John Elsworth

Summary

Affiliation: Yale University
Country: USA

Publications

  1. doi request reprint Coordinated expression of dopamine transporter and vesicular monoamine transporter in the primate striatum during development
    John D Elsworth
    Neuropsychopharmacology Research Laboratory, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Synapse 67:580-5. 2013
  2. pmc Loss of asymmetric spine synapses in prefrontal cortex of motor-asymptomatic, dopamine-depleted, cognitively impaired MPTP-treated monkeys
    John D Elsworth
    Neuropsychopharmacology Research Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Int J Neuropsychopharmacol 16:905-12. 2013
  3. pmc Prenatal exposure to bisphenol A impacts midbrain dopamine neurons and hippocampal spine synapses in non-human primates
    John D Elsworth
    Department of Psychiatry, Yale University, School of Medicine, New Haven, CT, USA
    Neurotoxicology 35:113-20. 2013
  4. pmc Phencyclidine-induced loss of asymmetric spine synapses in rodent prefrontal cortex is reversed by acute and chronic treatment with olanzapine
    John D Elsworth
    Laboratory of Neuropsychopharmacology, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 36:2054-61. 2011
  5. pmc AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons
    J D Elsworth
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Exp Neurol 211:252-8. 2008
  6. pmc Prenatal cocaine exposure enhances responsivity of locus coeruleus norepinephrine neurons: role of autoreceptors
    J D Elsworth
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuroscience 147:419-27. 2007
  7. ncbi request reprint Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine
    John D Elsworth
    Neuropsychopharmacology Research Unit, Departments of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 33:491-6. 2008
  8. ncbi request reprint Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stress
    J D Elsworth
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520 8068, USA
    Synapse 42:80-3. 2001
  9. ncbi request reprint Development of A9/A10 dopamine neurons during the second and third trimesters in the African green monkey
    Bret A Morrow
    Neuropsychopharmacology Research Unit, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CN 06511, USA
    J Comp Neurol 488:215-23. 2005
  10. ncbi request reprint Uncoupling protein-2 promotes nigrostriatal dopamine neuronal function
    Zane B Andrews
    Department of Obstetrics, Gynecology and Reproductive Services, Yale University School of Medicine, New Haven, CT 06510, USA
    Eur J Neurosci 24:32-6. 2006

Detail Information

Publications29

  1. doi request reprint Coordinated expression of dopamine transporter and vesicular monoamine transporter in the primate striatum during development
    John D Elsworth
    Neuropsychopharmacology Research Laboratory, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Synapse 67:580-5. 2013
    ..In addition, this study demonstrated that there is a coordinated expression of DAT and VMAT2 from the time of mid-gestation to adulthood...
  2. pmc Loss of asymmetric spine synapses in prefrontal cortex of motor-asymptomatic, dopamine-depleted, cognitively impaired MPTP-treated monkeys
    John D Elsworth
    Neuropsychopharmacology Research Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Int J Neuropsychopharmacol 16:905-12. 2013
    ....
  3. pmc Prenatal exposure to bisphenol A impacts midbrain dopamine neurons and hippocampal spine synapses in non-human primates
    John D Elsworth
    Department of Psychiatry, Yale University, School of Medicine, New Haven, CT, USA
    Neurotoxicology 35:113-20. 2013
    ..These data indicate that BPA exerts an age-dependent detrimental impact on primate brain development, at blood levels within the range measured in humans having only environmental contact with BPA...
  4. pmc Phencyclidine-induced loss of asymmetric spine synapses in rodent prefrontal cortex is reversed by acute and chronic treatment with olanzapine
    John D Elsworth
    Laboratory of Neuropsychopharmacology, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 36:2054-61. 2011
    ....
  5. pmc AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons
    J D Elsworth
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Exp Neurol 211:252-8. 2008
    ..Thus, the addition of GDNF gene therapy to neural transplantation may be a useful strategy to improve treatment for Parkinson's disease...
  6. pmc Prenatal cocaine exposure enhances responsivity of locus coeruleus norepinephrine neurons: role of autoreceptors
    J D Elsworth
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuroscience 147:419-27. 2007
    ....
  7. ncbi request reprint Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine
    John D Elsworth
    Neuropsychopharmacology Research Unit, Departments of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 33:491-6. 2008
    ..Thus, the present data support the hypothesis that the therapeutic effects of clozapine in this primate model and perhaps in schizophrenia may be related at least in part to the restoration of DA tone in the prefrontal cortex...
  8. ncbi request reprint Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stress
    J D Elsworth
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520 8068, USA
    Synapse 42:80-3. 2001
    ..Thus, this biochemical alteration may be central to some of the cognitive deficits exhibited by offspring that were exposed to cocaine during fetal development...
  9. ncbi request reprint Development of A9/A10 dopamine neurons during the second and third trimesters in the African green monkey
    Bret A Morrow
    Neuropsychopharmacology Research Unit, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CN 06511, USA
    J Comp Neurol 488:215-23. 2005
    ..These data have relevance to transplantation studies that employ fetal dopaminergic grafts, and to disorders hypothesized to result from damage to developing midbrain dopamine neurons...
  10. ncbi request reprint Uncoupling protein-2 promotes nigrostriatal dopamine neuronal function
    Zane B Andrews
    Department of Obstetrics, Gynecology and Reproductive Services, Yale University School of Medicine, New Haven, CT 06510, USA
    Eur J Neurosci 24:32-6. 2006
    ....
  11. ncbi request reprint Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease
    Zane B Andrews
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 25:184-91. 2005
    ..The present results expose the critical importance of UCP2 in normal nigral dopamine cell metabolism and offer a novel therapeutic target, UCP2, for the prevention/treatment of Parkinson's disease...
  12. ncbi request reprint Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex
    Bret A Morrow
    Department of Psychiatry, Neuropsychopharmacology Research Unit, Yale University School of Medicine, New Haven, CT 06511, USA
    Synapse 61:862-5. 2007
    ..The increase in number of excitatory synaptic inputs associated with prenatal cocaine exposure could contribute to the increased neuronal activation and cognitive deficits noted...
  13. ncbi request reprint Selective activation of the A10, but not A9, dopamine neurons in the rat by the predator odor, 2,5-dihydro-2,4,5-trimethylthiazoline
    Andy J Redmond
    Laboratory of Neuropsychopharmacology, Yale University School of Medicine, 333 Cedar Street, 06520 8066, New Haven, CT, USA
    Neurosci Lett 328:209-12. 2002
    ..Exposure to TMT may result in alterations in the A10 neurons that could contribute to an altered response to subsequent stresses...
  14. pmc Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism
    Zane B Andrews
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 29:14057-65. 2009
    ..Finally, we discuss the potential implications of these studies on the link between obesity and neurodegeneration...
  15. pmc Cellular repair in the parkinsonian nonhuman primate brain
    DONALD EUGENE REDMOND
    Department of Psychiatry and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Rejuvenation Res 13:188-94. 2010
    ..Studies to determine the optimum stage of differentiation from embryonic stem cells and to derive useful cells from somatic cell sources are in progress...
  16. ncbi request reprint Male rats exposed to cocaine in utero demonstrate elevated expression of Fos in the prefrontal cortex in response to environment
    Bret A Morrow
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8066, USA
    Neuropsychopharmacology 26:275-85. 2002
    ..The unusual activation of the neurons of the medial and ventral prefrontal cortex may be a consequence of in utero cocaine exposure that contributes to the reported deficit in cognition...
  17. ncbi request reprint Prenatal cocaine exposure disrupts non-spatial, short-term memory in adolescent and adult male rats
    Bret A Morrow
    Department of Psychiatry, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8066, USA
    Behav Brain Res 129:217-23. 2002
    ..This study suggests that prenatal exposure to cocaine can result in a long-lasting deficit in non-spatial, short-term memory in a spontaneously performed task...
  18. pmc Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells
    D Eugene Redmond
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:12175-80. 2007
    ..We propose that multiple modes of reciprocal interaction between exogenous hNSCs and the pathological host milieu underlie the functional improvement observed in this model of PD...
  19. ncbi request reprint Fear-like biochemical and behavioral responses in rats to the predator odor, TMT, are dependent on the exposure environment
    Bret A Morrow
    Department of Psychiatry, Laboratory of Neuropsychopharmacology, Yale University School of Medicine, New Haven, Connecticut 06520 8066, USA
    Synapse 46:11-8. 2002
    ....
  20. ncbi request reprint Prenatal exposure to cocaine selectively disrupts the development of parvalbumin containing local circuit neurons in the medial prefrontal cortex of the rat
    Bret A Morrow
    Neuropsychopharmacology Research Unit, Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520 8066, USA
    Synapse 56:1-11. 2005
    ..These changes to the excitatory/inhibitory balance in the frontal cortex may contribute to the cognitive deficits associated with prenatal cocaine exposure...
  21. ncbi request reprint Repeated phencyclidine in monkeys results in loss of parvalbumin-containing axo-axonic projections in the prefrontal cortex
    Bret A Morrow
    Yale University School of Medicine, New Haven, CT 06511, USA
    Psychopharmacology (Berl) 192:283-90. 2007
    ....
  22. ncbi request reprint Axo-axonic structures in the medial prefrontal cortex of the rat: reduction by prenatal exposure to cocaine
    Bret A Morrow
    Neuropsychopharmacology Research Unit, Departments of Pharmacology and Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520 8066, USA
    J Neurosci 23:5227-34. 2003
    ..We conclude that exposure to cocaine in utero disrupts the development of the axo-axonic cells in the prefrontal cortex and this disruption could contribute to the cognitive deficits reported with prenatal cocaine exposure...
  23. pmc Apoptotic natural cell death in developing primate dopamine midbrain neurons occurs during a restricted period in the second trimester of gestation
    Bret A Morrow
    Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA
    Exp Neurol 204:802-7. 2007
    ..Thus, marked apoptotic NCD occurs in the primate midbrain dopamine system half-way through gestation, and appears to be associated with the rapid developmental increase in striatal dopamine innervation...
  24. ncbi request reprint Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease
    Tamas L Horvath
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Endocrinology 144:2757-60. 2003
    ..Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys...
  25. pmc Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain
    Eleni A Markakis
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Mol Ther 18:588-93. 2010
    ..These results suggest that AAV5 is a more effective vector than AAV2 at delivering potentially therapeutic transgenes to the nigrostriatal system of the primate brain...
  26. pmc Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    Alfonso Abizaid
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06519, USA
    J Clin Invest 116:3229-39. 2006
    ..Taken together, these data suggest that the mesolimbic reward circuitry is targeted by peripheral ghrelin to influence physiological mechanisms related to feeding...
  27. pmc Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease
    Kimberly B Bjugstad
    Department of Pediatrics, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Exp Neurol 211:362-9. 2008
    ..The property of neural stem cells to align themselves along a neural pathway rendered dysfunctional by a given disease is potentially a valuable clinical tool...
  28. ncbi request reprint Partial dopamine loss enhances activated caspase-3 activity: differential outcomes in striatal projection systems
    Marjorie A Ariano
    Department of Neuroscience, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurosci Res 82:387-96. 2005
    ..These observations could be capitalized upon to develop therapeutic interventions in the preclinical phases of the disorder...
  29. ncbi request reprint Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 442:320-30. 2002
    ..These results encourage the further development of multiple-target grafting strategies as a means of restoring modulation of anatomically widespread basal ganglia structures relevant to treatment of Parkinson's disease...

Research Grants5

  1. Selective Prenatal Dopamine Damage in Non Human Primates
    John Elsworth; Fiscal Year: 2003
    ..Thus, the proposed work may lead ultimately to an animal model for one or more pediatric brain disorders. ..
  2. Susceptibility of Primate Dopamine Neurons to Toxicity During Development
    John Elsworth; Fiscal Year: 2008
    ..The studies have direct relevance to the risk of acquiring Parkinson's disease and to the behavioral consequences of exposure to drugs of abuse during development. ..
  3. Susceptibility of Primate Dopamine Neurons to Toxicity During Development
    John Elsworth; Fiscal Year: 2009
    ..The studies have direct relevance to the risk of acquiring Parkinson's disease and to the behavioral consequences of exposure to drugs of abuse during development. ..
  4. Susceptibility of Primate Dopamine Neurons to Toxicity During Development
    John D Elsworth; Fiscal Year: 2010
    ..The studies have direct relevance to the risk of acquiring Parkinson's disease and to the behavioral consequences of exposure to drugs of abuse during development. ..
  5. Dopamine Modulation of Cortical Spine Synapses and Cognition in MPTP Monkeys
    John D Elsworth; Fiscal Year: 2010
    ....