J F Cubells

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Human genetics of plasma dopamine beta-hydroxylase activity: applications to research in psychiatry and neurology
    J F Cubells
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, 950 Campbell Avenue, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 174:463-76. 2004
  2. ncbi request reprint A haplotype at the DBH locus, associated with low plasma dopamine beta-hydroxylase activity, also associates with cocaine-induced paranoia
    J F Cubells
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Mol Psychiatry 5:56-63. 2000
  3. ncbi request reprint Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects
    J Gelernter
    Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Hum Genet 101:243-6. 1997
  4. ncbi request reprint DRD2 allele frequencies and linkage disequilibria, including the -141CIns/Del promoter polymorphism, in European-American, African-American, and Japanese subjects
    J Gelernter
    Division of Molecular Psychiatry, Yale University School of Medicine, West Haven, Connecticut, 06516, USA
    Genomics 51:21-6. 1998
  5. pmc A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus
    C P Zabetian
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Am J Hum Genet 68:515-22. 2001
  6. ncbi request reprint Functional variants at CYP2A6: new genotyping methods, population genetics, and relevance to studies of tobacco dependence
    C P Zabetian
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet 96:638-45. 2000
  7. pmc Sex differences in cocaine-dependent individuals' response to disulfiram treatment
    Charla Nich
    Yale University School of Medicine, VA Connecticut Health Care System, West Haven, USA
    Addict Behav 29:1123-8. 2004
  8. ncbi request reprint Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP)
    Joseph F Cubells
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, CT 06516, USA
    Drug Alcohol Depend 80:23-33. 2005
  9. ncbi request reprint Opiate addiction in China: current situation and treatments
    Yi lang Tang
    Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China
    Addiction 101:657-65. 2006
  10. ncbi request reprint Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
    Addict Biol 11:76-83. 2006

Detail Information

Publications12

  1. ncbi request reprint Human genetics of plasma dopamine beta-hydroxylase activity: applications to research in psychiatry and neurology
    J F Cubells
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, 950 Campbell Avenue, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 174:463-76. 2004
    ..Dopamine beta-hydroxylase (DbetaH) catalyzes the synthesis of NE from dopamine (DA) and occurs in the plasma as a stable heritable trait. Studies of this trait have been useful in psychiatric and neurological research...
  2. ncbi request reprint A haplotype at the DBH locus, associated with low plasma dopamine beta-hydroxylase activity, also associates with cocaine-induced paranoia
    J F Cubells
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Mol Psychiatry 5:56-63. 2000
    ..Molecular Psychiatry (2000) 5, 56-63...
  3. ncbi request reprint Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects
    J Gelernter
    Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Hum Genet 101:243-6. 1997
    ....
  4. ncbi request reprint DRD2 allele frequencies and linkage disequilibria, including the -141CIns/Del promoter polymorphism, in European-American, African-American, and Japanese subjects
    J Gelernter
    Division of Molecular Psychiatry, Yale University School of Medicine, West Haven, Connecticut, 06516, USA
    Genomics 51:21-6. 1998
    ..This newly described functional variant therefore does not provide a straightforward physiological explanation for previously reported genetic associations with DRD2*A1 in European-American subjects...
  5. pmc A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus
    C P Zabetian
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Am J Hum Genet 68:515-22. 2001
    ..Our findings demonstrate that --1021C-->T is a major genetic marker for plasma-D beta H activity and provide new tools for investigation of the role of both D beta H and the DBH gene in human disease...
  6. ncbi request reprint Functional variants at CYP2A6: new genotyping methods, population genetics, and relevance to studies of tobacco dependence
    C P Zabetian
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Am J Med Genet 96:638-45. 2000
    ..The population results suggest that in many populations the frequencies of the variants examined are quite low, and might therefore limit the power of future genetic association studies of tobacco dependence based on these variants...
  7. pmc Sex differences in cocaine-dependent individuals' response to disulfiram treatment
    Charla Nich
    Yale University School of Medicine, VA Connecticut Health Care System, West Haven, USA
    Addict Behav 29:1123-8. 2004
    ..Reasons for this apparent sex-based response are not clear, but possible mechanisms worthy of greater study include differences in alcohol use by sex as well as differences in dopamine-mediated responses to cocaine and disulfiram...
  8. ncbi request reprint Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP)
    Joseph F Cubells
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, CT 06516, USA
    Drug Alcohol Depend 80:23-33. 2005
    ..We examined the phenomenology of such cocaine-induced psychosis (CIP) using a modified version of the Scale for Assessment of Positive Symptoms (SAPS), a well-validated instrument for the assessment of schizophrenic psychosis...
  9. ncbi request reprint Opiate addiction in China: current situation and treatments
    Yi lang Tang
    Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China
    Addiction 101:657-65. 2006
    ..Historically, China has had extraordinarily high rates of opiate dependence. These rates declined drastically following the 1949 revolution; however, opiate abuse has re-emerged in the late 1980's and has spread quickly since then...
  10. ncbi request reprint Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
    Addict Biol 11:76-83. 2006
    ..This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects...
  11. ncbi request reprint Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administration
    Rasmon Kalayasiri
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 61:1310-3. 2007
    ..Variation in the gene for dopamine beta-hydroxylase (DbetaH) has been reported to associate with cocaine-induced paranoia as assessed by retrospective self-report. This association has yet to be tested prospectively...
  12. ncbi request reprint Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects
    Yi lang Tang
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, CT, USA
    Am J Addict 16:343-51. 2007
    ..Comorbid substance use and psychiatric disorders are very common among individuals with cocaine dependence. Comorbid ADHD increases the odds of an individual endorsing CIP, suggesting some common basis for these phenomena...