Research Topics
Genomes and GenesSpecies | Vladimir CoricSummaryAffiliation: Yale University Country: USA Publications
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Publications
Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with obsessive-compulsive disorder and major depressive disorderVladimir Coric
Psychopharmacology (Berl) 167:219-20. 2003
N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorderDaniel L Lafleur
Psychopharmacology (Berl) 184:254-6. 2006..CONCLUSIONS: NAC augmentation was effective in treating SRI-refractory OCD in this single case. Further research is warranted to investigate the use of NAC and other glutamate modulating agents in the treatment of OCD...
Systematic review: pharmacological and behavioral treatment for trichotillomaniaMichael H Bloch
Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Biol Psychiatry 62:839-46. 2007..Future therapy and pharmacotherapy studies in trichotillomania should employ larger sample sizes and intention-to-treat analysis and seek to validate clinical rating scales of trichotillomania severity...
Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trialVladimir Coric
Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
Biol Psychiatry 58:424-8. 2005..Recent imaging data suggests glutamatergic dysfunction in the corticostriatal pathway in OCD. We investigated the efficacy of augmentation therapy with riluzole, a glutamate-modulating agent, in treatment-resistant OCD...
Dimensional predictors of response to SRI pharmacotherapy in obsessive-compulsive disorderAngeli Landeros-Weisenberger
Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
J Affect Disord 121:175-9. 2010..Our objective was to replicate these results in OCD patients who participated in one of four randomized, placebo-controlled, clinical trials (RCT)...
Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administrationRasmon Kalayasiri
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06519, USA
Biol Psychiatry 61:1310-3. 2007..Variation in the gene for dopamine beta-hydroxylase (DbetaH) has been reported to associate with cocaine-induced paranoia as assessed by retrospective self-report. This association has yet to be tested prospectively...
Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic reviewMichael H Bloch
Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Am J Med Genet B Neuropsychiatr Genet 147:850-8. 2008..Further meta-analyses based on individual patient data would be helpful in determining whether age of OCD onset, gender and the presence of comorbid illness (e.g., tics) moderates the relationship between 5-HTTLPR and OCD...
Preliminary evidence of riluzole efficacy in antidepressant-treated patients with residual depressive symptomsGerard Sanacora
Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 61:822-5. 2007..Recent evidence suggests that riluzole and other agents that target glutamate neurotransmission may show antidepressant activity...
Riluzole in the treatment of mood and anxiety disordersChristopher Pittenger
Clinical Neuroscience Research Unit, Yale University School of Medicine, New Haven, Connecticut, USA
CNS Drugs 22:761-86. 2008..Riluzole may hold promise for the treatment of several psychiatric conditions, possibly through its ability to modulate pathologically dysregulated glutamate levels, and merits further investigation...
Sleep architecture, cocaine and visual learningPeter T Morgan
Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06519, USA
Addiction 103:1344-52. 2008..We hypothesized that sleep-related cognitive function would be impaired in chronic cocaine users, and that this impairment would be associated with abstinence-related changes in sleep architecture...
Relationships among plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate, cortisol, symptoms of dissociation, and objective performance in humans exposed to underwater navigation stressCharles A Morgan
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 66:334-40. 2009....
Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smokingGraeme F Mason
NIAAA Center for the Translational Neuroscience of Alcoholism and Department of Psychiatry, Yale University, School of Medicine, New Haven, CT 06520, USA
Biol Psychiatry 59:85-93. 2006..This study's objective was to measure time-dependent cortical GABA levels with sobriety in ethanol-dependent patients with mild to moderate withdrawal severity, controlling for alcoholism-related neurotoxicity and smoking...
Sleep, sleep-dependent procedural learning and vigilance in chronic cocaine users: Evidence for occult insomniaPeter T Morgan
Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, Clinical Neuroscience Research Unit, 34 Park Street, New Haven, CT 06519, USA
Drug Alcohol Depend 82:238-49. 2006..However, they report subjectively improving sleep, indicating they are unaware of this "occult" insomnia. These results suggest the possibility of homeostatic sleep drive dysregulation in chronic cocaine users...
A paradigm to investigate the self-regulation of cocaine administration in humansAtapol Sughondhabirom
Department of Psychiatry, Yale University, New Haven, CT 06519, USA
Psychopharmacology (Berl) 180:436-46. 2005..Such procedures may enhance our ability to identify effective pharmacological treatments for cocaine addiction...
The impact of burnout on human physiology and on operational performance: a prospective study of soldiers enrolled in the combat diver qualification courseC A Morgan
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Yale J Biol Med 75:199-205. 2002
Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorderBenjamin Kelmendi
Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, United States
Neurosci Lett 496:195-9. 2011..These findings suggest HCN4 as a genetic susceptibility factor for mood and anxiety disorders; however, these results will require replication using a larger sample...
Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorderChristopher Pittenger
Yale University Department of Psychiatry, New Haven, Connecticut 06508, USA
NeuroRx 3:69-81. 2006..This new application of glutamate modulating agents holds promise for the treatment of this disabling and often inadequately treated disease...
Self-reported paranoia during laboratory "binge" cocaine self-administration in humansRasmon Kalayasiri
Department of Psychiatry, Yale School of Medicine, 34 Park Street, New Haven, CT 06519, USA
Pharmacol Biochem Behav 83:249-56. 2006..Such methods may facilitate our understanding of the vulnerability to CIP in humans...
Relation between cardiac vagal tone and performance in male military personnel exposed to high stress: three prospective studiesC A Morgan
Department of Psychiatry, Yale University, New Haven, Connecticut, USA
Psychophysiology 44:120-7. 2007..The data suggest that vagal suppression is associated with enhanced performance under conditions of high stress and that this enhanced performance may be related to emotion regulation and cognitive functioning...
Riluzole augmentation in treatment-refractory obsessive-compulsive disorder: a series of 13 cases, with long-term follow-upChristopher Pittenger
J Clin Psychopharmacol 28:363-7. 2008
Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with trichotillomaniaVladimir Coric
J Clin Psychiatry 68:170-1. 2007
Beneficial effects of the glutamate-modulating agent riluzole on disordered eating and pathological skin-picking behaviorsDavid A Sasso
J Clin Psychopharmacol 26:685-7. 2006
Visual hallucinations from the addition of riluzole to memantine and bupropionChristopher Pittenger
J Clin Psychopharmacol 26:218-20. 2006
Initial evidence of the beneficial effects of glutamate-modulating agents in the treatment of self-injurious behavior associated with borderline personality disorderChristopher Pittenger
J Clin Psychiatry 66:1492-3. 2005
Riluzole augmentation for treatment-resistant depressionGerard Sanacora
Am J Psychiatry 161:2132. 2004
