Steven G Coca

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Role of intensive glucose control in development of renal end points in type 2 diabetes mellitus: systematic review and meta-analysis intensive glucose control in type 2 diabetes
    Steven G Coca
    Department of InternalMedicine, Yale University and VAMC, 950 Campbell Ave, West Haven, CT 06516, USA
    Arch Intern Med 172:761-9. 2012
  2. pmc The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods
    Alan S Go
    Kaiser Permanente Northern California, Oakland, CA, USA
    BMC Nephrol 11:22. 2010
  3. pmc Acute kidney injury in elderly persons
    Steven G Coca
    Section of Nephrology, Yale University School of Medicine, New Haven, CT, USA
    Am J Kidney Dis 56:122-31. 2010
  4. ncbi request reprint The cardiovascular implications of hypokalemia
    Steven G Coca
    Section of Nephrology, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Am J Kidney Dis 45:233-47. 2005
  5. doi request reprint Long-term outcomes of acute kidney injury
    Steven G Coca
    Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Curr Opin Nephrol Hypertens 19:266-72. 2010
  6. pmc Preoperative proteinuria predicts acute kidney injury in patients undergoing cardiac surgery
    Steven G Coca
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06516, USA
    J Thorac Cardiovasc Surg 143:495-502. 2012
  7. pmc Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery
    Chirag R Parikh
    Program of Applied Translational Research, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Clin J Am Soc Nephrol 8:1079-88. 2013
  8. pmc Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery
    Chirag R Parikh
    Section of Nephrology, Yale University and VAMC, 950 Campbell Avenue, Mail Code 151B, West Haven, CT 06516, USA
    J Am Soc Nephrol 22:1737-47. 2011
  9. pmc Urine microscopy is associated with severity and worsening of acute kidney injury in hospitalized patients
    Mark A Perazella
    Section of Nephrology, Yale University, New Haven, CT 06520 8029, USA
    Clin J Am Soc Nephrol 5:402-8. 2010
  10. pmc IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation
    Isaac E Hall
    Department of Medicine, Yale University, West Haven, CT 06516, USA
    J Am Soc Nephrol 21:189-97. 2010

Research Grants

Collaborators

Detail Information

Publications49

  1. pmc Role of intensive glucose control in development of renal end points in type 2 diabetes mellitus: systematic review and meta-analysis intensive glucose control in type 2 diabetes
    Steven G Coca
    Department of InternalMedicine, Yale University and VAMC, 950 Campbell Ave, West Haven, CT 06516, USA
    Arch Intern Med 172:761-9. 2012
    ..A systematic review was conducted to summarize the benefits of intensive vs conventional glucose control on kidney-related outcomes for adults with type 2 diabetes...
  2. pmc The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods
    Alan S Go
    Kaiser Permanente Northern California, Oakland, CA, USA
    BMC Nephrol 11:22. 2010
    ..Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors...
  3. pmc Acute kidney injury in elderly persons
    Steven G Coca
    Section of Nephrology, Yale University School of Medicine, New Haven, CT, USA
    Am J Kidney Dis 56:122-31. 2010
    ....
  4. ncbi request reprint The cardiovascular implications of hypokalemia
    Steven G Coca
    Section of Nephrology, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Am J Kidney Dis 45:233-47. 2005
    ..We review the available data and draw conclusions about the relative benefits of modulating potassium balance versus nonrenal effects of aldosterone blockade in patients with cardiovascular disease...
  5. doi request reprint Long-term outcomes of acute kidney injury
    Steven G Coca
    Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Curr Opin Nephrol Hypertens 19:266-72. 2010
    ..The goal of this review is to summarize the recent plethora of data that relate to long-term outcomes after acute kidney injury (AKI)...
  6. pmc Preoperative proteinuria predicts acute kidney injury in patients undergoing cardiac surgery
    Steven G Coca
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06516, USA
    J Thorac Cardiovasc Surg 143:495-502. 2012
    ..Acute kidney injury is a common and important complication for patients undergoing cardiac surgery. Proteinuria, which reflects structural damage to the glomeruli or renal tubules, may aid the prediction of acute kidney injury...
  7. pmc Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery
    Chirag R Parikh
    Program of Applied Translational Research, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Clin J Am Soc Nephrol 8:1079-88. 2013
    ..AKI is common and novel biomarkers may help provide earlier diagnosis and prognosis of AKI in the postoperative period...
  8. pmc Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery
    Chirag R Parikh
    Section of Nephrology, Yale University and VAMC, 950 Campbell Avenue, Mail Code 151B, West Haven, CT 06516, USA
    J Am Soc Nephrol 22:1737-47. 2011
    ..In conclusion, urine IL-18 and urine NGAL, but not plasma NGAL, associate with subsequent AKI and poor outcomes among children undergoing cardiac surgery...
  9. pmc Urine microscopy is associated with severity and worsening of acute kidney injury in hospitalized patients
    Mark A Perazella
    Section of Nephrology, Yale University, New Haven, CT 06520 8029, USA
    Clin J Am Soc Nephrol 5:402-8. 2010
    ..Although urine microscopy is useful to differentiate AKI, its role in predicting adverse clinical outcomes has not been well described...
  10. pmc IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation
    Isaac E Hall
    Department of Medicine, Yale University, West Haven, CT 06516, USA
    J Am Soc Nephrol 21:189-97. 2010
    ..In summary, urinary NGAL and IL-18 are early, noninvasive, accurate predictors of both the need for dialysis within the first week of kidney transplantation and 3-mo recovery of graft function...
  11. pmc Preoperative serum brain natriuretic peptide and risk of acute kidney injury after cardiac surgery
    Uptal D Patel
    Section of Nephrology, Yale University and VAMC, 950 Campbell Ave, West Haven, CT 06516, USA
    Circulation 125:1347-55. 2012
    ..We conducted a prospective study to evaluate whether preoperative brain natriuretic peptide (BNP) levels predict postoperative AKI among patients undergoing cardiac surgery...
  12. pmc Biomarkers predict progression of acute kidney injury after cardiac surgery
    Jay L Koyner
    Section of Nephrology, Department of Medicine, University of Chicago, Pritzker School of Medicine, Illinois, USA
    J Am Soc Nephrol 23:905-14. 2012
    ..69, P<0.0001). In conclusion, biomarkers measured on the day of AKI diagnosis improve risk stratification and identify patients at higher risk for progression of AKI and worse patient outcomes...
  13. pmc Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery
    Chirag R Parikh
    Section of Nephrology, Yale University and Veterans Administration Medical Center, 950 Campbell Avenue, Mail Code 151B, West Haven, CT 06516, USA
    J Am Soc Nephrol 22:1748-57. 2011
    ..In conclusion, urine IL-18, urine NGAL, and plasma NGAL associate with subsequent AKI and poor outcomes among adults undergoing cardiac surgery...
  14. pmc Blood transfusions are associated with urinary biomarkers of kidney injury in cardiac surgery
    Usman A Khan
    Section of Nephrology, Yale University School of Medicine, Veterans Affairs Medical Center, and the Program of Applied Translational Research, New Haven, Conn
    J Thorac Cardiovasc Surg 148:726-32. 2014
    ..We examined this association further by using urinary biomarkers of kidney injury...
  15. pmc Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury
    Justin M Belcher
    Program of Applied Translational Research, Yale University School of Medicine, New Haven, CT Section of Nephrology, Yale University School of Medicine, New Haven, CT Clinical Epidemiology Research Center, VAMC, West Haven, CT
    Hepatology 60:622-32. 2014
    ..10%, but did not differ between those with PRA, 0.27%, or ATN, 0.31%, Pā€‰=ā€‰0.54. The likelihood of being diagnosed with ATN increased step-wise with the number of biomarkers above optimal diagnostic cutoffs...
  16. pmc Risk of poor outcomes with novel and traditional biomarkers at clinical AKI diagnosis
    Isaac E Hall
    Department of Medicine, Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin J Am Soc Nephrol 6:2740-9. 2011
    ..Thus, we sought to determine the prognostic utility of newer biomarkers or traditional markers (fractional excretion of sodium [FeNa] and urea [FeUrea] and microscopy) over clinical assessment alone...
  17. pmc Urinary biomarkers of AKI and mortality 3 years after cardiac surgery
    Steven G Coca
    Section of Nephrology, Yale University School of Medicine, Program of Applied Translational Research, Veterans Affairs Connecticut Healthcare System, New Haven, Connecticut
    J Am Soc Nephrol 25:1063-71. 2014
    ..In conclusion, urinary biomarkers of kidney injury, particularly IL-18 and KIM-1, in the immediate postoperative period provide additional prognostic information for 3-year mortality risk in patients with and without clinical AKI...
  18. pmc Acute kidney injury in the elderly: predisposition to chronic kidney disease and vice versa
    Steven G Coca
    Section of Nephrology, Yale University School of Medicine, New Haven, CT, USA
    Nephron Clin Pract 119:c19-24. 2011
    ..Since AKI heightens the risk for the development and acceleration of CKD, this implies significant public health concerns with regard to the absolute number of elderly persons developing incident CKD...
  19. pmc The duration of postoperative acute kidney injury is an additional parameter predicting long-term survival in diabetic veterans
    Steven G Coca
    Clinical Epidemiology Research Center, Veterans Affairs Medical Center, West Haven, Connecticut 06516, USA
    Kidney Int 78:926-33. 2010
    ..Hence, the duration of AKI adds additional information to predict long-term mortality...
  20. pmc Adjudication of etiology of acute kidney injury: experience from the TRIBE-AKI multi-center study
    Jay L Koyner
    Department of Internal Medicine, Program of Applied Translational Research, Yale University and Veterans Affairs Medical Center, 60 Temple Street, Suite 6C, New Haven, CT 06510, USA
    BMC Nephrol 15:105. 2014
    ..However minimal data exists on the adjudication process in the setting of Acute Kidney Injury (AKI) as well as the ability to judge different etiologies (e.g. Acute Tubular Necrosis (ATN), Pre-renal Azotemia (PRA))...
  21. pmc Preoperative angiotensin-converting enzyme inhibitors and angiotensin receptor blocker use and acute kidney injury in patients undergoing cardiac surgery
    Steven G Coca
    Section of Nephrology, Yale University School of Medicine, VA CT Healthcare System, New Haven, CT, USA
    Nephrol Dial Transplant 28:2787-99. 2013
    ..Whether the same is true for 'structural' AKI, measured with new urinary biomarkers, is unknown...
  22. pmc Diagnostic value of urine microscopy for differential diagnosis of acute kidney injury in hospitalized patients
    Mark A Perazella
    Section of Nephrology, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Clin J Am Soc Nephrol 3:1615-9. 2008
    ..Urine microscopy is the oldest and one of the most commonly used tests for differential diagnosis of acute kidney injury (AKI), but its performance has not been adequately studied in the setting of AKI...
  23. pmc Incidence, risk factors, and outcomes of acute kidney injury after pediatric cardiac surgery: a prospective multicenter study
    Simon Li
    Division of Pediatric Critical Care, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Crit Care Med 39:1493-9. 2011
    ..To determine the incidence, severity, and risk factors of acute kidney injury in children undergoing cardiac surgery for congenital heart defects...
  24. ncbi request reprint Impact of chronic kidney disease on health-related quality-of-life improvement after coronary artery bypass surgery
    Chirag R Parikh
    Clinical Epidemiology Research Center, Veterans Affairs Medical Center, West Haven, CT 06516, USA
    Arch Intern Med 166:2014-9. 2006
    ..Little is known about the impact of chronic kidney disease (CKD) on health-related quality-of-life outcomes after coronary artery bypass grafting (CABG)...
  25. doi request reprint Long-term prognosis of acute kidney injury after acute myocardial infarction
    Chirag R Parikh
    Department of Medicine, Clinical Epidemiology Research Center, Veterans Affairs Medical Center, West Haven, Connecticut 06516, USA
    Arch Intern Med 168:987-95. 2008
    ..Acute kidney injury (AKI) is a common complication during hospitalization and is an accepted risk factor for in-hospital mortality. However, the association of severity of AKI with the long-term risk of death is not well defined...
  26. doi request reprint Traditional urinary biomarkers in the assessment of hospital-acquired AKI
    Mark A Perazella
    Section of Nephrology, Yale University School of Medicine, BB 114, 330 Cedar Street, New Haven, CT 06520 8029, USA
    Clin J Am Soc Nephrol 7:167-74. 2012
    ....
  27. ncbi request reprint Underrepresentation of renal disease in randomized controlled trials of cardiovascular disease
    Steven G Coca
    Clinical Epidemiology Research Center, Veterans Affairs Medical Center, West Haven, Conn 06516, USA
    JAMA 296:1377-84. 2006
    ..Patients with renal disease are at high risk for cardiovascular mortality. Determining which interventions best offset this risk remains a health priority...
  28. pmc Prevention of chronic kidney disease and subsequent effect on mortality: a systematic review and meta-analysis
    Usman A Khan
    Section of Nephrology, Yale University School of Medicine, Veterans Affairs Medical Center, and the Program of Applied Translational Research, New Haven, Connecticut, USA
    PLoS ONE 8:e71784. 2013
    ....
  29. pmc Association of AKI with mortality and complications in hospitalized patients with cirrhosis
    Justin M Belcher
    Program of Applied Translational Research, Yale University School of Medicine, New Haven, CT 06515, USA
    Hepatology 57:753-62. 2013
    ..8, 95% confidence interval 1.3-11.1)...
  30. ncbi request reprint Contribution of acute kidney injury toward morbidity and mortality in burns: a contemporary analysis
    Steven G Coca
    Clinical Epidemiology Research Center, Veterans Affairs Medical Center, West Haven, CT 06516, USA
    Am J Kidney Dis 49:517-23. 2007
    ..It is not known whether milder forms of AKI have prognostic importance in burns...
  31. ncbi request reprint The prognostic importance of a small acute decrement in kidney function in hospitalized patients: a systematic review and meta-analysis
    Steven G Coca
    Clinical Epidemiology Research Center, VA Connecticut Healthcare System, West Haven, USA
    Am J Kidney Dis 50:712-20. 2007
    ..Recently, acute kidney injury defined by small changes in serum creatinine levels was associated with worse short-term outcomes; however, the precision and variability of this association was not fully explored...
  32. doi request reprint Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis
    Sri G Yarlagadda
    Section of Nephrology, University of Kansas Medical Center, Kansas City, KS, USA
    Nephrol Dial Transplant 24:1039-47. 2009
    ..We conducted a systematic review and meta-analysis to precisely estimate these relationships...
  33. pmc Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis
    Steven G Coca
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Kidney Int 81:442-8. 2012
    ..Meta-regression did not identify any study-level factors that were associated with the risk for CKD or ESRD. Our review identifies AKI as an independent risk factor for CKD, ESRD, death, and other important non-renal outcomes...
  34. pmc Potential effects of digoxin on long-term renal and clinical outcomes in chronic heart failure
    Jeffrey M Testani
    Department of Internal Medicine and Program of Applied Translational Research, Yale University School of Medicine, New Haven, Connecticut, USA
    J Card Fail 19:295-302. 2013
    ..The objective of this study was to determine if randomization to digoxin is associated with improvement in renal function (IRF) and to evaluate if patients with digoxin-induced IRF have improved clinical outcomes...
  35. ncbi request reprint Urinary biomarkers for acute kidney injury: perspectives on translation
    Steven G Coca
    Section of Nephrology, VAMC and Yale University School of Medicine, Clinical Epidemiology Research Center, West Haven, CT 06516, USA
    Clin J Am Soc Nephrol 3:481-90. 2008
    ..It is likely that a panel of biomarkers, rather than a single biomarker, will be needed to perform extremely well in these three situations...
  36. doi request reprint Tubular proteinuria in acute kidney injury: a critical evaluation of current status and future promise
    Chirag R Parikh
    Clinical Epidemiology Research Center, Veterans Affairs Medical Center, West Haven, CT, USA
    Ann Clin Biochem 47:301-12. 2010
    ..Future studies will need to address these limitations in order for further progress to be made...
  37. pmc Prevention and treatment of acute kidney injury in patients undergoing cardiac surgery: a systematic review
    Meyeon Park
    Clinical Epidemiology Research Center, Veterans Affairs Medical Center, West Haven, Conn 06516, USA
    Am J Nephrol 31:408-18. 2010
    ..We conducted a systematic review of randomized controlled trials for strategies to prevent or treat AKI in cardiac surgery...
  38. pmc Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis
    Steven G Coca
    Section of Nephrology, Yale University, West Haven, CT 06516, USA
    Am J Kidney Dis 53:961-73. 2009
    ..Acute kidney injury (AKI) is common in hospitalized patients. The impact of AKI on long-term outcomes is controversial...
  39. pmc Prognostic importance of early worsening renal function after initiation of angiotensin-converting enzyme inhibitor therapy in patients with cardiac dysfunction
    Jeffrey M Testani
    Cardiovascular Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Circ Heart Fail 4:685-91. 2011
    ....
  40. ncbi request reprint The role of aldosterone blockers in the management of chronic heart failure
    Steven G Coca
    Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Sci 330:176-83. 2005
    ..Herein, the pathophysiology of CHF, the beneficial role of aldosterone antagonists in this disease process, and potential adverse consequences of these agents are reviewed...
  41. ncbi request reprint Adverse cardiorenal effects of aldosterone: is aldosterone antagonism beneficial?
    Steven G Coca
    Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Expert Rev Cardiovasc Ther 3:497-512. 2005
    ..In particular, the authors review their effects on reductions in cardiovascular events and progression of chronic kidney disease, as well as the safety and tolerability of these agents...
  42. pmc Marked variation in the definition and diagnosis of delayed graft function: a systematic review
    Sri G Yarlagadda
    Section of Nephrology, Yale University and VAMC, 950 Campbell Ave, Mail Code 151B, Bldg 35 A, Room 219, West Haven, CT 06516, USA
    Nephrol Dial Transplant 23:2995-3003. 2008
    ..DGF increases morbidity after transplantation, prolongs hospitalization and may lead to premature graft failure. Various definitions of DGF are used in the literature without a uniformly accepted technique to identify DGF...
  43. pmc Searching for genes that matter in acute kidney injury: a systematic review
    Jonathan C T Lu
    Yale University School of Medicine, New Haven, Connecticut, USA
    Clin J Am Soc Nephrol 4:1020-31. 2009
    ..Another factor that likely affects risk is intrinsic genetic variability. Therefore, a systematic review of studies was performed that related the development or prognosis of AKI to genetic variation...
  44. doi request reprint Three feasible strategies to minimize kidney injury in 'incipient AKI'
    Mark A Perazella
    Yale University School of Medicine, Section of Nephrology, 330 Cedar Street, New Haven, CT 06520, USA
    Nat Rev Nephrol 9:484-90. 2013
    ....
  45. ncbi request reprint Effect of intravenous iron on haemodialysis catheter microbial colonization and blood-borne infection
    Ursula C Brewster
    Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    Nephrology (Carlton) 10:124-8. 2005
    ..v. iron increases infection risk. This pilot study examines whether i.v. iron gluconate acutely increases tunnelled haemodialysis catheter colonization, microbial growth, or blood-borne infection...
  46. ncbi request reprint Eplerenone in patients with left ventricular dysfunction
    Steven G Coca
    N Engl J Med 349:88-9; author reply 88-9. 2003
  47. ncbi request reprint Controversies in cardiology
    Steven G Coca
    Lancet 367:1313; author reply 1315-6. 2006
  48. ncbi request reprint Albuminuria and mortality in hypertension
    Steven G Coca
    Ann Intern Med 141:244-5. 2004
  49. ncbi request reprint COMET: a proposed mechanism of action to explain the results and concerns about dose
    Steven G Coca
    Lancet 362:1076; author reply 1077-8. 2003

Research Grants2

  1. Urinary Biomarkers for Acute Kidney Injury in Critical Illness
    Steven Coca; Fiscal Year: 2007
    ..Furthermore, it will help researchers to perform efficient studies of drug development studies to improve kidney failure by enabling them to identify and enroll patients will kidney failure more rapidily. ..