J Concato

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Effects of androgen deprivation on brain function in prostate cancer patients - a prospective observational cohort analysis
    Herta H Chao
    Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT 06519, USA
    BMC Cancer 12:371. 2012
  2. doi request reprint Study design and "evidence" in patient-oriented research
    John Concato
    Clinical Epidemiology Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
    Am J Respir Crit Care Med 187:1167-72. 2013
  3. ncbi request reprint The effectiveness of screening for prostate cancer: a nested case-control study
    John Concato
    Clinical Epidemiology Research Center and Cooperative Studies Program Coordinating Center, Department of Veterans Affairs Connecticut Healthcare System, West Haven Veterans Affairs Medical Center 06516, USA
    Arch Intern Med 166:38-43. 2006
  4. ncbi request reprint A nested case-control study of the effectiveness of screening for prostate cancer: research design
    J Concato
    Clinincal Epidemiology Unit, Department of Veterans Affairs VA Connecticut Health Care System, USA, West Haven, CT, USA
    J Clin Epidemiol 54:558-64. 2001
  5. ncbi request reprint Prostate-specific antigen 'velocity' as a diagnostic test for prostate cancer
    John Concato
    Department of Medicine, Clinical Epidemiology Research Center, VA Connecticut Healthcare System, New Haven 06516, USA
    J Investig Med 54:361-4. 2006
  6. pmc Randomized, controlled trials, observational studies, and the hierarchy of research designs
    J Concato
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn 06510, USA
    N Engl J Med 342:1887-92. 2000
  7. ncbi request reprint Acetylcholinesterase activity in veterans of the first Gulf War
    John Concato
    VA Connecticut Healthcare System, Clinical Epidemiology Research Center, West Haven, CT 06516, USA
    J Investig Med 55:360-7. 2007
  8. doi request reprint What will the emperor say? Screening for prostate cancer as of 2008
    John Concato
    Veterans Affairs VA Clinical Epidemiology Research Center CERC, VA Connecticut Healthcare System, West Haven, CT, USA
    Cancer J 15:7-12. 2009
  9. doi request reprint Comparative effectiveness research: what kind of studies do we need?
    John Concato
    Clinical Epidemiology Research Center, Veterans Affairs VA Connecticut Healthcare System, West Haven, CT 06516, USA
    J Investig Med 58:764-9. 2010
  10. doi request reprint Observational methods in comparative effectiveness research
    John Concato
    VA Clinical Epidemiology Research Center and VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Am J Med 123:e16-23. 2010

Detail Information

Publications88

  1. pmc Effects of androgen deprivation on brain function in prostate cancer patients - a prospective observational cohort analysis
    Herta H Chao
    Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, CT 06519, USA
    BMC Cancer 12:371. 2012
    ....
  2. doi request reprint Study design and "evidence" in patient-oriented research
    John Concato
    Clinical Epidemiology Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
    Am J Respir Crit Care Med 187:1167-72. 2013
    ..Examination of cause-effect associations in patient-oriented research should recognize both the strengths and limitations of randomized trials as well as observational studies...
  3. ncbi request reprint The effectiveness of screening for prostate cancer: a nested case-control study
    John Concato
    Clinical Epidemiology Research Center and Cooperative Studies Program Coordinating Center, Department of Veterans Affairs Connecticut Healthcare System, West Haven Veterans Affairs Medical Center 06516, USA
    Arch Intern Med 166:38-43. 2006
    ..Evidence is lacking, however, to confirm a survival benefit among screened patients. We evaluated the effectiveness of PSA, with or without DRE, in reducing mortality...
  4. ncbi request reprint A nested case-control study of the effectiveness of screening for prostate cancer: research design
    J Concato
    Clinincal Epidemiology Unit, Department of Veterans Affairs VA Connecticut Health Care System, USA, West Haven, CT, USA
    J Clin Epidemiol 54:558-64. 2001
    ..Potential sources of bias are discussed, as well as corresponding strategies used to avoid them. Results are expected in the year 2002...
  5. ncbi request reprint Prostate-specific antigen 'velocity' as a diagnostic test for prostate cancer
    John Concato
    Department of Medicine, Clinical Epidemiology Research Center, VA Connecticut Healthcare System, New Haven 06516, USA
    J Investig Med 54:361-4. 2006
    ..Accordingly, we evaluated the sensitivity of prostate-specific antigen (PSA) velocity among men who are diagnosed subsequently with prostate cancer...
  6. pmc Randomized, controlled trials, observational studies, and the hierarchy of research designs
    J Concato
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn 06510, USA
    N Engl J Med 342:1887-92. 2000
    ..We used published meta-analyses to identify randomized clinical trials and observational studies that examined the same clinical topics. We then compared the results of the original reports according to the type of research design...
  7. ncbi request reprint Acetylcholinesterase activity in veterans of the first Gulf War
    John Concato
    VA Connecticut Healthcare System, Clinical Epidemiology Research Center, West Haven, CT 06516, USA
    J Investig Med 55:360-7. 2007
    ..This study was designed to examine relationships of deployment to the Gulf, as well as symptoms after military service, with postdeployment activity of acetylcholinesterase (AChE) and related enzymes...
  8. doi request reprint What will the emperor say? Screening for prostate cancer as of 2008
    John Concato
    Veterans Affairs VA Clinical Epidemiology Research Center CERC, VA Connecticut Healthcare System, West Haven, CT, USA
    Cancer J 15:7-12. 2009
    ..As of 2008, the need to counsel patients regarding the possible benefits and harms that can result from screening for (and treating) prostate cancer remains justified...
  9. doi request reprint Comparative effectiveness research: what kind of studies do we need?
    John Concato
    Clinical Epidemiology Research Center, Veterans Affairs VA Connecticut Healthcare System, West Haven, CT 06516, USA
    J Investig Med 58:764-9. 2010
    ..A review of these (and other) selected projects, based on their type of study design, serves to highlight the strengths, limitations, and potential of CER...
  10. doi request reprint Observational methods in comparative effectiveness research
    John Concato
    VA Clinical Epidemiology Research Center and VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Am J Med 123:e16-23. 2010
    ....
  11. pmc Observational versus experimental studies: what's the evidence for a hierarchy?
    John Concato
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    NeuroRx 1:341-7. 2004
    ..Unless a more balanced strategy evolves, new claims of methodological authority may be just as problematic as the traditional claims of medical authority that have been criticized by proponents of evidence-based medicine...
  12. ncbi request reprint Association between functional status and use and effectiveness of beta-blocker prophylaxis in elderly survivors of acute myocardial infarction
    Gail Vitagliano
    Department of Medicine, School of Medicine, Yale University, New Haven, and Clinical Epidemiology Unit, Veterans Affairs Connecticuat Healthcare System, West Haven, Connecticut, USA
    J Am Geriatr Soc 52:495-501. 2004
    ..To examine whether physical and cognitive impairments explain low use of beta-blockers in elderly patients and whether functionally impaired older adults have improved survival if a beta-blocker is prescribed at hospital discharge...
  13. ncbi request reprint Factors associated with caregiver burden among caregivers of terminally ill patients with cancer
    Nathan E Goldstein
    Robert Wood Johnson Clinical Scholars Program, Yale University, New Haven, Connecticut, USA
    J Palliat Care 20:38-43. 2004
    ..To identify factors associated with caregiver burden among those caring for terminally ill patients with cancer...
  14. ncbi request reprint The prevalence and treatment of depression among patients starting dialysis
    Suzanne Watnick
    Department of Medicine, Yale University School of Medicine, New Haven, CT, USA
    Am J Kidney Dis 41:105-10. 2003
    ....
  15. pmc What is a screening test? Misclassification bias in observational studies of screening for cancer
    J Concato
    West Haven Veterans Affairs Medical Center, Department of Medicine, Yale University School of Medicine, New Haven, Conn 06510, USA
    J Gen Intern Med 12:607-12. 1997
    ..To demonstrate the importance of accurately identifying clinical distinctions of subjects in observational studies of screening...
  16. pmc Patient preferences for treatment of rheumatoid arthritis
    L Fraenkel
    VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Ann Rheum Dis 63:1372-8. 2004
    ..To elicit treatment preferences of patients with rheumatoid arthritis (RA) for disease modifying antirheumatic drugs (DMARDs) with varying risk profiles...
  17. ncbi request reprint Hyperglycaemia in patients with acute ischaemic stroke: how often do we screen for undiagnosed diabetes?
    D M Bravata
    Clinical Epidemiology Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
    QJM 96:491-7. 2003
    ..The under-diagnosis of diabetes in the general population, combined with the association of diabetes and stroke, suggests a rationale for screening for diabetes among hyperglycaemic stroke patients...
  18. ncbi request reprint Differences in cervical cancer mortality among black and white women
    E A Howell
    Robert Wood Johnson Clinical Scholars Program, The Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8025, USA
    Obstet Gynecol 94:509-15. 1999
    ..To determine whether stage of disease and treatment patterns account for mortality differences between black and white women with cervical cancer...
  19. ncbi request reprint Informed consent for thrombolytic therapy for patients with acute ischemic stroke treated in routine clinical practice
    Julie R Rosenbaum
    Department of Internal Medicine, Yale University School of Medicine, West Haven, Conn, USA
    Stroke 35:e353-5. 2004
    ..Our objectives were to determine how frequently informed consent is obtained when tPA is given to stroke patients in clinical practice and whether the person providing consent (patient or surrogate) was the appropriate decision-maker...
  20. pmc Peak expiratory flow as a predictor of subsequent disability and death in community-living older persons
    Carlos A Vaz Fragoso
    Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut 06504, USA
    J Am Geriatr Soc 56:1014-20. 2008
    ..To determine whether peak expiratory flow (PEF), when expressed by a validated method using standardized residual (SR) percentile, is associated with subsequent disability and death in older persons...
  21. ncbi request reprint Two measures of insulin sensitivity provided similar information in a U.S. population
    Dawn M Bravata
    Clinical Epidemiology Unit, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA
    J Clin Epidemiol 57:1214-7. 2004
    ..This project describes the range of observed values of the HOMA and FPI in a large sample of the U.S. population...
  22. pmc Improving sedative-hypnotic prescribing in older hospitalized patients: provider-perceived benefits and barriers of a computer-based reminder
    Joseph V Agostini
    Clinical Epidemiology Research Center 151B, VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA
    J Gen Intern Med 23:32-6. 2008
    ..Older adults are commonly prescribed sedative-hypnotic (SH) medications when hospitalized, yet these drugs are associated with important adverse effects such as falls and delirium...
  23. pmc Patterns of weight change preceding hospitalization for heart failure
    Sarwat I Chaudhry
    Department of Internal Medicine, Section of General Medicine, Yale School of Medicine, New Haven, CT 06520, USA
    Circulation 116:1549-54. 2007
    ....
  24. ncbi request reprint Validity of using an electronic medical record for assessing quality of care in an outpatient setting
    Andrea L Benin
    Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine, New Haven, Connecticut, USA
    Med Care 43:691-8. 2005
    ....
  25. ncbi request reprint Do age and comorbidity affect intensity of pharmacological therapy for poorly controlled diabetes mellitus?
    Sarwat I Chaudhry
    Clinical Epidemiology Research Center, Department of Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut 06520, USA
    J Am Geriatr Soc 53:1214-6. 2005
    ..To examine the influence of age and comorbidity on intensification of medical therapy for patients with poorly controlled diabetes mellitus (DM)...
  26. ncbi request reprint Doctor-patient communication about prognosis: the influence of race and financial status
    Nathan E Goldstein
    Robert Wood Johnson Clinical Scholars Program, Yale University, New Haven, Connecticut, USA
    J Palliat Med 8:998-1004. 2005
    ..Although many studies have documented problems in communication between physicians and patients, few have focused on discussions regarding prognosis among community dwelling patients with terminal illness...
  27. ncbi request reprint Effects of statin use on muscle strength, cognition, and depressive symptoms in older adults
    Joseph V Agostini
    Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    J Am Geriatr Soc 55:420-5. 2007
    ..To determine the relationship between hydroxymethyl glutaryl coenzyme A reductase inhibitor (statin) use and proximal muscle strength, cognition, and depression in older adults...
  28. ncbi request reprint Readmission and death after hospitalization for acute ischemic stroke: 5-year follow-up in the medicare population
    Dawn M Bravata
    Clinical Epidemiology Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
    Stroke 38:1899-904. 2007
    ..We sought to determine the rates of hospital readmissions and mortality and the reasons for readmission over a 5-year period after stroke...
  29. ncbi request reprint Gender and non-medical use of prescription opioids: results from a national US survey
    Jeanette M Tetrault
    Veterans Affairs Clinical Epidemiology Research Center, West Haven, CT, USA
    Addiction 103:258-68. 2008
    ..Gender differences exist regarding alcohol and illicit drug use disorders in the United States. Little is known about the gender-related factors associated with non-medical use of prescription opioids...
  30. ncbi request reprint Study designs in patient-oriented research
    Chirag R Parikh
    Department of Medicine, Clinical Epidemiology Research Center, Yale University School of Medicine, New Haven, CT, USA
    Am J Kidney Dis 47:356-64. 2006
  31. ncbi request reprint Long-term glycemic control and postoperative infectious complications
    Annika S Dronge
    Surgical Service, Yale University School of Medicine, West Haven, CT 06516, USA
    Arch Surg 141:375-80; discussion 380. 2006
    ..Good preoperative glycemic control (hemoglobin A(1c) [HbA(1c)] levels <7%) is associated with decreased postoperative infections...
  32. pmc Association between antihypertensive medication use and non-cardiovascular outcomes in older men
    Joseph V Agostini
    Clinical Epidemiology Research Center 151B, VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT, USA
    J Gen Intern Med 22:1661-7. 2007
    ....
  33. ncbi request reprint Dietary fish or seafood consumption is not related to cerebrovascular disease risk in twin veterans
    Dawn M Bravata
    Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, CN 06516, USA
    Neuroepidemiology 28:186-90. 2007
    ..The results of studies about dietary fish consumption and stroke risk have been conflicting. We sought to examine the relationship between dietary fish and seafood consumption and the risk of stroke or transient ischemic attack (TIA)...
  34. ncbi request reprint Racial disparities in stroke risk factors: the impact of socioeconomic status
    Dawn M Bravata
    Clinical Epidemiology Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
    Stroke 36:1507-11. 2005
    ..Our objective was to determine if differences in income, education, and insurance, as well as differences in the prevalence of stroke risk factors, accounted for the association between ethnicity and stroke...
  35. pmc Effects of marijuana smoking on pulmonary function and respiratory complications: a systematic review
    Jeanette M Tetrault
    Clinical Epidemiology Research Center, Department of Veterans Affairs Connecticut Healthcare System, West Haven Veterans Affairs Medical Center, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Intern Med 167:221-8. 2007
    ....
  36. ncbi request reprint Treatment options in knee osteoarthritis: the patient's perspective
    Liana Fraenkel
    Veterans Affairs Connecticut Healthcare System, West Haven, USA
    Arch Intern Med 164:1299-304. 2004
    ....
  37. doi request reprint Prostate cancer, comorbidity, and participation in randomized controlled trials of therapy
    Herta H Chao
    VA Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    J Investig Med 58:566-8. 2010
    ..Our objective was to determine the proportion of men with castrate-resistant prostate cancer (CRPC) in a clinical setting that would have been excluded from major phase 3 RCTs...
  38. ncbi request reprint The health-related effects of alcohol use in older persons: a systematic review
    M Carrington Reid
    Clinical Epidemiology Unit, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Subst Abus 23:149-64. 2002
    ..Prospective studies are needed to better define the health-related effects of alcohol use in older populations...
  39. doi request reprint Impact of biochemical recurrence in prostate cancer among US veterans
    Edward M Uchio
    Surgical Urology and Medical Service, VA Clinical Epidemiology Research Center, VA Connecticut Healthcare System, 950 Campbell Ave, 151B, West Haven, CT 06516, USA
    Arch Intern Med 170:1390-5. 2010
    ..The impact of BCR on subsequent mortality is uncertain, however, especially given competing causes of death...
  40. ncbi request reprint Risk communication in rheumatoid arthritis
    Liana Fraenkel
    VA Connecticut Healthcare System, West Haven, Connecticut 06520 8031, USA
    J Rheumatol 30:443-8. 2003
    ..quot; We investigated whether some patients with rheumatoid arthritis (RA) treat the risk of adverse effects (AE) as "protected values," i.e., as unacceptable regardless of how small the risk...
  41. ncbi request reprint Long-term mortality in cerebrovascular disease
    Dawn M Bravata
    Medical Service, Veterans Affairs Connecticut Healthcare System, West Haven, Conn, USA
    Stroke 34:699-704. 2003
    ..The objectives of this study were to identify predictors of 6-month mortality and to evaluate 5-year mortality in patients with cerebrovascular disease...
  42. ncbi request reprint Pain-related disability among older male veterans receiving primary care
    M Carrington Reid
    Clinical Epidemiology Unit, VA Connecticut Healthcare System, West Haven 06516, USA
    J Gerontol A Biol Sci Med Sci 57:M727-32. 2002
    ..We sought to identify factors associated with disability due to pain in a sample of older veterans receiving primary care...
  43. ncbi request reprint Utility of captopril renal scans for detecting renal artery stenosis
    Stephen J Huot
    Department of Internal Medicine, West Haven Veterans Affairs Medical Center, Conn, USA
    Arch Intern Med 162:1981-4. 2002
    ..Scant data are available, however, regarding the utility of CRS in clinical practice...
  44. pmc Chronic obstructive pulmonary disease in older persons: A comparison of two spirometric definitions
    Carlos A Vaz Fragoso
    Yale University School of Medicine, Department of Internal Medicine, New Haven, CT 06516, USA
    Respir Med 104:1189-96. 2010
    ..70, and an FEV(1) below the 5th or 10th standardized residual percentile ("SR-tile strategy")...
  45. ncbi request reprint Improving diagnostic testing and reducing overuse of antibiotics for children with pharyngitis: a useful role for the electronic medical record
    Andrea L Benin
    Yale School of Medicine, Robert Wood Johnson Clinical Scholars Program, New Haven, CT, USA
    Pediatr Infect Dis J 22:1043-7. 2003
    ..The purpose of this study was to use an electronic medical record (EMR) to assess use of diagnostic testing and of antibiotics for pharyngitis in a pediatric outpatient setting and to target areas for improvement...
  46. ncbi request reprint Resilience of community-dwelling older persons
    Susan E Hardy
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06504, USA
    J Am Geriatr Soc 52:257-62. 2004
    ..To assess resilience of community-dwelling older persons using a new scale based on response to a stressful life event and to identify the demographic, clinical, functional, and psychosocial factors associated with high resilience...
  47. ncbi request reprint Informed choice and the widespread use of antiinflammatory drugs
    Liana Fraenkel
    Veteran s Affairs Connecticut Healthcare System and Yale University, New Haven, Connecticut, USA
    Arthritis Rheum 51:210-4. 2004
    ..To examine whether the current widespread use of antiinflammatory drugs may reflect a lack of informed choice (i.e., unawareness of adverse effects or potential treatment alternatives) among older patients with knee osteoarthritis (OA)...
  48. pmc Defining chronic obstructive pulmonary disease in older persons
    Carlos A Vaz Fragoso
    Claude D Pepper Older Americans Independence Center, Yale University, New Haven, CT, USA
    Respir Med 103:1468-76. 2009
    ..To develop a more age-appropriate spirometric definition of chronic obstructive pulmonary disease (COPD) among older persons...
  49. ncbi request reprint Association between impaired insulin sensitivity and stroke
    Dawn M Bravata
    Clinical Epidemiology Research Center CERC, VA Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA
    Neuroepidemiology 25:69-74. 2005
    ..Prior research has indicated an association between insulin resistance and stroke; we sought to determine if this association persists after adjusting for stroke risk factors, including glycemic control...
  50. ncbi request reprint Are preferences for cyclooxygenase-2 inhibitors influenced by the certainty effect?
    Liana Fraenkel
    VA Connecticut Healthcare System, West Haven, Connecticut 06520 8031, USA
    J Rheumatol 31:591-3. 2004
    ..e., by a perception that COX-2 inhibitors eliminate the risk of serious gastrointestinal (GI) events in contrast to merely reduce their risk...
  51. pmc The ratio of FEV1 to FVC as a basis for establishing chronic obstructive pulmonary disease
    Carlos A Vaz Fragoso
    Yale Claude D Pepper Older Americans Independence Center, New Haven, Connecticut, USA
    Am J Respir Crit Care Med 181:446-51. 2010
    ..The clinical validity of this threshold as a basis for establishing chronic obstructive pulmonary disease is unknown...
  52. ncbi request reprint Thrombolysis for acute stroke in routine clinical practice
    Dawn M Bravata
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8025, USA
    Arch Intern Med 162:1994-2001. 2002
    ....
  53. ncbi request reprint Clinical epidemiological quality in molecular genetic research: the need for methodological standards
    S T Bogardus
    Department of Medicine, Yale University School of Medicine, New Haven, Conn 06504, USA
    JAMA 281:1919-26. 1999
    ..A genetic basis has been identified for many medical conditions and some molecular tests have been commercialized. However, little attention has been given to the quality of clinical epidemiology in molecular studies...
  54. ncbi request reprint Stressful life events among community-living older persons
    Susan E Hardy
    Yale University School of Medicine, Department of Internal Medicine, New Haven, Conn 06504, USA
    J Gen Intern Med 17:832-8. 2002
    ....
  55. doi request reprint Reporting of multivariable methods in the medical literature
    Jeanette M Tetrault
    Veterans Affairs Clinical Epidemiology Research Center, 950 Campbell Avenue, West Haven, CT 06516, USA
    J Investig Med 56:954-7. 2008
    ....
  56. pmc A framework for tailoring clinical guidelines to comorbidity at the point of care
    R Scott Braithwaite
    Section of General Internal Medicine, Yale University School of Medicine, West Haven Veterans Affairs Connecticut Healthcare System, VACS 11 ACSL G, 950 Campbell Ave, West Haven, CT 06516, USA
    Arch Intern Med 167:2361-5. 2007
    ..Evidence is accumulating to suggest that clinical guidelines should be modified for patients with comorbidities, yet there is no quantitative and objective approach that considers benefits together with risks...
  57. ncbi request reprint Measuring alcohol consumption among older adults: a comparison of available methods
    M Carrington Reid
    Clinical Epidemiology Unit, VA Connecticut Healthcare System, West Haven, USA
    Am J Addict 12:211-9. 2003
    ..Until optimal methods for measuring alcohol exposures in elderly adults are defined, we suggest that a combination of measures be used when obtaining alcohol histories in older persons...
  58. doi request reprint Obstructive sleep apnea as a risk factor for coronary events or cardiovascular death
    Neomi A Shah
    Yale Center for Sleep Medicine, New Haven, CT, USA
    Sleep Breath 14:131-6. 2010
    ..This study aims to determine whether obstructive sleep apnea independently increases the risk of coronary events, including death from cardiovascular causes...
  59. ncbi request reprint Obstructive sleep apnea as a risk factor for stroke and death
    H Klar Yaggi
    Section of Pulmonary and Critical Care Medicine, Yale Center for Sleep Medicine, Yale University School of Medicine, New Haven, Conn 06520, USA
    N Engl J Med 353:2034-41. 2005
    ..It has not been determined, however, whether the syndrome is independently related to the risk of stroke or death from any cause after adjustment for other risk factors, including hypertension...
  60. ncbi request reprint Risk adjustment for older hospitalized persons: a comparison of two methods of data collection for the Charlson index
    C van Doorn
    Yale University School of Medicine, Department of Internal Medicine, 20 York Street, TMP 15, New Haven, CT 06504, USA
    J Clin Epidemiol 54:694-701. 2001
    ..We suggest development of an empirically-derived index of comorbid conditions and weights may be warranted for older general medical patients...
  61. pmc Injury related infant death: the impact of race and birth weight
    A Jain
    Robert Wood Johnson Clinical Scholars Program, Yale University, New Haven, Connecticut, USA
    Inj Prev 7:135-40. 2001
    ..To examine the effect of race and birth weight independent of other sociodemographic factors on injury related infant death using national data...
  62. ncbi request reprint Molecular markers and death from prostate cancer
    John Concato
    Veterans Affairs Clinical Epidemiology Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Ann Intern Med 150:595-603. 2009
    ..Current methods to assess the prognosis of prostate cancer at the time of diagnosis are limited...
  63. doi request reprint Variation in results from randomized, controlled trials: stochastic or systematic?
    Daniel Jane-wit
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Clin Epidemiol 63:56-63. 2010
    ..Our objective was to assess whether variability in treatment protocols of RCTs investigating the same topic could explain distinct patterns of outcomes...
  64. doi request reprint Changes in Gleason scores for prostate cancer: what should we expect from a measurement?
    Jorge Ramos
    Department of Medicine, Yale University School of Medicine, New Haven, CT, USA
    J Investig Med 58:625-8. 2010
    ..An upward shift has occurred in the distribution of Gleason scores during the past decade; this change was influenced by reports suggesting that lower scores (range, 2-4) should not be assigned to biopsy specimens...
  65. pmc Obstructive sleep apnea as a risk factor for type 2 diabetes
    Nader Botros
    Division of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, Conn
    Am J Med 122:1122-7. 2009
    ..It has not been determined, however, whether sleep apnea is independently associated with the subsequent development of diabetes, accounting for established risk factors...
  66. ncbi request reprint Claims of equivalence in medical research: are they supported by the evidence?
    W L Greene
    Yale University School of Medicine, New Haven, Connecticut, USA
    Ann Intern Med 132:715-22. 2000
    ..Most clinical studies are done to show comparative superiority, but many reports now claim equivalence between the investigated entities. These assertions may not always be supported by the methods used and the results obtained...
  67. ncbi request reprint Renal artery revascularization in patients with atherosclerotic renal artery stenosis and impaired renal function: conservative management versus renal artery stenting
    L E Dichtel
    Medical Service, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Clin Nephrol 74:113-22. 2010
    ..The goal of this study was to compare renal outcomes in patients treated with PTRAS with those managed conservatively...
  68. ncbi request reprint Beyond diagnosis: patient mix and challenges to patient care in ambulatory training sites
    D A Fiellin
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8025, USA
    Am J Med Sci 319:106-10. 2000
    ..Educational experiences in ambulatory medicine vary by site. Purpose: To evaluate variations in patient mix and challenges in patient care at 3 ambulatory training sites...
  69. ncbi request reprint Unwillingness of rheumatoid arthritis patients to risk adverse effects
    L Fraenkel
    Department of Medicine, Yale University, New Haven, CT 06520, VA Connecticut Health Care System, West Haven, CT 06516, USA
    Rheumatology (Oxford) 41:253-61. 2002
    ..To evaluate patient willingness to accept the risk of adverse effects (AEs) commonly associated with arthritis medications...
  70. ncbi request reprint Preference for disclosure of information among patients with rheumatoid arthritis
    L Fraenkel
    Department of Medicine, Yale University, New Haven, Connecticut 06520-8031, USA
    Arthritis Rheum 45:136-9. 2001
    ..The challenge remaining for rheumatologists is how to effectively communicate the risks and benefits related to the many options that are currently available for RA patients...
  71. doi request reprint Lack of immunohistochemical detection of VEGF in prostate carcinoma
    Anitha Kamath
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Appl Immunohistochem Mol Morphol 17:227-32. 2009
    ..The objective of this study was to measure VEGF expression in PrCa specimens, using IHC analysis with antibodies from different manufacturers and different antigen retrieval techniques...
  72. ncbi request reprint Patient preferences for treatment of lupus nephritis
    Liana Fraenkel
    Yale University, New Haven, Connecticut and Veterans Administration Connecticut Healthcare System, West Haven, Connecticut 06520 8031, USA
    Arthritis Rheum 47:421-8. 2002
    ..To examine the amount of improvement in renal survival that lupus patients require before choosing cyclophosphamide over azathioprine for the treatment of lupus nephritis...
  73. ncbi request reprint Prognostic implications of clinical practice guidelines among hemodialysis patients
    John J Chang
    Medical Service and Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, Connecticut, USA
    Hemodial Int 10:399-407. 2006
    ..Such efforts are essential for the improvement of guidelines and to inform health policy optimally...
  74. ncbi request reprint Beyond randomised versus observational studies
    John Concato
    Clinical Epidemiology Research Center, West Haven Veterans Affairs Medical Center, West Haven, Connecticut, USA
    Lancet 363:1660-1. 2004
  75. ncbi request reprint Molecular markers and mortality in prostate cancer
    John Concato
    Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, CT, USA
    BJU Int 100:1259-63. 2007
    ..g. markers of cell-cycle regulation), in addition to the effect of traditional clinical factors (e.g. anatomical stage, histological grade), in predicting long-term mortality among men newly diagnosed with prostate cancer...
  76. pmc Physician awareness of alcohol use disorders among older patients
    M C Reid
    Clinical Epidemiology Unit, VA Connecticut Healthcare System, West Haven VA Medical Center, 06516, USA
    J Gen Intern Med 13:729-34. 1998
    ..CONCLUSIONS: Primary care physicians may "underdetect" AUDs among older patients. The development of age-specific screening methods and physician education may facilitate detection of older patients with (or at risk for) these disorders...
  77. ncbi request reprint Effect of non-insulin-dependent diabetes mellitus on myocardial insulin responsiveness in patients with ischemic heart disease
    D Jagasia
    Section of Cardiovascular Medicine, VA Connecticut Healthcare System and Yale University School of Medicine, New Haven, Connecticut, USA
    Circulation 103:1734-9. 2001
    ..This suggests that insulin resistance is mediated at the level of individual organs and that different mechanisms are involved in muscle and vascular tissue...
  78. pmc Delayed presentation for human immunodeficiency virus (HIV) care among veterans: a problem of access or screening?
    Neel R Gandhi
    Robert Wood Johnson Clinical Scholars Program and Section of General Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Med Care 45:1105-9. 2007
    ..Others argue that delays will persist until routine screening is adopted. The Veterans Health Administration (VA) is a unique laboratory to examine whether access to comprehensive health benefits results in earlier entry into HIV care...
  79. ncbi request reprint Use of alcohol, illicit drugs, and tobacco among characters on prime-time television
    Judith A Long
    Center for Health Equity and Research and Promotion, Philadelphia VA Medical Center, Philadelphia, Pennsylvania 19104 6021, USA
    Subst Abus 23:95-103. 2002
    ..S. ratio. These results indicate that contrary to prevailing beliefs, alcohol, illicit drug, and tobacco users are uncommon on prime-time TV and are less prevalent than in the U.S. population...
  80. ncbi request reprint Are commonly ordered lab tests useful screens for alcohol disorders in older male veterans receiving primary care&#63
    M C Reid
    Weill Medical College, Cornell University, 525 East 68th St, Box 39, New York, NY 10021, USA
    Subst Abus 26:25-32. 2005
    ..82 to 1.04. Areas under the receiver operating characteristic curve were similar (range = 0.50-0.58) across tests. In conclusion, MCV, AST, ALT, and the AST/ALT ratio are not useful markers of alcohol disorders in older male veterans...
  81. ncbi request reprint Race independently predicts prostate specific antigen testing frequency following a prostate carcinoma diagnosis
    Steven B Zeliadt
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer 98:496-503. 2003
    ....
  82. ncbi request reprint Light to moderate alcohol consumption is associated with better cognitive function among older male veterans receiving primary care
    M C Reid
    Division of Geriatrics and Gerontology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Geriatr Psychiatry Neurol 19:98-105. 2006
    ..These findings are consistent with the hypothesis that light to moderate drinking confers cognitive benefits to older persons...
  83. ncbi request reprint Depressive symptoms as a risk factor for disabling back pain in community-dwelling older persons
    M Carrington Reid
    Division of Geriatrics and Gerontology, Weill Medical College, Cornell University, New York, New York 10021, USA
    J Am Geriatr Soc 51:1710-7. 2003
    ..To determine whether the presence of depressive symptoms is an independent risk factor for disabling back pain in community-dwelling older persons...
  84. ncbi request reprint Obstetric patient satisfaction: asking patients what they like
    Elizabeth A Howell
    Department of Obstetrics and Gynecology, Mount Sinai Medical Center, New York, NY 10029 6574, USA
    Am J Obstet Gynecol 190:175-82. 2004
    ....
  85. ncbi request reprint Bathing disability in community-living older persons: common, consequential, and complex
    Aanand D Naik
    Robert Wood Johnson Clinical Scholars Program, Houston Center for Quality of Care and Utilization Studies, Baylor College of Medicine, 2002 Holcombe Road, Houston, TX 77030, USA
    J Am Geriatr Soc 52:1805-10. 2004
    ..To identify the specific bathing subtasks that are affected in community-living-older persons with bathing disability and to determine the self-reported reasons for bathing disability...
  86. ncbi request reprint Do women prefer female obstetricians?
    Elizabeth A Howell
    Department of Obstetrics and Gynecology, Mount Sinai Medical Center, New York, New York 10029 6574, USA
    Obstet Gynecol 99:1031-5. 2002
    ..To investigate gender preferences for obstetricians in a hospital setting and to examine its relationship to patient satisfaction...
  87. ncbi request reprint How good is the evidence linking breastfeeding and intelligence?
    Anjali Jain
    Section of General Pediatrics, Department of Pediatrics, University of Chicago Children s Hospital, Chicago, Illinois, USA
    Pediatrics 109:1044-53. 2002
    ..We conducted a critical review of the many studies that have tried to determine whether breastfeeding has a beneficial effect on intellect...
  88. pmc Vector model of complexity
    R Scott Braithwaite
    J Gen Intern Med 23:895; author reply 896. 2008