JONATHAN DRANOFF

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Intracellular calcium signals regulate growth of hepatic stellate cells via specific effects on cell cycle progression
    Elwy M Soliman
    Yale University School of Medicine, Department of Internal Medicine, Section of Digestive Diseases and Yale Liver Center, 333 Cedar St LMP 1080, New Haven, CT 06515, USA
    Cell Calcium 45:284-92. 2009
  2. ncbi Short-term regulation of bile acid uptake by microfilament-dependent translocation of rat ntcp to the plasma membrane
    J A Dranoff
    Department of Medicine, Yale University School of Medicine, New Haven, CT, USA
    Hepatology 30:223-9. 1999
  3. pmc Portal fibroblasts: Underappreciated mediators of biliary fibrosis
    Jonathan A Dranoff
    Section of Digestive Diseases, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA
    Hepatology 51:1438-44. 2010
  4. ncbi Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis
    Jonathan A Dranoff
    Section of Digestive Diseases and Yale Liver Center, Yale University School of Medicine, One Gilbert Street, New Haven, CT 06520, USA
    J Investig Med 52:475-82. 2004
  5. ncbi Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells
    Jonathan A Dranoff
    Yale Univ School of Medicine, Section of Digestive Diseases, 333 Cedar St LMP 1080, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 287:G417-24. 2004
  6. ncbi The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver
    Jonathan A Dranoff
    Yale University School of Medicine and Liver Center, New Haven, CT, USA
    Hepatology 36:1135-44. 2002
  7. ncbi Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia
    J A Dranoff
    Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut 06520 8019, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1059-67. 2001
  8. ncbi A primitive ATP receptor from the little skate Raja erinacea
    J A Dranoff
    Department of Medicine and Liver Study Unit, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 275:30701-6. 2000
  9. ncbi Isolation of primary rat liver fibroblasts
    Emma A Kruglov
    Department of Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Conn 06520, USA
    J Investig Med 50:179-84. 2002
  10. pmc Transcriptional regulation of IL-6 in bile duct epithelia by extracellular ATP
    Jin Yu
    Yale University School of Medicine Yale Liver Center, Section of Digestive Diseases, 333 Cedar St LMP 1080, New Haven, CT 06510, USA
    Am J Physiol Gastrointest Liver Physiol 296:G563-71. 2009

Research Grants

Collaborators

Detail Information

Publications23

  1. pmc Intracellular calcium signals regulate growth of hepatic stellate cells via specific effects on cell cycle progression
    Elwy M Soliman
    Yale University School of Medicine, Department of Internal Medicine, Section of Digestive Diseases and Yale Liver Center, 333 Cedar St LMP 1080, New Haven, CT 06515, USA
    Cell Calcium 45:284-92. 2009
    ..These data provide a new logical target for pharmacological therapy directed against progression of liver fibrosis...
  2. ncbi Short-term regulation of bile acid uptake by microfilament-dependent translocation of rat ntcp to the plasma membrane
    J A Dranoff
    Department of Medicine, Yale University School of Medicine, New Haven, CT, USA
    Hepatology 30:223-9. 1999
    ....
  3. pmc Portal fibroblasts: Underappreciated mediators of biliary fibrosis
    Jonathan A Dranoff
    Section of Digestive Diseases, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA
    Hepatology 51:1438-44. 2010
    ..Conclusion: PFs are an important and multifunctional nonparenchymal cell population in need of further study...
  4. ncbi Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis
    Jonathan A Dranoff
    Section of Digestive Diseases and Yale Liver Center, Yale University School of Medicine, One Gilbert Street, New Haven, CT 06520, USA
    J Investig Med 52:475-82. 2004
    ..The ectonucleotidase* nucleoside triphosphate diphosphohydrolase 2 (NTPDase2) is restricted to portal fibroblasts in the normal liver. However, the fate of NTPDase2 after bile duct ligation (BDL) is unknown...
  5. ncbi Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells
    Jonathan A Dranoff
    Yale Univ School of Medicine, Section of Digestive Diseases, 333 Cedar St LMP 1080, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 287:G417-24. 2004
    ..Because activation of P2Y receptors in activated HSC regulates procollagen-1 transcription, P2Y receptors may be an attractive target to prevent or treat liver fibrosis...
  6. ncbi The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver
    Jonathan A Dranoff
    Yale University School of Medicine and Liver Center, New Haven, CT, USA
    Hepatology 36:1135-44. 2002
    ..This distribution may represent a previously unrecognized mechanism for regulation of nucleotide signaling in bile ducts and other epithelia...
  7. ncbi Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia
    J A Dranoff
    Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut 06520 8019, USA
    Am J Physiol Gastrointest Liver Physiol 281:G1059-67. 2001
    ..Activation of ductular P2Y receptors induces net ductular alkalization, suggesting that nucleotide signaling may be an important regulator of bile secretion by the liver...
  8. ncbi A primitive ATP receptor from the little skate Raja erinacea
    J A Dranoff
    Department of Medicine and Liver Study Unit, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 275:30701-6. 2000
    ..This novel receptor should provide an effective comparative model for P2Y receptor pharmacology and may improve our understanding of nucleotide specificity among the family of P2Y ATP receptors...
  9. ncbi Isolation of primary rat liver fibroblasts
    Emma A Kruglov
    Department of Medicine and Yale Liver Center, Yale University School of Medicine, New Haven, Conn 06520, USA
    J Investig Med 50:179-84. 2002
    ..Consequently, we developed a technique to isolate primary rat liver fibroblasts...
  10. pmc Transcriptional regulation of IL-6 in bile duct epithelia by extracellular ATP
    Jin Yu
    Yale University School of Medicine Yale Liver Center, Section of Digestive Diseases, 333 Cedar St LMP 1080, New Haven, CT 06510, USA
    Am J Physiol Gastrointest Liver Physiol 296:G563-71. 2009
    ..Since IL-6 has such critical importance in the liver, it is likely that this pathway is of great relevance to the understanding of hepatic response to injury...
  11. doi IL-6 downregulates transcription of NTPDase2 via specific promoter elements
    Jin Yu
    Yale University School of Medicine, Yale Liver Center, New Haven, CT 06515, USA
    Am J Physiol Gastrointest Liver Physiol 294:G748-56. 2008
    ..This effect may represent a novel signaling pathway by which bile ductular proliferation is dysregulated in biliary cirrhosis and thus provides a potential therapeutic approach for the regulation of bile ductular growth...
  12. ncbi Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2
    M Nauman Jhandier
    Yale Liver Center and Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 280:22986-92. 2005
    ..This novel cross-talk signaling pathway may mediate pathologic alterations in bile ductular proliferation in other cholangiopathic conditions...
  13. pmc Adenosine inhibits cytosolic calcium signals and chemotaxis in hepatic stellate cells
    Ardeshir Z Hashmi
    Section of Digestive Diseases, Yale Univ, 333 Cedar St, 1080 LMP, PO Box 208019, New Haven, CT 06520 8019, USA
    Am J Physiol Gastrointest Liver Physiol 292:G395-401. 2007
    ....
  14. ncbi Molecular basis for calcium signaling in hepatic stellate cells
    Emma A Kruglov
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar St, LMP 1080, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 292:G975-82. 2007
    ..These autonomous units of subcellular signaling and response reveal a new level of subcellular organization, which, in turn, establishes a novel paradigm for the local control of fibrogenesis in the liver...
  15. ncbi Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts
    Emma A Kruglov
    Section of Digestive Diseases and Yale Liver Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 290:G765-71. 2006
    ..Together, these data suggest that BDE regulate PF proliferation and myofibroblastic transdifferentiation in a paracrine fashion via release of MCP-1...
  16. ncbi Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture
    Zhaodong Li
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hepatology 46:1246-56. 2007
    ....
  17. ncbi The type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes
    Keiji Hirata
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8019, USA
    Gastroenterology 122:1088-100. 2002
    ..Because the type II inositol 1,4,5-trisphosphate receptor is the predominant isoform in liver, we examined whether this isoform can trigger Ca2+ waves in hepatocytes...
  18. pmc Succinate is a paracrine signal for liver damage
    Paulo Renato A V Correa
    Section of Digestive Diseases, Department of Internal Medicine, Room TAC S241D, Yale University School of Medicine, New Haven, CT 06520 8019, USA
    J Hepatol 47:262-9. 2007
    ..The objectives of this work were to determine the hepatic cell types that express this receptor and to determine its physiological role...
  19. ncbi Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8
    Michel Fausther
    Centre de Recherche en Rhumatologie et Immunologie, 2705 Boulevard Laurier, Local T1 49, G1V 4G2 Quebec, QC, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G785-95. 2007
    ..The canalicular localization of this enzyme suggests its involvement in the regulation of bile secretion and/or nucleoside salvage...
  20. ncbi The anti-apoptotic protein Mcl-1 inhibits mitochondrial Ca2+ signals
    Noritaka Minagawa
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8019, USA
    J Biol Chem 280:33637-44. 2005
    ..These findings provide evidence that Mcl-1 directly inhibits Ca2+ signals within mitochondria, which may provide a novel mechanism to inhibit apoptosis and thereby promote neoplasia...
  21. ncbi Prevention of liver fibrosis by the purinoceptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS)
    Jonathan A Dranoff
    Section of Digestive Diseases, Yale Liver Center, Yale University School of Medicine, New Haven, CT 06520, USA
    In Vivo 21:957-65. 2007
    ..Pyridoxal-phosphate-6-azophenyl-2', 4'-disulfonate (PPADS) is a highly bioavailable purinoceptor inhibitor. We sought to determine whether PPADS could prevent experimental liver fibrosis in rats...
  22. pmc The spatial distribution of inositol 1,4,5-trisphosphate receptor isoforms shapes Ca2+ waves
    Erick Hernandez
    Department of Pediatrics, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 282:10057-67. 2007
    ..The subcellular distribution of InsP3R isoforms may critically determine the repertoire of spatial patterns of Ca(2+) signals...
  23. ncbi Autocrine release of TGF-beta by portal fibroblasts regulates cell growth
    Rebecca G Wells
    The University of Pennsylvania School of Medicine, 600 CRB 6140, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
    FEBS Lett 559:107-10. 2004
    ..Fibroblast growth factor (FGF)-2, but not platelet derived growth factor (PDGF), causes PF proliferation. These data suggest a mechanism whereby HSC eclipse PF as the dominant myofibroblast population in biliary fibrosis...

Research Grants11

  1. PARACRINE REGULATION OF BILE DUCT SECRETION BY ATP
    JONATHAN DRANOFF; Fiscal Year: 2004
    ..The Yale School of Medicine Department of Internal Medicine has pledged that the candidate will have extensive protected research time and excellent resources for the duration of the award. ..
  2. Regulation of Hepatic Stellate Cells by Extracellular Nucleotides
    Jonathan A Dranoff; Fiscal Year: 2010
    ..In the proposed work, we will identify novel pathways that are important in the pathogenesis of liver fibrosis, which should in turn lead to new approaches to prevent or liver fibrosis in patients. ..
  3. Regulation of Bile Ductular Proliferation
    JONATHAN DRANOFF; Fiscal Year: 2009
    ..We anticipate that the results of these proposed experiments will lead to novel pharmacologic approaches for the regulation of bile ductular proliferation in biliary cirrhosis. ..
  4. Regulation of Hepatic Stellate Cells by Extracellular Nucleotides
    JONATHAN DRANOFF; Fiscal Year: 2009
    ..In the proposed work, we will identify novel pathways that are important in the pathogenesis of liver fibrosis, which should in turn lead to new approaches to prevent or liver fibrosis in patients. ..
  5. NTPDase2 expression and function in the liver
    JONATHAN DRANOFF; Fiscal Year: 2005
    ..The experiments proposed in these specific aims will provide the basis of several new lines of liver disease research and should provide novel therapeutic targets for treatment of cholestatic and fibrotic liver disease. ..
  6. Regulation of Hepatic Stellate Cells by Extracellular Nucleotides
    JONATHAN DRANOFF; Fiscal Year: 2009
    ..In the proposed work, we will identify novel pathways that are important in the pathogenesis of liver fibrosis, which should in turn lead to new approaches to prevent or liver fibrosis in patients. ..