Research Topics
Species | KELLY COSGROVESummaryAffiliation: Yale University Country: USA Publications
Research Grants
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Detail Information
Publications
Evolving knowledge of sex differences in brain structure, function, and chemistryKelly P Cosgrove
Division of Psychiatry SPECT Imaging, Yale University School of Medicine and the Veterans Affairs Connecticut Healthcare System, New Haven, Connecticut 06516, USA
Biol Psychiatry 62:847-55. 2007....
Sex and estrogen influence drug abuseMarilyn E Carroll
Department of Psychiatry, Mayo Box 392, University of Minnesota, Minneapolis, MN 55455, USA
Trends Pharmacol Sci 25:273-9. 2004..In all phases of drug abuse, females seem to be more sensitive to the rewarding effects of drugs than males, and estrogen is a major factor that underlies these sex differences...- Sex differences in the vulnerability to drug abuse: a review of preclinical studiesMegan E Roth
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Neurosci Biobehav Rev 28:533-46. 2004..The animal literature on sex differences in drug abuse treatment effectiveness is also discussed... - 123I-5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual phaseKelly P Cosgrove
Yale University School of Medicine, New Haven, Connecticut, USA
J Nucl Med 48:1633-40. 2007..We examined the availability of nAChR containing the beta(2) subunit in healthy men and women and the influence of menstrual phase among women... - Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokersKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Arch Gen Psychiatry 69:418-27. 2012..Sex differences in availability of nicotinic acetylcholine receptors containing the β(2) subunit (β(2)*-nAChRs) may underlie differential nicotine and tobacco smoking effects and related behaviors in women vs men... - Decreased Beta(2)*-nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primatesKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine and the VACHS, New Haven, CT 06516, USA
Synapse 64:729-32. 2010..The decrease in beta(2)*-nAChR availability is influenced by alcohol consumption, suggesting the chronicity and severity of alcohol consumption may underlie persistent changes in beta(2)*-nAChR availability... - Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokersKelly P Cosgrove
Yale University School of Medicine and the VA Connecticut Healthcare System, Department of Psychiatry, 116A6, 950 Campbell Avenue, West Haven, CT 06516, USA
Nicotine Tob Res 12:535-9. 2010.... - beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smokingKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Ave, Mail Code 116A6, West Haven, CT 06516, USA
Arch Gen Psychiatry 66:666-76. 2009..Variations in beta(2)*-nAChR availability during the course of abstinence may be related to the urge to smoke, the extent of nicotine withdrawal, and successful abstinence... 
Dopamine and serotonin transporter availability during acute alcohol withdrawal: effects of comorbid tobacco smokingKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
Neuropsychopharmacology 34:2218-26. 2009..Smoking appears to suppress neuroadaptive changes in DA and 5-HT transporters during acute withdrawal from alcohol...- SPECT imaging with the serotonin transporter radiotracer [123I]p ZIENT in nonhuman primate brainKelly P Cosgrove
Yale University School of Medicine, VA Connecticut HCS 116A6, West Haven, CT 06516, USA
Nucl Med Biol 37:587-91. 2010..The purpose of this study was to characterize and determine the in vivo selectivity of iodine-123-labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane, [(123)I]p ZIENT, in nonhuman primate brain... - Dopamine and serotonin transporter availability in chronic heroin users: a [¹²³I]β-CIT SPECT imaging studyKelly P Cosgrove
Yale University School of Medicine and the VACHS, New Haven, CT 06516, United States
Psychiatry Res 184:192-5. 2010..Heroin users had statistically similar striatal DA and brainstem and diencephalon 5-HT transporter availability compared with controls. No associations between transporter availability and heroin use characteristics were found... - Imaging receptor changes in human drug abusersKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Curr Top Behav Neurosci 3:199-217. 2010..The development of novel radiotracers that target additional receptor systems will further our understanding of the neurochemical basis of addiction... - Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependenceKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine and the VACHS, West Haven, CT 06516, USA
Neuropharmacology 60:1318-25. 2011..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'... - Assessing the sensitivity of [¹¹C]p943, a novel 5-HT1B radioligand, to endogenous serotonin releaseKelly P Cosgrove
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Synapse 65:1113-7. 2011..Receptor occupancy by P943 (0.2 mg/kg) was 68 and 86% in the baboons. PET imaging of 5-HT(1B) receptors with [¹¹C]P943 may be a useful approach for measuring changes in endogenous 5-HT in the living human brain... - In vivo evaluation of [¹²³I]mZIENT as a SPECT radioligand for the serotonin transporterJeffery Batis
Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA
Nucl Med Biol 39:1137-41. 2012.... - Lower ß2*-nicotinic acetylcholine receptor availability in smokers with schizophreniaDEEPAK CYRIL D'SOUZA
Psychiatry Service, VA Connecticut Healthcare System, West Haven, USA
Am J Psychiatry 169:326-34. 2012..The purpose of this study was to measure β(2)*-nicotinic acetylcholine receptors in vivo and to relate levels to concurrent behavioral measures of smoking and schizophrenia... - Age-related decline in nicotinic receptor availability with [(123)I]5-IA-85380 SPECTEffie M Mitsis
Yale University School of Medicine, New Haven, CT 06510, USA
Neurobiol Aging 30:1490-7. 2009..These results in living human subjects corroborate postmortem reports of decline in high affinity nicotine binding with age and may aid in elucidating the role of beta(2)-nAChRs in cognitive aging... - Effects of bremazocine on self-administration of smoked cocaine base and orally delivered ethanol, phencyclidine, saccharin, and food in rhesus monkeys: a behavioral economic analysisKelly P Cosgrove
Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
J Pharmacol Exp Ther 301:993-1002. 2002..These results extend the findings that kappa-agonists reduce the self-administration of drug and nondrug reinforcers to smoked cocaine base and oral ethanol, PCP, and saccharin in rhesus monkeys... - SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individualsIrina Esterlis
Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System VACHS, West Haven, CT 06516, USA
Drug Alcohol Depend 108:146-50. 2010..We hypothesized that beta(2)*-nAChR availability would be altered by alcohol in heavy drinking nonsmokers... - GABAA-benzodiazepine receptor availability in smokers and nonsmokers: relationship to subsyndromal anxiety and depressionIrina Esterlis
Department of Psychiatry, Yale University School of Medicine, Veteran s Affairs Connecticut Healthcare System VACHS, 116A6 West Haven, Connecticut 06516, USA
Synapse 63:1089-99. 2009..Aberrant regulation of GABA(A)-BZR function in vulnerable smokers may explain why some smokers experience subsyndromal anxiety and depression... - Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokersJulie K Staley
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
J Neurosci 26:8707-14. 2006..Greater beta2*-nAChR availability during early abstinence may impact the ability of smokers to maintain abstinence... - Quantification of smoking-induced occupancy of beta2-nicotinic acetylcholine receptors: estimation of nondisplaceable bindingIrina Esterlis
Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, USA
J Nucl Med 51:1226-33. 2010..In this study, we measured nicotine occupancy and nondisplaceable binding in healthy smokers after they had smoked to satiety... - [123I]5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptor availability in the aging human brainEffie M Mitsis
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
Ann N Y Acad Sci 1097:168-70. 2007..Preliminary results have confirmed postmortem reports of age-related decline in high-affinity nicotine binding with age and may elucidate the role of beta(2)-nAChRs in the cognitive decline associated with aging... - Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhalerIrina Esterlis
Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
Int J Neuropsychopharmacol 14:389-98. 2011..13, p=0.04). These results demonstrate significant differences in occupancy of β2*-nAChRs by nicotine after use of the inhaler vs. a cigarette and confirm the ability of the nicotine inhaler to relieve withdrawal symptoms... - Differential effects of bremazocine on oral phencyclidine (PCP) self-administration in male and female rhesus monkeysKelly P Cosgrove
Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
Exp Clin Psychopharmacol 12:111-7. 2004.... - Wheel-running attenuates intravenous cocaine self-administration in rats: sex differencesKelly P Cosgrove
Department of Psychiatry, University of Minnesota, Mayo Box 392, Minneapolis 55455, USA
Pharmacol Biochem Behav 73:663-71. 2002..These results indicate that wheel-running activity had a greater suppressant effect on cocaine self-administration in females than in males, and in females, wheel-running and cocaine self-administration are substitutable as reinforcers... - Effects of a non-drug reinforcer, saccharin, on oral self-administration of phencyclidine in male and female rhesus monkeysKelly P Cosgrove
Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
Psychopharmacology (Berl) 170:9-16. 2003..Males show elevated drug-maintained responding compared with females, but when differential body weights are considered (mg/kg) females consume more than males only under limited schedule parameters...
Research Grants
- TREATMENT FOR ALCHOLISM: A PRIMATE MODELKELLY COSGROVE; Fiscal Year: 2002..Thus, the effects of bremazocine and naltrexone on ethanol self-administration as a function of sex will be investigated. ..
- Brain Imaging of Sex Differences in Tobacco SmokersKELLY COSGROVE; Fiscal Year: 2007..This will aid in the development of medications that are specifically designed to help both women and men quit smoking. ..
- GABAergic Mechanisms of Comorbid Alcohol and Nicotine DependenceKELLY COSGROVE; Fiscal Year: 2009..These studies will ultimately provide information on how to more successfully treat these costly addictions. ..
- GABAergic Mechanisms of Comorbid Alcohol and Nicotine DependenceKelly P Cosgrove; Fiscal Year: 2010..These studies will ultimately provide information on how to more successfully treat these costly addictions. ..