:332-5. 2010
    ..In addition, the E777K and N782T variants were found at low frequencies both in patients and population controls, suggesting that these variants have limited impact on risk for MDD...

Research Grants5

  1. NEURONAL DYSFUNCTION IN PREMENSTRUAL DYSPHORIC DISORDER
    C Epperson; Fiscal Year: 2004
    ..abstract_text> ..
  2. SSRI-INDUCED CHANGES IN CORTICAL GABA IN WOMEN WITH PMDD
    CYNTHIA EPPERSON; Fiscal Year: 2007
    ..We anticipate that our findings will provide further support for the role of GABA and neurosteroids in the pathogenesis and treatment of PMDD. ..
  3. Neuroactive Steroids, GABA & Glutamate in PMDD
    C Epperson; Fiscal Year: 2007
    ..abstract_text> ..
  4. Sex, GABA and Nicotine: A 1H-MRS Study
    C Epperson; Fiscal Year: 2007
    ....