Research Topics
| John ElsworthSummaryAffiliation: Yale University Country: USA Publications
Research Grants
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Publications
Prenatal exposure to bisphenol A impacts midbrain dopamine neurons and hippocampal spine synapses in non-human primatesJohn D Elsworth
Department of Psychiatry, Yale University, School of Medicine, New Haven, CT, USA
Neurotoxicology 35:113-20. 2013..These data indicate that BPA exerts an age-dependent detrimental impact on primate brain development, at blood levels within the range measured in humans having only environmental contact with BPA...
Phencyclidine-induced loss of asymmetric spine synapses in rodent prefrontal cortex is reversed by acute and chronic treatment with olanzapineJohn D Elsworth
Laboratory of Neuropsychopharmacology, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
Neuropsychopharmacology 36:2054-61. 2011....- AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neuronsJ D Elsworth
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Exp Neurol 211:252-8. 2008..Thus, the addition of GDNF gene therapy to neural transplantation may be a useful strategy to improve treatment for Parkinson's disease... - Prenatal cocaine exposure enhances responsivity of locus coeruleus norepinephrine neurons: role of autoreceptorsJ D Elsworth
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
Neuroscience 147:419-27. 2007.... 
Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidineJohn D Elsworth
Neuropsychopharmacology Research Unit, Departments of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
Neuropsychopharmacology 33:491-6. 2008..Thus, the present data support the hypothesis that the therapeutic effects of clozapine in this primate model and perhaps in schizophrenia may be related at least in part to the restoration of DA tone in the prefrontal cortex...- Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stressJ D Elsworth
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520 8068, USA
Synapse 42:80-3. 2001..Thus, this biochemical alteration may be central to some of the cognitive deficits exhibited by offspring that were exposed to cocaine during fetal development... - Development of A9/A10 dopamine neurons during the second and third trimesters in the African green monkeyBret A Morrow
Neuropsychopharmacology Research Unit, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CN 06511, USA
J Comp Neurol 488:215-23. 2005..These data have relevance to transplantation studies that employ fetal dopaminergic grafts, and to disorders hypothesized to result from damage to developing midbrain dopamine neurons... - Uncoupling protein-2 promotes nigrostriatal dopamine neuronal functionZane B Andrews
Department of Obstetrics, Gynecology and Reproductive Services, Yale University School of Medicine, New Haven, CT 06510, USA
Eur J Neurosci 24:32-6. 2006.... - Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's diseaseTamas L Horvath
Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Endocrinology 144:2757-60. 2003..Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys... - Male rats exposed to cocaine in utero demonstrate elevated expression of Fos in the prefrontal cortex in response to environmentBret A Morrow
Department of Pharmacology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8066, USA
Neuropsychopharmacology 26:275-85. 2002..The unusual activation of the neurons of the medial and ventral prefrontal cortex may be a consequence of in utero cocaine exposure that contributes to the reported deficit in cognition... - Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cellsD Eugene Redmond
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 104:12175-80. 2007..We propose that multiple modes of reciprocal interaction between exogenous hNSCs and the pathological host milieu underlie the functional improvement observed in this model of PD... - Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortexBret A Morrow
Department of Psychiatry, Neuropsychopharmacology Research Unit, Yale University School of Medicine, New Haven, CT 06511, USA
Synapse 61:862-5. 2007..The increase in number of excitatory synaptic inputs associated with prenatal cocaine exposure could contribute to the increased neuronal activation and cognitive deficits noted... - Prenatal cocaine exposure disrupts non-spatial, short-term memory in adolescent and adult male ratsBret A Morrow
Department of Psychiatry, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8066, USA
Behav Brain Res 129:217-23. 2002..This study suggests that prenatal exposure to cocaine can result in a long-lasting deficit in non-spatial, short-term memory in a spontaneously performed task... - Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanismZane B Andrews
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Neurosci 29:14057-65. 2009..Finally, we discuss the potential implications of these studies on the link between obesity and neurodegeneration... - Cellular repair in the parkinsonian nonhuman primate brainDONALD EUGENE REDMOND
Department of Psychiatry and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06511, USA
Rejuvenation Res 13:188-94. 2010..Studies to determine the optimum stage of differentiation from embryonic stem cells and to derive useful cells from somatic cell sources are in progress... - Selective activation of the A10, but not A9, dopamine neurons in the rat by the predator odor, 2,5-dihydro-2,4,5-trimethylthiazolineAndy J Redmond
Laboratory of Neuropsychopharmacology, Yale University School of Medicine, 333 Cedar Street, 06520-8066, New Haven, CT, USA
Neurosci Lett 328:209-12. 2002..Exposure to TMT may result in alterations in the A10 neurons that could contribute to an altered response to subsequent stresses... - Apoptotic natural cell death in developing primate dopamine midbrain neurons occurs during a restricted period in the second trimester of gestationBret A Morrow
Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA
Exp Neurol 204:802-7. 2007..Thus, marked apoptotic NCD occurs in the primate midbrain dopamine system half-way through gestation, and appears to be associated with the rapid developmental increase in striatal dopamine innervation... - Repeated phencyclidine in monkeys results in loss of parvalbumin-containing axo-axonic projections in the prefrontal cortexBret A Morrow
Yale University School of Medicine, New Haven, CT 06511, USA
Psychopharmacology (Berl) 192:283-90. 2007.... - Fear-like biochemical and behavioral responses in rats to the predator odor, TMT, are dependent on the exposure environmentBret A Morrow
Department of Psychiatry, Laboratory of Neuropsychopharmacology, Yale University School of Medicine, New Haven, Connecticut 06520 8066, USA
Synapse 46:11-8. 2002.... - Axo-axonic structures in the medial prefrontal cortex of the rat: reduction by prenatal exposure to cocaineBret A Morrow
Neuropsychopharmacology Research Unit, Departments of Pharmacology and Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520 8066, USA
J Neurosci 23:5227-34. 2003..We conclude that exposure to cocaine in utero disrupts the development of the axo-axonic cells in the prefrontal cortex and this disruption could contribute to the cognitive deficits reported with prenatal cocaine exposure... - Prenatal exposure to cocaine selectively disrupts the development of parvalbumin containing local circuit neurons in the medial prefrontal cortex of the ratBret A Morrow
Neuropsychopharmacology Research Unit, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520 8066, USA
Synapse 56:1-11. 2005..These changes to the excitatory/inhibitory balance in the frontal cortex may contribute to the cognitive deficits associated with prenatal cocaine exposure... - Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's diseaseZane B Andrews
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Neurosci 25:184-91. 2005..The present results expose the critical importance of UCP2 in normal nigral dopamine cell metabolism and offer a novel therapeutic target, UCP2, for the prevention/treatment of Parkinson's disease... - Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brainEleni A Markakis
Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06511, USA
Mol Ther 18:588-93. 2010..These results suggest that AAV5 is a more effective vector than AAV2 at delivering potentially therapeutic transgenes to the nigrostriatal system of the primate brain... - Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetiteAlfonso Abizaid
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06519, USA
J Clin Invest 116:3229-39. 2006..Taken together, these data suggest that the mesolimbic reward circuitry is targeted by peripheral ghrelin to influence physiological mechanisms related to feeding... - Partial dopamine loss enhances activated caspase-3 activity: differential outcomes in striatal projection systemsMarjorie A Ariano
Department of Neuroscience, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
J Neurosci Res 82:387-96. 2005..These observations could be capitalized upon to develop therapeutic interventions in the preclinical phases of the disorder... - Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's diseaseTimothy J Collier
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Comp Neurol 442:320-30. 2002..These results encourage the further development of multiple-target grafting strategies as a means of restoring modulation of anatomically widespread basal ganglia structures relevant to treatment of Parkinson's disease... - Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's diseaseKimberly B Bjugstad
Department of Pediatrics, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, CO 80045, USA
Exp Neurol 211:362-9. 2008..The property of neural stem cells to align themselves along a neural pathway rendered dysfunctional by a given disease is potentially a valuable clinical tool...
Research Grants
- Selective Prenatal Dopamine Damage in Non Human PrimatesJohn Elsworth; Fiscal Year: 2003..Thus, the proposed work may lead ultimately to an animal model for one or more pediatric brain disorders. ..
- Susceptibility of Primate Dopamine Neurons to Toxicity During DevelopmentJohn D Elsworth; Fiscal Year: 2010..The studies have direct relevance to the risk of acquiring Parkinson's disease and to the behavioral consequences of exposure to drugs of abuse during development. ..
- Dopamine Modulation of Cortical Spine Synapses and Cognition in MPTP MonkeysJohn D Elsworth; Fiscal Year: 2010....