Research Topics
| J CramerSummaryAffiliation: Yale University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Tolerability of levetiracetam in elderly patients with CNS disordersJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue G7E, Room 7 127, West Haven, CT 06516 2770, USA
Epilepsy Res 56:135-45. 2003..Overall, LEV was well tolerated by all patient groups. The favorable adverse event profile suggests that LEV might be suitable for use by elderly patients...- Tolerability of antiepileptic drugs: can we determine differences?Joyce A Cramer
Yale University School of Medicine, USA
Epilepsy Behav 23:187-92. 2012..A system of questioning every patient at every visit to elicit information may be helpful when balancing benefit-to-risk ratio of individualized therapy during everyday practice... - Suicide-related behaviors in older patients with new anti-epileptic drug use: data from the VA hospital systemAnne C Vancott
VA Pittsburgh Healthcare System, Neurology Division, Pittsburgh, PA, USA
BMC Med 8:4. 2010..We examined the relationship between suicide-related behaviors and different AEDs in older veterans receiving new AED monotherapy from the Veterans Health Administration (VA), controlling for potential confounders... - Treatment persistence and compliance with medications for chronic obstructive pulmonary diseaseJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516 2770, USA
Can Respir J 14:25-9. 2007..The present study assessed the patterns of persistence with the above mentioned inhaled medications... - Differentiating anxiety and depression symptoms in patients with partial epilepsyJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516 2770, USA
Epilepsy Behav 6:563-9. 2005..337 (anxiety) and 0.511 (depression)). The data suggest that patients may benefit from increased attention to the role of anxiety separately from depression... - Compliance with inhaled insulin treatment using the AERx iDMS Insulin Diabetes Management SystemJ A Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516 2770, USA
Diabetes Technol Ther 6:800-7. 2004..This investigation was designed as a pilot trial to demonstrate the ability of patients to use the electronic device to deliver mealtime inhaled insulin doses and explore the impact on compliance... - The influence of insulin use on glycemic control: How well do adults follow prescriptions for insulin?Joyce A Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Diabetes Care 28:78-83. 2005..The purposes of this study were to determine the relationship between insulin self-management and glycemic control and to identify patient characteristics associated with better control... - Improved mood states with lamotrigine in patients with epilepsyJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Epilepsy Behav 5:702-7. 2004..The improvement likely was not a synergy but attributable only to LTG because it remained stable after withdrawal of the other AEDs... - Results of a naturalistic study of treatment options: switching atypical antipsychotic drugs or augmenting with valproateJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, USA
Clin Ther 26:905-14. 2004..Combination therapy with atypical antipsychotic agents has not been well studied. Duration of persistence with a prescribed treatment regimen can be used to estimate overall treatment success... - The impact of comorbid depression on health resource utilization in a community sample of people with epilepsyJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Epilepsy Behav 5:337-42. 2004..001). These data highlight the impact of comorbid depression on health care utilization by people with epilepsy... - Quality of life improvement with conversion to lamotrigine monotherapyJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue G7E, West Haven, CT 06516 2770, USA
Epilepsy Behav 5:224-30. 2004..This study demonstrates the value of reduction to monotherapy from the patients' and physicians' perspectives... - A systematic review of adherence with medications for diabetesJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Diabetes Care 27:1218-24. 2004..The purpose of this study was to determine the extent to which patients omit doses of medications prescribed for diabetes... - Development of a growth hormone injection questionnaire for adolescentsJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, Yale VA Medical Center, Room 7 127 G7E, 950 Campbell Avenue, West Haven, CT 06516 2770, USA
J Adolesc Health 34:27-9. 2004..Summary scores did not differ significantly by cohort, age, gender, or diagnosis. Adolescents who were more comfortable with GH injections had higher health-related quality of life, functional capacity, and self-control... - Brief report: a quality of life instrument for adolescents with growth disordersJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
J Adolesc 28:595-600. 2005..Adolescents receiving growth hormone therapy differed significantly from adolescents with medical, surgical or psychiatric disorders. The VSP-AM shows reliability and validity for HRQOL measurement in adolescents with growth disorders... - Patient satisfaction with an injection device for multiple sclerosis treatmentJ A Cramer
Department of Psychiatry, Yale University, New Haven, CT 06516 2770, USA
Acta Neurol Scand 113:156-62. 2006.... - Non-interventional surveillance study of adverse events in patients with epilepsyJ A Cramer
Yale University, Epilepsy Therapy Project, Houston, TX 77027 9310, USA
Acta Neurol Scand 124:13-21. 2011..Compare adverse events (AEs) in patients with epilepsy taking different antiepileptic drugs (AEDs) using standardized physician-completed questionnaires... - Adverse effects of antiepileptic drugs: a brief overview of important issuesJoyce A Cramer
Yale University School of Medicine, New Haven, CT, USA
Expert Rev Neurother 10:885-91. 2010..This article describes three categories of prevalent adverse effects (CNS, behavioral and general medical issues) comparing profiles of second- and third-generation AEDs... - Medication compliance and persistence: terminology and definitionsJoyce A Cramer
Yale University School of Medicine, New Haven, CT, USA
Value Health 11:44-7. 2008..The aim of the study is to provide guidance regarding the meaning and use of the terms "compliance" and "persistence" as they relate to the study of medication use... - The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a reviewJ A Cramer
Yale University School of Medicine, West Haven, CT 06516 2770, USA
Int J Clin Pract 62:76-87. 2008.... - Methodological considerations in using claims databases to evaluate persistence with bisphosphonates for osteoporosisJoyce A Cramer
Department of Psychiatry, Yale UniversitySchool of Medicine, 950 Campbell Avenue 151D, West Haven, CT 06516 2770, USA
Curr Med Res Opin 23:2369-77. 2007..Bisphosphonates (BPs) are used as an example because of the availability of diverse dosing options that can create a unique set of challenges for persistence analyses... - The impact of seizures and adverse effects on global health ratingsJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Epilepsy Behav 11:179-84. 2007..These data provide insight into the risk-benefit concerns of patients at equipoise when addressing the efficacy and AEs of AEDs... - Women with epilepsy: hormonal issues from menarche through menopauseJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Epilepsy Behav 11:160-78. 2007..This overview provides physicians with a background on the multiple issues relevant to women of all ages in the reproductive years, including those planning to conceive and those who are pregnant, and beyond the childbearing years... - A systematic review of persistence and compliance with bisphosphonates for osteoporosisJ A Cramer
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, 151D, West Haven, CT 06516 2770, USA
Osteoporos Int 18:1023-31. 2007..These studies confirm that women with osteoporosis have suboptimal persistence and compliance rates with bisphosphonate therapy... - The effect of dosing frequency on compliance and persistence with bisphosphonate therapy in postmenopausal women: a comparison of studies in the United States, the United Kingdom, and FranceJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut 06516 2770, USA
Clin Ther 28:1686-94. 2006..The aim of this study was to determine the effect of dose frequency on compliance and persistence with bisphosphonate therapy in postmenopausal women and to compare findings from 3 different health care systems... - Persistence with bisphosphonate treatment for osteoporosis: finding the root of the problemJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516 2770, USA
Am J Med 119:S12-7. 2006..It should be assumed that every patient receiving therapy for osteoporosis needs regular reinforcement of the importance of continuing therapy... - The influence of comorbid depression on seizure severityJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue G7E, West Haven, CT 06516 2770, USA
Epilepsia 44:1578-84. 2003..To determine the relation between depressive symptoms and seizure severity among people with epilepsy... - Medication compliance feedback and monitoring in a clinical trial: predictors and outcomesJoyce Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Value Health 6:566-73. 2003..The objective of this study was to demonstrate the utility of continuous monitoring and enhancement of medication compliance during a long-term clinical trial, predictors of compliance, and relationships to drinking outcomes... - Compliance and persistence with bisphosphonate dosing regimens among women with postmenopausal osteoporosisJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Curr Med Res Opin 21:1453-60. 2005..This study compared compliance and persistence with weekly and daily bisphosphonate regimens for postmenopausal osteoporosis... - Assessing the severity of seizures and epilepsy: which scales are valid?J A Cramer
Departments of Neurology and Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Curr Opin Neurol 14:225-9. 2001..However, the disadvantages of each scale outweigh its usefulness. New approaches are needed to assess seizure severity for individuals and for use as an outcome measure after intervention such as surgery or medication changes... - Quality of life in schizophrenia: a comparison of instruments. Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory SchizophreniaJ A Cramer
VA Connecticut Healthcare System, West Haven 06516 2770, USA
Schizophr Bull 26:659-66. 2000..Health-related quality of life in schizophrenia is a more heterogeneous concept than previously appreciated... - Enhancing patient compliance in the elderly. Role of packaging aids and monitoringJ A Cramer
Health Services Research, Department of Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
Drugs Aging 12:7-15. 1998..Some systems are also designed to notify patients within a day if doses were omitted. No system is optimal for all patients, but elderly patients deserve a comprehensive assessment of their needs to enhance medication compliance... - Comparison between the QOLIE-31 and derived QOLIE-10 in a clinical trial of levetiracetamJ A Cramer
Department of Psychiatry, Yale University School of Medicine, Yale VA Medical Center, New Haven, CT 06516, USA
Epilepsy Res 41:29-38. 2000..to determine whether the QOLIE-10, an abbreviated quality of life questionnaire, provides results similar to the more detailed QOLIE-31 instrument when the ten items are derived from the QOLIE-31... - Effect of levetiracetam on epilepsy-related quality of life. N132 Study GroupJ A Cramer
Departments of Psychiatry and Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
Epilepsia 41:868-74. 2000..To evaluate the short-term effect of levetiracetam (LEV; UCB L059) as add-on therapy on health-related quality of life in the treatment of refractory partial-onset seizures... - The short-term impact of adjunctive tiagabine on health-related quality of lifeJ Cramer
Yale University School of Medicine, 950 Campbell Ave, West Haven, Connecticut 06516 2770, USA
Epilepsia 42:70-5. 2001..These exploratory analyses suggest a possible early positive effect of TGB on patient-perceived cognitive domains using the QOLIE-89. These findings are limited by the small sample size and could be related to reduction in seizures... - Development of the Quality of Life in Epilepsy Inventory for Adolescents: the QOLIE-AD-48J A Cramer
Yale University School of Medicine and VA Connecticut Healthcare System, Department of Psychiatry, New Haven 06516 2770, USA
Epilepsia 40:1114-21. 1999..We report the development of an instrument to assess health-related quality of life (HRQOL) in adolescents with epilepsy... - New antiepileptic drugs: comparison of key clinical trialsJ A Cramer
Yale University School of Medicine, New Haven, Connecticut, USA
Epilepsia 40:590-600. 1999..Drawbacks to use of these data also are demonstrated... - Consequences of intermittent treatment for hypertension: the case for medication compliance and persistenceJ A Cramer
Yale VA Medical Center, West Haven, CT 06516, USA
Am J Manag Care 4:1563-8. 1998..To review patient compliance with once-daily antihypertensive medications and the impact of partial compliance on healthcare outcomes... - Detecting improvement in quality of life and symptomatology in schizophreniaJ Cramer
Northeast Program Evaluation Center, VA Connecticut Healthcare System, West Haven 06516 2770, USA
Schizophr Bull 27:227-34. 2001..88 and 0.92, respectively). Thus, modest changes in psychometric scales assessing symptoms and quality of life reflect clinically detectable improvement... - The influence of comorbid depression on quality of life for people with epilepsyJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue G7E, New Haven, CT 06516 2770, USA
Epilepsy Behav 4:515-21. 2003..0001). Clinical depression is significantly associated with poorer HRQOL among people with all types of seizures... - Medicine partnershipsJ Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Heart 89:ii19-21; discussion ii35-7. 2003..Simple steps that can be taken include helping patients to select "cues" to remind them to take their tablets, use of dose reminder boxes, and visual feedback of compliance data from electronic monitors... - A systematic review of the behavioral effects of levetiracetam in adults with epilepsy, cognitive disorders, or an anxiety disorder during clinical trialsJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue G7E, Room 7 127, West Haven, CT 06516 2770, USA
Epilepsy Behav 4:124-32. 2003..These data support the hypothesis that some feature related to epilepsy is the cause of many behavioral events rather than the addition of a specific antiepileptic drug... - Principles of health-related quality of life: assessment in clinical trialsJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516-2770, USA
Epilepsia 43:1084-95. 2002 - Maintenance of improvement in health-related quality of life during long-term treatment with levetiracetamJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue Room 7 127, West Haven, CT 06516, USA
Epilepsy Behav 4:118-23. 2003..Thus, gains in HRQOL were maintained during long-term LEV treatment, whether LEV was initiated early or late. Patient distress and importance of domains are useful data in determining how treatments impact on HRQOL... - Effect of partial compliance on cardiovascular medication effectivenessJoyce A Cramer
Yale University School of Medicine, 950 Campbell Avenue (G7E, West Haven, CT 06516-2770, USA
Heart 88:203-6. 2002 - Development of a new seizure severity questionnaire: initial reliability and validity testingJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue G7E, New Haven, CT 06516 2770, USA
Epilepsy Res 48:187-97. 2002..This report describes the initial steps for development of a new scale to assess seizure severity as a treatment response... - Does participation in psychosocial treatment augment the benefit of clozapine? Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory SchizophreniaR Rosenheck
Veterans Affairs Connecticut Healthcare System, West Haven 06516 2770, USA
Arch Gen Psychiatry 55:618-25. 1998..This study examines the role of participation in psychosocial treatment as a mediator of the clinical effectiveness of clozapine... - Impact of clozapine on negative symptoms and on the deficit syndrome in refractory schizophrenia. Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory SchizophreniaR Rosenheck
VA Connecticut Healthcare System, West Haven 06516 2770, USA
Am J Psychiatry 156:88-93. 1999..This study compared the effect of clozapine and haloperidol on positive and negative symptoms of schizophrenia and in patients with high levels of negative symptoms or the deficit syndrome... - Medication continuation and compliance: a comparison of patients treated with clozapine and haloperidolR Rosenheck
VA Connecticut Healthcare System, West Haven, 06516 2770, USA
J Clin Psychiatry 61:382-6. 2000..This study compares medication continuation and regimen compliance with the atypical antipsychotic medication clozapine versus the conventional antipsychotic haloperidol... - Clinical and psychopharmacologic factors influencing family burden in refractory schizophrenia. The Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory SchizophreniaR Rosenheck
VA Connecticut Health Care System, West Haven, Conn 06516 2770, USA
J Clin Psychiatry 61:671-6. 2000..This study compares the effect of clozapine and haloperidol and identifies other factors related to family burden as experienced by relatives of patients with refractory schizophrenia (DSM-III-R)... - Cost-effectiveness of clozapine in patients with high and low levels of hospital use. Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory SchizophreniaR Rosenheck
Veterans Affairs Connecticut Healthcare System, West Haven 06516 2770, USA
Arch Gen Psychiatry 56:565-72. 1999..This study examined the relationship between pretreatment hospital use and the cost-effectiveness of clozapine in the treatment of refractory schizophrenia... - How long to wait for a response to clozapine: a comparison of time course of response to clozapine and conventional antipsychotic medication in refractory schizophreniaR Rosenheck
VA s Northeast Evaluation Center, VA Connecticut Healthcare System, West Haven 06516 2770, USA
Schizophr Bull 25:709-19. 1999..04). Significant differential symptom response to clozapine occurred exclusively during the first 6 weeks of treatment... - Interrater reliability levels of multiple clinical examiners in the evaluation of a schizophrenic patient: quality of life, level of functioning, and neuropsychological symptomatologyD V Cicchetti
Child Study Center, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Clin Neuropsychol 13:157-70. 1999..The authors develop just such an approach and apply it successfully to the evaluation of the functioning, quality of life, and neuropsychological symptomatology of a single schizophrenic patient... - The role of comorbid psychiatric conditions in health status in epilepsyJohn E Zeber
South Texas Veterans Health Care System HSR and D Verdict, San Antonio, TX 78229 4404, USA
Epilepsy Behav 10:539-46. 2007..Patients with epilepsy are uniquely at risk for high physical-psychiatric comorbidity profiles, with concomitant losses in perceived health status... - The impact of epilepsy on health status among younger and older adultsMary Jo V Pugh
Veterans Affairs HSR and D, South Texas Veterans Health Care System Verdict, San Antonio, Texas 78229 4404, USA
Epilepsia 46:1820-7. 2005..This study examines the impact of epilepsy on patients' subjective health status in a population that includes both younger and older adults... - Validity and reliability of the Portuguese version of the quality of life in epilepsy inventory (QOLIE-31) for BrazilTatiana Indelicato da Silva
Department of Neurology, Escola Paulista de Medicina UNIFESP, Sao Paulo, Brazil
Epilepsy Behav 10:234-41. 2007..We report the cultural adaptation and psychometric properties of the Quality of Life in Epilepsy-31 Inventory (QOLIE-31) for the Portuguese language and Brazilian culture... - Eslicarbazepine acetate: a double-blind, add-on, placebo-controlled exploratory trial in adult patients with partial-onset seizuresChristian Elger
Department of Epileptology, University of Bonn, Bonn, Germany
Epilepsia 48:497-504. 2007..To explore the efficacy and safety of eslicarbazepine acetate (BIA 2-093), a new antiepileptic drug, as adjunctive therapy in adult patients with partial epilepsy... - Electronic monitoring and counseling to improve medication adherenceMarc I Rosen
VA Connecticut Healthcare System, Department of Psychiatry 116A, 950 Campbell Avenue, West Haven, CT 06516, USA
Behav Res Ther 42:409-22. 2004..Data from nine patients who reviewed pill cap-generated data with their primary care providers suggested that both patients and providers found the discussion moderately helpful and not at all uncomfortable... - Neuropsychological correlates of suboptimal adherence to metforminMarc I Rosen
Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, Connecticut, USA
J Behav Med 26:349-60. 2003..None of the neuropsychological variables were associated with glycosylated hemoglobin. These results suggest that cognitive abilities should be considered when counseling patients concerning their adherence... - Effects of illicit drug use on adherence to prescribed antiretroviral medicationMarc I Rosen
Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT 06516, USA
Am J Addict 12:455-8. 2003..Thus, in a subset of patients, the actions involved in procuring drugs and the acute effects of using them contribute to non-adherence on those specific drug use days, associated with substance abuse. (Am J Addict 2003;12:455-458).. - Persistence across weekly and monthly bisphosphonates: analysis of US retail pharmacy prescription refillsThomas W Weiss
US Outcomes Research, Merck and Co, Inc, West Point, PA 19486 0004, USA
Curr Med Res Opin 23:2193-203. 2007..Determine whether monthly dosing of bisphosphonates has an impact on persistence relative to weekly dosing... - Reduced fracture rates observed only in patients with proper persistence and compliance with bisphosphonate therapiesStuart L Silverman
Department of Medicine and Rheumatology, Cedars Sinai Medical Center UCLA, Beverly Hills, California 90211, USA
South Med J 100:1214-8. 2007..Measures to improve persistence and compliance with osteoporosis medications are needed if patients are to achieve the full clinical benefit of treatment... - Obtaining optimal compliance with drug therapyJoyce A Cramer
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
Manag Care 12:9-11; discussion 23-5. 2003 - A checklist for medication compliance and persistence studies using retrospective databasesAndrew M Peterson
Department of Pharmacy Practice Pharmacy Administration, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, PA 19104, USA
Value Health 10:3-12. 2007..If followed, this checklist should improve the consistency and quality of C&P analyses, which in turn will help providers and payers understand the impact of C&P on health outcomes... - Psychiatric disease burden profiles among veterans with epilepsy: the association with health services utilizationMary Jo V Pugh
Veterans Evidence Based Research Dissemination Implementation Center, Health Services Research and Development Service, Department of Veterans Affairs, South Texas Veterans Healthcare System, San Antonio, TX 78229, USA
Psychiatr Serv 59:925-8. 2008..This brief report describes patterns of psychiatric comorbidities among patients with epilepsy and their relationship with health care utilization... - Psychiatric safety of ketamine in psychopharmacology researchEdward B Perry
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Psychopharmacology (Berl) 192:253-60. 2007..Therefore, it is timely to revisit the safety of subanesthetic doses of ketamine in experimental psychopharmacology studies... - Cost analysis of divalproex sodium extended-release compared to valproic acid in the treatment of bipolar disorderGlen T Schumock
Center for Pharmacoeconomic Research, University of Illinois at Chicago College of Pharmacy, Chicago, IL 60612, USA
Curr Med Res Opin 23:1997-2004. 2007..To analyze, from a payer perspective, the net pharmaceutical and medical costs of prescribing divalproex sodium extended-release (DVPX-ER) versus valproic acid (VPA) in patients with bipolar disorder...