Frank Detterbeck

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint The international thymic malignancy interest group
    Frank C Detterbeck
    Yale University School of Medicine, Section of Thoracic Surgery, New Haven, Connecticut 06520 8062, USA
    J Natl Compr Canc Netw 11:589-93. 2013
  2. pmc Screening for lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines
    Frank C Detterbeck
    Yale School of Medicine, 330 Cedar St, PO Box 208062, New Haven, CT 06520 8062, USA
    Chest 143:e78S-92S. 2013
  3. ncbi request reprint Thymoma: current diagnosis and treatment
    Frank C Detterbeck
    Section of Thoracic Surgery, Yale School of Medicine, Yale University, 330 Cedar St, New Haven, CT 06520, USA
    Chin Med J (Engl) 126:2186-91. 2013
  4. doi request reprint The stage classification of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines
    Frank C Detterbeck
    Yale School of Medicine, 330 Cedar St, PO Box 208062, New Haven, CT 06520 8062, USA
    Chest 143:e191S-210S. 2013
  5. doi request reprint A new method to predict postoperative lung function: quantitative breath sound measurements
    Frank Detterbeck
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Ann Thorac Surg 95:968-75. 2013
  6. doi request reprint Thoracoscopy: a real-life perspective
    Frank C Detterbeck
    Department of Thoracic Surgery, Yale University School of Medicine, 330 Cedar Street, BB205, New Haven, CT 06520 8062, USA
    Clin Chest Med 34:93-8. 2013
  7. doi request reprint Approach to the ground-glass nodule
    Frank C Detterbeck
    Yale Thoracic Surgery, Yale School of Medicine, 330 Cedar Street, PO Box 208062, New Haven, CT 06520 8062, USA
    Clin Chest Med 32:799-810. 2011
  8. doi request reprint Neoadjuvant chemotherapy with gemcitabine-containing regimens in patients with early-stage non-small cell lung cancer
    Frank C Detterbeck
    Yale Comprehensive Cancer Center, Yale University, New Haven, Connecticut 06520 8062, USA
    J Thorac Oncol 3:37-45. 2008
  9. ncbi request reprint Clinical value of the WHO classification system of thymoma
    Frank C Detterbeck
    Division of Thoracic Surgery, Yale University, New Haven, Connecticut 06520 8062, USA
    Ann Thorac Surg 81:2328-34. 2006
  10. doi request reprint Classification of the thoroughness of mediastinal staging of lung cancer
    Frank Detterbeck
    Section of Thoracic Surgery, Yale University School of Medicine, Yale Thoracic Oncology Program, New Haven, CT 06520 8062, USA
    Chest 137:436-42. 2010

Detail Information

Publications69

  1. ncbi request reprint The international thymic malignancy interest group
    Frank C Detterbeck
    Yale University School of Medicine, Section of Thoracic Surgery, New Haven, Connecticut 06520 8062, USA
    J Natl Compr Canc Netw 11:589-93. 2013
    ..The ITMIG provides the foundation for development of more evidence-based guidelines in the future...
  2. pmc Screening for lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines
    Frank C Detterbeck
    Yale School of Medicine, 330 Cedar St, PO Box 208062, New Haven, CT 06520 8062, USA
    Chest 143:e78S-92S. 2013
    ..This article examines the data regarding the ability of screening to decrease the number of lung cancer deaths...
  3. ncbi request reprint Thymoma: current diagnosis and treatment
    Frank C Detterbeck
    Section of Thoracic Surgery, Yale School of Medicine, Yale University, 330 Cedar St, New Haven, CT 06520, USA
    Chin Med J (Engl) 126:2186-91. 2013
    ..To review the presentation, diagnosis, staging and treatment of thymoma...
  4. doi request reprint The stage classification of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines
    Frank C Detterbeck
    Yale School of Medicine, 330 Cedar St, PO Box 208062, New Haven, CT 06520 8062, USA
    Chest 143:e191S-210S. 2013
    ..The current Lung Cancer Stage Classification system is the seventh edition, which took effect in January 2010. This article reviews the definitions for the TNM descriptors and the stage grouping in this system...
  5. doi request reprint A new method to predict postoperative lung function: quantitative breath sound measurements
    Frank Detterbeck
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Ann Thorac Surg 95:968-75. 2013
    ..Single-center studies suggest that this noninvasive, radiation-free method of quantifying lung function is comparable to the reference standard...
  6. doi request reprint Thoracoscopy: a real-life perspective
    Frank C Detterbeck
    Department of Thoracic Surgery, Yale University School of Medicine, 330 Cedar Street, BB205, New Haven, CT 06520 8062, USA
    Clin Chest Med 34:93-8. 2013
    ..How thinking should be structured regarding the management of pleural disease in the modern context of available approaches and interventions is also discussed...
  7. doi request reprint Approach to the ground-glass nodule
    Frank C Detterbeck
    Yale Thoracic Surgery, Yale School of Medicine, 330 Cedar Street, PO Box 208062, New Haven, CT 06520 8062, USA
    Clin Chest Med 32:799-810. 2011
    ....
  8. doi request reprint Neoadjuvant chemotherapy with gemcitabine-containing regimens in patients with early-stage non-small cell lung cancer
    Frank C Detterbeck
    Yale Comprehensive Cancer Center, Yale University, New Haven, Connecticut 06520 8062, USA
    J Thorac Oncol 3:37-45. 2008
    ..Surgical resection alone remains suboptimal for patients with early-stage (I or II) non-small cell lung cancer. Two similar randomized phase II trials were conducted to define an active preoperative regimen in this disease state...
  9. ncbi request reprint Clinical value of the WHO classification system of thymoma
    Frank C Detterbeck
    Division of Thoracic Surgery, Yale University, New Haven, Connecticut 06520 8062, USA
    Ann Thorac Surg 81:2328-34. 2006
    ....
  10. doi request reprint Classification of the thoroughness of mediastinal staging of lung cancer
    Frank Detterbeck
    Section of Thoracic Surgery, Yale University School of Medicine, Yale Thoracic Oncology Program, New Haven, CT 06520 8062, USA
    Chest 137:436-42. 2010
    ..Such a schema is needed for a thoughtful discussion of how mediastinal staging tests should be integrated and for the development of standards of good quality care for patients with non-small cell lung cancer...
  11. ncbi request reprint Coping with the unexpected at surgery
    Frank C Detterbeck
    Yale University School of Medicine, Thoracic Surgery, 330 Cedar Street, BB 205, New Haven, CT 06520 8062, USA
    Expert Rev Respir Med 4:115-22. 2010
    ..Collaborative organization via multidisciplinary tumor boards or inter-institutional interaction allows collective wisdom to promote better outcomes for all...
  12. doi request reprint What to do with "Surprise" N2?: intraoperative management of patients with non-small cell lung cancer
    Frank Detterbeck
    Division of Thoracic Surgery, Department of Surgery, Yale University, New Haven, Connecticut, USA
    J Thorac Oncol 3:289-302. 2008
    ..Reasonable arguments can be made that the approach should include a mediastinal lymph node dissection and adjuvant therapy...
  13. doi request reprint The new lung cancer staging system
    Frank C Detterbeck
    Thoracic Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Chest 136:260-71. 2009
    ..This article reviews the recommendations of the IASLC International Staging Committee for the definitions for the TNM descriptors and the stage grouping in the new non-small cell lung cancer staging system...
  14. ncbi request reprint Invited commentary
    Frank C Detterbeck
    Division of Thoracic Surgery, Yale University, FMB 128, 330 Cedar St, New Haven, CT 06520 8062, USA
    Ann Thorac Surg 83:1984-5. 2007
  15. doi request reprint Management algorithms for stage IIIA non-small cell lung cancer with N2 node involvement
    Frank Detterbeck
    Department of Surgery, Section of Thoracic Surgery, Yale University, 333 Cedar Street, FMB 128, P O Box 208062, New Haven, CT 06520, USA
    Thorac Surg Clin 18:437-41, vii. 2008
    ..A simple, pragmatic approach is taken in this article to define algorithms for the management of these patients...
  16. doi request reprint Turning gray: the natural history of lung cancer over time
    Frank C Detterbeck
    Department of Surgery, Division of Thoracic Surgery, Yale Cancer Center, Yale University, New Haven, Connecticut, USA
    J Thorac Oncol 3:781-92. 2008
    ..Models of tumor growth, however, are not understood well enough to use the observed doubling time to predict length of survival without treatment...
  17. ncbi request reprint Invasive mediastinal staging of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    Frank C Detterbeck
    Division of Thoracic Surgery, Department of Surgery, Yale University, 330 Cedar St, FMB 128, New Haven, CT 06520 8062, USA
    Chest 132:202S-220S. 2007
    ..Although imaging studies can provide some guidance, in many situations invasive staging is necessary. Many different complementary techniques are available...
  18. ncbi request reprint Integration of mediastinal staging techniques for lung cancer
    Frank C Detterbeck
    Division of Thoracic Surgery, Department of Surgery, Yale University, 330 Cedar St, FMB 128, New Haven, CT 06520 8062, USA
    Semin Thorac Cardiovasc Surg 19:217-24. 2007
    ..The goal is to maximize efficiency by enhancing staging accuracy while minimizing the number of tests each patient is subjected to...
  19. ncbi request reprint Invited commentary
    Frank C Detterbeck
    Division of Thoracic Surgery, Yale University, FMB 128, New Haven, CT 06520 8062, USA
    Ann Thorac Surg 81:330. 2006
  20. doi request reprint Imaging requirements in the practice of pulmonary metastasectomy
    Frank C Detterbeck
    Section of Thoracic Surgery, Yale University School of Medicine, Yale Cancer Center Thoracic Oncology Program, New Haven, Connecticut, USA
    J Thorac Oncol 5:S134-9. 2010
    ..Despite helical CT scan, palpation identifies the metastases not detected by imaging in 20 to 25% of patients and remains the standard. No data define the optimal interval for follow-up surveillance imaging...
  21. doi request reprint Evaluation and treatment of stage I and II thymoma
    Frank C Detterbeck
    Thoracic Surgery, Department of Surgery, Yale University, New Haven, Connecticut 06520 8062, USA
    J Thorac Oncol 5:S318-22. 2010
    ..Surgical resection is the mainstay of treatment, and every effort must be made to achieve a complete resection...
  22. doi request reprint Management of carcinoid tumors
    Frank C Detterbeck
    Thoracic Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Ann Thorac Surg 89:998-1005. 2010
    ..For a high suspicion of atypical carcinoid (central cN2, peripheral cN1, 2), imaging for distant metastases and mediastinoscopy is suggested, with multimodality treatment for an atypical carcinoid with N2 involvement...
  23. doi request reprint Management of stage I and II thymoma
    Frank C Detterbeck
    Section of Thoracic Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Thorac Surg Clin 21:59-67, vi-vii. 2011
    ..Adjuvant radiotherapy after a complete resection does not appear to be of benefit. In the rare event of a recurrence, an aggressive approach should be taken with re-resection whenever possible...
  24. doi request reprint Stage classification and prognosis: an intersection of medicine, quantum physics and religion?
    Frank C Detterbeck
    Yale University School of Medicine, 330 Cedar St, Thoracic Surgery, Yale University, New Haven, CT, 06520 8062, USA
    Thorax 66:1016-7. 2011
    ..However, predicting prognosis is complicated and depends on many factors. Simply amassing more data alone is not the answer; we have to learn to intellectually manage the inherent complexity and uncertainty if we are to make progress...
  25. pmc Use of new treatment modalities for non-small cell lung cancer care in the Medicare population
    Michael T Vest
    Department of Internal Medicine, Section of Pulmonary and Critical Care Medicine, Yale School of Medicine, New Haven, CT 06520, USA
    Chest 143:429-35. 2013
    ..The adoption of these techniques and their impact on access to cancer care among Medicare beneficiaries with stage I NSCLC are unknown...
  26. pmc High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology
    Valsamo K Anagnostou
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
    BMC Cancer 10:186. 2010
    ..Bcl-2 has been investigated as a prognostic factor in non small cell lung cancer (NSCLC) patients with conflicting results...
  27. pmc Thoroughness of mediastinal staging in stage IIIA non-small cell lung cancer
    Michael T Vest
    Department of Internal Medicine, Section of Pulmonary and Critical Care Medicine, Yale Comprehensive Cancer Center, New Haven, Connecticut, USA
    J Thorac Oncol 7:188-95. 2012
    ..Studies have suggested that invasive mediastinal staging is underutilized, although practice patterns have not been rigorously evaluated...
  28. doi request reprint High expression of mammalian target of rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma
    Valsamo K Anagnostou
    Department of Pathology, Section of Medical Oncology, Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    Clin Cancer Res 15:4157-64. 2009
    ..Here, we quantitatively assessed mTOR protein expression in two large data sets to investigate the impact of mTOR expression on patient survival...
  29. ncbi request reprint Invasive staging of non-small cell lung cancer: a review of the current evidence
    Eric M Toloza
    Department of Surgery, Duke Thoracic Oncology, Duke University Medical Center Box 3048, Durham, NC 27710, USA
    Chest 123:157S-166S. 2003
    ....
  30. ncbi request reprint Clinical practice. Superior vena cava syndrome with malignant causes
    Lynn D Wilson
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    N Engl J Med 356:1862-9. 2007
  31. doi request reprint Should the 7th edition of the lung cancer stage classification system change treatment algorithms in non-small cell lung cancer?
    Daniel J Boffa
    Department of Thoracic Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    J Thorac Oncol 5:1779-83. 2010
    ..However, the staging system revision was not designed to evaluate treatment, and attempts to make parallel adjustments in treatment plans may not be justified...
  32. doi request reprint New TNM classification for non-small-cell lung cancer
    Lynn T Tanoue
    Section of Pulmonary and Critical Care Medicine, Yale Thoracic Oncology Program, Yale School of Medicine, 105 LCI, 333 Cedar Street, New Haven, CT 06520, USA
    Expert Rev Anticancer Ther 9:413-23. 2009
    ....
  33. ncbi request reprint Changes in the treatment of Pancoast tumors
    Frank C Detterbeck
    Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7065, USA
    Ann Thorac Surg 75:1990-7. 2003
    ....
  34. ncbi request reprint Accuracy of helical CT in the detection of pulmonary metastases: is intraoperative palpation still necessary?
    Alden M Parsons
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7065, USA
    Ann Thorac Surg 78:1910-6; discussion 1916-8. 2004
    ..Helical CT detects more nodules than conventional CT, raising the question of whether palpation of the lungs is still necessary if helical CT is used...
  35. ncbi request reprint Seeking a home for a PET, part 2: Defining the appropriate place for positron emission tomography imaging in the staging of patients with suspected lung cancer
    Frank C Detterbeck
    Division of Cardiothoracic Surgery, Department of Surgery, Members of the Multidisciplinary Thoracic Oncology Program, University of North Carolina, Chapel Hill, NC, USA
    Chest 125:2300-8. 2004
    ..It is unclear and controversial whether a biopsy is needed in patients with clinical stage II lung cancer who have no PET uptake in the mediastinum...
  36. ncbi request reprint Perforated viscus in a patient with non-small cell lung cancer receiving bevacizumab
    Jhanelle Gray
    Department of Thoracic Oncology, Yale New Haven Medical Center, New Haven, Connecticut, USA
    J Thorac Oncol 2:571-3. 2007
    ..In this report, we present the first known case of visceral perforation in a patient with metastatic non-small cell lung cancer after treatment with bevacizumab...
  37. ncbi request reprint Thymic tumors
    Frank C Detterbeck
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7065, USA
    Ann Thorac Surg 77:1860-9. 2004
    ..Preoperative chemotherapy appears to increase the rate of complete resection and survival of patients with a stage III or IVa thymoma and should strongly be considered in such cases...
  38. doi request reprint Anatomy, biology and concepts, pertaining to lung cancer stage classification
    Frank C Detterbeck
    Thoracic Oncology Program, Yale Cancer Center, New Haven, Connecticut, USA frank detterbeck yale edu
    J Thorac Oncol 4:437-43. 2009
    ..This article explores concepts regarding tumor biology that can be applied to the anatomically based new staging system...
  39. doi request reprint Surveillance epidemiology and end results evaluation of the role of surgery for stage I small cell lung cancer
    James B Yu
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Thorac Oncol 5:215-9. 2010
    ..This study was performed to evaluate the clinical outcomes of surgery for stage I small cell lung cancer (SCLC)...
  40. ncbi request reprint Evaluation and definitive management of medically inoperable early stage non-small-cell lung cancer. Part 2: newer treatment modalities
    Roy H Decker
    Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Oncology (Williston Park) 20:899-905; discussion 905-8, 913. 2006
    ..Additionally, emerging evidence suggests that new modalities, such as stereotactic radiosurgery and radiofrequency ablation, may also be potentially curative treatment alternatives. These modalities are addressed in part 2...
  41. ncbi request reprint Seeking a home for a PET, part 1: Defining the appropriate place for positron emission tomography imaging in the diagnosis of pulmonary nodules or masses
    Frank C Detterbeck
    Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina at Chapel Hill, USA
    Chest 125:2294-9. 2004
    ....
  42. ncbi request reprint Airway complications after pulmonary resection
    Emily A Farkas
    Division of Thoracic Surgery, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520 8062, USA
    Thorac Surg Clin 16:243-51. 2006
    ....
  43. ncbi request reprint Fulminant development of mega-aorta due to Takayasu's arteritis: case report and review of the literature
    William P Robinson
    Department of Surgery, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Vascular 13:178-83. 2005
    ..We report an unusual case of Takayasu's arteritis in a 43-year-old man who presented with severe back pain and provide a brief review of the literature...
  44. ncbi request reprint Lung cancer. Invasive staging: the guidelines
    Frank C Detterbeck
    Multidisciplinary Thoracic Oncology Program, Division of Cardiothoracic Surgery, University of North Carolina, CB 7065, 108 Burnett Womack Building, Chapel Hill, NC 27599 7065, USA
    Chest 123:167S-175S. 2003
    ..Selection of the optimal approach is best achieved through a multidisciplinary discussion so that all aspects can be weighed appropriately...
  45. ncbi request reprint Life in the real world
    Frank C Detterbeck
    Chest 127:699-701. 2005
  46. ncbi request reprint Systematic review evaluating the timing of thoracic radiation therapy in combined modality therapy for limited-stage small-cell lung cancer
    Daniel B Fried
    Multidisciplinary Thoracic Oncology Program, Lineberger Comprehensive Cancer Center, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Clin Oncol 22:4837-45. 2004
    ..In addition, we assessed the impact of radiation fractionation and chemotherapeutic regimen on timing...
  47. ncbi request reprint The risk of death from heart disease in patients with nonsmall cell lung cancer who receive postoperative radiotherapy: analysis of the Surveillance, Epidemiology, and End Results database
    Brian E Lally
    Department of Radiation Oncology, Wake Forest University Health Sciences, Winston Salem, NC 27157 1030, USA
    Cancer 110:911-7. 2007
    ..This study was designed to investigate whether the mortality from heart disease, a manifestation of intercurrent disease after postoperative radiotherapy (PORT), has decreased over time for patients with nonsmall cell lung cancer (NSCLC)...
  48. ncbi request reprint Induction and concurrent chemotherapy with high-dose thoracic conformal radiation therapy in unresectable stage IIIA and IIIB non-small-cell lung cancer: a dose-escalation phase I trial
    Mark A Socinski
    Multidisciplinary Thoracic Oncology Program, Lineberger Comprehensive Cancer Center, University of North Carolina, CB 7305, Chapel Hill, NC 27599 7305, USA
    J Clin Oncol 22:4341-50. 2004
    ..Dose escalation using three-dimensional thoracic conformal radiation therapy (TCRT) is one strategy to improve local control and perhaps survival...
  49. ncbi request reprint Lung cancer. Special treatment issues
    Frank C Detterbeck
    Multidisciplinary Thoracic Oncology Program, Division of Cardiothoracic Surgery, University of North Carolina, CB 7605, 108 Burnett Womack Building, Chapel Hill, NC 27599 7065, USA
    Chest 123:244S-258S. 2003
    ..Finally, some patients with a solitary focus of metastatic disease in the brain or adrenal gland appear to benefit substantially from resection...
  50. ncbi request reprint Relearning the lessons of the past: are we making progress?
    Frank C Detterbeck
    Ann Thorac Surg 80:1979-80; author reply 1980-1. 2005
  51. ncbi request reprint Postoperative radiotherapy for stage II or III non-small-cell lung cancer using the surveillance, epidemiology, and end results database
    Brian E Lally
    Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1030, USA
    J Clin Oncol 24:2998-3006. 2006
    ..To investigate the association between survival and postoperative radiotherapy (PORT) in patients with resected non-small-cell lung cancer (NSCLC)...
  52. ncbi request reprint Beliefs among physicians in the diagnostic and therapeutic approach to non-small cell lung cancer
    Thomas E Stinchcombe
    Multidisciplinary Thoracic Oncology Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Thorac Oncol 2:819-26. 2007
    ..Physicians' beliefs and practice patterns may differ significantly from established guidelines. We conducted a survey to assess and compare physician beliefs against the evidence-based guidelines...
  53. doi request reprint Please lead, but don't mislead
    Frank C Detterbeck
    Chest 134:672; author reply 672-3. 2008
  54. pmc Evolution and science, progress and change
    Frank C Detterbeck
    Thorax 62:654-5. 2007
  55. ncbi request reprint Positron emission tomographic scanning in the diagnosis and staging of non-small cell lung cancer 2 cm in size or less
    Amir H Khandani
    J Thorac Cardiovasc Surg 132:214-5; author reply 215. 2006
  56. ncbi request reprint Evaluation and definitive management of medically inoperable early-stage non-small-cell lung cancer. Part 1: Assessment and conventional radiotherapy
    Roy H Decker
    Yale University School of Medicine New Haven, Connecticut 06520 8040, USA
    Oncology (Williston Park) 20:727-36. 2006
    ..Additionally, emerging evidence suggests that new modalities, such as stereotactic radiosurgery and radiofrequency ablation, may also be potentially curative treatment alternatives. These modalities will be addressed in part 2...
  57. doi request reprint The feasibility of adjuvant carboplatin and docetaxel in patients with curatively resected non-small cell lung cancer
    Thomas E Stinchcombe
    Multidisciplinary Thoracic Oncology Program, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Thorac Oncol 3:145-51. 2008
    ..Carboplatin (C) is better tolerated than cisplatin, and carboplatin-based adjuvant therapy may have better chemotherapy compliance...
  58. ncbi request reprint A phase I study of gemcitabine and docetaxel for advanced stage solid tumors
    Michael E Poole
    Division of Hematology Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Cancer Invest 21:350-4. 2003
    ..We conducted a phase I study to determine the maximum tolerated dose of docetaxel in combination with gemcitabine for patients with refractory solid tumors...
  59. ncbi request reprint Thoracoscopy using a substernal handport for palpation
    Frank C Detterbeck
    Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7065, USA
    Ann Thorac Surg 78:1031-6. 2004
    ..A substernal handport allows palpation of the lung and thus circumvents one of the major limitations of thoracoscopy...
  60. ncbi request reprint The ABCs of LTX for BAC
    Thomas M Egan
    J Thorac Cardiovasc Surg 125:20-2. 2003
  61. ncbi request reprint Bronchial margins in lung cancer resection specimens: utility of frozen section and gross evaluation
    Susan J Maygarden
    Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Mod Pathol 17:1080-6. 2004
    ..In lobectomies following wedge resection in which no gross tumor remained, all had negative margins. Salivary gland-type tumors have a high incidence of positive margins, and frozen section is particularly indicated in these tumors...
  62. ncbi request reprint Seeking a home for a PET, part 3: Emerging applications of positron emission tomography imaging in the management of patients with lung cancer
    Frank C Detterbeck
    Division of Cardiothoracic Surgery, Medical School Wing C Room 354, CB 7065, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7065, USA
    Chest 126:1656-66. 2004
    ..Further technologic improvements in PET scanners are likely to bring further benefits to the management of patients with lung cancer in the future...
  63. ncbi request reprint Subpleural catheter placement for pain relief after thoracoscopic resection
    Frank C Detterbeck
    Division of Cardiothoracic Surgery, University of North Carolina, Chapel Hill, North Carolina 27599 7065, USA
    Ann Thorac Surg 81:1522-3. 2006
    ..This report describes a simple, rapid technique of subpleural catheter placement that lends itself well to thoracoscopic procedures...
  64. pmc Assessment of real-time 3D visualization for cardiothoracic diagnostic evaluation and surgery planning
    Bradley M Hemminger
    Department of Radiology and School of Information and Library Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3360, USA
    J Digit Imaging 18:145-53. 2005
    ..We test whether advanced real-time rendering techniques combined with an effective user interface will allow radiologists and surgeons to improve their performance for cardiothoracic surgery planning and diagnostic evaluation...
  65. ncbi request reprint Chromosomal abnormalities in bronchial epithelium from smokers, nonsmokers, and lung cancer patients
    Robbert J C Slebos
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Cancer Genet Cytogenet 159:137-42. 2005
    ..These specific alterations were found almost exclusively in patients with a history of tobacco smoking. The results did not indicate that general chromosomal abnormalities are a useful marker for tobacco smoke exposure or cancer risk...
  66. ncbi request reprint Lumping, splitting, and sorting
    Frank C Detterbeck
    J Thorac Oncol 2:581-2. 2007
  67. ncbi request reprint Does an anecdote substantiate dogma?
    Frank C Detterbeck
    Ann Thorac Surg 81:1182; author reply 1182-3. 2006
  68. ncbi request reprint Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells
    Hyeon Woo Yim
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Cancer Lett 246:24-33. 2007
    ..An increase in telomerase activity in normal bronchial epithelium might extend the lifespan of cells at risk for malignant transformation, and thus contribute to lung carcinogenesis...
  69. ncbi request reprint Helical computed tomography inaccuracy in the detection of pulmonary metastases: can it be improved?
    Alden M Parsons
    Division of Cardiothoracic Surgery, University of North Carolina, Chapel Hill, North Carolina 27599 7065, USA
    Ann Thorac Surg 84:1830-6. 2007
    ..We hypothesized that this may be improved by scan interpretation with adequate clinical history and focused documentation of all pulmonary lesions, and may be influenced by the training of the reader...