Chuhan Chung

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator
    Chuhan Chung
    Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Gastroenterology 136:331-340.e2. 2009
  2. ncbi The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer
    Chuhan Chung
    Department of Medicine, Section of Digestive Diseases, VA CT Research, VA CT Healthcare System, Yale University School of Medicine, West Haven, CT 06516, USA
    Lab Invest 91:732-43. 2011
  3. ncbi Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL)
    Chuhan Chung
    Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA
    J Hepatol 48:471-8. 2008
  4. ncbi Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1
    John C Schmitz
    Section of Digestive Diseases, VA Connecticut Healthcare System, New Haven, Connecticut, USA
    Am J Pathol 179:2990-9. 2011
  5. ncbi Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha
    Chuhan Chung
    Section of Digestive Disease, Yale University School of Medicine, West Haven, CT, USA
    Adv Exp Med Biol 617:591-7. 2008
  6. ncbi Insulin resistance is associated with elevated serum pigment epithelium-derived factor (PEDF) levels in morbidly obese patients
    Arijeet K Gattu
    Veteran s Affairs Medical Center, West Haven, CT 06516, USA
    Acta Diabetol 49:S161-9. 2012
  7. ncbi Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis
    Dahai Zhang
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Hepatology 53:1306-15. 2011

Collaborators

  • Fred Gorelick
  • Yasuko Iwakiri
  • Varman Samuel
  • Koji Yamaguchi
  • Aurelia Lugea
  • Arijeet K Gattu
  • Susan E Crawford
  • Dahai Zhang
  • Teruo Utsumi
  • John C Schmitz
  • Christopher D Still
  • Fangyong Li
  • Andreas L Birkenfeld
  • Xin Chu
  • Glenn S Gerhard
  • James Dziura
  • François Jornayvaz
  • Antonio G Neto
  • Mona L Cornwell
  • Roberto J Groszmann
  • Kohji Okamoto
  • Philip Fitchev
  • Lili Gao
  • Hui Chun Huang
  • Panjamaporn Sangwung
  • Margo Quinn
  • William C Sessa
  • Levente Jozsef
  • Kazunori Shibao
  • Petr Protiva
  • Zhengrong Hao

Detail Information

Publications7

  1. ncbi Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator
    Chuhan Chung
    Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Gastroenterology 136:331-340.e2. 2009
    ..Because matrix metalloproteinase (MMP)-2/9 activity regulates PEDF levels, we investigated whether PEDF degradation by MMPs has a permissive role in ethanol-induced hepatic steatosis...
  2. ncbi The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer
    Chuhan Chung
    Department of Medicine, Section of Digestive Diseases, VA CT Research, VA CT Healthcare System, Yale University School of Medicine, West Haven, CT 06516, USA
    Lab Invest 91:732-43. 2011
    ..Thus, v-ATPase selectively modulates specific MMPs that may be linked to an invasive cancer phenotype...
  3. ncbi Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL)
    Chuhan Chung
    Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA
    J Hepatol 48:471-8. 2008
    ..We postulated that hepatocyte triglyceride metabolism was dependent on interactions between PEDF and ATGL, and loss of PEDF would impair mobilization of triglycerides in the liver...
  4. ncbi Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1
    John C Schmitz
    Section of Digestive Diseases, VA Connecticut Healthcare System, New Haven, Connecticut, USA
    Am J Pathol 179:2990-9. 2011
    ..PEDF-null mice, however, demonstrated enhanced early fibrotic responses compared with wild-type mice with pancreatitis. These findings indicate that PEDF acts as a compensatory antifibrotic cytokine in pancreatitis...
  5. ncbi Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha
    Chuhan Chung
    Section of Digestive Disease, Yale University School of Medicine, West Haven, CT, USA
    Adv Exp Med Biol 617:591-7. 2008
    ..These data show that PEDF regulates lipid metabolism through activation of the transcription factor PPARalpha...
  6. ncbi Insulin resistance is associated with elevated serum pigment epithelium-derived factor (PEDF) levels in morbidly obese patients
    Arijeet K Gattu
    Veteran s Affairs Medical Center, West Haven, CT 06516, USA
    Acta Diabetol 49:S161-9. 2012
    ..016). These data demonstrate that serum PEDF concentrations better relate to insulin resistance than to adiposity and suggest that PEDF expression is closely linked to the development of insulin resistance...
  7. ncbi Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis
    Dahai Zhang
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Hepatology 53:1306-15. 2011
    ..Because absence of Nogo-B ameliorates liver fibrosis and portal hypertension, Nogo-B blockade may be a potential therapeutic target in fibrosis/cirrhosis...