JUDY CHO

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Pathway analysis comparison using Crohn's disease genome wide association studies
    David Ballard
    Robert S Boas Center for Human Genetics and Genomics, Feinstein Institute for Medical Research, Manhasset, New York, USA
    BMC Med Genomics 3:25. 2010
  2. doi request reprint Recent insights into the genetics of inflammatory bowel disease
    Judy H Cho
    Department of Medicine and Genetics, Yale University, New Haven, Connecticut, USA
    Gastroenterology 140:1704-12. 2011
  3. doi request reprint The genetics and immunopathogenesis of inflammatory bowel disease
    Judy H Cho
    Inflammatory Bowel Disease Center, Section of Digestive Diseases, Yale University, 333 Cedar Street, LMP 1080, New Haven, Connecticut 06520, USA
    Nat Rev Immunol 8:458-66. 2008
  4. pmc Inflammatory bowel disease: genetic and epidemiologic considerations
    Judy H Cho
    Inflammatory Bowel Disease Center, Yale University, 300 Cedar Street, New Haven, CT 06519, USA
    World J Gastroenterol 14:338-47. 2008
  5. ncbi request reprint The genetics of inflammatory bowel disease
    Judy H Cho
    Inflammatory Bowel Disease Center, Section of Digestive Diseases, Yale University, New Haven, Connecticut 06520 8019, USA
    Gastroenterology 133:1327-39. 2007
  6. ncbi request reprint Inflammatory bowel disease genetics: Nod2
    Judy H Cho
    Department of Medicine, Yale University, New Haven, Connecticut 06510, USA
    Annu Rev Med 58:401-16. 2007
  7. doi request reprint Identification of association between disease and multiple markers via sparse partial least-squares regression
    Hyonho Chun
    Department of Epidemiology and Public Health, Yale University, 300 George Street 503, New Haven, CT 06511, USA
    Genet Epidemiol 35:479-86. 2011
  8. pmc Comparisons of multi-marker association methods to detect association between a candidate region and disease
    David H Ballard
    Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06511, USA
    Genet Epidemiol 34:201-12. 2010
  9. ncbi request reprint A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    Richard H Duerr
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian, Mezzanine Level, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Science 314:1461-3. 2006
  10. doi request reprint IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease
    Clara Abraham
    Section of Digestive Diseases, Departments of 1Medicine, Yale University, New Haven, Connecticut 06520, USA
    Annu Rev Med 60:97-110. 2009

Collaborators

Detail Information

Publications38

  1. pmc Pathway analysis comparison using Crohn's disease genome wide association studies
    David Ballard
    Robert S Boas Center for Human Genetics and Genomics, Feinstein Institute for Medical Research, Manhasset, New York, USA
    BMC Med Genomics 3:25. 2010
    ....
  2. doi request reprint Recent insights into the genetics of inflammatory bowel disease
    Judy H Cho
    Department of Medicine and Genetics, Yale University, New Haven, Connecticut, USA
    Gastroenterology 140:1704-12. 2011
    ..Future genetic studies will be directed toward identifying uncommon variations with potentially greater statistical effects, defining population differences, and more completely accounting for familial transmission of disease...
  3. doi request reprint The genetics and immunopathogenesis of inflammatory bowel disease
    Judy H Cho
    Inflammatory Bowel Disease Center, Section of Digestive Diseases, Yale University, 333 Cedar Street, LMP 1080, New Haven, Connecticut 06520, USA
    Nat Rev Immunol 8:458-66. 2008
    ..Comparative analyses of gene associations between these two inflammatory bowel diseases reveal common and unique mechanisms of their immunopathogenesis...
  4. pmc Inflammatory bowel disease: genetic and epidemiologic considerations
    Judy H Cho
    Inflammatory Bowel Disease Center, Yale University, 300 Cedar Street, New Haven, CT 06519, USA
    World J Gastroenterol 14:338-47. 2008
    ..Future challenges include: (1) the establishment of precisely causal alleles, (2) definition of altered functional outcomes of associated and causal alleles and (3) integration of genetic findings with environmental factors...
  5. ncbi request reprint The genetics of inflammatory bowel disease
    Judy H Cho
    Inflammatory Bowel Disease Center, Section of Digestive Diseases, Yale University, New Haven, Connecticut 06520 8019, USA
    Gastroenterology 133:1327-39. 2007
  6. ncbi request reprint Inflammatory bowel disease genetics: Nod2
    Judy H Cho
    Department of Medicine, Yale University, New Haven, Connecticut 06510, USA
    Annu Rev Med 58:401-16. 2007
    ..Here we review general aspects of IBD genetics with particular focus on the role of Nod2 in CD...
  7. doi request reprint Identification of association between disease and multiple markers via sparse partial least-squares regression
    Hyonho Chun
    Department of Epidemiology and Public Health, Yale University, 300 George Street 503, New Haven, CT 06511, USA
    Genet Epidemiol 35:479-86. 2011
    ..This approach is able to use information from both traits and marker genotypes. Extensive simulations and real data analyses on a Crohn's disease data set suggest the superiority of this approach over existing methods...
  8. pmc Comparisons of multi-marker association methods to detect association between a candidate region and disease
    David H Ballard
    Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06511, USA
    Genet Epidemiol 34:201-12. 2010
    ....
  9. ncbi request reprint A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    Richard H Duerr
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, University of Pittsburgh Medical Center Presbyterian, Mezzanine Level, C Wing, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Science 314:1461-3. 2006
    ..These results and previous studies on the proinflammatory role of IL-23 prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease...
  10. doi request reprint IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease
    Clara Abraham
    Section of Digestive Diseases, Departments of 1Medicine, Yale University, New Haven, Connecticut 06520, USA
    Annu Rev Med 60:97-110. 2009
    ..The identification of IL-23 pathway and Th17 expressed genes in IBD pathogenesis highlights the importance of the proper regulation of the IL-23/Th17 pathway in maintaining intestinal immune homeostasis...
  11. ncbi request reprint Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan
    Denise K Bonen
    Martin Boyer Laboratories, Gastroenterology Section, Department of Medicine, University of Chicago Hospitals, Chicago, Illinois, USA
    Gastroenterology 124:140-6. 2003
    ..Except for the L1007fsinsC mutation, which produces a truncated NOD2 protein, the functional activity of the major CD-associated variants G908R and R702W is unknown...
  12. pmc Practical issues in building risk-predicting models for complex diseases
    Jia Kang
    Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, USA
    J Biopharm Stat 20:415-40. 2010
    ..We also demonstrate the performance of different methods through both simulation studies and application to real-world data...
  13. pmc MDR1 Ala893 polymorphism is associated with inflammatory bowel disease
    Steven R Brant
    The Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Hum Genet 73:1282-92. 2003
    ..Taken together, these data support the association of the common Ala893 polymorphism with IBD specifically and, more broadly, provides additional support for its contribution to interindividual pharmacogenetic variation...
  14. ncbi request reprint Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease
    Guo Zhong Tao
    Department of Medicine, Palo Alto Veterans Affairs Medical Center and Stanford University Digestive Disease Center, Palo Alto, California 94304, USA
    Clin Gastroenterol Hepatol 5:857-64. 2007
    ..We asked whether mutations in KRT8 or KRT19, the major intestinal keratins, are associated with UC/CD...
  15. doi request reprint Interleukin-23/Th17 pathways and inflammatory bowel disease
    Clara Abraham
    Department of Medicine, Digestive Diseases, Yale University, New Haven, Connecticut 06520, USA
    Inflamm Bowel Dis 15:1090-100. 2009
    ..As such, the IL-23/Th17 pathway contributes to immune responses that play a role in defenses to microbial infection, as well as in the intestinal inflammation observed in both animal models of colitis and human IBD...
  16. ncbi request reprint Inflammatory bowel disease characteristics among African Americans, Hispanics, and non-Hispanic Whites: characterization of a large North American cohort
    Geoffrey C Nguyen
    Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Gastroenterol 101:1012-23. 2006
    ..This study was undertaken to characterize racial differences in disease phenotype in a predominantly adult population...
  17. ncbi request reprint Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations
    Jing Li
    The Martin Boyer Laboratories, Gastroenterology Section, Department of Medicine, The University of Chicago, IL 60637, USA
    Hum Mol Genet 13:1715-25. 2004
    ..Taken together, these studies suggest that a signaling defect of innate immunity to MDP may be an essential underlying defect in the pathogenesis of some CD patients...
  18. ncbi request reprint The genetics of inflammatory bowel disease
    Denise K Bonen
    The Martin Boyer Laboratories, Gastroenterology Section, Department of Medicine, University of Chicago Hospitals, Illinois 60637, USA
    Gastroenterology 124:521-36. 2003
    ....
  19. ncbi request reprint Bugging of the intestinal mucosa
    Clara Abraham
    Department of Medicine, University of Chicago, Chicago, USA
    N Engl J Med 357:708-10. 2007
  20. ncbi request reprint Functional consequences of NOD2 (CARD15) mutations
    Clara Abraham
    Department of Medicine, Section of Gastroenterology, University of Chicago, Chicago, Illinois 60637, USA
    Inflamm Bowel Dis 12:641-50. 2006
    ..Improved understanding of NOD2-mediated pathways may lead to identification of other molecules that can also contribute to the development of Crohn's disease in humans...
  21. pmc L-histidine decarboxylase and Tourette's syndrome
    A Gulhan Ercan-Sencicek
    Yale University School of Medicine, New Haven, CT 06520, USA
    N Engl J Med 362:1901-8. 2010
    ..Our findings, together with previously published data from model systems, point to a role for histaminergic neurotransmission in the mechanism and modulation of Tourette's syndrome and tics...
  22. pmc Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    Jeffrey C Barrett
    Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 40:955-62. 2008
    ..The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development...
  23. ncbi request reprint Significant role of genetics in IBD: the NOD2 gene
    Judy H Cho
    Committee of Genetics, University of Chicago, Chicago, IL, USA
    Rev Gastroenterol Disord 3:S18-22. 2003
    ..The presence of an NOD2 risk allele has been shown to be associated with ilial disease as well as an earlier age of disease onset. Further studies are needed to clarify the relationship between IBD genotype and disease behavior...
  24. ncbi request reprint Defining complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes
    Steven R Brant
    The Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Dept of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, U S A
    Inflamm Bowel Dis 9:281-9. 2003
    ..Multiple factors, particularly IBD family history, tobacco use, age at diagnosis and recently, NOD2 mutant genotypes may influence Crohn's disease (CD) heterogeneity...
  25. pmc Clinical aspects and pathophysiology of inflammatory bowel disease
    Barbara A Hendrickson
    Section of Infectious Diseases, Department of Pediatrics and the The Martin Boyer Laboratories, University of Chicago, Chicago, Illinois 60637, USA
    Clin Microbiol Rev 15:79-94. 2002
    ..Current investigations promise to yield fresh insights in these areas...
  26. pmc Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    John D Rioux
    Université de Montréal and the Montreal Heart Institute, Research Center, 5000 rue Belanger, Montreal, Quebec H1T 1C8, Canada
    Nat Genet 39:596-604. 2007
    ..Together, these findings suggest that autophagy and host cell responses to intracellular microbes are involved in the pathogenesis of Crohn disease...
  27. ncbi request reprint A genome scan in 260 inflammatory bowel disease-affected relative pairs
    M Michael Barmada
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Inflamm Bowel Dis 10:513-20. 2004
    ....
  28. ncbi request reprint Advances in the genetics of inflammatory bowel disease
    Judy H Cho
    University of Chicago, 5841 South Maryland Avenue, MC 6084, Chicago, IL 60637, USA
    Curr Gastroenterol Rep 6:467-73. 2004
    ..Identification of these key pathways will potentially highlight novel therapeutic targets...
  29. ncbi request reprint The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction
    Marie Pierik
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Inflamm Bowel Dis 11:1-7. 2005
    ..To further characterize this locus, we assessed gene-environment interaction (IBD4 x smoking) and phenotypic heterogeneity in a large cohort of IBD-affected sibling pairs as part of an ongoing international collaborative effort...
  30. ncbi request reprint Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease
    Andrew T Gewirtz
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1157-63. 2006
    ..These results demonstrate that natural acquisition of immune responses to flagellin are regulated by TLR5 and suggest that immune responses to flagellin are not merely associated with CD but rather promote the pathogenic response...
  31. ncbi request reprint Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus
    Jean Paul Achkar
    Center for Inflammatory Bowel Disease, Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Gastroenterol 101:572-80. 2006
    ..The purpose of this study was to assess phenotypic subsets that contribute to the major IBD susceptibility loci...
  32. ncbi request reprint A genome scan in 260 inflammatory bowel disease-affected relative pairs
    M Michael Barmada
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Inflamm Bowel Dis 10:15-22. 2004
    ....
  33. ncbi request reprint Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease
    Mark S Silverberg
    Department of Medicine, Mount Sinai Hospital IBD Centre, University of Toronto, Toronto, Ontario, Canada
    Eur J Hum Genet 15:328-35. 2007
    ....
  34. ncbi request reprint Smoking and inflammatory bowel disease: trends in familial and sporadic cohorts
    Jeffrey A Tuvlin
    Midwest Gastroenterology Associates, Louisville, Kentucky, USA
    Inflamm Bowel Dis 13:573-9. 2007
    ..Never smoking and formerly smoking increase the risk of UC, whereas smoking exacerbates the course of CD. We sought to define the age-dependent effects of smoking on the development of UC and CD in familial and sporadic cohorts...
  35. ncbi request reprint Assessment of reliability and validity of IBD phenotyping within the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) IBD Genetics Consortium (IBDGC)
    Themistocles Dassopoulos
    Johns Hopkins University Meyerhoff Inflammatory Bowel Disease Center, Baltimore MD, USA
    Inflamm Bowel Dis 13:975-83. 2007
    ..Our aim was to determine the reliability and validity of these phenotypic assessments...
  36. ncbi request reprint Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis
    Amir S Karban
    Johns Hopkins University School of Medicine, 1503 E Jefferson Street, Room B136, Baltimore, MD 21231, USA
    Hum Mol Genet 13:35-45. 2004
    ..Therefore, we have identified the first potentially functional polymorphism of NFKB1 and demonstrated its genetic association with a common human disease, ulcerative colitis...
  37. ncbi request reprint Evidence for an inflammatory bowel disease locus on chromosome 3p26: linkage, transmission/disequilibrium and partitioning of linkage
    Richard H Duerr
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
    Hum Mol Genet 11:2599-606. 2002
    ..12). Thus, the existence of an inflammatory bowel disease locus on chromosome 3p26 is supported by significant linkage, transmission/disequilibrium and partitioning of linkage evidence...
  38. pmc Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy
    Jing Wang
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 113:826-35. 2004
    ..These observations indicate the critical contributions of dysregulated LIGHT expression and intestinal inflammation to the pathogenesis of IgAN...

Research Grants11

  1. IBD Genetics Consortium Data Coordinating Center
    JUDY CHO; Fiscal Year: 2007
    ....
  2. Yale University IBD Genetics Research Center
    JUDY CHO; Fiscal Year: 2007
    ..Well-powered gene-gene interactions along the Nod2 and IL23R pathways will be examined based on biologic and genetic models. ..
  3. Mapping Chromosome 3q Inflammatory Bowel Disease Genes
    JUDY CHO; Fiscal Year: 2006
    ..Genotyping of all putative functional SNPs in the region will be performed in Jewish and non-Jewish CD and UC to comprehensively define the nature of IBD association contributed by functional variants in this region. ..
  4. IDENTIFYING MAJOR SUSCEPTIBILITY GENES OF IBD
    JUDY CHO; Fiscal Year: 2003
    ..Once risk alleles are identified in multiplex families, characterization of the nature and broad significance of specific risk alleles for IBD in a variety of populations will be performed. ..