Research Topics
| R A EhrenkranzSummaryAffiliation: Yale University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Inhaled nitric oxide in preterm infants: a systematic review and individual patient data meta-analysisLisa M Askie
NHMRC Clinical Trials Centre, University of Sydney, Australia
BMC Pediatr 10:15. 2010....
NICHD neonatal research network: contributions and future challengesRichard A Ehrenkranz
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
Semin Perinatol 27:264-80. 2003....- Growth in the neonatal intensive care unit influences neurodevelopmental and growth outcomes of extremely low birth weight infantsRichard A Ehrenkranz
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
Pediatrics 117:1253-61. 2006.... - Estimated fetal weights versus birth weights: should the reference intrauterine growth curves based on birth weights be retired?Richard A Ehrenkranz
Yale University School of Medicine, 333 Cedar Street, PO Box 208064, New Haven, CT 06520 8064
Arch Dis Child Fetal Neonatal Ed 92:F161-2. 2007 - Early, aggressive nutritional management for very low birth weight infants: what is the evidence?Richard A Ehrenkranz
Department of Pediatrics and Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520 8064, USA
Semin Perinatol 31:48-55. 2007..It is important that neonatal clinicians recognize the barriers and obstacles to the implementation of these recommendations... - Early nutrition mediates the influence of severity of illness on extremely LBW infantsRichard A Ehrenkranz
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Pediatr Res 69:522-9. 2011.... - Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasiaRichard A Ehrenkranz
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
Pediatrics 116:1353-60. 2005..The objective of this study was to determine the predictive validity of the severity-based, consensus definition of BPD... 
Early nutritional support and outcomes in ELBW infantsRichard A Ehrenkranz
Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Early Hum Dev 86:21-5. 2010..This paper will review the evidence supporting the provision of early nutritional support to extremely preterm infants by examining the outcomes associated with such practices...- Growth outcomes of very low-birth weight infants in the newborn intensive care unitR A Ehrenkranz
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
Clin Perinatol 27:325-45. 2000..Longitudinal growth curves of hospitalized VLBW infants, such as the ones described in this article, should not be considered optimal and should be updated as ways safely to improve the growth of VLBW infants are identified... - Longitudinal growth of hospitalized very low birth weight infantsR A Ehrenkranz
Yale University, New Haven, Connecticut, USA
Pediatrics 104:280-9. 1999..The interpretation of growth rates for very low birth weight infants is obscured by limited data, recent changes in perinatal care, and the uncertain effects of multiple therapies... - Sex differences in outcomes of very low birthweight infants: the newborn male disadvantageD K Stevenson
Department of Pediatrics, Stanford University, Palo Alto, CA 94305 5119, USA
Arch Dis Child Fetal Neonatal Ed 83:F182-5. 2000..To determine the differences in short term outcome of very low birthweight infants attributable to sex... - Clinical parameters do not adequately predict outcome in necrotizing enterocolitis: a multi-institutional studyR L Moss
Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
J Perinatol 28:665-74. 2008..We hypothesized that comprehensive prospective data collection at multiple centers would allow us to develop a model which would identify those babies at risk for progressive NEC... - Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birth weight preterm infantsK M Shannon
Department of Pediatrics, University of California, San Francisco 94143 0724, USA
Pediatrics 95:1-8. 1995..All patients received oral iron and were managed according to uniform conservative transfusion guidelines... - A randomized controlled trial of synchronized nasal intermittent positive pressure ventilation in RDSV Bhandari
Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, PA, USA
J Perinatol 27:697-703. 2007..Comparison of outcomes of infants with respiratory distress syndrome (RDS), post-surfactant, extubated to synchronized nasal intermittent positive pressure ventilation (SNIPPV) or continued on conventional ventilation (CV)... - Randomized trial of enteral protein and energy supplementation in infants less than or equal to 1250 g at birthH L Brumberg
Division of Newborn Medicine, Department of Pediatrics, New York Medical College, Maria Fareri Children s Hospital, Westchester Medical Center, Valhalla, NY 10595, USA
J Perinatol 30:517-21. 2010..To determine if enteral protein and energy supplementation would significantly improve weight gain as compared with energy supplementation alone in <or=1250 g infants... - Changes in arterial oxygen tension when weaning neonates from inhaled nitric oxideG M Sokol
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202 5271, USA
Pediatr Pulmonol 32:14-9. 2001..51). In conclusion, a graded decline in PaO(2) occurs when reducing INO. INO should be weaned to less than 1 ppm before discontinuing its use. Prior surfactant treatment appears to enhance the oxygenation reserve when weaning INO... - Predictors of death or bronchopulmonary dysplasia in preterm infants with respiratory failureN Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
J Perinatol 28:420-6. 2008..To identify the variables that predict death/physiologic bronchopulmonary dysplasia (BPD) in preterm infants with severe respiratory failure... - Neonatal auditory activation detected by functional magnetic resonance imagingA W Anderson
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA
Magn Reson Imaging 19:1-5. 2001..In contrast, signal decreases were detected during auditory stimulation in 9 of 14 newborns with BOLD response. fMRI can be used to detect brain activation with auditory stimulation in human infants... - Growth failure in the preterm infant: can we catch up?Anna M Dusick
Section of Developmental Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202 5119, USA
Semin Perinatol 27:302-10. 2003..Additional trials are needed to address a number of important questions concerning the role of nutrition and growth on ultimate development... - Parenteral nutrition-associated cholestasis in small for gestational age infantsDaniel T Robinson
Yale University School of Medicine, New Haven, Connecticut, USA
J Pediatr 152:59-62. 2008..To identify small for gestational age (SGA) as an independent risk factor for parenteral nutrition-associated cholestasis (PNAC)... - Early inhaled nitric oxide therapy for term and near-term newborn infants with hypoxic respiratory failure: neurodevelopmental follow-upG Ganesh Konduri
Medical College of WI, Dept of Pediatrics and the Children s Research Institute, Milwaukee, WI 53201 1997, USA
J Pediatr 150:235-40, 240.e1. 2007..To report the neurodevelopmental outcome of infants enrolled in a randomized multicenter trial of early inhaled nitric oxide (iNO) in term and near-term neonates with hypoxic respiratory failure and pulmonary hypertension... - Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research NetworkBarbara J Stoll
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Pediatrics 110:285-91. 2002..Strategies to reduce late-onset sepsis and its medical, social, and economic toll need to be addressed urgently... - Neurodevelopmental outcomes of premature infants with severe respiratory failure enrolled in a randomized controlled trial of inhaled nitric oxideSusan R Hintz
NICHD Neonatal Research Network
J Pediatr 151:16-22, 22.e1-3. 2007.... - Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposureSeetha Shankaran
Wayne State University, Detroit, MI, USA
Am J Obstet Gynecol 187:171-7. 2002.... - Community supports after surviving extremely low-birth-weight, extremely preterm birth: special outpatient services in early childhoodSusan R Hintz
Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California 94304, USA
Arch Pediatr Adolesc Med 162:748-55. 2008..To determine special outpatient services (SOS) use, need, associated factors, and neurodevelopmental and functional outcomes among extremely preterm infants at 18 to 22 months' corrected age... - Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 monthsConrad R Cole
Emory University School of Medicine, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, 2015 Uppergate Dr, Atlanta, GA 30322, USA
Pediatrics 122:e573-82. 2008.... - Effect of introduction of synchronized nasal intermittent positive-pressure ventilation in a neonatal intensive care unit on bronchopulmonary dysplasia and growth in preterm infantsAmeya Kulkarni
Division of Perinatal Medicine, Department of Pediatrics, Yale-New Haven Children's Hospital, New Haven, Connecticut 06520-8064, USA
Am J Perinatol 23:233-40. 2006.... - Early provision of parenteral amino acids in extremely low birth weight infants: relation to growth and neurodevelopmental outcomeBrenda B Poindexter
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, 46202, USA
J Pediatr 148:300-305. 2006..To determine if postnatal growth failure exerts an adverse effect on subsequent growth and neurodevelopment... - Parenteral glutamine supplementation does not reduce the risk of mortality or late-onset sepsis in extremely low birth weight infantsBrenda B Poindexter
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Pediatrics 113:1209-15. 2004..Whether glutamine supplementation would provide a similar benefit to extremely low birth weight (ELBW) infants is not known... - Neurodevelopmental outcome and growth at 18 to 22 months' corrected age in extremely low birth weight infants treated with early erythropoietin and ironRobin K Ohls
Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Pediatrics 114:1287-91. 2004..Clinical trials evaluating the use of erythropoietin (Epo) have demonstrated a limited reduction in transfusions; however, long-term developmental follow-up data are scarce... - Impact of postnatal systemic corticosteroids on mortality and cerebral palsy in preterm infants: effect modification by risk for chronic lung diseaseLex W Doyle
Division of Paediatrics, Royal Women s Hospital, 132 Grattan St, Carlton 3053, Australia
Pediatrics 115:655-61. 2005..The objective of this study was to determine the effect of systemic postnatal corticosteroid treatment on death and CP and to assess any modification of effect arising from risk for CLD... - Risk factors for early death among extremely low-birth-weight infantsSeetha Shankaran
Wayne State University, Detroit, Michigan, USA
Am J Obstet Gynecol 186:796-802. 2002..4; 95% CI, 1.3-1.6), and lower birth weight per 50 g (95% CI, 1.2-1.4). CONCLUSION: Early death (<12 hours of age) among extremely low-birth-weight infants may reflect an assessment of non-viability by obstetricians and neonatologists... - Inhaled nitric oxide for premature infants with severe respiratory failureKrisa P Van Meurs
Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, Calif 94304, USA
N Engl J Med 353:13-22. 2005..We conducted a multicenter, randomized, blinded, controlled trial to determine whether inhaled nitric oxide reduced the rate of death or bronchopulmonary dysplasia in such infants... - Effect of parenteral glutamine supplementation on plasma amino acid concentrations in extremely low-birth-weight infantsBrenda B Poindexter
Indiana University, Indianapolis, USA
Am J Clin Nutr 77:737-43. 2003..Currently available amino acid solutions are likely to be suboptimal in their supply of phenylalanine, tyrosine, or both for these infants... - Association between fluid intake and weight loss during the first ten days of life and risk of bronchopulmonary dysplasia in extremely low birth weight infantsWilliam Oh
Neonatal Research Center, Bethesda, MD, USA
J Pediatr 147:786-90. 2005..To demonstrate the association between fluid intake and weight loss during the first 10 days of life and the risk of bronchopulmonary dysplasia (BPD) in extremely low birth weight (ELBW) infants... - Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathySeetha Shankaran
Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA
Pediatrics 122:e791-8. 2008..Whole-body hypothermia reduced the frequency of death or moderate/severe disabilities in neonates with hypoxic-ischemic encephalopathy in a randomized, controlled multicenter trial... - Aggressive vs. conservative phototherapy for infants with extremely low birth weightBrenda H Morris
University of Texas Medical School, Houston, TX 77030, USA
N Engl J Med 359:1885-96. 2008..It is unclear whether aggressive phototherapy to prevent neurotoxic effects of bilirubin benefits or harms infants with extremely low birth weight (1000 g or less)... - To tap or not to tap: high likelihood of meningitis without sepsis among very low birth weight infantsBarbara J Stoll
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Pediatrics 113:1181-6. 2004..Because CSF cultures were performed only half as often as BCs, this discordance in blood and CSF culture results suggests that meningitis may be underdiagnosed among VLBW infants... - Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infantsWilliam Oh
Women and Infants Hospital of Rhode Island Brown University, Providence, Rhode Island 02905, USA
Pediatrics 112:773-9. 2003..To assess the association between peak total serum bilirubin (PSB) levels during the first 2 weeks of life and neurodevelopmental outcomes of extremely low birth weight (ELBW) infants at 18 to 22 months' postmenstrual age... - Inhaled nitric oxide therapy in neonatal hypoxic respiratory failure: insights beyond primary outcomesGregory M Sokol
Section of Neonatal Perinatal Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202 5271, USA
Semin Perinatol 27:311-9. 2003..It will review the Network's contributions toward advancing the clinical care of the newborn with severe hypoxic respiratory failure... - Differential diagnosis and management of anemia in the newbornMatthew J Bizzarro
Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208064, New Haven, CT 06520-8064, USA
Pediatr Clin North Am 51:1087-107, xi. 2004..Proper history taking, physical examination, and interpretation of diagnostic tests can narrow this focus and aid in establishing an accurate diagnosis and in directing the appropriate therapeutic interventions... - Association between urinary lactate to creatinine ratio and neurodevelopmental outcome in term infants with hypoxic-ischemic encephalopathyWilliam Oh
Department of Pediatrics, Warren Alpert Medical School of Brown University, Providence, RI, USA
J Pediatr 153:375-8. 2008..To assess the association between urinary lactate to creatinine ratio (ULCR) and neurodevelopmental outcome in term infants with hypoxic ischemic encephalopathy and examine the effect of hypothermia on the change in ULCR... - Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertionIra Adams-Chapman
Department of Pediatrics Division of Neonatology, Emory University School of Medicine, 46 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
Pediatrics 121:e1167-77. 2008..We aimed to evaluate neurodevelopmental and growth outcomes among extremely low birth weight infants who had severe intraventricular hemorrhage that required shunt insertion compared with infants without shunt insertion... - Extremely low birthweight neonates with protracted ventilation: mortality and 18-month neurodevelopmental outcomesMichele C Walsh
Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
J Pediatr 146:798-804. 2005..To compare duration of ventilation to mortality and adverse neurodevelopmental outcomes among extremely low birth weight (ELBW; 501-1000 g) infants... - Changes in pathogens causing early-onset sepsis in very-low-birth-weight infantsBarbara J Stoll
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
N Engl J Med 347:240-7. 2002..The change in pathogens over time from predominantly gram-positive to predominantly gram-negative requires confirmation by ongoing surveillance... - Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathySeetha Shankaran
Division of Neonatal Perinatal Medicine, Wayne State University, Children s Hospital of Michigan, Detroit, MI 48201, USA
N Engl J Med 353:1574-84. 2005..Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia in term infants with encephalopathy is uncertain... - Somatic growth of preterm infants during skin-to-skin care versus traditional holding: a randomized, controlled trialMario A Rojas
Department of Pediatrics, Childre s Hospitak at Yale New Haven, Connecticut, USA
J Dev Behav Pediatr 24:163-8. 2003..However, exposure to SSC was associated with greater head growth, even after controlling for head circumference at birth (p =.03). SSC may increase the likelihood of successful breastfeeding... - Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathyNamasivayam Ambalavanan
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Pediatrics 118:2084-93. 2006..The goals were to identify predictor variables and to develop scoring systems and classification trees to predict death/disability or death in infants with hypoxic-ischemic encephalopathy... - The role of nutrition in the prevention and management of bronchopulmonary dysplasiaManoj A Biniwale
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
Semin Perinatol 30:200-8. 2006..Close post discharge follow up of infants with BPD is necessary to monitor growth and to ensure intake of sufficient protein and calories... - Trends in neonatal morbidity and mortality for very low birthweight infantsAvroy A Fanaroff
Department of Pediatrics, Case Western Reserve University, Cleveland, OH
Am J Obstet Gynecol 196:147.e1-8. 2007..To document the mortality and morbidity of infants weighing 501-1500 g at birth according to gestational age, birthweight, and sex...
Research Grants
- NICHD Cooperative Multicenter Neonatal Research NetworkRichard Ehrenkranz; Fiscal Year: 2007..The NICHD Cooperative Multicenter Neonatal Research Network was established to perform some of those critical studies and to change the culture of neonatology to one of evidence-based medicine. ..