G L Chupp

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Tissue and T cell distribution of precursor and mature IL-16
    G L Chupp
    Pulmonary Center, Boston University School of Medicine, MA 02118, USA
    J Immunol 161:3114-9. 1998
  2. ncbi A chitinase-like protein in the lung and circulation of patients with severe asthma
    Geoffrey L Chupp
    Yale University School of Medicine, New Haven, CT, USA
    N Engl J Med 357:2016-27. 2007
  3. ncbi Asthma: mechanisms of disease persistence and progression
    Lauren Cohn
    Yale University School of Medicine, Section of Pulmonary and Critical Care Medicine, New Haven, Connecticut, USA
    Annu Rev Immunol 22:789-815. 2004
  4. ncbi Novel biomarkers in asthma: chemokines and chitinase-like proteins
    Dominik Hartl
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Curr Opin Allergy Clin Immunol 9:60-6. 2009
  5. ncbi Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium
    Xuchen Zhang
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Respir Cell Mol Biol 28:305-15. 2003
  6. ncbi Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function
    Carole Ober
    University of Chicago, Chicago, IL 60637, USA
    N Engl J Med 358:1682-91. 2008
  7. ncbi Say what, beta-blockers for asthma?
    Geoffrey L Chupp
    Am J Respir Cell Mol Biol 38:249-50. 2008

Research Grants

  1. BIOLOGY OF IL-16 IN IL-1680 AND IL-1614 TRANSGENIC MICE
    Geoffrey Chupp; Fiscal Year: 2003
  2. Gene Expression Profiling in Asthma Severity: CHI3L1 Genotypes and Serum YKL-40
    Geoffrey Chupp; Fiscal Year: 2009
  3. Gene Expression Profiling in Asthma Severity: CHI3L1 Genotypes and Serum YKL-40
    Geoffrey L Chupp; Fiscal Year: 2010

Detail Information

Publications7

  1. ncbi Tissue and T cell distribution of precursor and mature IL-16
    G L Chupp
    Pulmonary Center, Boston University School of Medicine, MA 02118, USA
    J Immunol 161:3114-9. 1998
    ..These results show that pro-IL-16 is widely and constitutively expressed and suggest that the amino terminus of the protein can be processed upon cell activation...
  2. ncbi A chitinase-like protein in the lung and circulation of patients with severe asthma
    Geoffrey L Chupp
    Yale University School of Medicine, New Haven, CT, USA
    N Engl J Med 357:2016-27. 2007
    ..The related chitinase-like protein, YKL-40 (also called human cartilage glycoprotein 39 [HCgp-39] and chitinase 3-like 1), can be readily measured in the serum. However, its relationship to asthma has not been evaluated...
  3. ncbi Asthma: mechanisms of disease persistence and progression
    Lauren Cohn
    Yale University School of Medicine, Section of Pulmonary and Critical Care Medicine, New Haven, Connecticut, USA
    Annu Rev Immunol 22:789-815. 2004
    ..We review human and animal data detailing the cellular and molecular interactions in established allergic asthma that promote persistent disease, amplify inflammation, and, in turn, cause disease progression...
  4. ncbi Novel biomarkers in asthma: chemokines and chitinase-like proteins
    Dominik Hartl
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Curr Opin Allergy Clin Immunol 9:60-6. 2009
    ..Thus, there is a need for specific biomarkers to detect asthma as soon as possible and to initiate the correct clinical treatment...
  5. ncbi Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium
    Xuchen Zhang
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Respir Cell Mol Biol 28:305-15. 2003
    ....
  6. ncbi Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function
    Carole Ober
    University of Chicago, Chicago, IL 60637, USA
    N Engl J Med 358:1682-91. 2008
    ..We hypothesized that single-nucleotide polymorphisms (SNPs) that affect YKL-40 levels also influence asthma status and lung function...
  7. ncbi Say what, beta-blockers for asthma?
    Geoffrey L Chupp
    Am J Respir Cell Mol Biol 38:249-50. 2008

Research Grants4

  1. BIOLOGY OF IL-16 IN IL-1680 AND IL-1614 TRANSGENIC MICE
    Geoffrey Chupp; Fiscal Year: 2003
    ..These finding swill have impressive implications via-a-vis our knowledge of the biology of IL-16 and mechanisms of airway inflammation and healing in asthma. ..
  2. Gene Expression Profiling in Asthma Severity: CHI3L1 Genotypes and Serum YKL-40
    Geoffrey Chupp; Fiscal Year: 2009
    ....
  3. Gene Expression Profiling in Asthma Severity: CHI3L1 Genotypes and Serum YKL-40
    Geoffrey L Chupp; Fiscal Year: 2010
    ....