Pietro V De Camilli

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle
    M H Butler
    Department of Cell Biology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cell Biol 137:1355-67. 1997
  2. pmc Recognition of the F&H motif by the Lowe syndrome protein OCRL
    Michelle Pirruccello
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Struct Mol Biol 18:789-95. 2011
  3. pmc Coupling between clathrin-dependent endocytic budding and F-BAR-dependent tubulation in a cell-free system
    Min Wu
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Cell Biol 12:902-8. 2010
  4. pmc The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics
    Fubito Nakatsu
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Biol 190:307-15. 2010
  5. pmc Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain
    Laura A Volpicelli-Daley
    Department of Cell Biology, Program in Cellular Neuroscience, Neurodegeneration and Repair, The Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 285:28708-14. 2010
  6. pmc PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity
    Fubito Nakatsu
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Biol 199:1003-16. 2012
  7. pmc Regulation of the interaction between PIPKI gamma and talin by proline-directed protein kinases
    Sang Yoon Lee
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Biol 168:789-99. 2005
  8. pmc A role for talin in presynaptic function
    Jennifer R Morgan
    Department of Cell Biology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06519, USA
    J Cell Biol 167:43-50. 2004
  9. pmc Generation of high curvature membranes mediated by direct endophilin bilayer interactions
    K Farsad
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06511, USA
    J Cell Biol 155:193-200. 2001
  10. pmc A functional link between dynamin and the actin cytoskeleton at podosomes
    G C Ochoa
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cell Biol 150:377-89. 2000

Research Grants

  1. OCRL and the pathogenesis of Lowe Syndrome and Dent Disease
    Pietro De Camilli; Fiscal Year: 2010
  2. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2005
  3. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2004
  4. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2003
  5. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2002
  6. MOLECULAR AND FUNCTIONAL ANALYSIS OF ICA 512
    Pietro De Camilli; Fiscal Year: 2002
  7. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2000
  8. OCRL and the pathogenesis of Lowe Syndrome and Dent Disease
    Pietro De Camilli; Fiscal Year: 2009
  9. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2009
  10. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2009

Collaborators

Detail Information

Publications14

  1. pmc Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle
    M H Butler
    Department of Cell Biology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cell Biol 137:1355-67. 1997
    ..Since amphiphysin II (BIN1) was reported to interact with Myc, it may also be implicated in a signaling pathway linking the cortical cytoplasm to nuclear function...
  2. pmc Recognition of the F&H motif by the Lowe syndrome protein OCRL
    Michelle Pirruccello
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Struct Mol Biol 18:789-95. 2011
    ..Our study predicts the existence of other OCRL binding partners and shows that the perturbation of OCRL interactions has a crucial role in disease...
  3. pmc Coupling between clathrin-dependent endocytic budding and F-BAR-dependent tubulation in a cell-free system
    Min Wu
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Cell Biol 12:902-8. 2010
    ..They also show that clathrin spatially directs plasma membrane invaginations that lead to the generation of endocytic vesicles larger than those enclosed by the coat...
  4. pmc The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics
    Fubito Nakatsu
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Biol 190:307-15. 2010
    ..Because SHIP2 is a negative regulator of insulin signaling, our findings suggest the importance of the phosphoinositide metabolism at CCPs in the regulation of insulin signal output...
  5. pmc Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain
    Laura A Volpicelli-Daley
    Department of Cell Biology, Program in Cellular Neuroscience, Neurodegeneration and Repair, The Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 285:28708-14. 2010
    ....
  6. pmc PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity
    Fubito Nakatsu
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Biol 199:1003-16. 2012
    ....
  7. pmc Regulation of the interaction between PIPKI gamma and talin by proline-directed protein kinases
    Sang Yoon Lee
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Biol 168:789-99. 2005
    ..The opposite effects of the phosphorylation of Y649 and S650 likely play a critical role in regulating synaptic function as well as the balance between cell adhesion and cell motility...
  8. pmc A role for talin in presynaptic function
    Jennifer R Morgan
    Department of Cell Biology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06519, USA
    J Cell Biol 167:43-50. 2004
    ....
  9. pmc Generation of high curvature membranes mediated by direct endophilin bilayer interactions
    K Farsad
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06511, USA
    J Cell Biol 155:193-200. 2001
    ....
  10. pmc A functional link between dynamin and the actin cytoskeleton at podosomes
    G C Ochoa
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cell Biol 150:377-89. 2000
    ..These data demonstrate a functional link between a member of the dynamin family and actin at attachment sites between cells and the substratum...
  11. ncbi request reprint The ENTH domain
    Pietro De Camilli
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    FEBS Lett 513:11-8. 2002
    ..The ENTH domain is structurally similar to the VHS domain. These domains define two families of adaptor proteins which function in membrane traffic and whose interaction with membranes is regulated, in part, by phosphoinositides...
  12. ncbi request reprint Phosphoinositides in cell regulation and membrane dynamics
    Gilbert Di Paolo
    Department of Pathology and Cell Biology, The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, New York 10032, USA
    Nature 443:651-7. 2006
    ..Their functions, besides classical signal transduction at the cell surface, include regulation of membrane traffic, the cytoskeleton, nuclear events and the permeability and transport functions of membranes...
  13. pmc Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate
    Roberto Zoncu
    Department of Cell Biology and Howard Hughes Medical Institute, Kavli Institute For Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:3793-8. 2007
    ..These findings demonstrate the critical importance of PI(4,5)P(2) in clathrin coat dynamics and Arp2/3-dependent actin regulation...
  14. pmc Rapid Ca2+-dependent decrease of protein ubiquitination at synapses
    Hong Chen
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 100:14908-13. 2003
    ..In nerve terminals, protein ubiquitination may play a role both in the regulation of synaptic function, including vesicle traffic, and in the coordination of protein turnover with synaptic use...

Research Grants18

  1. OCRL and the pathogenesis of Lowe Syndrome and Dent Disease
    Pietro De Camilli; Fiscal Year: 2010
    ..The goal of this proposal is to understand how disruption of OCRL function leads to kidney disease with the hope that this information may help to develop therapeutic strategies for these conditions. ..
  2. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2005
    ....
  3. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2004
    ....
  4. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2003
    ....
  5. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2002
    ....
  6. MOLECULAR AND FUNCTIONAL ANALYSIS OF ICA 512
    Pietro De Camilli; Fiscal Year: 2002
    ..In addition, since atypical PTP domains similar to that of ICA512 are present in an increasing number of orphan genes, our studies on ICA512 may provide insight into the general significance of such protein motifs. ..
  7. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2000
    ....
  8. OCRL and the pathogenesis of Lowe Syndrome and Dent Disease
    Pietro De Camilli; Fiscal Year: 2009
    ..The goal of this proposal is to understand how disruption of OCRL function leads to kidney disease with the hope that this information may help to develop therapeutic strategies for these conditions. ..
  9. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2009
    ..The importance of this field is underscored by several disorders of the nervous system in mice and humans that have already been shown to result from abnormal phosphoinositide metabolism. ..
  10. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2009
    ..The importance of this field is underscored by several disorders of the nervous system in mice and humans that have already been shown to result from abnormal phosphoinositide metabolism. ..
  11. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2007
    ..The importance of this field is underscored by several disorders of the nervous system in mice and humans that have already been shown to result from abnormal phosphoinositide metabolism. ..
  12. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2006
    ..The importance of this field is underscored by several disorders of the nervous system in mice and humans that have already been shown to result from abnormal phosphoinositide metabolism. ..
  13. MOLECULAR AND FUNCTIONAL ANALYSIS OF ICA 512
    Pietro De Camilli; Fiscal Year: 2001
    ..In addition, since atypical PTP domains similar to that of ICA512 are present in an increasing number of orphan genes, our studies on ICA512 may provide insight into the general significance of such protein motifs. ..
  14. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 2001
    ....
  15. MOLECULAR MECHANISMS IN SYNAPTIC VESICLE RECYCLING
    Pietro De Camilli; Fiscal Year: 1999
    ....