S Diano

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity
    Jin Kwon Jeong
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, Connecticut 06520 208063, USA
    Am J Physiol Endocrinol Metab 302:E1502-10. 2012
  2. doi request reprint Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism
    Sabrina Diano
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Mol Med 18:52-8. 2012
  3. pmc Ecto-nucleoside triphosphate diphosphohydrolase 3 in the ventral and lateral hypothalamic area of female rats: morphological characterization and functional implications
    David S Kiss
    Department of Physiology and Biochemistry, Szent Istvan University Faculty of Veterinary Science, Budapest, Hungary
    Reprod Biol Endocrinol 7:31. 2009
  4. pmc NTPDases in the neuroendocrine hypothalamus: possible energy regulators of the positive gonadotrophin feedback
    Attila Zsarnovszky
    Department of Physiology and Biochemistry, Szent Istvan University Faculty of Veterinary Sciences, Budapest, Hungary
    Reprod Biol Endocrinol 7:63. 2009
  5. doi request reprint New aspects of melanocortin signaling: a role for PRCP in α-MSH degradation
    Sabrina Diano
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Departments of Ob Gyn and Reproductive Sciences and Neurobiology, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA
    Front Neuroendocrinol 32:70-83. 2011
  6. ncbi request reprint Hypothalamic type II iodothyronine deiodinase: a light and electron microscopic study
    Sabrina Diano
    Department Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar St FMB 338A New Haven, CT 06520, USA
    Brain Res 976:130-4. 2003
  7. doi request reprint Type 3 deiodinase in hypoxia: to cool or to kill?
    Sabrina Diano
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell Metab 7:363-4. 2008
  8. pmc Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity
    Sabrina Diano
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Med 17:1121-7. 2011
  9. pmc Prolyl carboxypeptidase regulates energy expenditure and the thyroid axis
    Jin Kwon Jeong
    Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, P O Box 208063, New Haven, Connecticut 06520 208063, USA
    Endocrinology 153:683-9. 2012
  10. ncbi request reprint Mitochondrial uncoupling protein 2 (UCP2) in the nonhuman primate brain and pituitary
    S Diano
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Endocrinology 141:4226-38. 2000

Detail Information

Publications58

  1. pmc Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity
    Jin Kwon Jeong
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, Connecticut 06520 208063, USA
    Am J Physiol Endocrinol Metab 302:E1502-10. 2012
    ..Altogether, our data suggest that PRCP is an important regulator of energy and glucose homeostasis since its deletion significantly improves metabolic parameters in mice exposed to both SD and HFD...
  2. doi request reprint Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism
    Sabrina Diano
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Mol Med 18:52-8. 2012
    ..The goal is to provide a framework for discussion of future therapeutic strategies for metabolism-related chronic diseases...
  3. pmc Ecto-nucleoside triphosphate diphosphohydrolase 3 in the ventral and lateral hypothalamic area of female rats: morphological characterization and functional implications
    David S Kiss
    Department of Physiology and Biochemistry, Szent Istvan University Faculty of Veterinary Science, Budapest, Hungary
    Reprod Biol Endocrinol 7:31. 2009
    ..The cellular and subcellular localization of NTPDase3; 2.) The effects of 17beta-estradiol on the expression level of hypothalamic NTPDase3; and 3.) The effects of NTPDase inhibition in hypothalamic synaptosomal preparations...
  4. pmc NTPDases in the neuroendocrine hypothalamus: possible energy regulators of the positive gonadotrophin feedback
    Attila Zsarnovszky
    Department of Physiology and Biochemistry, Szent Istvan University Faculty of Veterinary Sciences, Budapest, Hungary
    Reprod Biol Endocrinol 7:63. 2009
    ....
  5. doi request reprint New aspects of melanocortin signaling: a role for PRCP in α-MSH degradation
    Sabrina Diano
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Departments of Ob Gyn and Reproductive Sciences and Neurobiology, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, USA
    Front Neuroendocrinol 32:70-83. 2011
    ..This review summarizes the current knowledge on the melanocortin system with particular focus on PRCP, a newly discovered component of the melanocortin system...
  6. ncbi request reprint Hypothalamic type II iodothyronine deiodinase: a light and electron microscopic study
    Sabrina Diano
    Department Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar St FMB 338A New Haven, CT 06520, USA
    Brain Res 976:130-4. 2003
    ....
  7. doi request reprint Type 3 deiodinase in hypoxia: to cool or to kill?
    Sabrina Diano
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell Metab 7:363-4. 2008
    ....
  8. pmc Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity
    Sabrina Diano
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Med 17:1121-7. 2011
    ..These observations unmask a previously unknown hypothalamic cellular process associated with peroxisomes and ROS in the central regulation of energy metabolism in states of leptin resistance...
  9. pmc Prolyl carboxypeptidase regulates energy expenditure and the thyroid axis
    Jin Kwon Jeong
    Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, P O Box 208063, New Haven, Connecticut 06520 208063, USA
    Endocrinology 153:683-9. 2012
    ..All together, these data confirm that PRCP plays a role in the regulation of energy metabolism...
  10. ncbi request reprint Mitochondrial uncoupling protein 2 (UCP2) in the nonhuman primate brain and pituitary
    S Diano
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Endocrinology 141:4226-38. 2000
    ..The abundance and distribution pattern of UCP2 in the primate brain and pituitary suggest that this protein is evolutionary conserved and may relate to central autonomic, endocrine and metabolic regulation...
  11. ncbi request reprint Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers
    T L Horvath
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 19:10417-27. 1999
    ....
  12. pmc A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2
    Anna Coppola
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Metab 5:21-33. 2007
    ..These results reveal a physiological role for a thyroid-hormone-regulated mitochondrial uncoupling in hypothalamic neuronal networks...
  13. ncbi request reprint Leptin receptors in estrogen receptor-containing neurons of the female rat hypothalamus
    S Diano
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar St, FMB 339, New Haven, CT, USA
    Brain Res 812:256-9. 1998
    ....
  14. ncbi request reprint Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning
    Sabrina Diano
    Department of Obstetrics and Gynecology, Yale Medical School, 333 Cedar Street, New Haven Connecticut 06520, USA
    Endocrinology 144:5014-21. 2003
    ....
  15. ncbi request reprint Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice
    T L Horvath
    Department of Obstetrics and Gynecology, Yale University, School of Medicine, New Haven, CT 06520, USA
    Int J Obes Relat Metab Disord 27:433-42. 2003
    ..To test the hypothesis that either uncoupling protein-2 UCP2 or UCP3 or both together influence obesity and inflammation in transgenic mice...
  16. ncbi request reprint Fasting-induced increase in type II iodothyronine deiodinase activity and messenger ribonucleic acid levels is not reversed by thyroxine in the rat hypothalamus
    S Diano
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Endocrinology 139:2879-84. 1998
    ..This local hyperthyroidism may, in turn, induce the suppression of TRH under these conditions...
  17. ncbi request reprint UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
    Zane B Andrews
    Section of Comparative Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Howard Hughes Medical Institute, New York, New York 10021, USA
    Nature 454:846-51. 2008
    ..These results reveal a signalling modality connecting mitochondria-mediated effects of G-protein-coupled receptors on neuronal function and associated behaviour...
  18. ncbi request reprint Mitochondrial uncoupling proteins in the CNS: in support of function and survival
    Zane B Andrews
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, FMB 339, New Haven, Connecticut 06510, USA
    Nat Rev Neurosci 6:829-40. 2005
    ..Insights into the regulation and function of these proteins offer unsuspected avenues for a better understanding of synaptic transmission and neurodegeneration...
  19. pmc Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
    Tamas L Horvath
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 107:14875-80. 2010
    ..Taken together, these data suggest that consumption of an HFD has a major impact on the cytoarchitecture of the arcuate nucleus in vulnerable subjects, with changes that might be irreversible due to reactive gliosis...
  20. pmc Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity
    Marcelo O Dietrich
    Program on Cell and Neurobiology of Energy Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 30:11815-25. 2010
    ..The present data indicate that Sirt1 has a central mode of action by acting on the NPY/Agrp neurons to affect body metabolism...
  21. ncbi request reprint A GABA-neuropeptide Y (NPY) interplay in LH release
    T L Horvath
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA
    Peptides 22:473-81. 2001
    ..These results support the possibility that in the event of co-release of these neurotransmitters/neuromodulators, GABA may act to restrain stimulation of LH release by NPY during the basal episodic and cyclic release of LH in vivo...
  22. ncbi request reprint Leptin receptor immunoreactivity is associated with the Golgi apparatus of hypothalamic neurons and glial cells
    S Diano
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    J Neuroendocrinol 10:647-50. 1998
    ..These data indicate an extremely high turnover of leptin receptors in hypothalamic target sites, but also raise the possibility that leptin may interact with the Golgi apparatus-related mechanisms to alter intracellular mechanisms...
  23. ncbi request reprint Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system
    T L Horvath
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 415:145-59. 1999
    ..Thus, the hypocretin innervation of the LC may serve to focus cognitive processes to compliment hypocretin-mediated activation of autonomic centers already described...
  24. ncbi request reprint Palmitoylethanolamide prevents metabolic alterations and restores leptin sensitivity in ovariectomized rats
    G Mattace Raso
    Department of Pharmacy G M R, A s, R R, R S, A C, R M, University of Naples Federico II, Naples, 80131, Italy Department of Pathology and Animal Health O P, University of Naples Federico II, Naples, 80137, Italy Department of Neurosciences, Odontostomatologic and Reproductive Sciences C D C, University of Naples Federico II Naples 80131, Italy and Department of Obstetrics, Gynecology, and Reproductive Sciences S D, Yale University School of Medicine, New Haven, Connecticut 06510
    Endocrinology 155:1291-301. 2014
    ..Therefore, our data provide a rationale for the therapeutic use of PEA in obese postmenopausal woman. ..
  25. ncbi request reprint Fuel utilization by hypothalamic neurons: roles for ROS
    Tamas L Horvath
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Endocrinol Metab 20:78-87. 2009
    ..The effects of glucose and fatty acids are discussed with emphasis on free radical production in orexigenic and anorexigenic neurons of the arcuate nucleus...
  26. ncbi request reprint Brain circuits regulating energy homeostasis
    Tamas L Horvath
    Department of Obstetrics Gynecology and Reproductive Sciences, Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, Email
    Neuroscientist 10:235-46. 2004
    ..This review offers a look at central neuronal circuitries that are implicated in metabolism regulation and strongly suggests that without a blueprint, attempts to intervene and control energy balance will remain futile...
  27. ncbi request reprint Fasting activates the nonhuman primate hypocretin (orexin) system and its postsynaptic targets
    Sabrina Diano
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Endocrinology 144:3774-8. 2003
    ....
  28. ncbi request reprint Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease
    Tamas L Horvath
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Endocrinology 144:2757-60. 2003
    ..Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys...
  29. ncbi request reprint Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector
    Tamas L Horvath
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, FMB 339, New Haven, CT 06520, USA
    Biochem Pharmacol 65:1917-21. 2003
    ..These previously unknown functions of UCPs offer new avenues not only for the better understanding of these proteins but also for the furthering of our knowledge on the central nervous system in healthy and disease states...
  30. ncbi request reprint The floating blueprint of hypothalamic feeding circuits
    Tamas L Horvath
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street FMB 339, New Haven, Connecticut 06520, USA
    Nat Rev Neurosci 5:662-7. 2004
  31. ncbi request reprint Ghrelin in hypothalamic regulation of energy balance
    Tamas L Horvath
    Reproductive Neuroscience Unit, Department of Obstetrics and Gynecology, Yale Medical School, New Haven, Connecticut, 06520, USA
    Curr Top Med Chem 3:921-7. 2003
    ..It is our goal to emphasize the critical significance of the hypothalamic signaling modalities induced by ghrelin for a better understanding of how this novel hormone affects energy balance and metabolism...
  32. ncbi request reprint Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals
    Qian Gao
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Med 13:89-94. 2007
    ....
  33. ncbi request reprint Minireview: ghrelin and the regulation of energy balance--a hypothalamic perspective
    T L Horvath
    Reproductive Neuroscience Unit, Department of Obstetrics and Gynecology, Yale Medical School, New Haven, Connecticut 06520, USA
    Endocrinology 142:4163-9. 2001
    ..In this overview, we summarize recent findings and strategies on the integration of ghrelin into neuroendocrine networks that regulate energy homeostasis...
  34. ncbi request reprint Estrogen receptor beta and progesterone receptor mRNA in the intergeniculate leaflet of the female rat
    T L Horvath
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Brain Res 844:196-200. 1999
    ....
  35. ncbi request reprint Inverse shift in circulating corticosterone and leptin levels elevates hypothalamic deiodinase type 2 in fasted rats
    Anna Coppola
    Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, FMB 339, New Haven, Connecticut 06510, USA
    Endocrinology 146:2827-33. 2005
    ..Thus, our observations suggest that appropriate induction of D2 activity during negative energy balance is dependent upon both leptin and glucocorticoid signaling...
  36. pmc Corticosterone regulates synaptic input organization of POMC and NPY/AgRP neurons in adult mice
    Erika Gyengesi
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, P O Box 208063, New Haven, Connecticut 06520 208063, USA
    Endocrinology 151:5395-402. 2010
    ..These results reveal that the known orexigenic action of corticosteroids is mediated, at least in part, by synaptic changes and altered excitability of the melanocortin system...
  37. ncbi request reprint Hormonal regulation of the arcuate nucleus melanocortin system
    Anna Coppola
    Dept of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06511, USA
    Front Biosci 12:3519-30. 2007
    ..In this review, we focus on the hormonal regulation of the neuronal circuits of the arcuate nucleus of the hypothalamus: the melanocortin system...
  38. pmc Anticonvulsant effects of leptin in epilepsy
    Sabrina Diano
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut 06510 8016, USA
    J Clin Invest 118:26-8. 2008
    ....
  39. pmc Susceptibility to a parkinsonian toxin varies during primate development
    B A Morrow
    Neuropsychopharmacology Research Laboratory, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Exp Neurol 235:273-81. 2012
    ..In addition, the data suggest that uncoupling protein-2 may be a target for retarding the progressive loss of nigrostriatal dopamine neurons that occurs in Parkinson's disease and aging...
  40. pmc Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents
    Nicholas Wallingford
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 119:2291-303. 2009
    ..Our results suggest that PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-MSH1-13 levels...
  41. ncbi request reprint Ghrelin controls hippocampal spine synapse density and memory performance
    Sabrina Diano
    Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Neurosci 9:381-8. 2006
    ..Our observations reveal an endogenous function of ghrelin that links metabolic control with higher brain functions and suggest novel therapeutic strategies to enhance learning and memory processes...
  42. ncbi request reprint Suppression of hypothalamic deiodinase type II activity blunts TRH mRNA decline during fasting
    Anna Coppola
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St FMB 339, New Haven, CT 06520, USA
    FEBS Lett 579:4654-8. 2005
    ....
  43. ncbi request reprint Uncoupling protein 2 in primary pain and temperature afferents of the spinal cord
    Balazs Horvath
    Department of Anesthesiology and Operative Intensive Medicine, Humboldt University, Charite, Berlin, Germany
    Brain Res 955:260-3. 2002
    ..The expression of UCP2 in primary sensory afferents of the spinal cord suggests that this mitochondrial uncoupler is involved in the mechanism of pain and temperature sensation...
  44. ncbi request reprint Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold
    Balazs Horvath
    Department of Anesthesiology and Operative Intensive Medicine, Humboldt University, Charite, Berlin, Germany
    Biochem Pharmacol 64:369-74. 2002
    ..Enhancement of UCP2 activation after acute alcohol consumption might decrease the time of recovery from intoxication, whereas UCP2 inhibition might decrease the tolerance to ethanol...
  45. ncbi request reprint Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury
    Ingo Bechmann
    Department of Anatomy and Cell Biology, Humboldt University, Charite, Berlin, Germany
    Biochem Pharmacol 64:363-7. 2002
    ....
  46. ncbi request reprint ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury
    C Dominique Toran-Allerand
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 22:8391-401. 2002
    ....
  47. ncbi request reprint The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    Michael A Cowley
    The Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
    Neuron 37:649-61. 2003
    ..We propose that at these sites, release of ghrelin may stimulate the release of orexigenic peptides and neurotransmitters, thus representing a novel regulatory circuit controlling energy homeostasis...
  48. pmc Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia
    Xinmin Xie
    Biosciences Division, SRI International, Menlo Park, California 94025, USA
    J Clin Invest 118:2471-81. 2008
    ..These results establish what is, to our knowledge, a novel interaction between the N/OFQ and Hcrt systems in which the corticotropin-releasing factor and N/OFQ systems coordinately modulate the Hcrt neurons to regulate SIA...
  49. ncbi request reprint Obesity and the neuroendocrine control of energy homeostasis: the role of spontaneous locomotor activity
    Tamara R Castaneda
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, OH, USA
    J Nutr 135:1314-9. 2005
    ..Despite this, very little is known about the molecular mechanisms by which SPA is regulated. The overview will attempt to summarize available information on neuroendocrine factors regulating SPA...
  50. ncbi request reprint Agouti-related protein-deficient mice display an age-related lean phenotype
    Katherine E Wortley
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell Metab 2:421-7. 2005
    ..These results provide further proof of the importance of the AgRP neuronal system in the regulation of energy homeostasis...
  51. ncbi request reprint Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response
    Raphaelle Winsky-Sommerer
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 24:11439-48. 2004
    ..We propose that, after stressor stimuli, CRF stimulates the release of hypocretins and that this circuit contributes to activation and maintenance of arousal associated with the stress response...
  52. pmc gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor
    Ruth Janoschek
    Institute for Genetics and Center for Molecular Medicine Cologne, Department of Mouse Genetics and Metabolism, University of Cologne, D 50674 Cologne, Germany
    Proc Natl Acad Sci U S A 103:10707-12. 2006
    ..These data reveal POMC neurons as a critical site of CNTF action in mediating its anorectic effect...
  53. ncbi request reprint A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain
    Heather A Halem
    IPSEN Group, Milford, MA 01757, USA
    Neuroendocrinology 81:339-49. 2005
    ....
  54. pmc Overexpression of UCP2 protects thalamic neurons following global ischemia in the mouse
    Tomas Deierborg
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University BMC A13, Lund, Sweden
    J Cereb Blood Flow Metab 28:1186-95. 2008
    ..Consequently, neuroprotection in the thalamus correlated with a high expression of UCP2, which is neuroprotective in a number of models of neurodegenerative diseases...
  55. ncbi request reprint Rapid rewiring of arcuate nucleus feeding circuits by leptin
    Shirly Pinto
    Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 304:110-5. 2004
    ..These data suggest that leptin-mediated plasticity in the ob/ob hypothalamus may underlie some of the hormone's behavioral effects...
  56. ncbi request reprint Novel analogs of ghrelin: physiological and clinical implications
    Heather A Halem
    IPSEN, 27 Maple Street, Milford, Massachusetts 01757, USA
    Eur J Endocrinol 151:S71-5. 2004
    ..These studies demonstrate the feasibility of creating ghrelin analogs that are selective for specific activities, as well as their utility in dissecting the role of ghrelin in both normal physiology and specific pathologies...
  57. ncbi request reprint Leptin induces nitric oxide synthase type II in C6 glioma cells. Role for nuclear factor-kappaB in hormone effect
    Giuseppina Mattace Raso
    Department of Experimental Pharmacology, University of Naples, Federico II, via D Montesano, 49 80131 Naples, Italy
    Neurosci Lett 396:121-6. 2006
    ..These results confirm the pro-inflammatory role of leptin and identify it as a potential up-regulator of cytokine-induced inflammatory response in the CNS...

Research Grants10

  1. Hypothalamic Type 2 Deiodinase in Metabolism Regulation
    Sabrina Diano; Fiscal Year: 2002
    ....
  2. Learning and Memory in the Melanocortin System
    Sabrina Diano; Fiscal Year: 2007
    ..abstract_text> ..
  3. Learning and Memory in the Melanocortin System
    Sabrina Diano; Fiscal Year: 2006
    ..abstract_text> ..
  4. Learning and Memory in the Melanocortin System
    Sabrina Diano; Fiscal Year: 2005
    ..abstract_text> ..
  5. Hypothalamic Type 2 Deiodinase in Metabolism Regulation
    Sabrina Diano; Fiscal Year: 2004
    ....
  6. Hypothalamic Type 2 Deiodinase in Metabolism Regulation
    Sabrina Diano; Fiscal Year: 2005
    ....
  7. Hypothalamic Type 2 Deiodinase in Metabolism Regulation
    Sabrina Diano; Fiscal Year: 2004
    ....
  8. Hypothalamic Type 2 Deiodinase in Metabolism Regulation
    Sabrina Diano; Fiscal Year: 2003
    ....
  9. A carboxypeptidase in the regulation of hypothalamic circuitry
    Sabrina Diano; Fiscal Year: 2010
    ..Successful completion of these studies will deliver new drug targets for metabolic disorders, including obesity and type 2 diabetes. ..