Eloïse Dray

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2
    Eloïse Dray
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Struct Mol Biol 17:1255-9. 2010
  2. pmc Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1)
    Eloïse Dray
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:3560-5. 2011
  3. pmc Mechanistic insights into RAD51-associated protein 1 (RAD51AP1) action in homologous DNA repair
    Myun Hwa Dunlop
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 287:12343-7. 2012
  4. pmc RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif
    Myun Hwa Dunlop
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 286:37328-34. 2011
  5. pmc Targeting cancer with a lupus autoantibody
    James E Hansen
    Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520, USA
    Sci Transl Med 4:157ra142. 2012
  6. pmc Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination
    Rohit Prakash
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 23:67-79. 2009

Collaborators

Detail Information

Publications6

  1. pmc Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2
    Eloïse Dray
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Struct Mol Biol 17:1255-9. 2010
    ..Our results demonstrate the multifaceted role of PALB2 in chromosome damage repair. Because PALB2 mutations can cause cancer or Fanconi anemia, our findings shed light on the mechanism of tumor suppression in humans...
  2. pmc Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1)
    Eloïse Dray
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:3560-5. 2011
    ..These results suggest that RAD51AP1 also serves an important role in meiotic homologous recombination...
  3. pmc Mechanistic insights into RAD51-associated protein 1 (RAD51AP1) action in homologous DNA repair
    Myun Hwa Dunlop
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 287:12343-7. 2012
    ..Examination of these mutants reveals that both domains are indispensable for RAD51AP1 function in cells. These and other results illuminate the mechanistic basis of RAD51AP1 action in homologous DNA repair...
  4. pmc RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif
    Myun Hwa Dunlop
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 286:37328-34. 2011
    ..This RAD51AP1 motif is reminiscent of the FVPP motif in the tumor suppressor protein BRCA2 that mediates DMC1 interaction. These results further implicate RAD51AP1 in meiotic HR via RAD51 and DMC1...
  5. pmc Targeting cancer with a lupus autoantibody
    James E Hansen
    Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520, USA
    Sci Transl Med 4:157ra142. 2012
    ..In summary, this study provides the basis for the potential use of a lupus anti-DNA antibody in cancer therapy and identifies lupus autoantibodies as a potentially rich source of therapeutic agents...
  6. pmc Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination
    Rohit Prakash
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 23:67-79. 2009
    ..Importantly, Mph1, but not a helicase-defective variant, dissociates Rad51-made D-loops. Overall, the results from our analyses suggest a new role of Mph1 in promoting the noncrossover repair of DNA double-strand breaks...