Patrick H Degnan

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Illumina-based analysis of microbial community diversity
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA
    ISME J 6:183-94. 2012
  2. pmc Origin and examination of a leafhopper facultative endosymbiont
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA
    Curr Microbiol 62:1565-72. 2011
  3. pmc Sequence conservation and functional constraint on intergenic spacers in reduced genomes of the obligate symbiont Buchnera
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America
    PLoS Genet 7:e1002252. 2011
  4. pmc Diverse phage-encoded toxins in a protective insect endosymbiont
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721 0088, USA
    Appl Environ Microbiol 74:6782-91. 2008
  5. pmc Chimpanzees and humans harbour compositionally similar gut enterotypes
    Andrew H Moeller
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06511, USA
    Nat Commun 3:1179. 2012
  6. doi request reprint Evolutionary genetics of a defensive facultative symbiont of insects: exchange of toxin-encoding bacteriophage
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Biosciences West, Room 310, 1041 E Lowell Street, University of Arizona, Tucson, AZ 85721 0088, USA
    Mol Ecol 17:916-29. 2008
  7. pmc Dynamics of genome evolution in facultative symbionts of aphids
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Environ Microbiol 12:2060-9. 2010
  8. pmc Human gut microbes use multiple transporters to distinguish vitamin B₁₂ analogs and compete in the gut
    Patrick H Degnan
    Department of Microbial Pathogenesis and Microbial Diversity Institute, Yale University, New Haven, CT 06536, USA
    Cell Host Microbe 15:47-57. 2014
  9. ncbi request reprint Functional genomics of Buchnera and the ecology of aphid hosts
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Mol Ecol 15:1251-61. 2006
  10. pmc Factors associated with the diversification of the gut microbial communities within chimpanzees from Gombe National Park
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 109:13034-9. 2012

Detail Information

Publications11

  1. pmc Illumina-based analysis of microbial community diversity
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA
    ISME J 6:183-94. 2012
    ..By considering each source of error, we delineate ways to make biologically relevant and robust conclusions from the millions of sequencing reads that can be readily generated by this technology...
  2. pmc Origin and examination of a leafhopper facultative endosymbiont
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA
    Curr Microbiol 62:1565-72. 2011
    ..However, the slightly reduced genome size, abundance of mobile DNA, fastidious growth in culture, and efficient vertical transmission suggest that symbiosis with E. variegatus has had a significant impact on genome evolution in BEV...
  3. pmc Sequence conservation and functional constraint on intergenic spacers in reduced genomes of the obligate symbiont Buchnera
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America
    PLoS Genet 7:e1002252. 2011
    ..Although pseudogene formation, and thus IGS formation, are ongoing processes in these genomes, a large proportion of intergenic spacers contain functional sequences...
  4. pmc Diverse phage-encoded toxins in a protective insect endosymbiont
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721 0088, USA
    Appl Environ Microbiol 74:6782-91. 2008
    ..Thus, phage may act as a conduit for ongoing gene exchange among heritable endosymbionts...
  5. pmc Chimpanzees and humans harbour compositionally similar gut enterotypes
    Andrew H Moeller
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06511, USA
    Nat Commun 3:1179. 2012
    ..These results support the hypothesis that enterotypic variation was present in populations of great apes before the divergence of humans and chimpanzees...
  6. doi request reprint Evolutionary genetics of a defensive facultative symbiont of insects: exchange of toxin-encoding bacteriophage
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Biosciences West, Room 310, 1041 E Lowell Street, University of Arizona, Tucson, AZ 85721 0088, USA
    Mol Ecol 17:916-29. 2008
    ..pisum, one subclade of H. defensa appears to be universal within a subclade of the aphid genus Uroleucon, suggesting a transition from facultative, horizontal transmission to strictly vertical inheritance...
  7. pmc Dynamics of genome evolution in facultative symbionts of aphids
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Environ Microbiol 12:2060-9. 2010
    ..The divergence in gene sets and in genome architecture implies a history of rampant recombination and gene inactivation and the ongoing integration of mobile DNA (insertion sequence elements, prophage and plasmids)...
  8. pmc Human gut microbes use multiple transporters to distinguish vitamin B₁₂ analogs and compete in the gut
    Patrick H Degnan
    Department of Microbial Pathogenesis and Microbial Diversity Institute, Yale University, New Haven, CT 06536, USA
    Cell Host Microbe 15:47-57. 2014
    ....
  9. ncbi request reprint Functional genomics of Buchnera and the ecology of aphid hosts
    Nancy A Moran
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Mol Ecol 15:1251-61. 2006
    ..Although information for other insect symbioses is relatively limited, studies on symbionts of carpenter ants and tsetse flies indicate many similarities to Buchnera...
  10. pmc Factors associated with the diversification of the gut microbial communities within chimpanzees from Gombe National Park
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 109:13034-9. 2012
    ..This pattern was reinforced in several chimpanzees sampled over long temporal scales, in which the major constituents of the gut microbiota were maintained for nearly a decade...
  11. ncbi request reprint Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage lambda
    Patrick H Degnan
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Mol Microbiol 64:232-44. 2007
    ..Extensive mosaicism was observed for several elements flanking the immunity region. Very short sequence elements or microhomologies were also identified. Our findings suggest mechanisms by which fine-scale mosaicism arises...