KELLY COSGROVE

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Evolving knowledge of sex differences in brain structure, function, and chemistry
    Kelly P Cosgrove
    Division of Psychiatry SPECT Imaging, Yale University School of Medicine and the Veterans Affairs Connecticut Healthcare System, New Haven, Connecticut 06516, USA
    Biol Psychiatry 62:847-55. 2007
  2. ncbi request reprint Sex and estrogen influence drug abuse
    Marilyn E Carroll
    Department of Psychiatry, Mayo Box 392, University of Minnesota, Minneapolis, MN 55455, USA
    Trends Pharmacol Sci 25:273-9. 2004
  3. ncbi request reprint Sex differences in the vulnerability to drug abuse: a review of preclinical studies
    Megan E Roth
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neurosci Biobehav Rev 28:533-46. 2004
  4. ncbi request reprint 123I-5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual phase
    Kelly P Cosgrove
    Yale University School of Medicine, New Haven, Connecticut, USA
    J Nucl Med 48:1633-40. 2007
  5. pmc Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Arch Gen Psychiatry 69:418-27. 2012
  6. pmc Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers
    Kelly P Cosgrove
    Yale University School of Medicine and the VA Connecticut Healthcare System, Department of Psychiatry, 116A6, 950 Campbell Avenue, West Haven, CT 06516, USA
    Nicotine Tob Res 12:535-9. 2010
  7. pmc Decreased Beta(2)*-nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primates
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine and the VACHS, New Haven, CT 06516, USA
    Synapse 64:729-32. 2010
  8. pmc SPECT imaging with the serotonin transporter radiotracer [123I]p ZIENT in nonhuman primate brain
    Kelly P Cosgrove
    Yale University School of Medicine, VA Connecticut HCS 116A6, West Haven, CT 06516, USA
    Nucl Med Biol 37:587-91. 2010
  9. pmc Dopamine and serotonin transporter availability in chronic heroin users: a [¹²³I]β-CIT SPECT imaging study
    Kelly P Cosgrove
    Yale University School of Medicine and the VACHS, New Haven, CT 06516, United States
    Psychiatry Res 184:192-5. 2010
  10. pmc beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Ave, Mail Code 116A6, West Haven, CT 06516, USA
    Arch Gen Psychiatry 66:666-76. 2009

Research Grants

Detail Information

Publications29

  1. pmc Evolving knowledge of sex differences in brain structure, function, and chemistry
    Kelly P Cosgrove
    Division of Psychiatry SPECT Imaging, Yale University School of Medicine and the Veterans Affairs Connecticut Healthcare System, New Haven, Connecticut 06516, USA
    Biol Psychiatry 62:847-55. 2007
    ....
  2. ncbi request reprint Sex and estrogen influence drug abuse
    Marilyn E Carroll
    Department of Psychiatry, Mayo Box 392, University of Minnesota, Minneapolis, MN 55455, USA
    Trends Pharmacol Sci 25:273-9. 2004
    ..In all phases of drug abuse, females seem to be more sensitive to the rewarding effects of drugs than males, and estrogen is a major factor that underlies these sex differences...
  3. ncbi request reprint Sex differences in the vulnerability to drug abuse: a review of preclinical studies
    Megan E Roth
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neurosci Biobehav Rev 28:533-46. 2004
    ..The animal literature on sex differences in drug abuse treatment effectiveness is also discussed...
  4. ncbi request reprint 123I-5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual phase
    Kelly P Cosgrove
    Yale University School of Medicine, New Haven, Connecticut, USA
    J Nucl Med 48:1633-40. 2007
    ..We examined the availability of nAChR containing the beta(2) subunit in healthy men and women and the influence of menstrual phase among women...
  5. pmc Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Arch Gen Psychiatry 69:418-27. 2012
    ..Sex differences in availability of nicotinic acetylcholine receptors containing the β(2) subunit (β(2)*-nAChRs) may underlie differential nicotine and tobacco smoking effects and related behaviors in women vs men...
  6. pmc Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers
    Kelly P Cosgrove
    Yale University School of Medicine and the VA Connecticut Healthcare System, Department of Psychiatry, 116A6, 950 Campbell Avenue, West Haven, CT 06516, USA
    Nicotine Tob Res 12:535-9. 2010
    ....
  7. pmc Decreased Beta(2)*-nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primates
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine and the VACHS, New Haven, CT 06516, USA
    Synapse 64:729-32. 2010
    ..The decrease in beta(2)*-nAChR availability is influenced by alcohol consumption, suggesting the chronicity and severity of alcohol consumption may underlie persistent changes in beta(2)*-nAChR availability...
  8. pmc SPECT imaging with the serotonin transporter radiotracer [123I]p ZIENT in nonhuman primate brain
    Kelly P Cosgrove
    Yale University School of Medicine, VA Connecticut HCS 116A6, West Haven, CT 06516, USA
    Nucl Med Biol 37:587-91. 2010
    ..The purpose of this study was to characterize and determine the in vivo selectivity of iodine-123-labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane, [(123)I]p ZIENT, in nonhuman primate brain...
  9. pmc Dopamine and serotonin transporter availability in chronic heroin users: a [¹²³I]β-CIT SPECT imaging study
    Kelly P Cosgrove
    Yale University School of Medicine and the VACHS, New Haven, CT 06516, United States
    Psychiatry Res 184:192-5. 2010
    ..Heroin users had statistically similar striatal DA and brainstem and diencephalon 5-HT transporter availability compared with controls. No associations between transporter availability and heroin use characteristics were found...
  10. pmc beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Ave, Mail Code 116A6, West Haven, CT 06516, USA
    Arch Gen Psychiatry 66:666-76. 2009
    ..Variations in beta(2)*-nAChR availability during the course of abstinence may be related to the urge to smoke, the extent of nicotine withdrawal, and successful abstinence...
  11. doi request reprint Dopamine and serotonin transporter availability during acute alcohol withdrawal: effects of comorbid tobacco smoking
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 34:2218-26. 2009
    ..Smoking appears to suppress neuroadaptive changes in DA and 5-HT transporters during acute withdrawal from alcohol...
  12. pmc Imaging receptor changes in human drug abusers
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Curr Top Behav Neurosci 3:199-217. 2010
    ..The development of novel radiotracers that target additional receptor systems will further our understanding of the neurochemical basis of addiction...
  13. pmc Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine and the VACHS, West Haven, CT 06516, USA
    Neuropharmacology 60:1318-25. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  14. pmc Assessing the sensitivity of [¹¹C]p943, a novel 5-HT1B radioligand, to endogenous serotonin release
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Synapse 65:1113-7. 2011
    ..Receptor occupancy by P943 (0.2 mg/kg) was 68 and 86% in the baboons. PET imaging of 5-HT(1B) receptors with [¹¹C]P943 may be a useful approach for measuring changes in endogenous 5-HT in the living human brain...
  15. doi request reprint In vivo evaluation of [¹²³I]mZIENT as a SPECT radioligand for the serotonin transporter
    Jeffery Batis
    Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA
    Nucl Med Biol 39:1137-41. 2012
    ....
  16. pmc Studies of the metabotropic glutamate receptor 5 radioligand [¹¹C]ABP688 with N-acetylcysteine challenge in rhesus monkeys
    Christine M Sandiego
    Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06520, USA
    Synapse 67:489-501. 2013
    ..Additionally, the net reduction in BP(ND) from the baseline-NAC scans may be obscured due to observed increases in test-retest BP(ND). Thus, we did not strictly replicate the findings in the baboon study based on BP(ND)...
  17. doi request reprint Lower ß2*-nicotinic acetylcholine receptor availability in smokers with schizophrenia
    DEEPAK CYRIL D'SOUZA
    Psychiatry Service, VA Connecticut Healthcare System, West Haven, USA
    Am J Psychiatry 169:326-34. 2012
    ..The purpose of this study was to measure β(2)*-nicotinic acetylcholine receptors in vivo and to relate levels to concurrent behavioral measures of smoking and schizophrenia...
  18. pmc Age-related decline in nicotinic receptor availability with [(123)I]5-IA-85380 SPECT
    Effie M Mitsis
    Yale University School of Medicine, New Haven, CT 06510, USA
    Neurobiol Aging 30:1490-7. 2009
    ..These results in living human subjects corroborate postmortem reports of decline in high affinity nicotine binding with age and may aid in elucidating the role of beta(2)-nAChRs in cognitive aging...
  19. pmc Awake nonhuman primate brain PET imaging with minimal head restraint: evaluation of GABAA-benzodiazepine binding with 11C-flumazenil in awake and anesthetized animals
    Christine M Sandiego
    Department of Biomedical Engineering, Yale University, New Haven, Connecticut
    J Nucl Med 54:1962-8. 2013
    ..We hypothesized that (11)C-flumazenil binding potential (BPND) would be higher in isoflurane-anesthetized monkeys...
  20. ncbi request reprint Effects of bremazocine on self-administration of smoked cocaine base and orally delivered ethanol, phencyclidine, saccharin, and food in rhesus monkeys: a behavioral economic analysis
    Kelly P Cosgrove
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    J Pharmacol Exp Ther 301:993-1002. 2002
    ..These results extend the findings that kappa-agonists reduce the self-administration of drug and nondrug reinforcers to smoked cocaine base and oral ethanol, PCP, and saccharin in rhesus monkeys...
  21. pmc SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System VACHS, West Haven, CT 06516, USA
    Drug Alcohol Depend 108:146-50. 2010
    ..We hypothesized that beta(2)*-nAChR availability would be altered by alcohol in heavy drinking nonsmokers...
  22. ncbi request reprint Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers
    Julie K Staley
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    J Neurosci 26:8707-14. 2006
    ..Greater beta2*-nAChR availability during early abstinence may impact the ability of smokers to maintain abstinence...
  23. ncbi request reprint [123I]5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptor availability in the aging human brain
    Effie M Mitsis
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Ann N Y Acad Sci 1097:168-70. 2007
    ..Preliminary results have confirmed postmortem reports of age-related decline in high-affinity nicotine binding with age and may elucidate the role of beta(2)-nAChRs in the cognitive decline associated with aging...
  24. pmc GABAA-benzodiazepine receptor availability in smokers and nonsmokers: relationship to subsyndromal anxiety and depression
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine, Veteran s Affairs Connecticut Healthcare System VACHS, 116A6 West Haven, Connecticut 06516, USA
    Synapse 63:1089-99. 2009
    ..Aberrant regulation of GABA(A)-BZR function in vulnerable smokers may explain why some smokers experience subsyndromal anxiety and depression...
  25. pmc Quantification of smoking-induced occupancy of beta2-nicotinic acetylcholine receptors: estimation of nondisplaceable binding
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    J Nucl Med 51:1226-33. 2010
    ..In this study, we measured nicotine occupancy and nondisplaceable binding in healthy smokers after they had smoked to satiety...
  26. pmc Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Int J Neuropsychopharmacol 14:389-98. 2011
    ..13, p=0.04). These results demonstrate significant differences in occupancy of β2*-nAChRs by nicotine after use of the inhaler vs. a cigarette and confirm the ability of the nicotine inhaler to relieve withdrawal symptoms...
  27. ncbi request reprint Differential effects of bremazocine on oral phencyclidine (PCP) self-administration in male and female rhesus monkeys
    Kelly P Cosgrove
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Clin Psychopharmacol 12:111-7. 2004
    ....
  28. ncbi request reprint Wheel-running attenuates intravenous cocaine self-administration in rats: sex differences
    Kelly P Cosgrove
    Department of Psychiatry, University of Minnesota, Mayo Box 392, Minneapolis 55455, USA
    Pharmacol Biochem Behav 73:663-71. 2002
    ..These results indicate that wheel-running activity had a greater suppressant effect on cocaine self-administration in females than in males, and in females, wheel-running and cocaine self-administration are substitutable as reinforcers...
  29. ncbi request reprint Effects of a non-drug reinforcer, saccharin, on oral self-administration of phencyclidine in male and female rhesus monkeys
    Kelly P Cosgrove
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 170:9-16. 2003
    ....

Research Grants5

  1. TREATMENT FOR ALCHOLISM: A PRIMATE MODEL
    KELLY COSGROVE; Fiscal Year: 2002
    ..Thus, the effects of bremazocine and naltrexone on ethanol self-administration as a function of sex will be investigated. ..
  2. Brain Imaging of Sex Differences in Tobacco Smokers
    KELLY COSGROVE; Fiscal Year: 2007
    ..This will aid in the development of medications that are specifically designed to help both women and men quit smoking. ..
  3. GABAergic Mechanisms of Comorbid Alcohol and Nicotine Dependence
    KELLY COSGROVE; Fiscal Year: 2009
    ..These studies will ultimately provide information on how to more successfully treat these costly addictions. ..
  4. GABAergic Mechanisms of Comorbid Alcohol and Nicotine Dependence
    Kelly P Cosgrove; Fiscal Year: 2010
    ..These studies will ultimately provide information on how to more successfully treat these costly addictions. ..