Research Topics
| Patrick H DegnanSummaryAffiliation: Yale University Country: USA Publications
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Detail Information
Publications
Illumina-based analysis of microbial community diversityPatrick H Degnan
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA
ISME J 6:183-94. 2012..By considering each source of error, we delineate ways to make biologically relevant and robust conclusions from the millions of sequencing reads that can be readily generated by this technology...- Origin and examination of a leafhopper facultative endosymbiontPatrick H Degnan
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA
Curr Microbiol 62:1565-72. 2011..However, the slightly reduced genome size, abundance of mobile DNA, fastidious growth in culture, and efficient vertical transmission suggest that symbiosis with E. variegatus has had a significant impact on genome evolution in BEV... - Sequence conservation and functional constraint on intergenic spacers in reduced genomes of the obligate symbiont BuchneraPatrick H Degnan
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America
PLoS Genet 7:e1002252. 2011..Although pseudogene formation, and thus IGS formation, are ongoing processes in these genomes, a large proportion of intergenic spacers contain functional sequences... - Diverse phage-encoded toxins in a protective insect endosymbiontPatrick H Degnan
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721 0088, USA
Appl Environ Microbiol 74:6782-91. 2008..Thus, phage may act as a conduit for ongoing gene exchange among heritable endosymbionts... 
Evolutionary genetics of a defensive facultative symbiont of insects: exchange of toxin-encoding bacteriophagePatrick H Degnan
Department of Ecology and Evolutionary Biology, Biosciences West, Room 310, 1041 E Lowell Street, University of Arizona, Tucson, AZ 85721 0088, USA
Mol Ecol 17:916-29. 2008..pisum, one subclade of H. defensa appears to be universal within a subclade of the aphid genus Uroleucon, suggesting a transition from facultative, horizontal transmission to strictly vertical inheritance...- Dynamics of genome evolution in facultative symbionts of aphidsPatrick H Degnan
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Environ Microbiol 12:2060-9. 2010..The divergence in gene sets and in genome architecture implies a history of rampant recombination and gene inactivation and the ongoing integration of mobile DNA (insertion sequence elements, prophage and plasmids)... - Chimpanzees and humans harbour compositionally similar gut enterotypesAndrew H Moeller
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06511, USA
Nat Commun 3:1179. 2012..These results support the hypothesis that enterotypic variation was present in populations of great apes before the divergence of humans and chimpanzees... 
Functional genomics of Buchnera and the ecology of aphid hostsNancy A Moran
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Mol Ecol 15:1251-61. 2006..Although information for other insect symbioses is relatively limited, studies on symbionts of carpenter ants and tsetse flies indicate many similarities to Buchnera...- Factors associated with the diversification of the gut microbial communities within chimpanzees from Gombe National ParkPatrick H Degnan
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 109:13034-9. 2012..This pattern was reinforced in several chimpanzees sampled over long temporal scales, in which the major constituents of the gut microbiota were maintained for nearly a decade... - Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage lambdaPatrick H Degnan
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Mol Microbiol 64:232-44. 2007..Extensive mosaicism was observed for several elements flanking the immunity region. Very short sequence elements or microhomologies were also identified. Our findings suggest mechanisms by which fine-scale mosaicism arises...