Robert T Constable

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Repetition time in echo planar functional MRI
    R T Constable
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    Magn Reson Med 46:748-55. 2001
  2. pmc A left cerebellar pathway mediates language in prematurely-born young adults
    R Todd Constable
    Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Neuroimage 64:371-8. 2013
  3. ncbi request reprint Sentence complexity and input modality effects in sentence comprehension: an fMRI study
    R Todd Constable
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520 8042, USA
    Neuroimage 22:11-21. 2004
  4. ncbi request reprint MR physics of body MR imaging
    R Todd Constable
    Department of Diagnostic Radiology, Yale University School Medical Center, 330 Cedar Street Fitkin B, Post Office Box 208042, New Haven, CT 06520 8042, USA
    Radiol Clin North Am 41:1-15, v. 2003
  5. doi request reprint Prematurely born children demonstrate white matter microstructural differences at 12 years of age, relative to term control subjects: an investigation of group and gender effects
    R Todd Constable
    Department of Diagnostic Imaging, Yale University School of Medicine, New Haven, CT 06520, USA
    Pediatrics 121:306-16. 2008
  6. pmc Functional connectivity to a right hemisphere language center in prematurely born adolescents
    Eliza H Myers
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Neuroimage 51:1445-52. 2010
  7. pmc More accurate Talairach coordinates for neuroimaging using non-linear registration
    Cheryl M Lacadie
    Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT, USA
    Neuroimage 42:717-25. 2008
  8. doi request reprint Variation in language networks in monolingual and bilingual English speakers: consequences for language mapping for surgical preplanning
    Robin J Schafer
    Department of Diagnostic Imaging, Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Exp Neuropsychol 31:945-54. 2009
  9. pmc Alterations in functional connectivity for language in prematurely born adolescents
    Robin J Schafer
    Department of Diagnostic Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, PO Box 208043, New Haven, CT 06520, USA
    Brain 132:661-70. 2009
  10. pmc Role of variation in the serotonin transporter protein gene (SLC6A4) in trait disturbances in the ventral anterior cingulate in bipolar disorder
    Maulik P Shah
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 34:1301-10. 2009

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Repetition time in echo planar functional MRI
    R T Constable
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    Magn Reson Med 46:748-55. 2001
    ..Results are shown for modeling the functional imaging experiment and for three different paradigms performed on normal subjects...
  2. pmc A left cerebellar pathway mediates language in prematurely-born young adults
    R Todd Constable
    Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Neuroimage 64:371-8. 2013
    ..These findings may represent either a delay in maturation or the engagement of alternative neural pathways for language in the developing PT brain...
  3. ncbi request reprint Sentence complexity and input modality effects in sentence comprehension: an fMRI study
    R Todd Constable
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520 8042, USA
    Neuroimage 22:11-21. 2004
    ..These sites showing modulation of activity as a function of sentence type, independent of input mode, arguably form the core of a cortical system essential to sentence parsing...
  4. ncbi request reprint MR physics of body MR imaging
    R Todd Constable
    Department of Diagnostic Radiology, Yale University School Medical Center, 330 Cedar Street Fitkin B, Post Office Box 208042, New Haven, CT 06520 8042, USA
    Radiol Clin North Am 41:1-15, v. 2003
    ..Fast imaging sequences and approaches to reducing the data acquired without sacrificing image quality are described...
  5. doi request reprint Prematurely born children demonstrate white matter microstructural differences at 12 years of age, relative to term control subjects: an investigation of group and gender effects
    R Todd Constable
    Department of Diagnostic Imaging, Yale University School of Medicine, New Haven, CT 06520, USA
    Pediatrics 121:306-16. 2008
    ..The goal was to use diffusion tensor imaging to test the hypothesis that prematurely born children demonstrate long-term, white matter, microstructural differences, relative to term control subjects...
  6. pmc Functional connectivity to a right hemisphere language center in prematurely born adolescents
    Eliza H Myers
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Neuroimage 51:1445-52. 2010
    ..439, p=0.019). Preterm adolescents engage a dorsal right hemisphere region for language at age 16years. Those with the greatest cognitive deficits demonstrate increasing reliance on this alternate pathway...
  7. pmc More accurate Talairach coordinates for neuroimaging using non-linear registration
    Cheryl M Lacadie
    Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT, USA
    Neuroimage 42:717-25. 2008
    ..We present examples in this paper and note that the method is available freely online as a Java applet...
  8. doi request reprint Variation in language networks in monolingual and bilingual English speakers: consequences for language mapping for surgical preplanning
    Robin J Schafer
    Department of Diagnostic Imaging, Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Exp Neuropsychol 31:945-54. 2009
    ..We found significant differences between the monolinguals and the two bilingual groups. We interpret our results as evidence for a difference between the language network of early bilinguals and that of monolinguals...
  9. pmc Alterations in functional connectivity for language in prematurely born adolescents
    Robin J Schafer
    Department of Diagnostic Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, PO Box 208043, New Haven, CT 06520, USA
    Brain 132:661-70. 2009
    ..Plasticity in network connections may provide the substrate for improving language skills in the prematurely born...
  10. pmc Role of variation in the serotonin transporter protein gene (SLC6A4) in trait disturbances in the ventral anterior cingulate in bipolar disorder
    Maulik P Shah
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 34:1301-10. 2009
    ..Future treatment may be optimized for this BD subgroup by targeting the serotonergic system and the vACC...
  11. doi request reprint Induced hepatic fibrosis in rats: hepatic steatosis, macromolecule content, perfusion parameters, and their correlations--preliminary MR imaging in rats
    Hyeonjin Kim
    Department of Diagnostic Radiology, Section of Comparative Medicine, Yale University, New Haven, Conn, USA
    Radiology 247:696-705. 2008
    ..To prospectively evaluate magnetic resonance (MR) imaging for the characterization of liver fibrosis by estimating fat and extracellular matrix content and hepatic perfusion parameters in CCl(4)-treated rats...
  12. pmc Brain areas coactivating with motor cortex during chronic motor tics and intentional movements
    Michelle Hampson
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520 8043, USA
    Biol Psychiatry 65:594-9. 2009
    ....
  13. pmc Small decrements in systemic glucose provoke increases in hypothalamic blood flow prior to the release of counterregulatory hormones
    Kathleen A Page
    Department of Internal Medicine, Division of Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes 58:448-52. 2009
    ..The aim of this study was to determine the time sequence relationship between hypothalamic activation and the initiation of the counterregulatory hormonal response to small decrements in systemic glucose...
  14. pmc Comparator and non-comparator mechanisms of change detection in the context of speech--an ERP study
    Ilan Laufer
    Department of Diagnostic Radiology, Yale University School of Medicine, The Anlyan Center, New Haven, CT 06520 8043, USA
    Neuroimage 44:546-62. 2009
    ..This result pattern also resembled the one displayed by the non-comparator mechanism. These findings suggest spatially and temporally distinct brain activities of comparator mechanisms of change detection in the context of speech...
  15. pmc Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidence
    Naomi R Driesen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 64:1026-34. 2008
    ..This study featured a spatial working memory task, similar to that used in nonhuman primates, that was designed to facilitate separating brain activation into encoding, maintenance, and response phases...
  16. pmc Transverse patterning dissociates human EEG theta power and hippocampal BOLD activation
    Jed A Meltzer
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut, USA
    Psychophysiology 46:153-62. 2009
    ..Thus, theta and alpha dynamics are dissociable from positive BOLD activation, and may, in fact, colocalize with negative BOLD responses...
  17. pmc Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging
    Fei Wang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Br J Psychiatry 193:126-9. 2008
    ..The cingulum is an important candidate structure for study in bipolar disorder as it provides substantial white matter connections within the corticolimbic neural system that subserves emotional regulation involved in the disorder...
  18. pmc Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL
    Hyeonjin Kim
    Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8043, USA
    Magn Reson Med 59:521-7. 2008
    ..Therefore, protocol-specific establishment of cutoffs for liver fat content may be necessary...
  19. pmc Maternal brain response to own baby-cry is affected by cesarean section delivery
    James E Swain
    Yale Child Study Center, Program for Risk, Resilience and Recovery, USA
    J Child Psychol Psychiatry 49:1042-52. 2008
    ..Second, independent of mode of delivery, parental worries and mood are related to specific brain activations in response to own baby-cry...
  20. pmc Longitudinal brain volume changes in preterm and term control subjects during late childhood and adolescence
    Laura R Ment
    Departments of Pediatrics, Yale University School of Medicine, Department of Pediatrics, New Haven, CT 06520, USA
    Pediatrics 123:503-11. 2009
    ..Our goal was to test the hypothesis that preterm birth results in long-term dynamic changes in the developing brain...
  21. pmc Phonological awareness predicts activation patterns for print and speech
    Stephen J Frost
    Haskins Laboratories, 300 George Street, New Haven, CT 06511, USA
    Ann Dyslexia 59:78-97. 2009
    ....
  22. doi request reprint Evaluation of hepatic fibrosis with portal pressure gradient in rats
    Yuenan Wang
    Biomedical Engineering, Yale University, New Haven, CT 06520 8043, USA
    Magn Reson Med 61:1185-92. 2009
    ..002, alpha < 0.006) was also significant. Without the administration of any contrast agent, the MRI-PPG approach shows promise as a noninvasive means of evaluating liver fibrosis...
  23. pmc O-space imaging: Highly efficient parallel imaging using second-order nonlinear fields as encoding gradients with no phase encoding
    Jason P Stockmann
    Department of Biomedical Engineering, Yale University, New Haven, CT, USA
    Magn Reson Med 64:447-56. 2010
    ....
  24. pmc Functional connectivity between task-positive and task-negative brain areas and its relation to working memory performance
    Michelle Hampson
    Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT 06511, USA
    Magn Reson Imaging 28:1051-7. 2010
    ....
  25. pmc Unification of sentence processing via ear and eye: an fMRI study
    David Braze
    Haskins Laboratories, 300 George Street, New Haven, Connecticut 06511, USA
    Cortex 47:416-31. 2011
    ..Voxel-by-voxel exploration over the whole brain based on a cosine similarity measure of common function confirmed the specificity of supramodal zones...
  26. pmc Surgically implantable magnetic resonance angiography coils improve resolution to allow visualization of blood flow dynamics
    Tamara N Fitzgerald
    Department of Surgery, Yale University School of Medicine, New Haven, CT, USA
    Ann Vasc Surg 24:242-53. 2010
    ..We determined whether surgically implantable, extravascular MRA coils increase signal resolution adequately to examine blood flow dynamics..
  27. pmc Arterial transit time effects in pulsed arterial spin labeling CBF mapping: insight from a PET and MR study in normal human subjects
    Maolin Qiu
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 2048, USA
    Magn Reson Med 63:374-84. 2010
    ..The results also provide spatially specific ATT data that may aid in optimizing the ASL imaging parameters...
  28. pmc Functional connectivity and alterations in baseline brain state in humans
    Roberto Martuzzi
    Department of Diagnostic Radiology, Yale University School of Medicine, The Anlyan Center, 300 Cedar Street, New Haven, CT 06520 8042, USA
    Neuroimage 49:823-34. 2010
    ..These findings provide further evidence that fc-fMRI reflects intrinsic brain properties, while also demonstrating that 0.5 MAC sevoflurane anesthesia preferentially modulates higher-order connections...
  29. pmc Similar and dissociable mechanisms for attention to internal versus external information
    Jennifer K Roth
    Magnetic Resonance Research Center, Department of Diagnostic Radiology, Yale School of Medicine, 300 Cedar St, New Haven, CT 06520 8043, USA
    Neuroimage 48:601-8. 2009
    ..These findings help account for the similarity in areas activated across different cognitive tasks and may help specify the particular executive processes engaged in more complex tasks...
  30. pmc Alterations in neural connectivity in preterm children at school age
    Yeisid Gozzo
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, P O Box 208064, New Haven, CT 06520 8064, USA
    Neuroimage 48:458-63. 2009
    ....
  31. pmc Relation between amygdala structure and function in adolescents with bipolar disorder
    Jessica H Kalmar
    Department of Psychiatry, Yale School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511, USA
    J Am Acad Child Adolesc Psychiatry 48:636-42. 2009
    ..We hypothesized that amygdala volume would be inversely associated with amygdala response to emotional stimuli, such that BD participants with the smallest amygdala volumes would exhibit the highest amygdala response...
  32. pmc Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder
    Fei Wang
    Department of Psychiatry, Yale School of Medicine, 300 George Street, Suite 901, New Haven CT 06511, USA
    Biol Psychiatry 66:516-21. 2009
    ..This study investigates the potential disruptions in pACC-amygdala functional connectivity and associated abnormalities in white matter that provides structural connections between the two brain regions in BD...
  33. pmc Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder
    Jessica H Kalmar
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06511, USA
    J Int Neuropsychol Soc 15:476-81. 2009
    ..While data should be interpreted cautiously due to modest sample size, this study provides preliminary evidence to support the presence of accelerated loss in VPFC and rostral PFC volume in adolescents/young adults with BD...
  34. pmc Sensory and cognitive mechanisms of change detection in the context of speech
    Ilan Laufer
    Department of Diagnostic Radiology, Yale University School of Medicine, The Anlyan Center, 300 Cedar Street, P O Box 208043, New Haven, CT 06520 8043, USA
    Brain Struct Funct 212:427-42. 2008
    ..Thus, the more salient the deviant stimulus is the more likely it is to be released from the effects of adaptation exerted by the posterior auditory cortex...
  35. pmc Anesthetic effects on regional CBF, BOLD, and the coupling between task-induced changes in CBF and BOLD: an fMRI study in normal human subjects
    Maolin Qiu
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 2048, USA
    Magn Reson Med 60:987-96. 2008
    ....
  36. ncbi request reprint Factors influencing flip angle mapping in MRI: RF pulse shape, slice-select gradients, off-resonance excitation, and B0 inhomogeneities
    Jinghua Wang
    Department of Diagnostic Radiology, Yale University School Medical Center, New Haven, Connecticut 06520 8042, USA
    Magn Reson Med 56:463-8. 2006
    ....
  37. ncbi request reprint Connectivity-behavior analysis reveals that functional connectivity between left BA39 and Broca's area varies with reading ability
    Michelle Hampson
    Department of Diagnostic Radiology, Yale School of Medicine, P O Box 208042, TAC, New Haven, CT 06520 8042, USA
    Neuroimage 31:513-9. 2006
    ..In addition, it illustrates the potential power of paradigms that examine correlations between behavior and functional brain connections...
  38. ncbi request reprint Evidence that autobiographic memory retrieval does not become independent of the hippocampus: an fMRI study contrasting very recent with remote events
    P V Rekkas
    Department of Diagnostic Radiology, Yale University School of Medicine, TAC MRRC N127, P O Box 208042, New Haven, CT 06520 8042, USA
    J Cogn Neurosci 17:1950-61. 2005
    ....
  39. ncbi request reprint Differentiation of speech and nonspeech processing within primary auditory cortex
    D H Whalen
    Haskins Laboratories, 300 George Street, New Haven, Connecticut 06511, USA
    J Acoust Soc Am 119:575-81. 2006
    ..These results are consistent with the existence of a specialized speech system which bypasses more typical processes at the earliest cortical level...
  40. ncbi request reprint Imaging response inhibition in a stop-signal task: neural correlates independent of signal monitoring and post-response processing
    Chiang Shan Ray Li
    Department of Psychiatry, Magnetic Resonance Research Center, Yale University, New Haven, Connecticut 06519, USA
    J Neurosci 26:186-92. 2006
    ..These brain regions may represent the neural substrata of response inhibition independent of other cognitive and affective functions...
  41. pmc White matter tractography by anisotropic wavefront evolution and diffusion tensor imaging
    Marcel Jackowski
    Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA
    Med Image Anal 9:427-40. 2005
    ..We also compared our method with a similar level set-based tractography technique, and found that the anisotropic evolution increased the validity index of the obtained pathways by 18%...
  42. ncbi request reprint In vivo method for correcting transmit/receive nonuniformities with phased array coils
    Jinghua Wang
    Department of Diagnostic Radiology, Yale University School Medical Center, The Anlyan Center, 300 Cedar Street, New Haven, CT 06510, USA
    Magn Reson Med 53:666-74. 2005
    ..The method is general and can be applied with most pulse sequences, any coil combination for transmission and reception, and in any anatomic region...
  43. ncbi request reprint Measurement and correction of transmitter and receiver induced nonuniformities in vivo
    Jinghua Wang
    Department of Diagnostic Radiology, Yale University School Medical Center, The Anlyan Center, New Haven, Connecticut 06520, USA
    Magn Reson Med 53:408-17. 2005
    ..Although the correction presented here is demonstrated with a simultaneous transmit and receive volume coil, it can be extended to the case of separate transmission and reception coils, including surface and phase array coils...
  44. ncbi request reprint Activation of human hippocampal formation reflects success in both encoding and cued recall of paired associates
    Jed A Meltzer
    Department of Diagnostic Radiology, Yale University School of Medicine, TAC N134 C, New Haven, CT 06520 0843, USA
    Neuroimage 24:384-97. 2005
    ..The conjunction of these effects suggests that it is correct to view both encoding and recall of associative memories as functions of an integrated hippocampal system...
  45. ncbi request reprint Nonlinear estimation and modeling of fMRI data using spatio-temporal support vector regression
    Yongmei Michelle Wang
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Inf Process Med Imaging 18:647-59. 2003
    ..Other advantages of the approach are: avoidance of interpolation after motion estimation, embedded removal of low-frequency noise components, and easy incorporation of multi-run, multi-subject, and multi-task studies into the framework...
  46. ncbi request reprint The neurobiology of adaptive learning in reading: a contrast of different training conditions
    Rebecca Sandak
    Haskins Laboratories, New Haven, Connecticut 06511 6695, USA
    Cogn Affect Behav Neurosci 4:67-88. 2004
    ..The findings indicate that the putative ventral visual word form area is sensitive to the phonological structure of words, with phonologically analytic processing contributing to the specialization of this region...
  47. ncbi request reprint Sex differences and correlations in a virtual Morris water task, a virtual radial arm maze, and mental rotation
    Robert S Astur
    Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA
    Behav Brain Res 151:103-15. 2004
    ..This suggests that caution should be taken when utilizing these two tasks interchangeable as tests of spatial memory...
  48. ncbi request reprint Estimation of 3-D left ventricular deformation from medical images using biomechanical models
    Xenophon Papademetris
    Department of Diagnostic Radiology, Yale University, New Haven, CT 06520 8042, USA
    IEEE Trans Med Imaging 21:786-800. 2002
    ..Further, they show good agreement with previously published results in the literature. This proposed method provides quantitative regional 3-D estimates of heart deformation...
  49. ncbi request reprint Gender differences in the neural correlates of response inhibition during a stop signal task
    Chiang Shan Ray Li
    Department of Psychiatry, Yale University, New Haven, CT 06519, USA
    Neuroimage 32:1918-29. 2006
    ..Men activated the motor circuitry while women appeared to involve visual association or habit learning during stop signal performance...
  50. ncbi request reprint T1 measurements incorporating flip angle calibration and correction in vivo
    Jinghua Wang
    Department of Diagnostic Radiology, Yale University School Medical Center, The Anlyan Center, 330 Cedar Street, P O Box 208042, New Haven, CT 06520 8042, USA
    J Magn Reson 182:283-92. 2006
    ..The novelty of this method lies in the in vivo calibration and the correction of the FAs, thereby allowing a rapid and accurate T(1) mapping at high field for many applications...
  51. pmc A functional magnetic resonance imaging study of the long-term influences of early indomethacin exposure on language processing in the brains of prematurely born children
    Laura R Ment
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, Connecticut 06520, USA
    Pediatrics 118:961-70. 2006
    ..Previous studies have demonstrated that indomethacin lowers the incidence and decreases the severity of intraventricular hemorrhage, as well as improves the cognitive outcome, in prematurely born male infants...
  52. pmc Effects of working memory load on oscillatory power in human intracranial EEG
    Jed A Meltzer
    Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06510, USA
    Cereb Cortex 18:1843-55. 2008
    ....
  53. pmc Individual differences in EEG theta and alpha dynamics during working memory correlate with fMRI responses across subjects
    Jed A Meltzer
    Yale University, Interdepartmental Neuroscience Program, PO Box 208043, TAC N134, New Haven, CT 06520 8043, USA
    Clin Neurophysiol 118:2419-36. 2007
    ..We explored individual differences in EEG reactivity to determine whether it is positively or negatively correlated with BOLD across subjects...
  54. pmc Origin of the radio frequency pulse artifact in simultaneous EEG-fMRI recording: rectification at the carbon-metal interface
    Michiro Negishi
    Department of Diagnostic Radiology, School of Medicine, Yale University, New Haven, CT 06520 8043, USA
    IEEE Trans Biomed Eng 54:1725-7. 2007
    ..In this paper, we investigate the cause of the RF pulse artifact in EEG systems that use carbon wires...
  55. ncbi request reprint On the application of chemical shift-based multipoint water-fat separation methods in balanced SSFP imaging
    Hyeonjin Kim
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Magn Reson Med 58:413-8. 2007
    ..Given that local tissue characteristics in affected liver can be substantially variable, this study is of particular importance in liver imaging...
  56. ncbi request reprint Acupuncture-induced blood oxygenation level-dependent signals in awake and anesthetized volunteers: a pilot study
    Shu Ming Wang
    Center for Advancement of Perioperative Health, Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Anesth Analg 105:499-506. 2007
    ..We hypothesize that these conflicting data are a result of the inhibitory effect of anesthesia on acupuncture-induced central nervous system activity that can be demonstrated using magnetic resonance imaging...
  57. ncbi request reprint Impact of smoking abstinence on working memory neurocircuitry in adolescent daily tobacco smokers
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, 2 Church Street South, Suite 207, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 193:557-66. 2007
    ..Work in rodents has shown that exposure to nicotine during adolescence leads to nicotine withdrawal emergent alterations in cortical and subcortical dopamine neurotransmission...
  58. ncbi request reprint Non-invasive assessment of language lateralization by transcranial near infrared optical topography and functional MRI
    Richard P Kennan
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Hum Brain Mapp 16:183-9. 2002
    ..Due to the ease of use and portable nature of OT, it is anticipated that optical topography will be valuable tool for neurological examinations of cognitive function...
  59. pmc Biphasic hemodynamic responses influence deactivation and may mask activation in block-design fMRI paradigms
    Jed A Meltzer
    Interdepartmental Neuroscience Program, Yale University School of Medicine, Yale University, New Haven, Connecticut 06520 8043, USA
    Hum Brain Mapp 29:385-99. 2008
    ..In this case, default mode deactivations are timelocked to stimulus presentation as much as positive activations are, but in a later time range, suggesting a specific role of negative transient signals in task performance...
  60. ncbi request reprint Age-related changes in reading systems of dyslexic children
    Bennett A Shaywitz
    Department of Pediatrics, Section of Pediatric Neurology, Yale University School of Medicine, New Haven, CT 06510 8064, USA
    Ann Neurol 61:363-70. 2007
    ..To examine age-related changes in the neural systems for reading in nonimpaired and dyslexic children and adolescents...
  61. pmc Probing the pathophysiology of auditory/verbal hallucinations by combining functional magnetic resonance imaging and transcranial magnetic stimulation
    Ralph E Hoffman
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06519, USA
    Cereb Cortex 17:2733-43. 2007
    ..These findings suggest that dominant hemisphere temporoparietal areas are involved in expressing AVHs, with higher levels of coactivation and/or coupling involving inferior frontal regions reinforcing underlying pathophysiology...
  62. pmc Brain connectivity related to working memory performance
    Michelle Hampson
    Department of Diagnostic Radiology, Yale School of Medicine, New Haven, Connecticut 06520 8042, USA
    J Neurosci 26:13338-43. 2006
    ..In addition, these data raise the possibility that the individual differences in coupling strength between these two regions at rest predict differences in cognitive abilities important for this working memory task...
  63. ncbi request reprint Hemodynamic retrieval intensity in hippocampus is decreased by pre-exposure to autobiographic test items
    P Vivien Rekkas
    Department of Diagnostic Radiology, Yale University School of Medicine, TAC MRRC N127, PO Box 208042, New Haven, CT 06520 8042, USA
    Brain Res Bull 70:467-73. 2006
    ..This point is of particular importance to the on-going consolidation debate, as it often centers on a failure to detect an effect in the hippocampus in one or both conditions...
  64. pmc Cortical recruitment patterns in children born prematurely compared with control subjects during a passive listening functional magnetic resonance imaging task
    Laura R Ment
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    J Pediatr 149:490-8. 2006
    ..To use functional magnetic resonance imaging (fMRI) to test the hypothesis that subjects who were born prematurely develop alternative systems for processing language...
  65. ncbi request reprint Prenatal and adolescent exposure to tobacco smoke modulates the development of white matter microstructure
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Neurosci 27:13491-8. 2007
    ....
  66. ncbi request reprint Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, Connecticut 06519, USA
    Biol Psychiatry 61:31-40. 2007
    ..Human studies have shown that both cannabis and tobacco exert effects on cognitive function; however, little is known about possible interacting effects of these drugs on brain function and cognition during adolescent development...
  67. pmc Dynamic time course of typical childhood absence seizures: EEG, behavior, and functional magnetic resonance imaging
    Xiaoxiao Bai
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 30:5884-93. 2010
    ..These results may be important mechanistically for seizure initiation and termination and may also contribute to changes in EEG and behavior...

Research Grants28

  1. Towards an Improved Understanding of BOLD Signal Changes
    R Constable; Fiscal Year: 2007
    ..This work will provide insight into the relationship between MR signal changes in cognitive tasks, and EEC changes as measured with surface, and in a limited number of patients, subdural electrodes. ..
  2. Epileptogenic Tissue Localization using EEG-fMRI
    R Constable; Fiscal Year: 2007
    ..A large epilepsy population exists that could benefit greatly from better mapping techniques and these techniques may ultimately replace invasive methods decreasing health care costs and morbidity. ..
  3. Influence of Baseline Brain State on fMRI
    R Constable; Fiscal Year: 2007
    ..These experiments will also lay the ground work for future studies investigating higher order cognitive function such as those associated with attention and memory. ..
  4. Towards an Improved Understanding of BOLD Signal Changes
    R Todd Constable; Fiscal Year: 2010
    ..This work will provide insight into the relationship between MR signal changes in cognitive tasks, and EEC changes as measured with surface, and in a limited number of patients, subdural electrodes. ..
  5. Influence of Baseline Brain State on fMRI
    R Todd Constable; Fiscal Year: 2010
    ..These experiments will also lay the ground work for future studies investigating higher order cognitive function such as those associated with attention and memory. ..
  6. Method for Measuring Functional Subunits in Human Cortex
    R Todd Constable; Fiscal Year: 2010
    ..It also represents the first step in the path towards a human connectome. ..
  7. FUNCTIONAL MRI FOR NEUROSURGICAL PLANNING IN EPILEPSY
    R Constable; Fiscal Year: 2001
    ..Successful completion of this project may allow fMRI to be used as the primary source of functional localization in the brain for Neurosurgical planning reducing the need for invasive mapping techniques. ..
  8. FUNCTIONAL HETEREOGENEITY OF THE HIPPOCAMPAL FORMATION
    R Constable; Fiscal Year: 2003
    ..This work will have significant impact in both the neuroscience and medical communities. ..
  9. FUNCTIONAL MRI FOR NEUROSURGICAL PLANNING IN EPILEPSY
    R Constable; Fiscal Year: 2006
    ..Such a study will provide evidence not only of language reorganization but also of the specific cortical regions that reorganize, and the impact this reorganization has on performance and surgical outcome. ..
  10. Null Space Imaging - A Novel Approach to Accelerating MR Imaging
    R Todd Constable; Fiscal Year: 2010
    ....