R S Duman

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment
    Jennifer L Warner-Schmidt
    Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Hippocampus 16:239-49. 2006
  2. doi request reprint Synaptic dysfunction in depression: potential therapeutic targets
    Ronald S Duman
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Science 338:68-72. 2012
  3. pmc A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists
    Ronald S Duman
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Philos Trans R Soc Lond B Biol Sci 367:2475-84. 2012
  4. pmc Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents
    Ronald S Duman
    Departments of Psychiatry and Neurobiology, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Trends Neurosci 35:47-56. 2012
  5. ncbi request reprint Neurotrophic factors and regulation of mood: role of exercise, diet and metabolism
    Ronald S Duman
    Division of Molecular Psychiatry, Departments of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Neurobiol Aging 26:88-93. 2005
  6. ncbi request reprint A silver bullet for the treatment of depression?
    Ronald S Duman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuron 55:679-81. 2007
  7. ncbi request reprint Targeting neurotrophic/growth factor expression and signaling for antidepressant drug development
    Keith Q Tanis
    Division of Molecular Psychiatry, Abraham Ribibcoff Research Facilities, Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    CNS Neurol Disord Drug Targets 6:151-60. 2007
  8. ncbi request reprint A neurotrophic model for stress-related mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 59:1116-27. 2006
  9. ncbi request reprint Epigenetic marking and neuronal plasticity
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 62:1-3. 2007
  10. ncbi request reprint Pathophysiology of depression: the concept of synaptic plasticity
    R S Duman
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT, USA
    Eur Psychiatry 17:306-10. 2002

Research Grants

  1. ANTIDEPRESSANTS AND SIGNAL TRANSDUCTION IN BRAIN
    Ronald Duman; Fiscal Year: 2004
  2. ANTIDEPRESSANTS: SIGNAL TRANSDUCTION AND GENE EXPRESSION
    Ronald Duman; Fiscal Year: 2007
  3. RESEARCH TRAINING - BIOLOGICAL SCIENCES
    Ronald Duman; Fiscal Year: 2007
  4. Profiling Gene Expression in Major Depression
    Ronald Duman; Fiscal Year: 2007
  5. Gene Expression Profile of Antidepressants
    Ronald Duman; Fiscal Year: 2003
  6. ANTIDEPRESSANTS AND SIGNAL TRANSDUCTION IN BRAIN
    Ronald Duman; Fiscal Year: 1999

Detail Information

Publications89

  1. ncbi request reprint Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment
    Jennifer L Warner-Schmidt
    Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Hippocampus 16:239-49. 2006
    ....
  2. doi request reprint Synaptic dysfunction in depression: potential therapeutic targets
    Ronald S Duman
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Science 338:68-72. 2012
    ..These findings highlight the central importance of homeostatic control of mood circuit connections and form the basis of a synaptogenic hypothesis of depression and treatment response...
  3. pmc A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists
    Ronald S Duman
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Philos Trans R Soc Lond B Biol Sci 367:2475-84. 2012
    ..Characterization of a novel signalling pathway also identifies new cellular targets that could result in rapid and efficacious antidepressant actions without the side effects of ketamine...
  4. pmc Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents
    Ronald S Duman
    Departments of Psychiatry and Neurobiology, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Trends Neurosci 35:47-56. 2012
    ....
  5. ncbi request reprint Neurotrophic factors and regulation of mood: role of exercise, diet and metabolism
    Ronald S Duman
    Division of Molecular Psychiatry, Departments of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Neurobiol Aging 26:88-93. 2005
    ..A brief overview of this work and the specific neurotrophic factors involved are discussed in this review...
  6. ncbi request reprint A silver bullet for the treatment of depression?
    Ronald S Duman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuron 55:679-81. 2007
    ..However, caution is warranted, as results from animal studies are not always predictive of therapeutic actions in humans...
  7. ncbi request reprint Targeting neurotrophic/growth factor expression and signaling for antidepressant drug development
    Keith Q Tanis
    Division of Molecular Psychiatry, Abraham Ribibcoff Research Facilities, Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    CNS Neurol Disord Drug Targets 6:151-60. 2007
    ..Below we review the current data supporting the neurotrophic hypothesis of depression, and discuss potential approaches to pharmacologically upregulate neurotrophic/growth factor signaling to elicit antidepressant responses...
  8. ncbi request reprint A neurotrophic model for stress-related mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 59:1116-27. 2006
    ....
  9. ncbi request reprint Epigenetic marking and neuronal plasticity
    Ronald S Duman
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 62:1-3. 2007
  10. ncbi request reprint Pathophysiology of depression: the concept of synaptic plasticity
    R S Duman
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT, USA
    Eur Psychiatry 17:306-10. 2002
    ..These findings comprise a novel conceptual framework for future studies of the etiology of mood disorders and for the development of novel therapeutic interventions...
  11. ncbi request reprint Role of neurotrophic factors in the etiology and treatment of mood disorders
    Ronald S Duman
    Division of Molecular Psychiatry, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT, USA
    Neuromolecular Med 5:11-25. 2004
    ..This article reviews the primary work leading to a neurotrophic hypothesis of depression and antidepressant action and the cellular mechanisms and signal transduction pathways that underlie these effects...
  12. ncbi request reprint Synaptic plasticity and mood disorders
    R S Duman
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT, USA
    Mol Psychiatry 7:S29-34. 2002
    ..The possibility that these atypical antipsychotic drugs also influence the molecular determinants of synaptic plasticity that are involved in the response to drugs used for the treatment of mood disorders, is discussed...
  13. pmc Signaling pathways underlying the rapid antidepressant actions of ketamine
    Ronald S Duman
    Departments of Psychiatry and Neurobiology, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Neuropharmacology 62:35-41. 2012
    ..These findings identify new targets for rapid acting antidepressants that are safer than ketamine. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  14. pmc Neuronal damage and protection in the pathophysiology and treatment of psychiatric illness: stress and depression
    Ronald S Duman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Dialogues Clin Neurosci 11:239-55. 2009
    ..This exciting area of research holds promise and potential for further elucidating the pathophysiology of psychiatric illness and for development of novel therapeutic interventions...
  15. ncbi request reprint Regulation of adult neurogenesis by antidepressant treatment
    R S Duman
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    Neuropsychopharmacology 25:836-44. 2001
    ....
  16. ncbi request reprint Regulation of adult neurogenesis by psychotropic drugs and stress
    R S Duman
    Abraham Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, Hew Haven 06508, USA
    J Pharmacol Exp Ther 299:401-7. 2001
    ....
  17. ncbi request reprint TNFalpha signaling in depression and anxiety: behavioral consequences of individual receptor targeting
    Birgitte B Simen
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, Connecticut, USA
    Biol Psychiatry 59:775-85. 2006
    ..Interpretation of these effects is complicated by the malaise caused by acute injections of pro-inflammatory cytokines, however. Thus, it is unclear whether cytokines are involved in the etiology of depressive symptoms...
  18. ncbi request reprint Regulation of activin mRNA and Smad2 phosphorylation by antidepressant treatment in the rat brain: effects in behavioral models
    Antonia L Dow
    Laboratory of Molecular Psychiatry, Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 25:4908-16. 2005
    ..The results suggest that regulation of activin and Smad signaling may contribute to the actions of antidepressant treatment and may represent novel targets for antidepressant drug development...
  19. ncbi request reprint Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
    Yukihiko Shirayama
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 22:3251-61. 2002
    ..Infusions of BDNF and NT-3 did not influence locomotor activity or passive avoidance. The results provide further support for the hypothesis that BDNF contributes to the therapeutic action of antidepressant treatment...
  20. ncbi request reprint A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment
    Catharine H Duman
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:661-70. 2007
    ..BDNF-regulated signaling pathways are thus potential targets for investigation of antidepressant mechanisms...
  21. ncbi request reprint Effects of cyclic adenosine monophosphate response element binding protein overexpression in the basolateral amygdala on behavioral models of depression and anxiety
    Tanya L Wallace
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 56:151-60. 2004
    ..Chronic antidepressant administration increases the cyclic adenosine monophosphate response element binding protein (CREB) in the amygdala, a critical neural substrate involved in the physiologic responses to stress, fear, and anxiety...
  22. pmc A postpartum model in rat: behavioral and gene expression changes induced by ovarian steroid deprivation
    Shiro Suda
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 64:311-9. 2008
    ..However, the underlying neurobiological mechanisms that contribute to PPD have not been determined...
  23. ncbi request reprint Electroconvulsive seizure-induced gene expression profile of the hippocampus dentate gyrus granule cell layer
    Jonathan E Ploski
    Laboratory of Molecular Psychiatry, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurochem 99:1122-32. 2006
    ..This study demonstrates the utility of microarray analysis of microdissected subregions of limbic brain regions and identifies novel ECS-regulated genes...
  24. ncbi request reprint Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat
    Mounira Banasr
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 62:496-504. 2007
    ..However, little is known about the mechanisms that contribute to this decrease in cell number...
  25. pmc Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    Biol Psychiatry 63:353-9. 2008
    ..The intracellular factors by which ADTs and glucocorticoids, causal factors in depression, regulate depression-like behavior remain unclear, but extracellular signal-regulated kinase 1/2 (ERK1/2), upstream of CREB, is a likely candidate...
  26. pmc Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole
    M Banasr
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06437, USA
    Mol Psychiatry 15:501-11. 2010
    ....
  27. ncbi request reprint Influence of estradiol, stress, and 5-HT2A agonist treatment on brain-derived neurotrophic factor expression in female rats
    Idil Cavus
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 54:59-69. 2003
    ..The roles of 5-HT2A receptors and of stress on the BDNF mRNA regulation were also explored...
  28. ncbi request reprint Antidepressant actions of the exercise-regulated gene VGF
    Joshua G Hunsberger
    Department of Psychiatry, Yale University, 34 Park Street, New Haven, Connecticut 06508 USA
    Nat Med 13:1476-82. 2007
    ..The results suggest a new role for VGF and identify VGF signaling as a potential therapeutic target for antidepressant drug development...
  29. ncbi request reprint Activation of cAMP signaling facilitates the morphological maturation of newborn neurons in adult hippocampus
    Takashi Fujioka
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 24:319-28. 2004
    ..These findings indicate that the cAMP-CREB cascade plays an important role in the differentiation and maturation of newborn neurons in hippocampus...
  30. ncbi request reprint Downregulation of the CCAAT-enhancer binding protein beta in deltaFosB transgenic mice and by electroconvulsive seizures
    Jingshan Chen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuropsychopharmacology 29:23-31. 2004
    ....
  31. ncbi request reprint Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus
    Shin Nakagawa
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 22:9868-76. 2002
    ..These findings indicate that the cAMP-CREB pathway regulates the survival, and possibly the differentiation and function, of newborn neurons...
  32. pmc Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors
    Mounira Banasr
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 64:863-70. 2008
    ..However, it is unclear whether this glial loss plays a direct role in the expression of depressive symptoms...
  33. ncbi request reprint Electroconvulsive seizures increase the expression of MAP kinase phosphatases in limbic regions of rat brain
    Masafumi Kodama
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuropsychopharmacology 30:360-71. 2005
    ..Upregulation of MKP expression could dampen the actions of ECS, indicating that blockade of the MKPs could enhance the actions of antidepressant treatment...
  34. pmc A double dissociation revealing bidirectional competition between striatum and hippocampus during learning
    Anni S Lee
    Departments of Psychiatry and Pharmacology, Yale University, New Haven, CT 06508, USA
    Proc Natl Acad Sci U S A 105:17163-8. 2008
    ..This double dissociation demonstrates bidirectional competition that constitutes strong evidence for the parallel operation of distinct memory systems...
  35. pmc A negative regulator of MAP kinase causes depressive behavior
    Vanja Duric
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Nat Med 16:1328-32. 2010
    ..These postmortem and preclinical studies identify MKP-1 as a key factor in MDD pathophysiology and as a new target for therapeutic interventions...
  36. ncbi request reprint Repeated unpredictable stress and antidepressants differentially regulate expression of the bcl-2 family of apoptotic genes in rat cortical, hippocampal, and limbic brain structures
    Therese A Kosten
    Department of Psychiatry, Menninger Department of Psychiatry, Baylor College of Medicine and Michael E DeBakey Veterans Affairs, Houston, TX, USA
    Neuropsychopharmacology 33:1545-58. 2008
    ....
  37. ncbi request reprint Depression: a case of neuronal life and death?
    Ronald S Duman
    Division of Molecular Psychiatry, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 56:140-5. 2004
    ..This perspective reviews the literature in support of the hypothesis that altered birth of new neurons in the adult brain contributes to the etiology and treatment of depression and considers research strategies to test this hypothesis...
  38. ncbi request reprint Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect
    Samuel S Newton
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 22:10883-90. 2002
    ..Together, the results demonstrate that nucleus accumbens CREB-dynorphin influence behavior in the learned helplessness model and suggest that this signaling cascade may contribute to symptoms of depression...
  39. ncbi request reprint Genetics of childhood disorders: XXXIX. Stem cell research, part 3: Regulation of neurogenesis by stress and antidepressant treatment
    Ronald S Duman
    Division of Molecular Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven 06520, USA
    J Am Acad Child Adolesc Psychiatry 41:745-8. 2002
  40. pmc Electroconvulsive seizure and VEGF increase the proliferation of neural stem-like cells in rat hippocampus
    Eri Segi-Nishida
    Laboratory of Molecular Psychiatry, Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT 06508, USA
    Proc Natl Acad Sci U S A 105:11352-7. 2008
    ....
  41. pmc Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior
    Ja Wook Koo
    Department of Psychiatry and Pharmacology, Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Yale University School of Medicine, New Haven, CT 06519, USA
    Proc Natl Acad Sci U S A 107:2669-74. 2010
    ..Together, these data identify NF-kappaB signaling as a critical mediator of the antineurogenic and behavioral actions of stress and suggest previously undescribed therapeutical targets for depression...
  42. ncbi request reprint Gene profile of electroconvulsive seizures: induction of neurotrophic and angiogenic factors
    Samuel S Newton
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 23:10841-51. 2003
    ..This study demonstrates the applicability of custom-focused microarray technology in addressing hypothesis-driven questions regarding the action of antidepressants...
  43. pmc IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress
    Ja Wook Koo
    Department of Psychology, Yale University, New Haven, CT 06520 8205, USA
    Proc Natl Acad Sci U S A 105:751-6. 2008
    ..These findings demonstrate that IL-1beta is a critical mediator of the antineurogenic and depressive-like behavior caused by acute and chronic stress...
  44. ncbi request reprint Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein
    Shin Nakagawa
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 22:3673-82. 2002
    ..The results suggest that the cAMP-CREB cascade could contribute to the actions of neurotransmitters and neurotrophic factors on adult neurogenesis...
  45. pmc Vascular endothelial growth factor signaling is required for the behavioral actions of antidepressant treatment: pharmacological and cellular characterization
    Joshua Greene
    Department of Psychiatry, Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuropsychopharmacology 34:2459-68. 2009
    ....
  46. ncbi request reprint Antidepressant effect of the calcium-activated tyrosine kinase Pyk2 in the lateral septum
    Teige P Sheehan
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    Biol Psychiatry 54:540-51. 2003
    ....
  47. ncbi request reprint Chronic electroconvulsive seizure up-regulates beta-catenin expression in rat hippocampus: role in adult neurogenesis
    Torsten M Madsen
    Departments of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 54:1006-14. 2003
    ..Aside from this function, beta-catenin is a key effector molecule in the Wnt signaling pathway, serving as a downstream transcription factor...
  48. ncbi request reprint ECS-Induced mossy fiber sprouting and BDNF expression are attenuated by ketamine pretreatment
    A C Chen
    Abraham Ribicoff Research Facilities, Yale University School of Medicine, Connecticut Mental Health Center, New Haven 06508, USA
    J ECT 17:27-32. 2001
    ..These findings are of increasing interest, as they relate to the use of ECT in the treatment of depression, and the specific anesthetic agents that are used...
  49. doi request reprint The roles of neurotrophic factor and Wnt signaling in depression
    B Voleti
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Pharmacol Ther 91:333-8. 2012
    ..This review focuses on intracellular signaling cascades that underlie depression and treatment response...
  50. ncbi request reprint Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect
    A C Chen
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven 06508, USA
    Biol Psychiatry 49:753-62. 2001
    ..CONCLUSIONS: These results demonstrate that over-expression of CREB in hippocampus results in an antidepressant effect and suggest that CREB may serve as a potential molecular target for novel therapeutic agents...
  51. ncbi request reprint Regulation of neurogenesis and gliogenesis by stress and antidepressant treatment
    Mounira Banasr
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    CNS Neurol Disord Drug Targets 6:311-20. 2007
    ..This information has contributed to novel antidepressant medication development that utilizes adult neurogenesis and gliogenesis as preclinical cellular markers for predicting antidepressant properties of novel compounds...
  52. pmc mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists
    Nanxin Li
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Science 329:959-64. 2010
    ..Our results demonstrate that these effects of ketamine are opposite to the synaptic deficits that result from exposure to stress and could contribute to the fast antidepressant actions of ketamine...
  53. ncbi request reprint Regulation of cAMP-specific phosphodiesterases type 4B and 4D (PDE4) splice variants by cAMP signaling in primary cortical neurons
    Carrol D'Sa
    Laboratory of Molecular Psychiatry, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    J Neurochem 81:745-57. 2002
    ..These data demonstrate that in cortical neurons, a short PDE4B2 intronic promoter is regulated by CREB, confers cAMP responsitivity and directs PDE4B2 mRNA and protein expression...
  54. pmc Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice
    Catharine H Duman
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT 06508, USA
    Brain Res 1199:148-58. 2008
    ..In summary, chronic wheel-running exercise in mice results in antidepressant-like behavioral changes that may involve a BDNF related mechanism similar to that hypothesized for antidepressant drug treatment...
  55. pmc Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise
    Catharine H Duman
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Behav Brain Res 198:366-71. 2009
    ..These results support the functional relevance of neurotrophic mechanisms to depression and extend this idea to include neurotrophic factors in the periphery...
  56. pmc Remodeling of hippocampal spine synapses in the rat learned helplessness model of depression
    Tibor Hajszan
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Psychiatry 65:392-400. 2009
    ....
  57. doi request reprint It is time to take a stand for medical research and against terrorism targeting medical scientists
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 63:725-7. 2008
  58. pmc Effects of estradiol on learned helplessness and associated remodeling of hippocampal spine synapses in female rats
    Tibor Hajszan
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Psychiatry 67:168-74. 2010
    ....
  59. pmc Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder
    Lara G Chepenik
    Deparment of Psychiatry, Yale University School of Medicine, New Haven, CT 6511, USA
    Neuropsychopharmacology 34:944-51. 2009
    ....
  60. ncbi request reprint Stress, depression, and neuroplasticity: a convergence of mechanisms
    Christopher Pittenger
    Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT 6508, USA
    Neuropsychopharmacology 33:88-109. 2008
    ..Greater appreciation of the convergence of mechanisms between stress, depression, and neuroplasticity is likely to lead to the identification of novel targets for more efficacious treatments...
  61. ncbi request reprint Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat
    Masafumi Kodama
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 56:570-80. 2004
    ..There has been increasing evidence that atypical antipsychotics are effective in the treatment of mood disorders or for augmenting 5-hydroxytryptamine selective reuptake inhibitors for treatment-resistant depression...
  62. ncbi request reprint Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neurons
    Robert D Beech
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor, New Haven, CT 06508, USA
    J Comp Neurol 475:128-41. 2004
    ..The ability to express different transgenes within this subpopulation of neuronal precursors provides a powerful system to define the signals regulating the differentiation and survival of adult-generated neurons in the olfactory bulb...
  63. pmc Blockade of melanocortin transmission inhibits cocaine reward
    Richard Hsu
    Laboratory of Molecular Psychiatry, Center for Genes and Behaviour, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Eur J Neurosci 21:2233-42. 2005
    ..Modulation of cocaine reward is a novel action of the melanocortin-MC4-R system and could be targeted for the development of new medications for cocaine addiction...
  64. ncbi request reprint Gene profiling the response to kainic acid induced seizures
    Joshua G Hunsberger
    Yale University School of Medicine, 34 Park Street, CMHC, New Haven, CT 06520, USA
    Brain Res Mol Brain Res 141:95-112. 2005
    ..Gene regulation was confirmed via quantitative real time polymerase chain reaction and in situ hybridization...
  65. ncbi request reprint Differential expression and regulation of the cAMP-selective phosphodiesterase type 4A splice variants in rat brain by chronic antidepressant administration
    Carrol D'Sa
    Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CT 06508, USA
    Eur J Neurosci 22:1463-75. 2005
    ....
  66. ncbi request reprint Production of custom microarrays for neuroscience research
    Samuel S Newton
    Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Methods 37:238-46. 2005
    ..The custom microarray approach is presented with procedural details for design and production in the context of neurobiological investigations...
  67. ncbi request reprint Finding the intracellular signaling pathways affected by mood disorder treatments
    Joseph T Coyle
    Harvard Medical School, Department of Psychiatry, McLean Hospital, Belmont, MA 02478, USA
    Neuron 38:157-60. 2003
    ..These insights should assist in understanding the pathophysiology of severe mood disorders as well as aid in the development of more effective treatments...
  68. ncbi request reprint Molecular and behavioral interactions between central melanocortins and cocaine
    John D Alvaro
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    J Pharmacol Exp Ther 304:391-9. 2003
    ..These data further support a role for the melanocortin-MC4-R neuropeptide system in the biochemical and behavioral effects of cocaine...
  69. ncbi request reprint Electroconvulsive seizure increases adult hippocampal angiogenesis in rats
    Samuel S Newton
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT, USA
    Eur J Neurosci 24:819-28. 2006
    ..Increases in the vascular density of the SLM could be in response to enhanced metabolic activity in this region. This is supported by the induction of glutamine synthetase and the glutamate transporter GLT1...
  70. ncbi request reprint Antidepressants and neuroplasticity
    Carrol D'Sa
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT, USA
    Bipolar Disord 4:183-94. 2002
    ..We discuss the molecular, cellular and structural adaptations that underlie the therapeutic responses of different classes of antidepressants and contribute to the adaptive plasticity induced in the brain by these drugs...
  71. ncbi request reprint The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior
    Heath D Schmidt
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Department of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA
    Behav Pharmacol 18:391-418. 2007
    ..Aberrant regulation of neuronal plasticity, including neurogenesis, in the hippocampus and other limbic nuclei may result in maladaptive changes in neural networks that underlie the pathophysiology of MDD...
  72. ncbi request reprint cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment
    J Thome
    Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 20:4030-6. 2000
    ....
  73. ncbi request reprint Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline
    Brian P Ramos
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 40:835-45. 2003
    ..These data demonstrate that PKA inhibition, rather than activation, is the appropriate strategy for restoring prefrontal cortical cognitive abilities in the elderly...
  74. doi request reprint Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection
    Jeffrey A Lieberman
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, 1051 Riverside Dr, Unit 4, New York, NY 10032, USA
    Pharmacol Rev 60:358-403. 2008
    ....
  75. ncbi request reprint Regulation of neurogenesis and angiogenesis in depression
    Samuel S Newton
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Curr Neurovasc Res 1:261-7. 2004
    ..This review will focus on the research that has led us to this current understanding of antidepressant action in context with the pathophysiology of depression using examples from basic, preclinical and clinical investigations...
  76. ncbi request reprint Inducible and brain region-specific CREB transgenic mice
    Norio Sakai
    Division of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    Mol Pharmacol 61:1453-64. 2002
    ..Finally, there was a significant reduction in cocaine-induced locomotor activity in the CREB bitransgenic mice. These results are consistent with a role for CREB in mediating adaptive changes that occur in response to drugs of abuse...
  77. ncbi request reprint Polymorphisms of the human apolipoprotein E promoter and bleomycin hydrolase gene: risk factors for Alzheimer's dementia?
    J Thome
    Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Neurosci Lett 274:37-40. 1999
    ..We found a significant linkage disequilibrium between the -491A/T and ApoE polymorphisms. However, no direct association was observed between the -491A/T or BH-PEN polymorphism and AD...
  78. ncbi request reprint Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures
    N Hiroi
    Laboratory of Molecular Psychiatry, Departments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 18:6952-62. 1998
    ..These findings identify fosB gene products as transcription factors critical for molecular, electrophysiological, and behavioral adaptations to motor seizures...
  79. ncbi request reprint Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures
    V A Vaidya
    Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, 06508, USA
    Neuroscience 89:157-66. 1999
    ..Although the functional consequences remain unclear, sprouting of the mossy fiber pathway would appear to oppose the actions of stress and could thereby contribute to the therapeutic actions of electroconvulsive seizure therapy...
  80. ncbi request reprint Chromatin remodeling: a novel mechanism of psychotropic drug action
    Samuel S Newton
    Laboratory of Molecular Psychiatry, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Mol Pharmacol 70:440-3. 2006
    ..in this issue of Molecular Pharmacology, address this question and demonstrate that psychotropic drugs modify specific methyl-CpG-binding proteins that control histone acetylation and gene expression...
  81. ncbi request reprint Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus
    Amrita Nair
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India
    Neuropsychopharmacology 32:1504-19. 2007
    ..These results suggest that alterations in CREB/BDNF may contribute to the generation of individual differences in stress neurocircuitry, providing a substrate for altered vulnerability to depressive disorders...
  82. ncbi request reprint Norepinephrine activates extracellular-regulated kinase in cortical neurons
    Lara M Tolbert
    Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 54:983-93. 2003
    ..The influence of norepinephrine on the phosphorylation of extracellular-regulated protein kinase is characterized...
  83. ncbi request reprint Preclinical models: status of basic research in depression
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Biol Psychiatry 52:503-28. 2002
    ....
  84. ncbi request reprint Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects
    Yukihiko Shirayama
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Japan
    J Neurochem 90:1258-68. 2004
    ..These results indicate that both dynorphin A and dynorphin B contribute to the effects of stress, and suggest that blockade of kappa-opioid receptors may have therapeutic potential for the treatment of depression...
  85. ncbi request reprint Induction of deltaFosB in reward-related brain structures after chronic stress
    Linda I Perrotti
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 24:10594-602. 2004
    ..These findings establish that chronic stress induces DeltaFosB in several discrete regions of the brain. Such induction could contribute to the long-term effects of stress on the brain...
  86. ncbi request reprint Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment
    Jessica E Malberg
    Wyeth Neuroscience, Princeton, NJ, USA
    Neuropsychopharmacology 28:1562-71. 2003
    ..These findings demonstrate that exposure to IS, which results in a state of behavioral despair, decreases hippocampal cell proliferation and that this effect can be reversed by fluoxetine treatment...
  87. pmc Gene expression profiling in postmortem prefrontal cortex of major depressive disorder
    Hyo Jung Kang
    Department Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    J Neurosci 27:13329-40. 2007
    ..These findings identify abnormal gene expression in a discrete region of MDD subjects and contribute to further elucidation of the molecular alterations of this complex mood disorder...
  88. pmc VEGF as a potential target for therapeutic intervention in depression
    Jennifer L Warner-Schmidt
    The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Curr Opin Pharmacol 8:14-9. 2008
    ..Because VEGF has been implicated in a variety of diseases, understanding the molecular and cellular specificity of antidepressant-induced VEGF will be crucial to determine its potential as a therapeutic target in depression...
  89. ncbi request reprint Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawal
    Tamara Z Shaw-Lutchman
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 22:3663-72. 2002
    ..CRE-mediated transcription may itself contribute to re-establishing homeostasis in the organism through target gene regulation in these regions...

Research Grants20

  1. ANTIDEPRESSANTS AND SIGNAL TRANSDUCTION IN BRAIN
    Ronald Duman; Fiscal Year: 2004
    ..Finally, studies to identify the isoforms of cAMP phophodiesterase (PDE4) that catalyzes the breakdown of cAMP are proposed, including regulation of PDE4 isoforms by antidepressant treatment and development of PDE4 null mutant mice. ..
  2. ANTIDEPRESSANTS: SIGNAL TRANSDUCTION AND GENE EXPRESSION
    Ronald Duman; Fiscal Year: 2007
    ..These studies will further characterize the mechanisms underlying the action of ADT and identify novel drug targets for the development of faster acting and more efficacious medications. ..
  3. RESEARCH TRAINING - BIOLOGICAL SCIENCES
    Ronald Duman; Fiscal Year: 2007
    ..Thus, basic and clinical research is carried out in areas related to anxiety (e.g., panic and post-traumatic stress disorder), obsessive compulsive disorder, schizophrenia, and affective illness. ..
  4. Profiling Gene Expression in Major Depression
    Ronald Duman; Fiscal Year: 2007
    ..abstract_text> ..
  5. Gene Expression Profile of Antidepressants
    Ronald Duman; Fiscal Year: 2003
    ..abstract_text> ..
  6. ANTIDEPRESSANTS AND SIGNAL TRANSDUCTION IN BRAIN
    Ronald Duman; Fiscal Year: 1999
    ..Activation of the PKA-CREB cascade and induction of BDNF could mediate long-term adaptations of neuronal function in response to antidepressant treatments. ..