Chuhan Chung

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator
    Chuhan Chung
    Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Gastroenterology 136:331-340.e2. 2009
  2. pmc The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer
    Chuhan Chung
    Department of Medicine, Section of Digestive Diseases, VA CT Research, VA CT Healthcare System, Yale University School of Medicine, West Haven, CT 06516, USA
    Lab Invest 91:732-43. 2011
  3. doi request reprint Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL)
    Chuhan Chung
    Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA
    J Hepatol 48:471-8. 2008
  4. pmc Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1
    John C Schmitz
    Section of Digestive Diseases, VA Connecticut Healthcare System, New Haven, Connecticut, USA
    Am J Pathol 179:2990-9. 2011
  5. doi request reprint Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha
    Chuhan Chung
    Section of Digestive Disease, Yale University School of Medicine, West Haven, CT, USA
    Adv Exp Med Biol 617:591-7. 2008
  6. doi request reprint Insulin resistance is associated with elevated serum pigment epithelium-derived factor (PEDF) levels in morbidly obese patients
    Arijeet K Gattu
    Veteran s Affairs Medical Center, West Haven, CT 06516, USA
    Acta Diabetol 49:S161-9. 2012
  7. pmc Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice
    Keitaro Tashiro
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Pathol 182:786-95. 2013
  8. pmc The lymphatic vascular system in liver diseases: its role in ascites formation
    Chuhan Chung
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Mol Hepatol 19:99-104. 2013
  9. pmc Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis
    Dahai Zhang
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Hepatology 53:1306-15. 2011

Collaborators

  • Yasuko Iwakiri
  • Fred Gorelick
  • Varman Samuel
  • Koji Yamaguchi
  • Aurelia Lugea
  • Teruo Utsumi
  • Arijeet K Gattu
  • Keitaro Tashiro
  • Susan E Crawford
  • John C Schmitz
  • Dahai Zhang
  • Ayano Satoh
  • Fangyong Li
  • Xin Chu
  • James Dziura
  • Fran├žois Jornayvaz
  • Glenn S Gerhard
  • Christopher D Still
  • Andreas L Birkenfeld
  • Margo Quinn
  • Levente Jozsef
  • Antonio G Neto
  • Zhengrong Hao
  • Kazunori Shibao
  • Panjamaporn Sangwung
  • Mona L Cornwell
  • Kohji Okamoto
  • Lili Gao
  • Petr Protiva
  • Roberto J Groszmann
  • Hui Chun Huang
  • Philip Fitchev
  • William C Sessa

Detail Information

Publications9

  1. pmc Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator
    Chuhan Chung
    Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Gastroenterology 136:331-340.e2. 2009
    ..Because matrix metalloproteinase (MMP)-2/9 activity regulates PEDF levels, we investigated whether PEDF degradation by MMPs has a permissive role in ethanol-induced hepatic steatosis...
  2. pmc The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer
    Chuhan Chung
    Department of Medicine, Section of Digestive Diseases, VA CT Research, VA CT Healthcare System, Yale University School of Medicine, West Haven, CT 06516, USA
    Lab Invest 91:732-43. 2011
    ..Thus, v-ATPase selectively modulates specific MMPs that may be linked to an invasive cancer phenotype...
  3. doi request reprint Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL)
    Chuhan Chung
    Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA
    J Hepatol 48:471-8. 2008
    ..We postulated that hepatocyte triglyceride metabolism was dependent on interactions between PEDF and ATGL, and loss of PEDF would impair mobilization of triglycerides in the liver...
  4. pmc Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1
    John C Schmitz
    Section of Digestive Diseases, VA Connecticut Healthcare System, New Haven, Connecticut, USA
    Am J Pathol 179:2990-9. 2011
    ..PEDF-null mice, however, demonstrated enhanced early fibrotic responses compared with wild-type mice with pancreatitis. These findings indicate that PEDF acts as a compensatory antifibrotic cytokine in pancreatitis...
  5. doi request reprint Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha
    Chuhan Chung
    Section of Digestive Disease, Yale University School of Medicine, West Haven, CT, USA
    Adv Exp Med Biol 617:591-7. 2008
    ..These data show that PEDF regulates lipid metabolism through activation of the transcription factor PPARalpha...
  6. doi request reprint Insulin resistance is associated with elevated serum pigment epithelium-derived factor (PEDF) levels in morbidly obese patients
    Arijeet K Gattu
    Veteran s Affairs Medical Center, West Haven, CT 06516, USA
    Acta Diabetol 49:S161-9. 2012
    ..016). These data demonstrate that serum PEDF concentrations better relate to insulin resistance than to adiposity and suggest that PEDF expression is closely linked to the development of insulin resistance...
  7. pmc Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice
    Keitaro Tashiro
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Pathol 182:786-95. 2013
    ..The absence of Nogo-B enhances apoptosis of HSCs in experimental cirrhosis. Selective blockade of Nogo-B in HSCs may represent a potential therapeutic strategy to mitigate liver fibrosis...
  8. pmc The lymphatic vascular system in liver diseases: its role in ascites formation
    Chuhan Chung
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Mol Hepatol 19:99-104. 2013
    ..This article summarizes: 1) the lymphatic vascular system; 2) its role in liver tumors, liver fibrosis/cirrhosis and portal hypertension; and 3) its role in ascites formation. ..
  9. pmc Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis
    Dahai Zhang
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Hepatology 53:1306-15. 2011
    ..Four weeks after BDL, portal pressure was significantly increased in WT mice by 47%, compared with sham-operated controls (P = 0.03), whereas such an increase in portal pressure was not observed in NGB KO mice (P = NS)...