Affiliation: Yale University
Kim S, Choi J, Laínez B, Schulz V, Karas D, Baum E, et al
. Human Extrafollicular CD4+ Th Cells Help Memory B Cells Produce Igs. J Immunol. 2018;201:1359-1372 pubmed publisher
..They promote memory B cells to produce Abs via CD40L, IL-10, and IL-21. Our results reveal a unique extrafollicular CD4+ T cell subset in human tonsils, which specialize in promoting T cell-dependent humoral recall responses. ..
Laidlaw B, Zhang N, Marshall H, Staron M, Guan T, Hu Y, et al
. CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity. 2014;41:633-45 pubmed publisher
..Thus, CD4(+) T cell-dependent signals are important to limit expression of T-bet and allow for the development of CD103(+) CD8(+) Trm cells in the lung airways following respiratory infection. ..
Ray J, Staron M, Shyer J, Ho P, Marshall H, Gray S, et al
. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015;43:690-702 pubmed publisher
..These data identify the interleukin-2 (IL-2)-mTORc1 axis as a critical orchestrator of the reciprocal balance between Tfh and Th1 cell fates and their respective metabolic activities after acute viral infection. ..
Choi J, Seth A, Kashgarian M, Terrillon S, Fung E, Huang L, et al
. Disruption of Pathogenic Cellular Networks by IL-21 Blockade Leads to Disease Amelioration in Murine Lupus. J Immunol. 2017;198:2578-2588 pubmed publisher
Shah K, Lee W, Lee S, Kim S, Kang S, Craft J, et al
. Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Res Ther. 2010;12:R53 pubmed publisher
..We suggest that CCR4 and CCR6 expression on CD4(+) T cells should be considered as markers of disease activity, and that IL-17 blocking may offer a therapeutic target in SLE. ..
Craft J. Follicular helper T cells in immunity and systemic autoimmunity. Nat Rev Rheumatol. 2012;8:337-47 pubmed publisher
..Such information might improve our understanding of autoimmune diseases, such as SLE, and highlights the potential of T(FH) cells as therapeutic targets in these diseases. ..
Ray J, Marshall H, Laidlaw B, Staron M, Kaech S, Craft J. Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells. Immunity. 2014;40:367-77 pubmed publisher
..These data suggest mutually repressive roles for STAT3 and type I IFN signaling pathways in the differentiation of Tfh cells following viral infection. ..
Laidlaw B, Lu Y, Amezquita R, Weinstein J, Vander Heiden J, Gupta N, et al
. Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response. Sci Immunol. 2017;2: pubmed publisher
..These data indicate that Tfr cells play a multifaceted role in the fine-tuning of the GC response and identify IL-10 as an important mediator by which Tfr cells support the GC reaction. ..
Weinstein J, Laidlaw B, Lu Y, Wang J, Schulz V, Li N, et al
. STAT4 and T-bet control follicular helper T cell development in viral infections. J Exp Med. 2018;215:337-355 pubmed publisher
..These data indicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN-γ production and for promotion of the GC response after acute viral challenge. ..