Research Topics
Genomes and Genes | Nihal C de LanerolleSummaryAffiliation: Yale University Country: USA Publications
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Publications
Characteristics of an explosive blast-induced brain injury in an experimental modelNihal C de Lanerolle
Departments of Neurosurgery, Yale School of Medicine, New Haven, Connecticut 06520 8082, USA
J Neuropathol Exp Neurol 70:1046-57. 2011....- Astrocytes and epilepsyNihal C de Lanerolle
Department of Neurosurgery, Yale School of Medicine, New Haven, Connecticut 06520, USA
Neurotherapeutics 7:424-38. 2010..The functions of the astrocyte vascular interface may be more critical to the processes involved in epileptogenesis... 
New facets of the neuropathology and molecular profile of human temporal lobe epilepsyNihal C de Lanerolle
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
Epilepsy Behav 7:190-203. 2005..Such a focal pool of glutamate may diffuse to surrounding neuron-rich areas to generate seizure activity in TLE...
Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytesTih Shih Lee
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520 8082, USA
Mol Med 13:1-13. 2007..Such glutamate release may excite surrounding neurons and elicit seizure activity...- GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampusTih-Shih Lee
Department of Psychiatry, Yale University School of Medicine, Park Street, New Haven, CT 06520, USA
Acta Neuropathol (Berl) 111:351-63. 2006.... - Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsyTih Shih Lee
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Acta Neuropathol (Berl) 108:493-502. 2004.... - Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy?Tore Eid
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Epilepsia 49:42-52. 2008..Here, we assess recent data regarding the glutamate excess in epilepsy, review the role of glutamine synthetase, and discuss the implications of astrocytes in the pathophysiology of MTLE... - Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsyTore Eid
Departments of Laboratory Medicine Psychiatry Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8035, USA
Epilepsia 54:228-38. 2013..However, the molecular mechanism of the enzyme perturbations remains unclear. A better understanding of the regulatory mechanisms of GS and PAG could facilitate the discovery of novel therapeutics for TLE... - Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in ratsTore Eid
Department of Laboratory Medicine, Yale University School of Medicine, 333 Cedar Street, P O Box 208035, New Haven, CT 06520 8035, USA
Brain 131:2061-70. 2008.... - Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampusTore Eid
Department of Neurosurgery, Laboratory Medicine, and Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 102:1193-8. 2005..We postulate that the loss of perivascular AQP4 in MTLE is likely to result in a perturbed flux of water through astrocytes leading to an impaired buffering of extracellular K+ and an increased propensity for seizures... - Increased expression of erythropoietin receptor on blood vessels in the human epileptogenic hippocampus with sclerosisTore Eid
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
J Neuropathol Exp Neurol 63:73-83. 2004..Moreover, the presence of EPO-r in the MTLE hippocampus may provide a new vehicle for highly efficient delivery of hitherto impermeable drugs into the epileptic brain... - Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsyTore Eid
Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, P O Box 208082, New Haven, CT 06520 8082, USA
Acta Neuropathol 113:137-52. 2007..This increase suggests an enhanced capacity for glutamate synthesis-a finding that might contribute to the disrupted glutamate homeostasis in MTLE... - A retrospective analysis of hippocampal pathology in human temporal lobe epilepsy: evidence for distinctive patient subcategoriesNihal C de Lanerolle
Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8082, U S A
Epilepsia 44:677-87. 2003..We attempted to relate neuronal density, immunohistochemistry, electrophysiologic data, and surgical outcome... - Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampusFredrik Lauritzen
The Brain and Muscle Energy Group, Department of Anatomy and Centre for Molecular Biology and Neuroscience, University of Oslo, Blindern, NO 0317 Oslo, Norway
Glia 60:1172-81. 2012..We propose that the altered distribution of MCT1 and MCT2 in TLE (especially MTLE) limits the flux of monocarboxylates across the blood-brain barrier and enhances the exchange of monocarboxylates within the brain parenchyma... - Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampusFredrik Lauritzen
The Brain and Muscle Energy Group, Centre for Molecular Biology and Neuroscience and Institute of Basic Medical Sciences, University of Oslo, P O Box 1105 Blindern, NO 0317 Oslo, Norway
Neurobiol Dis 41:577-84. 2011..We hypothesize that the loss of MCT1 on brain microvessels is mechanistically involved in the pathophysiology of drug-resistant TLE, and propose that re-expression of MCT1 may represent a novel therapeutic approach for this disease... - Novel expression of AMPA-receptor subunit GluR1 on mossy cells and CA3 pyramidal neurons in the human epileptogenic hippocampusTore Eid
Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, PO Box 208082, New Haven, CT 06520 8082, USA
Eur J Neurosci 15:517-27. 2002..Such a circuit could be critically involved in the genesis and maintenance of temporal lobe epilepsy... - Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null miceMahmood Amiry-Moghaddam
Centre for Molecular Biology and Neuroscience, University of Oslo, 0317 Oslo, Norway
Proc Natl Acad Sci U S A 100:13615-20. 2003..These studies lead us to propose that water flux through perivascular AQP4 is needed to sustain efficient removal of K+ after neuronal activation... - 2-Deoxyglucose uptake during vocalization in the squirrel monkey brainUwe Jürgens
German Primate Centre, Kellnerweg 4, 37077 Gottingen, Germany
Behav Brain Res 136:605-10. 2002..The study makes clear that vocalization, even in the case of genetically pre-programmed patterns, depends upon an extensive network, beyond the well-known periaqueductal grey, nucl. retroambiguus and cranial motor nuclei pathway...
Research Grants
- Genetic Signatures in Human Temporal Lobe EpilespyNihal de Lanerolle; Fiscal Year: 2005..abstract_text> ..
- Proteomic Profiles in Human Temporal Lobe EpilepsyNihal de Lanerolle; Fiscal Year: 2007..These studies are essential to identify molecules unique to TLE, which will be the candidates for study in future research that explores their role(s) in seizure mechanisms. ..