Marcelo O Dietrich

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity
    Marcelo O Dietrich
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035, Brazil Electronic address
    Cell 155:188-99. 2013
  2. ncbi request reprint Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons
    Marcelo O Dietrich
    Program in Integrative Cell Signalling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Rev Drug Discov 11:675-91. 2012
  3. pmc Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity
    Marcelo O Dietrich
    Program on Cell and Neurobiology of Energy Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 30:11815-25. 2010
  4. pmc Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity
    Sabrina Diano
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Med 17:1121-7. 2011
  5. pmc AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors
    Marcelo O Dietrich
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Neurosci 15:1108-10. 2012
  6. pmc The role of mitochondrial uncoupling proteins in lifespan
    Marcelo O Dietrich
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Pflugers Arch 459:269-75. 2010
  7. doi request reprint Hypothalamic control of energy balance: insights into the role of synaptic plasticity
    Marcelo O Dietrich
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Neurosci 36:65-73. 2013
  8. doi request reprint Feeding signals and brain circuitry
    Marcelo O Dietrich
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Eur J Neurosci 30:1688-96. 2009
  9. ncbi request reprint Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
    Jae Geun Kim
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Neurosci 17:908-10. 2014
  10. ncbi request reprint GABA keeps up an appetite for life
    Marcelo O Dietrich
    Program on Cell and Neurobiology of Energy Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 137:1177-9. 2009

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity
    Marcelo O Dietrich
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035, Brazil Electronic address
    Cell 155:188-99. 2013
    ..Overall, our data unmask an important role for mitochondrial dynamics governed by Mfn1 and Mfn2 in Agrp neurons in central regulation of whole-body energy metabolism. ..
  2. ncbi request reprint Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons
    Marcelo O Dietrich
    Program in Integrative Cell Signalling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Rev Drug Discov 11:675-91. 2012
    ..Targeting the molecular pathways that mediate the beneficial effects of calorie restriction and exercise may represent an alternative therapeutic approach for the treatment of chronic metabolic disorders such as obesity...
  3. pmc Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity
    Marcelo O Dietrich
    Program on Cell and Neurobiology of Energy Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 30:11815-25. 2010
    ..The present data indicate that Sirt1 has a central mode of action by acting on the NPY/Agrp neurons to affect body metabolism...
  4. pmc Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity
    Sabrina Diano
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Med 17:1121-7. 2011
    ..These observations unmask a previously unknown hypothalamic cellular process associated with peroxisomes and ROS in the central regulation of energy metabolism in states of leptin resistance...
  5. pmc AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors
    Marcelo O Dietrich
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Neurosci 15:1108-10. 2012
    ..Thus, AgRP neurons determine the set point of the reward circuitry and associated behaviors...
  6. pmc The role of mitochondrial uncoupling proteins in lifespan
    Marcelo O Dietrich
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Pflugers Arch 459:269-75. 2010
    ..Thus, induction of uncoupling through UCPs could decrease the cellular damage that occurs during aging due to excess of ROS. This review will focus on the evidence supporting these mechanisms...
  7. doi request reprint Hypothalamic control of energy balance: insights into the role of synaptic plasticity
    Marcelo O Dietrich
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Neurosci 36:65-73. 2013
    ..In this review, we discuss these findings and focus on the role of neurons and glial cells in the dynamic process of plasticity, which is fundamental to the regulation of physiological and pathological metabolic events...
  8. doi request reprint Feeding signals and brain circuitry
    Marcelo O Dietrich
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Eur J Neurosci 30:1688-96. 2009
    ..This review will provide an overview of recent discoveries relevant to understanding these issues...
  9. ncbi request reprint Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
    Jae Geun Kim
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Neurosci 17:908-10. 2014
    ..These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin. ..
  10. ncbi request reprint GABA keeps up an appetite for life
    Marcelo O Dietrich
    Program on Cell and Neurobiology of Energy Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 137:1177-9. 2009
    ..In this issue, Wu et al. (2009) show that these neurons modulate feeding behavior in mice by providing GABAergic input to the parabrachial nucleus in the brainstem...
  11. pmc Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation
    Marcelo O Dietrich
    Section of Comparative Medicine and Department of Obstetrics, Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 28:10766-71. 2008
    ..Together, these observations reveal that a mitochondrial mechanism related to UCP2 function is essential for appropriate bioenergetic adaptation of neurons to increased neuronal activity and synaptic plasticity in response to exercise...
  12. doi request reprint Phosphoribosomes for fingerprinting neurons
    Marcelo O Dietrich
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 151:934-6. 2012
    ..Fine characterization of specific subpopulations of neurons, however, has been a technical challenge. Here, Knight et al. describe an elegant technique for high throughput of molecular profiling of activated hypothalamic neurons...
  13. ncbi request reprint Synaptic plasticity of feeding circuits: hormones and hysteresis
    Marcelo O Dietrich
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 146:863-5. 2011
    ..In this issue of Cell, Yang et al. (2011) reveal an AMPK-dependent synaptic pathway that sustains excitatory stimulation of the NPY/AgRP neurons that promote feeding behavior until satiety signals kick in...