Research Topics
Species | DAVID DONNELLYSummaryAffiliation: Yale University Country: USA Publications
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Publications
Voltage-gated Na(+) channels in chemoreceptor afferent neurons--potential roles and changes with developmentDavid F Donnelly
Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510, USA
Respir Physiol Neurobiol 185:67-74. 2013..This may be a significant contributor to maturation of chemoreceptor activity in the post-natal period...
Developmental changes in the magnitude and activation characteristics of Na(+) currents of petrosal neurons projecting to the carotid bodyDavid F Donnelly
Department of Pediatrics, Division of Respiratory Medicine, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
Respir Physiol Neurobiol 177:284-93. 2011..These results suggest that a developmental shift in Na(+) current activation plays a role in chemoreceptor maturation by enhancing excitability of the afferent neuron...- Nicotinic acetylcholine receptors do not mediate excitatory transmission in young rat carotid bodyDavid F Donnelly
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Appl Physiol 107:1806-16. 2009.... - Spontaneous action potential generation due to persistent sodium channel currents in simulated carotid body afferent fibersDavid F Donnelly
Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
J Appl Physiol 104:1394-401. 2008..Taken together, the results suggest that an endogenous process in chemoreceptor nerve terminals may underlie AP generation, a process independent of synaptic depolarizing events... - Orthodromic spike generation from electrical stimuli in the rat carotid body: implications for the afferent spike generation processDavid F Donnelly
Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
J Physiol 580:275-84. 2007..These results suggest that AP generation is not due to SDP events; rather, AP generation is likely to be due to a process endogenous to the nerve terminals that modulates the variability of nerve terminal excitability... 
Mitochondrial function and carotid body transductionDavid F Donnelly
Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
High Alt Med Biol 6:121-32. 2005..Such manipulation may be useful for the treatment of hypoventilation syndromes or high altitude accommodation...- Development of carotid body/petrosal ganglion response to hypoxiaDavid F Donnelly
Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Respir Physiol Neurobiol 149:191-9. 2005..Thus, developmental changes and environmental factors may significantly change the ability of an animal to detect and respond to hypoxic insults, perhaps leading to periods of heightened vulnerability to hypoxic stresses... - Developmental aspects of oxygen sensing by the carotid bodyD F Donnelly
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
J Appl Physiol 88:2296-301. 2000..Although many questions remain, especially with regard to the coupling of glomus cells to nerve endings, the use of cellular and molecular techniques should offer resolution in the near future... - Single-unit recordings of arterial chemoreceptors from mouse petrosal ganglia in vitroD F Donnelly
Division of Respiratory Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Appl Physiol 88:1489-95. 2000..The use of mice for chemoreceptor studies may be advantageous because targeted gene deletions are well developed in the mouse model and may be useful in addressing unresolved questions regarding the mechanism of chemotransduction... - O2 deprivation induces a major depolarization in brain stem neurons in the adult but not in the neonatal ratG G Haddad
Department of Pediatrics Section of Respiratory Medicine, Yale University School of Medicine, New Haven, CT 06510
J Physiol 429:411-28. 1990..The reason(s) for the difference in Ko+ is not known but could be due, to some extent, to different rates of intracellular ATP depletion and failure of the Na(+)-K+ pump... - Are oxygen dependent K+ channels essential for carotid body chemo-transduction?D F Donnelly
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06524, USA
Respir Physiol 110:211-8. 1997.... - Patch clamp recording from the intact dorsal root ganglionJ M Zhang
Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520, USA
J Neurosci Methods 79:97-103. 1998..Both TTX-resistant (TTX-R) and TTX-sensitive (TTX-S currents) were demonstrated in the present study. The results demonstrate the feasibility of patch-clamp recording from intact, identified DRG cells in vitro... - K+ currents of glomus cells and chemosensory functions of carotid bodyD F Donnelly
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06524, USA
Respir Physiol 115:151-60. 1999..Thus, at present, hypoxic inhibition to a K+ channel in the glomus cell may initiate chemotransduction but there are many unanswered questions, especially the failure of K+ channel blocking agents to emulate the hypoxic response... - Effect of sodium perturbations on rat chemoreceptor spike generation: implications for a Poisson modelD F Donnelly
Department of Pediatrics, Section of Respiratory Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
J Physiol 511:301-11. 1998.... - Chemotransduction by carotid body chemoreceptors is dependent on bicarbonate currentsJ M Panisello
Section of Critical Care and Applied Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
Respir Physiol 112:265-81. 1998..We conclude that bicarbonate greatly enhances stimulus/secretion coupling in glomus cells, probably through modulation of an anion current carried by bicarbonate... - MCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root gangliaJ H Sun
Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510, USA
J Neurophysiol 96:2189-99. 2006.... - Effects of a chronic compression of the dorsal root ganglion on voltage-gated Na+ and K+ currents in cutaneous afferent neuronsZ Y Tan
Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510, USA
J Neurophysiol 95:1115-23. 2006..The reduction in Ka, the hyperpolarizing shift in TTX-S Na+ current activation, and the enhanced TTX-R Na+ current may all contribute to the enhanced neuronal excitability and thus to the pain and hyperalgesia associated with CCD... - Time-dependence of hyperoxia-induced impairment in peripheral chemoreceptor activity and glomus cell calcium responseJ L Carroll
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Adv Exp Med Biol 648:299-306. 2009..The time course indicates that hyperoxia exerts these effects within days... - Prolonged apnea and impaired survival in piglets after sinus and aortic nerve sectionD F Donnelly
Department of Pediatrics, Yale University, New Haven, Connecticut 06520
J Appl Physiol 68:1048-52. 1990.... - Fluoresceinated peanut agglutinin (PNA) is a marker for live O(2) sensing glomus cells in rat carotid bodyI Kim
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, USA
Adv Exp Med Biol 648:185-90. 2009..Thus fluoresceinated PNA may be a useful marker for live CB glomus studies, without adversely affecting their physiologic response... - Integration of bronchomotor and ventilatory responses to chemoreceptor stimulation in developing sheepJ J PEREZ FONTAN
Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
Respir Physiol 111:1-13. 1998.... - Characterization and developmental changes of Na+ currents of petrosal neurons with projections to the carotid bodyTheodore R Cummins
Department of Neurology, Yale University School of Medicine, New Haven Connecticut 06510, USA
J Neurophysiol 88:2993-3002. 2002.... - Assisting Mother Nature in postnatal chemoreceptor maturationDavid F Donnelly
J Appl Physiol 104:1260-1. 2008 - Chemoreceptor activity is normal in mice lacking the NK1 receptorRicardo Rigual
Departamento de Bioquímica y Biología Molecular y Fisiología Instituto de Biología y Genética Molecular Facultad de Medicina, Universidad de Valladolid Consejo Superior de Investigaciones Científicas, Valladolid, Spain
Eur J Neurosci 16:2078-84. 2002..It may therefore be concluded that loss of NK1 receptors has little effect on chemoreceptor function in the mouse, and thus they play, at best, a minor role in the hypoxic chemoreception process... - Lamotrigine and phenytoin, but not amiodarone, impair peripheral chemoreceptor responses to hypoxiaEdward Vincent S Faustino
Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, PO Box 208064, New Haven, CT 06520 8064, USA
J Appl Physiol 101:1633-40. 2006..These are consistent with I(NaP) serving an important function in AP generation and may be clinically important in the care of patients using these drugs... - An important functional role of persistent Na+ current in carotid body hypoxia transductionEdward Vincent S Faustino
Department of Pediatrics, Section of Critical Care and Applied Physiology, Yale University School of Medicine, 333 Cedar St, PO Box 208064, New Haven, CT 06520 8064, USA
J Appl Physiol 101:1076-84. 2006..We conclude that I(NaP) is present in chemoreceptor afferent neurons and serves an important role in peripheral chemoreceptor function and, hence, in the ventilatory response to hypoxia... - Upregulation of the hyperpolarization-activated cation current after chronic compression of the dorsal root ganglionHang Yao
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 23:2069-74. 2003..Because I(h) activation provides a depolarizing current to the neuron, thus enhancing neuronal excitability, our results are consistent with the hypothesis that I(h) contributes to hyperalgesia after CCD-induced nerve injury... - Modulation of gene expression in subfamilies of TASK K+ channels by chronic hyperoxia exposure in rat carotid bodyInsook Kim
Dept of Pediatrics, University of Arkansas Medical Sciences, Little Rock, USA
Adv Exp Med Biol 580:37-41; discussion 351-9. 2006 - Perinatal hyperoxia for 14 days increases nerve conduction time and the acute unitary response to hypoxia of rat carotid body chemoreceptorsDavid F Donnelly
Dept. of Pediatrics, University of Arkansas for Medical Sciences, College of Medicine, 800 Marshall St, Little Rock, AR 72202-3591, USA
J Appl Physiol 99:114-9. 2005.... - Cortical delta-opioid receptors potentiate K+ homeostasis during anoxia and oxygen-glucose deprivationDongman Chao
Department of Pediatrics, Section of Respiratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Cereb Blood Flow Metab 27:356-68. 2007..We conclude that an important aspect of DOR-mediated neuroprotection is its early action against derangement of K(+) homeostasis during anoxia or ischemia... - The effect of development on the pattern of A1 and A2a-adenosine receptor gene and protein expression in rat peripheral arterial chemoreceptorsEstelle B Gauda
Department of Pediatrics, Division of Neonatology Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Adv Exp Med Biol 580:121-9; discussion 351-9. 2006
Research Grants
- Carotid Body Chemoreception: Mechanism & DevelopmentDAVID DONNELLY; Fiscal Year: 2006..If supported, the model should lead to a pharmacologic targeting of these processes for the improved treatment of apnea and/or dyspnea. ..
- Mechanism of perinatal-hyperoxic suppression of chemoreceptor functionDAVID DONNELLY; Fiscal Year: 2007..Since hyperoxia is extensively used clinically in newborn and, especially in premature infants, these results are important in understanding physiologic alterations caused by this intervention. ..
- Mechanism of perinatal-hyperoxic suppression of chemoreceptor functionDavid F Donnelly; Fiscal Year: 2010..Since hyperoxia is extensively used clinically in newborn and, especially in premature infants, these results are important in understanding physiologic alterations caused by this intervention. ..