DEEPAK CYRIL D'SOUZA

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Feasibility, safety, and efficacy of the combination of D-serine and computerized cognitive retraining in schizophrenia: an international collaborative pilot study
    DEEPAK C D'SOUZA
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 38:492-503. 2013
  2. pmc Dose-related modulation of event-related potentials to novel and target stimuli by intravenous Δ⁹-THC in humans
    DEEPAK CYRIL D'SOUZA
    Psychiatry Service, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 37:1632-46. 2012
  3. doi request reprint Nicotine fails to attenuate ketamine-induced cognitive deficits and negative and positive symptoms in humans: implications for schizophrenia
    DEEPAK CYRIL D'SOUZA
    Psychiatry Service, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
    Biol Psychiatry 72:785-94. 2012
  4. pmc Lower ß2*-nicotinic acetylcholine receptor availability in smokers with schizophrenia
    DEEPAK CYRIL D'SOUZA
    Psychiatry Service, VA Connecticut Healthcare System, West Haven, USA
    Am J Psychiatry 169:326-34. 2012
  5. pmc Glycine transporter inhibitor attenuates the psychotomimetic effects of ketamine in healthy males: preliminary evidence
    DEEPAK CYRIL D'SOUZA
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 37:1036-46. 2012
  6. pmc Effects of haloperidol on the behavioral, subjective, cognitive, motor, and neuroendocrine effects of Delta-9-tetrahydrocannabinol in humans
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT, USA
    Psychopharmacology (Berl) 198:587-603. 2008
  7. pmc Blunted psychotomimetic and amnestic effects of delta-9-tetrahydrocannabinol in frequent users of cannabis
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 33:2505-16. 2008
  8. pmc Cannabis and psychosis/schizophrenia: human studies
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, Psychiatry Service, VA Connecticut Healthcare System, 116A, 950 Campbell Avenue, West Haven, CT 06516, USA
    Eur Arch Psychiatry Clin Neurosci 259:413-31. 2009
  9. ncbi request reprint Enhanced sensitivity to the euphoric effects of alcohol in schizophrenia
    DEEPAK C D'SOUZA
    Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 31:2767-75. 2006
  10. pmc Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 202:569-78. 2009

Research Grants

  1. NEUROBIOLOGY OF CANNABIS BEHAVIORAL EFFECTS
    DEEPAK D SOUZA; Fiscal Year: 2003
  2. NEUROBIOLOGY OF CANNABIS EFFECTS
    DEEPAK D SOUZA; Fiscal Year: 2009
  3. NEUROBIOLOGY OF CANNABIS BEHAVIORAL EFFECTS
    DEEPAK D SOUZA; Fiscal Year: 2001
  4. Imaging Nicotinic Acetylcholine Receptors in Schizophrenia
    DEEPAK D SOUZA; Fiscal Year: 2009
  5. Cannabinoids, Neural Synchrony and Information Processing
    DEEPAK D SOUZA; Fiscal Year: 2007
  6. Cannabinoid Receptor Function in Alcoholism: Effects of D-9-THC
    DEEPAK D SOUZA; Fiscal Year: 2007
  7. NEUROBIOLOGY OF CANNABIS EFFECTS
    DEEPAK D SOUZA; Fiscal Year: 2007
  8. GLYCINE-KETAMINE INTERACTIONS IN HEALTHY SUBJECTS
    DEEPAK D SOUZA; Fiscal Year: 2002
  9. NEUROBIOLOGY OF CANNABIS BEHAVIORAL EFFECTS
    DEEPAK D SOUZA; Fiscal Year: 2002
  10. GLYCINE-KETAMINE INTERACTIONS IN HEALTHY SUBJECTS
    DEEPAK D SOUZA; Fiscal Year: 2001

Detail Information

Publications34

  1. pmc Feasibility, safety, and efficacy of the combination of D-serine and computerized cognitive retraining in schizophrenia: an international collaborative pilot study
    DEEPAK C D'SOUZA
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 38:492-503. 2013
    ....
  2. pmc Dose-related modulation of event-related potentials to novel and target stimuli by intravenous Δ⁹-THC in humans
    DEEPAK CYRIL D'SOUZA
    Psychiatry Service, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 37:1632-46. 2012
    ..Collectively, the findings suggest that CB1R systems modulate top-down and bottom-up processing...
  3. doi request reprint Nicotine fails to attenuate ketamine-induced cognitive deficits and negative and positive symptoms in humans: implications for schizophrenia
    DEEPAK CYRIL D'SOUZA
    Psychiatry Service, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
    Biol Psychiatry 72:785-94. 2012
    ..Accordingly, we examined the modulatory effects of brain nAChR systems on NMDAR antagonist-induced effects...
  4. pmc Lower ß2*-nicotinic acetylcholine receptor availability in smokers with schizophrenia
    DEEPAK CYRIL D'SOUZA
    Psychiatry Service, VA Connecticut Healthcare System, West Haven, USA
    Am J Psychiatry 169:326-34. 2012
    ..The purpose of this study was to measure β(2)*-nicotinic acetylcholine receptors in vivo and to relate levels to concurrent behavioral measures of smoking and schizophrenia...
  5. pmc Glycine transporter inhibitor attenuates the psychotomimetic effects of ketamine in healthy males: preliminary evidence
    DEEPAK CYRIL D'SOUZA
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 37:1036-46. 2012
    ..These findings provide preliminary support for further study of the antipsychotic potential of GlyT1 inhibitors...
  6. pmc Effects of haloperidol on the behavioral, subjective, cognitive, motor, and neuroendocrine effects of Delta-9-tetrahydrocannabinol in humans
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT, USA
    Psychopharmacology (Berl) 198:587-603. 2008
    ..This study evaluated whether pretreatment with a dopamine receptor antagonist altered the effects of Delta-9-THC in humans...
  7. pmc Blunted psychotomimetic and amnestic effects of delta-9-tetrahydrocannabinol in frequent users of cannabis
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 33:2505-16. 2008
    ..These data suggest that frequent users of cannabis are either inherently blunted in their response to, and/or develop tolerance to the psychotomimetic, perceptual altering, amnestic, endocrine, and other effects of cannabinoids...
  8. pmc Cannabis and psychosis/schizophrenia: human studies
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, Psychiatry Service, VA Connecticut Healthcare System, 116A, 950 Campbell Avenue, West Haven, CT 06516, USA
    Eur Arch Psychiatry Clin Neurosci 259:413-31. 2009
    ..However, novel hypotheses including the role of cannabinoids on neurodevelopmental processes relevant to psychotic disorders are being studied...
  9. ncbi request reprint Enhanced sensitivity to the euphoric effects of alcohol in schizophrenia
    DEEPAK C D'SOUZA
    Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 31:2767-75. 2006
    ..The absence of 'beneficial' effects of alcohol does not support a self-medication hypothesis of alcohol use in schizophrenia...
  10. pmc Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 202:569-78. 2009
    ..Accordingly, we hypothesized that Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the principal active component of cannabis, would alter BDNF levels in humans...
  11. ncbi request reprint gamma-Aminobutyric acid-serotonin interactions in healthy men: implications for network models of psychosis and dissociation
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, West Haven Veterans Affairs Medical Center, West Haven, Connecticut, USA
    Biol Psychiatry 59:128-37. 2006
    ....
  12. ncbi request reprint Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Biol Psychiatry 57:594-608. 2005
    ..Recent advances in the neurobiology of cannabinoids have renewed interest in the association between cannabis and psychotic disorders...
  13. ncbi request reprint The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 29:1558-72. 2004
    ..These data warrant further study of whether brain cannabinoid receptor function contributes to the pathophysiology of psychotic disorders...
  14. ncbi request reprint Greater vulnerability to the amnestic effects of ketamine in males
    Celia J A Morgan
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Psychopharmacology (Berl) 187:405-14. 2006
    ....
  15. pmc Dose-related behavioral, subjective, endocrine, and psychophysiological effects of the κ opioid agonist Salvinorin A in humans
    Mohini Ranganathan
    Psychiatry Service, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
    Biol Psychiatry 72:871-9. 2012
    ..However, there is little experimental data on the effects of SA in humans...
  16. pmc The effects of cannabinoids on serum cortisol and prolactin in humans
    Mohini Ranganathan
    Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT, USA
    Psychopharmacology (Berl) 203:737-44. 2009
    ..Furthermore, relative to controls, frequent users of cannabis were hypothesized to show altered baseline levels of these hormones and blunted Delta-9-THC-induced changes of these hormones...
  17. doi request reprint The safety of studies with intravenous Δ⁹-tetrahydrocannabinol in humans, with case histories
    Michelle Carbuto
    Psychiatry Service, VA Connecticut Healthcare System, 116A, VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 219:885-96. 2012
    ..Despite increasing interest in the cannabinoid receptor system, use of intravenous THC as a research tool has been limited by concerns about its abuse liability and psychoactive effects...
  18. doi request reprint Cannabinoids and psychosis
    R Andrew Sewell
    Psychiatry Service, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Int Rev Psychiatry 21:152-62. 2009
    ..Further work is necessary to identify the factors that underlie individual vulnerability to cannabinoid-related psychosis and to elucidate the biological mechanisms underlying this risk...
  19. ncbi request reprint Effects of Δ9-tetrahydrocannabinol in individuals with a familial vulnerability to alcoholism
    Mohini Ranganathan
    Schizophrenia and Neuropharmacology Research Group, VA Connecticut Healthcare System, West Haven, CT, USA
    Psychopharmacology (Berl) 231:2385-93. 2014
    ..In this first human study, we probed CB1R function in individuals vulnerable to alcoholism with the exogenous cannabinoid Δ(9)-tetrahydrocannabinol (Δ(9)-THC)...
  20. ncbi request reprint The acute effects of cannabinoids on memory in humans: a review
    Mohini Ranganathan
    Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 188:425-44. 2006
    ..Recent advances in the knowledge of cannabinoid receptors' function have rekindled interest in examining effects of exogenous cannabinoids on memory and in understanding the mechanism of these effects...
  21. ncbi request reprint Potentiation of low dose ketamine effects by naltrexone: potential implications for the pharmacotherapy of alcoholism
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1793-800. 2006
    ..However, these data suggest that at levels of NMDA receptor antagonism associated with heavy drinking, this protective effect of naltrexone on drinking is no longer present...
  22. pmc Probing GABA receptor function in schizophrenia with iomazenil
    Kyungheup Ahn
    Psychiatry Service, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 36:677-83. 2011
    ..The greater vulnerability of schizophrenia patients to the effects of iomazenil relative to controls provides further support for the GABA-deficit hypothesis of schizophrenia...
  23. ncbi request reprint [Behavioral, cognitive and psychophysiological effects of cannabinoids: relevance to psychosis and schizophrenia]
    R Andrew Sewell
    Servico de Psiquiatria, VA Connecticut Healthcare System, West Haven, CT 06516, EUA
    Rev Bras Psiquiatr 32:S15-30. 2010
    ..Finally, further work is necessary to identify the factors that underlie individual vulnerability to cannabinoid-related psychosis and to elucidate the biological mechanisms underlying this risk...
  24. ncbi request reprint Cannabinoids and psychosis
    DEEPAK CYRIL D'SOUZA
    Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Int Rev Neurobiol 78:289-326. 2007
    ....
  25. pmc beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Ave, Mail Code 116A6, West Haven, CT 06516, USA
    Arch Gen Psychiatry 66:666-76. 2009
    ..Variations in beta(2)*-nAChR availability during the course of abstinence may be related to the urge to smoke, the extent of nicotine withdrawal, and successful abstinence...
  26. ncbi request reprint Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects
    John H Krystal
    Schizophrenia Biological Research Center 116 A, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 179:303-9. 2005
    ..Some of the behavioral consequences of deficits in N-methyl-D-aspartate (NMDA) glutamate receptor function are thought to arise from the disinhibition of cortical glutamatergic circuitry...
  27. ncbi request reprint Cortical gamma-aminobutyric acid type A-benzodiazepine receptors in recovery from alcohol dependence: relationship to features of alcohol dependence and cigarette smoking
    Julie K Staley
    Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Arch Gen Psychiatry 62:877-88. 2005
    ..Adaptations in gamma-aminobutyric acid type A (GABA(A))-benzodiazepine receptors contribute to the neurobiology of human alcohol dependence and withdrawal...
  28. ncbi request reprint Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers
    Julie K Staley
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    J Neurosci 26:8707-14. 2006
    ..Greater beta2*-nAChR availability during early abstinence may impact the ability of smokers to maintain abstinence...
  29. ncbi request reprint Absence of significant interactive effects of high-dose D-cycloserine and ethanol in healthy human subjects: preliminary insights into ethanol actions at the glycine B site of NMDA glutamate receptors
    Louis Trevisan
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 32:36-42. 2008
    ....
  30. pmc GABAA-benzodiazepine receptor availability in smokers and nonsmokers: relationship to subsyndromal anxiety and depression
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine, Veteran s Affairs Connecticut Healthcare System VACHS, 116A6 West Haven, Connecticut 06516, USA
    Synapse 63:1089-99. 2009
    ..Aberrant regulation of GABA(A)-BZR function in vulnerable smokers may explain why some smokers experience subsyndromal anxiety and depression...
  31. ncbi request reprint 123I-5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual phase
    Kelly P Cosgrove
    Yale University School of Medicine, New Haven, Connecticut, USA
    J Nucl Med 48:1633-40. 2007
    ..We examined the availability of nAChR containing the beta(2) subunit in healthy men and women and the influence of menstrual phase among women...
  32. ncbi request reprint NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development
    John H Krystal
    Schizophrenia Biological Research Center 116 A, VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 169:215-33. 2003
    ..The purpose of this review is to consider the possibility that agents that attenuate these two components of NMDA receptor antagonist response may play complementary roles in the treatment of schizophrenia...
  33. pmc Spicing things up: synthetic cannabinoids
    Max Spaderna
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Psychopharmacology (Berl) 228:525-40. 2013
    ..Recently, products containing synthetic cannabinoids, collectively referred to as Spice, are increasingly being used recreationally...
  34. ncbi request reprint Revisiting cycloid psychosis: a case of an acute, transient and recurring psychotic disorder
    Vinod H Srihari
    Department of Psychiatry, Yale University School of Medicine, CMHC, 34 Park Street, New Haven, CT 06508, USA
    Schizophr Res 82:261-4. 2006
    ..While this disorder, of unknown incidence, is not well reported in the U.S., it is worthy of further investigation and clinical attention given its generally favorable prognosis and potentially distinct pathophysiology and treatment...

Research Grants15

  1. NEUROBIOLOGY OF CANNABIS BEHAVIORAL EFFECTS
    DEEPAK D SOUZA; Fiscal Year: 2003
    ..Secondary measures include measures of drug liking, movement rating scales and long term follow-up assessment of cannabis use. ..
  2. NEUROBIOLOGY OF CANNABIS EFFECTS
    DEEPAK D SOUZA; Fiscal Year: 2009
    ....
  3. NEUROBIOLOGY OF CANNABIS BEHAVIORAL EFFECTS
    DEEPAK D SOUZA; Fiscal Year: 2001
    ..Secondary measures include measures of drug liking, movement rating scales and long term follow-up assessment of cannabis use. ..
  4. Imaging Nicotinic Acetylcholine Receptors in Schizophrenia
    DEEPAK D SOUZA; Fiscal Year: 2009
    ..This grant application proposes to use brain imaging to study the nicotine receptor system in schizophrenia. ..
  5. Cannabinoids, Neural Synchrony and Information Processing
    DEEPAK D SOUZA; Fiscal Year: 2007
    ....
  6. Cannabinoid Receptor Function in Alcoholism: Effects of D-9-THC
    DEEPAK D SOUZA; Fiscal Year: 2007
    ..These results may reflect indirect evidence of altered CB-1R function in FHP individuals. ..
  7. NEUROBIOLOGY OF CANNABIS EFFECTS
    DEEPAK D SOUZA; Fiscal Year: 2007
    ....
  8. GLYCINE-KETAMINE INTERACTIONS IN HEALTHY SUBJECTS
    DEEPAK D SOUZA; Fiscal Year: 2002
    ..Pilot data (n=12) towards this proposal suggests that glycine reduces ketamine-induced perceptual alterations, negative symptoms and impairments on recall without worsening positive symptoms. ..
  9. NEUROBIOLOGY OF CANNABIS BEHAVIORAL EFFECTS
    DEEPAK D SOUZA; Fiscal Year: 2002
    ..Secondary measures include measures of drug liking, movement rating scales and long term follow-up assessment of cannabis use. ..
  10. GLYCINE-KETAMINE INTERACTIONS IN HEALTHY SUBJECTS
    DEEPAK D SOUZA; Fiscal Year: 2001
    ..Pilot data (n=12) towards this proposal suggests that glycine reduces ketamine-induced perceptual alterations, negative symptoms and impairments on recall without worsening positive symptoms. ..
  11. GLYCINE-KETAMINE INTERACTIONS IN HEALTHY SUBJECTS
    DEEPAK D SOUZA; Fiscal Year: 2000
    ..Pilot data (n=12) towards this proposal suggests that glycine reduces ketamine-induced perceptual alterations, negative symptoms and impairments on recall without worsening positive symptoms. ..
  12. Imaging Nicotinic Acetylcholine Receptors in Schizophrenia
    DEEPAK CYRIL contact D apos SOUZA; Fiscal Year: 2010
    ..This grant application proposes to use brain imaging to study the nicotine receptor system in schizophrenia. ..