Nihal C de Lanerolle

Summary

Affiliation: Yale University
Country: USA

Publications

  1. doi request reprint Characteristics of an explosive blast-induced brain injury in an experimental model
    Nihal C de Lanerolle
    Departments of Neurosurgery, Yale School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Neuropathol Exp Neurol 70:1046-57. 2011
  2. doi request reprint Astrocytes and epilepsy
    Nihal C de Lanerolle
    Department of Neurosurgery, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Neurotherapeutics 7:424-38. 2010
  3. ncbi request reprint New facets of the neuropathology and molecular profile of human temporal lobe epilepsy
    Nihal C de Lanerolle
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Epilepsy Behav 7:190-203. 2005
  4. pmc Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes
    Tih Shih Lee
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520 8082, USA
    Mol Med 13:1-13. 2007
  5. ncbi request reprint GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampus
    Tih Shih Lee
    Department of Psychiatry, Yale University School of Medicine, Park Street, New Haven, CT 06520, USA
    Acta Neuropathol 111:351-63. 2006
  6. ncbi request reprint Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsy
    Tih Shih Lee
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Acta Neuropathol 108:493-502. 2004
  7. doi request reprint Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy?
    Tore Eid
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Epilepsia 49:42-52. 2008
  8. pmc Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy
    Tore Eid
    Departments of Laboratory Medicine Psychiatry Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8035, USA
    Epilepsia 54:228-38. 2013
  9. pmc Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats
    Tore Eid
    Department of Laboratory Medicine, Yale University School of Medicine, 333 Cedar Street, P O Box 208035, New Haven, CT 06520 8035, USA
    Brain 131:2061-70. 2008
  10. pmc Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus
    Tore Eid
    Department of Neurosurgery, Laboratory Medicine, and Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 102:1193-8. 2005

Research Grants

  1. Genetic Signatures in Human Temporal Lobe Epilespy
    Nihal de Lanerolle; Fiscal Year: 2005
  2. Proteomic Profiles in Human Temporal Lobe Epilepsy
    Nihal de Lanerolle; Fiscal Year: 2007

Collaborators

Detail Information

Publications18

  1. doi request reprint Characteristics of an explosive blast-induced brain injury in an experimental model
    Nihal C de Lanerolle
    Departments of Neurosurgery, Yale School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Neuropathol Exp Neurol 70:1046-57. 2011
    ....
  2. doi request reprint Astrocytes and epilepsy
    Nihal C de Lanerolle
    Department of Neurosurgery, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Neurotherapeutics 7:424-38. 2010
    ..The functions of the astrocyte vascular interface may be more critical to the processes involved in epileptogenesis...
  3. ncbi request reprint New facets of the neuropathology and molecular profile of human temporal lobe epilepsy
    Nihal C de Lanerolle
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Epilepsy Behav 7:190-203. 2005
    ..Such a focal pool of glutamate may diffuse to surrounding neuron-rich areas to generate seizure activity in TLE...
  4. pmc Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes
    Tih Shih Lee
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520 8082, USA
    Mol Med 13:1-13. 2007
    ..Such glutamate release may excite surrounding neurons and elicit seizure activity...
  5. ncbi request reprint GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampus
    Tih Shih Lee
    Department of Psychiatry, Yale University School of Medicine, Park Street, New Haven, CT 06520, USA
    Acta Neuropathol 111:351-63. 2006
    ....
  6. ncbi request reprint Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsy
    Tih Shih Lee
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Acta Neuropathol 108:493-502. 2004
    ....
  7. doi request reprint Glutamate and astrocytes--key players in human mesial temporal lobe epilepsy?
    Tore Eid
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Epilepsia 49:42-52. 2008
    ..Here, we assess recent data regarding the glutamate excess in epilepsy, review the role of glutamine synthetase, and discuss the implications of astrocytes in the pathophysiology of MTLE...
  8. pmc Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy
    Tore Eid
    Departments of Laboratory Medicine Psychiatry Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8035, USA
    Epilepsia 54:228-38. 2013
    ..However, the molecular mechanism of the enzyme perturbations remains unclear. A better understanding of the regulatory mechanisms of GS and PAG could facilitate the discovery of novel therapeutics for TLE...
  9. pmc Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats
    Tore Eid
    Department of Laboratory Medicine, Yale University School of Medicine, 333 Cedar Street, P O Box 208035, New Haven, CT 06520 8035, USA
    Brain 131:2061-70. 2008
    ....
  10. pmc Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus
    Tore Eid
    Department of Neurosurgery, Laboratory Medicine, and Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 102:1193-8. 2005
    ..We postulate that the loss of perivascular AQP4 in MTLE is likely to result in a perturbed flux of water through astrocytes leading to an impaired buffering of extracellular K+ and an increased propensity for seizures...
  11. ncbi request reprint Increased expression of erythropoietin receptor on blood vessels in the human epileptogenic hippocampus with sclerosis
    Tore Eid
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Neuropathol Exp Neurol 63:73-83. 2004
    ..Moreover, the presence of EPO-r in the MTLE hippocampus may provide a new vehicle for highly efficient delivery of hitherto impermeable drugs into the epileptic brain...
  12. ncbi request reprint Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy
    Tore Eid
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, P O Box 208082, New Haven, CT 06520 8082, USA
    Acta Neuropathol 113:137-52. 2007
    ..This increase suggests an enhanced capacity for glutamate synthesis-a finding that might contribute to the disrupted glutamate homeostasis in MTLE...
  13. ncbi request reprint A retrospective analysis of hippocampal pathology in human temporal lobe epilepsy: evidence for distinctive patient subcategories
    Nihal C de Lanerolle
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8082, U S A
    Epilepsia 44:677-87. 2003
    ..We attempted to relate neuronal density, immunohistochemistry, electrophysiologic data, and surgical outcome...
  14. pmc Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus
    Fredrik Lauritzen
    The Brain and Muscle Energy Group, Department of Anatomy and Centre for Molecular Biology and Neuroscience, University of Oslo, Blindern, NO 0317 Oslo, Norway
    Glia 60:1172-81. 2012
    ..We propose that the altered distribution of MCT1 and MCT2 in TLE (especially MTLE) limits the flux of monocarboxylates across the blood-brain barrier and enhances the exchange of monocarboxylates within the brain parenchyma...
  15. pmc Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus
    Fredrik Lauritzen
    The Brain and Muscle Energy Group, Centre for Molecular Biology and Neuroscience and Institute of Basic Medical Sciences, University of Oslo, P O Box 1105 Blindern, NO 0317 Oslo, Norway
    Neurobiol Dis 41:577-84. 2011
    ..We hypothesize that the loss of MCT1 on brain microvessels is mechanistically involved in the pathophysiology of drug-resistant TLE, and propose that re-expression of MCT1 may represent a novel therapeutic approach for this disease...
  16. ncbi request reprint Novel expression of AMPA-receptor subunit GluR1 on mossy cells and CA3 pyramidal neurons in the human epileptogenic hippocampus
    Tore Eid
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, PO Box 208082, New Haven, CT 06520 8082, USA
    Eur J Neurosci 15:517-27. 2002
    ..Such a circuit could be critically involved in the genesis and maintenance of temporal lobe epilepsy...
  17. pmc Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice
    Mahmood Amiry-Moghaddam
    Centre for Molecular Biology and Neuroscience, University of Oslo, 0317 Oslo, Norway
    Proc Natl Acad Sci U S A 100:13615-20. 2003
    ..These studies lead us to propose that water flux through perivascular AQP4 is needed to sustain efficient removal of K+ after neuronal activation...
  18. ncbi request reprint 2-Deoxyglucose uptake during vocalization in the squirrel monkey brain
    Uwe Jürgens
    German Primate Centre, Kellnerweg 4, 37077 Gottingen, Germany
    Behav Brain Res 136:605-10. 2002
    ..The study makes clear that vocalization, even in the case of genetically pre-programmed patterns, depends upon an extensive network, beyond the well-known periaqueductal grey, nucl. retroambiguus and cranial motor nuclei pathway...

Research Grants2

  1. Genetic Signatures in Human Temporal Lobe Epilespy
    Nihal de Lanerolle; Fiscal Year: 2005
    ..abstract_text> ..
  2. Proteomic Profiles in Human Temporal Lobe Epilepsy
    Nihal de Lanerolle; Fiscal Year: 2007
    ..These studies are essential to identify molecules unique to TLE, which will be the candidates for study in future research that explores their role(s) in seizure mechanisms. ..