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Genomes and Genes | Antonette T DulaySummaryAffiliation: Yale University Country: USA Publications
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Publications
First-trimester ultrasound: current uses and applicationsAntonette T Dulay
Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Semin Ultrasound CT MR 29:121-31. 2008..We also cover the utility of the first-trimester ultrasound in screening for fetal aneuploidy. Attention is also given to the role of the first-trimester ultrasound in the prediction of adverse perinatal and maternal outcomes...
Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsisAntonette T Dulay
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
Am J Obstet Gynecol 198:426.e1-9. 2008..We sought to determine whether fetal inflammation is associated with an elevation in neonatal NRBC count in the setting of inflammation-associated preterm birth...- Soluble TLR2 is present in human amniotic fluid and modulates the intraamniotic inflammatory response to infectionAntonette T Dulay
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 182:7244-53. 2009..We conclude that sTLR2 is part of the amniotic fluid innate immune system and participates in regulating the inflammatory response to microbial pathogens... 
Activation of the receptor for advanced glycation end products system in women with severe preeclampsiaEmily A Oliver
Yale University School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, 333 Cedar Street, LLCI 804, New Haven, Connecticut 06520, USA
J Clin Endocrinol Metab 96:689-98. 2011..Soluble forms of RAGE [soluble RAGE (sRAGE), endogenous secretory (esRAGE)] bind RAGE ligands, thereby preventing downstream signaling and damage...- Cord blood erythropoietin and interleukin-6 for prediction of intraventricular hemorrhage in the preterm neonateVineet Bhandari
Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
J Matern Fetal Neonatal Med 24:673-9. 2011..To evaluate cord blood erythropoietin (EPO) and interleukin-6 (IL-6) levels to predict preterm infants at risk of developing intraventricular hemorrhage (IVH)... - Proteomics mapping of cord blood identifies haptoglobin "switch-on" pattern as biomarker of early-onset neonatal sepsis in preterm newbornsCatalin S Buhimschi
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United States of America
PLoS ONE 6:e26111. 2011..A prompt and accurate diagnosis of EONS is critical for improved neonatal outcomes. We sought to explore the cord blood proteome and identify biomarkers and functional protein networks characterizing EONS in preterm newborns... - IL-6 trans-signaling system in intra-amniotic inflammation, preterm birth, and preterm premature rupture of the membranesSarah Y Lee
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 186:3226-36. 2011..We conclude that IL-6 trans-signaling molecules are physiologic constituents of the AF regulated by gestational age and inflammation. PPROM likely involves functional loss of sgp130... - Fetal heart rate monitoring patterns in women with amniotic fluid proteomic profiles indicative of inflammationCatalin S Buhimschi
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
Am J Perinatol 25:359-72. 2008..An abnormal FHR-MP can thus raise the level of awareness that a fetus with EONS may be born, but it is not a useful clinical indicator of the need for antibiotic treatment of the neonate... - Interpretation of amniotic fluid white blood cell count in "bloody tap" amniocenteses in women with symptoms of preterm laborSonya S Abdel-Razeq
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
Obstet Gynecol 116:344-54. 2010..To estimate whether blood-contaminated amniotic fluid affects the performance of white blood cell (WBC) count in diagnosing intraamniotic inflammation and infection... - Fetal renal artery impedance as assessed by Doppler ultrasound in pregnancies complicated by intraamniotic inflammation and preterm birthHumberto Azpurua
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Obstet Gynecol 200:203.e1-11. 2009..The objective of the study was to evaluate the fetal renal artery impedance in the context of inflammation-associated preterm birth... - Ultrasonographic evaluation of myometrial thickness and prediction of a successful external cephalic versionCatalin S Buhimschi
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, CT, USA
Obstet Gynecol 118:913-20. 2011..To test the hypothesis that myometrial thickness predicts the success of external cephalic version... - Amniotic fluid angiopoietin-1, angiopoietin-2, and soluble receptor tunica interna endothelial cell kinase-2 levels and regulation in normal pregnancy and intraamniotic inflammation-induced preterm birthCatalin S Buhimschi
Yale University School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA
J Clin Endocrinol Metab 95:3428-36. 2010..Ang-2/Ang-1 ratio may play a role in modulating the fetal inflammatory response to IAI. Placental sTie2 shedding likely involves a Golgi-mediated mechanism... - Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the futureCatalin S Buhimschi
Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Curr Opin Infect Dis 22:235-43. 2009..Proteomics offers the opportunity for detecting fetuses at risk of sepsis and neurological injury... - Modulation of amniotic fluid activin-a and inhibin-a in women with preterm premature rupture of the membranes and infection-induced preterm birthVictor A Rosenberg
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Reprod Immunol 67:122-31. 2012..We explored activation of amniotic fluid (AF) activin-A and inhibin-A system in women with intra-amniotic infection and preterm premature rupture of the membranes (PPROM)... - Is the rate of congenital heart defects detected by fetal echocardiography among pregnancies conceived by in vitro fertilization really increased?: a case-historical control studyMert Ozan Bahtiyar
Section of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, PO Box 208063, New Haven, CT 06520 8063, USA
J Ultrasound Med 29:917-22. 2010..We investigated the prenatal prevalence of congenital heart defects (CHDs) among in vitro fertilization (IVF) pregnancies at a referral program in the United States... - Multidimensional system biology: genetic markers and proteomic biomarkers of adverse pregnancy outcome in preterm birthCatalin S Buhimschi
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
Am J Perinatol 25:175-87. 2008..Genomics and proteomics have emerged to provide a better comprehension of the pathophysiological conditions leading to preterm birth, thereby providing a perspective for improving neonatal outcome... - Heparin elevates circulating soluble fms-like tyrosine kinase-1 immunoreactivity in pregnant women receiving anticoagulation therapyVictor A Rosenberg
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, 333 Cedar Street, New Haven, CT 06520, USA
Circulation 124:2543-53. 2011..Alterations in circulating levels of pro- and antiangiogenic factors have been associated with adverse pregnancy outcomes. Heparin is routinely administered to pregnant women, but without clear knowledge of its impact on these factors... - Characterization of RAGE, HMGB1, and S100beta in inflammation-induced preterm birth and fetal tissue injuryCatalin S Buhimschi
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, 333 Cedar Street, New Haven, CT 06520, USA
Am J Pathol 175:958-75. 2009..Our findings indicate that RAGE and HMGB1 may be important mediators of cellular injury in fetuses delivered in the setting of inflammation-induced preterm birth... - Prenatal course of isolated muscular ventricular septal defects diagnosed only by color Doppler sonography: single-institution experienceMert Ozan Bahtiyar
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
J Ultrasound Med 27:715-20. 2008..The prevalence of these lesions is not yet completely described, and the frequency with which muscular VSDs resolve in utero has also not been extensively reported... - Prevalence of congenital heart defects in monochorionic/diamniotic twin gestations: a systematic literature reviewMert Ozan Bahtiyar
Section of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
J Ultrasound Med 26:1491-8. 2007..5% of all neonates. Recent literature points to a possible increase in the CHD prevalence among monochorionic/diamniotic (MC/DA) twin gestations. We hypothesized that MC/DA twin pregnancy is a risk factor for CHD... - Advances in medical diagnosis of intra-amniotic infectionIrina A Buhimschi
Yale University, Department of Obstetrics, Gynecology and Reprod Science, New Haven, CT 06520, USA
Expert Opin Med Diagn 7:5-16. 2013..The small number of validation studies along with barriers to implementation of technological innovations in the clinical setting are current limitations... - Single nucleotide polymorphisms in the human progesterone receptor gene and spontaneous preterm birth- Guoyang Luo
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
Reprod Sci 15:147-55. 2008..5 kg/m(2) (relative risk, 10.8; 95% confidence interval, 1.4-82.6; P = .02). Maternal carriage of minor alleles of +331(G>A), +770(C>T), and +660(G> T) SNPs in the PR gene is not associated with spontaneous preterm birth... - Relationships of maternal serum levels of vascular endothelial growth factor and tensile strength properties of the cervix in a rat model of chronic hypoxiaAnna K Sfakianaki
Department of Obstetrics, Gynecology, and Reproductive Science, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Obstet Gynecol 198:223.e1-7. 2008..In this study, we sought to test the hypothesis that chronic hypoxia increases maternal serum levels of VEGF, which in turn cause measurable changes in the viscoelastic properties of the rat uterine cervix...