Research Topics
Species | T EidSummaryAffiliation: Yale University Country: USA Publications
Research Grants
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Detail Information
Publications
Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsyTore Eid
Departments of Laboratory Medicine Psychiatry Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8035, USA
Epilepsia 54:228-38. 2013..However, the molecular mechanism of the enzyme perturbations remains unclear. A better understanding of the regulatory mechanisms of GS and PAG could facilitate the discovery of novel therapeutics for TLE...
Roles of glutamine synthetase inhibition in epilepsyTore Eid
Department of Laboratory Medicine, Yale University School of Medicine, 330 Cedar Street, P O Box 208035, New Haven, CT 06520 8035, USA
Neurochem Res 37:2339-50. 2012..The goals of this review are to summarize key features of mammalian GS under normal conditions, and discuss the consequences of GS deficiency in brain disorders, specifically MTLE...- Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy?Tore Eid
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Epilepsia 49:42-52. 2008..Here, we assess recent data regarding the glutamate excess in epilepsy, review the role of glutamine synthetase, and discuss the implications of astrocytes in the pathophysiology of MTLE... - Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampusTore Eid
Department of Neurosurgery, Laboratory Medicine, and Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 102:1193-8. 2005..We postulate that the loss of perivascular AQP4 in MTLE is likely to result in a perturbed flux of water through astrocytes leading to an impaired buffering of extracellular K+ and an increased propensity for seizures... 
Increased expression of erythropoietin receptor on blood vessels in the human epileptogenic hippocampus with sclerosisTore Eid
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
J Neuropathol Exp Neurol 63:73-83. 2004..Moreover, the presence of EPO-r in the MTLE hippocampus may provide a new vehicle for highly efficient delivery of hitherto impermeable drugs into the epileptic brain...- Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsyT Eid
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA
Lancet 363:28-37. 2004..We investigated whether a deficiency in glutamine synthetase, a key enzyme in catabolism of extracellular glutamate in the brain, could explain the perturbed glutamate homoeostasis in MTLE... - Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in ratsTore Eid
Department of Laboratory Medicine, Yale University School of Medicine, 333 Cedar Street, P O Box 208035, New Haven, CT 06520 8035, USA
Brain 131:2061-70. 2008.... - Recombinant human erythropoietin for neuroprotection: what is the evidence?Tore Eid
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Clin Breast Cancer 3:S109-15. 2002..While all these studies are based on experiments in animal models, the effectiveness of rHuEPO in ischemic stroke in human patients has recently been suggested in a proof-of-concept trial, which is also discussed... - Novel expression of AMPA-receptor subunit GluR1 on mossy cells and CA3 pyramidal neurons in the human epileptogenic hippocampusTore Eid
Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, PO Box 208082, New Haven, CT 06520 8082, USA
Eur J Neurosci 15:517-27. 2002..Such a circuit could be critically involved in the genesis and maintenance of temporal lobe epilepsy... - Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsyTore Eid
Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, P O Box 208082, New Haven, CT 06520 8082, USA
Acta Neuropathol 113:137-52. 2007..This increase suggests an enhanced capacity for glutamate synthesis-a finding that might contribute to the disrupted glutamate homeostasis in MTLE... - Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsyTih Shih Lee
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Acta Neuropathol (Berl) 108:493-502. 2004.... - Glutamate receptor subunits GluR1 and GluR2/3 distribution shows reorganization in the human epileptogenic hippocampusN C de Lanerolle
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
Eur J Neurosci 10:1687-703. 1998..GluR2/3 was also significantly increased on the dendrites of dentate granule cells in the epileptogenic hippocampus and may provide some protection against excitotoxic injury by reducing calcium flux into neurons... - False negative PCR despite high levels of JC virus DNA in spinal fluid: Implications for diagnostic testingMarie L Landry
Department of Laboratory Medicine, 333 Cedar Street, Yale University School of Medicine, New Haven, CT 06520 8035, USA
J Clin Virol 43:247-9. 2008..Ultimately, brain biopsy established the diagnosis of progressive multifocal leukoencephalopathy (PML). Repeat PCR testing of the same CSF targeting a different region of the genome yielded a high positive result... - The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: a video-intracranial electroencephalographic studyYue Wang
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA
Exp Neurol 220:293-302. 2009..In conclusion, the model of intrahippocampal MSO infusion replicates key features of human MTLE and may represent a useful tool for further studies of the cellular, molecular and electrophysiological mechanisms of this disorder... - A retrospective analysis of hippocampal pathology in human temporal lobe epilepsy: evidence for distinctive patient subcategoriesNihal C de Lanerolle
Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8082, U S A
Epilepsia 44:677-87. 2003..We attempted to relate neuronal density, immunohistochemistry, electrophysiologic data, and surgical outcome... - GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampusTih-Shih Lee
Department of Psychiatry, Yale University School of Medicine, Park Street, New Haven, CT 06520, USA
Acta Neuropathol (Berl) 111:351-63. 2006.... - Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytesTih Shih Lee
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520 8082, USA
Mol Med 13:1-13. 2007..Such glutamate release may excite surrounding neurons and elicit seizure activity... - Differential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsyGauri H Malthankar-Phatak
Department of Pharmaceutical Sciences, College of Pharmacy, Idaho State University, Pocatello, Idaho 83209, USA
Epilepsia 47:1292-9. 2006..It is proposed that significant alterations in the enzyme activities may be contributing to decreased metabolism of glutamate, leading to its accumulation... - Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null miceMahmood Amiry-Moghaddam
Centre for Molecular Biology and Neuroscience, University of Oslo, 0317 Oslo, Norway
Proc Natl Acad Sci U S A 100:13615-20. 2003..These studies lead us to propose that water flux through perivascular AQP4 is needed to sustain efficient removal of K+ after neuronal activation...
Research Grants
- Herpes Simplex Virus, Early Brain Injury and EpilepsyTore Eid; Fiscal Year: 2004..If a viral causation of TLE is established, then this would not only open new avenues for prevention and control of this disorder, but also improve our understanding of viral-induced brain injury. ..
- Temporal lobe epilepsy - validation of a new animal modelTore Eid; Fiscal Year: 2007..More effective therapies of epilepsy are therefore needed. This proposal seeks to validate a new animal model that may greatly speed up the search for better therapies against this disorder. ..
- Glutamine Synthetase and the Mechanism of Seizures in Mesial Temporal Lobe EpilepTore Eid; Fiscal Year: 2010..This proposal seeks to identify novel diagnostic markers and treatments of one of the most common forms of drug resistant epilepsies, mesial temporal lobe epilepsy (MTLE). ..