Sabrina Diano


Affiliation: Yale University
Country: USA


  1. Toda C, Santoro A, Kim J, Diano S. POMC Neurons: From Birth to Death. Annu Rev Physiol. 2017;79:209-236 pubmed publisher
    ..Here, we review and discuss the current understanding of POMC neurons from their development and intracellular regulators to their physiological functions and pathological dysregulation. ..
  2. Bruschetta G, Kim J, Diano S, Chan L. Overexpression of melanocortin 2 receptor accessory protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditure. Mol Metab. 2018;18:79-87 pubmed publisher
    ..Our data indicate a site-specific role for MRAP2 in PVN MC4R-expressing neurons in potentiating MC4R neuronal activation at baseline conditions in the regulation of food intake and energy expenditure. ..
  3. Toda C, Diano S. Mitochondrial UCP2 in the central regulation of metabolism. Best Pract Res Clin Endocrinol Metab. 2014;28:757-64 pubmed publisher
    ..In this review, we will describe recent findings on central UCP2 and discuss its role in CNS regulation of homeostasis. ..
  4. request reprint
    Diano S, Urbanski H, Horvath B, Bechmann I, Kagiya A, Nemeth G, et al. Mitochondrial uncoupling protein 2 (UCP2) in the nonhuman primate brain and pituitary. Endocrinology. 2000;141:4226-38 pubmed
    ..The abundance and distribution pattern of UCP2 in the primate brain and pituitary suggest that this protein is evolutionary conserved and may relate to central autonomic, endocrine and metabolic regulation. ..
  5. Diano S. New aspects of melanocortin signaling: a role for PRCP in ?-MSH degradation. Front Neuroendocrinol. 2011;32:70-83 pubmed publisher
    ..This review summarizes the current knowledge on the melanocortin system with particular focus on PRCP, a newly discovered component of the melanocortin system. ..
  6. Diano S, Liu Z, Jeong J, Dietrich M, Ruan H, Kim E, et al. Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med. 2011;17:1121-7 pubmed publisher
    ..These observations unmask a previously unknown hypothalamic cellular process associated with peroxisomes and ROS in the central regulation of energy metabolism in states of leptin resistance. ..
  7. Toda C, Kim J, Impellizzeri D, Cuzzocrea S, Liu Z, Diano S. UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness. Cell. 2016;164:872-83 pubmed publisher
    ..Thus, our data unmasked a critical cellular biological process controlled by mitochondrial dynamics in VMH regulation of systemic glucose homeostasis. ..
  8. Santoro A, Campolo M, Liu C, Sesaki H, Meli R, Liu Z, et al. DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Cell Metab. 2017;25:647-660 pubmed publisher
    ..Together, these data unmasked a role for mitochondrial fission in leptin sensitivity and glucose sensing of POMC neurons. ..
  9. Kim J, Toda C, Ramírez C, Fernandez Hernando C, Diano S. Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity. Diabetes. 2017;66:2102-2111 pubmed publisher
    ..VMH-specific inhibition of TBK-1 in mice with diet-induced obesity impaired glucose metabolism and AKT activation. Altogether, our data show a TBK-1-dependent role for central Lin28a in glucose homeostasis. ..

More Information


  1. Bruschetta G, Jin S, Kim J, Diano S. Prolyl carboxypeptidase in Agouti-related Peptide neurons modulates food intake and body weight. Mol Metab. 2018;10:28-38 pubmed publisher
    ..Altogether, our data indicate that PRCP is released at the synaptic levels and that PRCP in AgRP neurons contributes to the modulation of ?-MSH degradation and related metabolic control in mice. ..
  2. Jeong J, Diano S. Prolyl carboxypeptidase mRNA expression in the mouse brain. Brain Res. 2014;1542:85-92 pubmed publisher
    ..In addition, using a gene-trap mouse model for PRCP deletion, X-gal staining was performed to further determine PRCP distribution. Results from both approaches showed that PRCP gene is broadly expressed in the brain. ..
  3. Kim J, Toda C, D Agostino G, Zeiss C, DiLeone R, Elsworth J, et al. Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Proc Natl Acad Sci U S A. 2014;111:11876-81 pubmed publisher
    ..Taken together, our results unmask a previously unknown player in central regulation of glucose metabolism and pancreatic function. ..