Thomas O Carpenter

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors
    Thomas O Carpenter
    Endocrine Sections of the Department of Pediatrics, Yale University School of Medicine, P O Box 208064, New Haven, Connecticut 06520 8064, USA
    J Clin Endocrinol Metab 90:1012-20. 2005
  2. pmc Vitamin D binding protein is a key determinant of 25-hydroxyvitamin D levels in infants and toddlers
    Thomas O Carpenter
    Department of Pediatrics Endocrinology, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    J Bone Miner Res 28:213-21. 2013
  3. pmc Demographic, dietary, and biochemical determinants of vitamin D status in inner-city children
    Thomas O Carpenter
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Am J Clin Nutr 95:137-46. 2012
  4. pmc A clinician's guide to X-linked hypophosphatemia
    Thomas O Carpenter
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    J Bone Miner Res 26:1381-8. 2011
  5. pmc Circulating levels of soluble klotho and FGF23 in X-linked hypophosphatemia: circadian variance, effects of treatment, and relationship to parathyroid status
    Thomas O Carpenter
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    J Clin Endocrinol Metab 95:E352-7. 2010
  6. ncbi request reprint The expanding family of hypophosphatemic syndromes
    Thomas O Carpenter
    Department of Pediatrics Endocrinology, Yale University School of Medicine, 333 Cedar Street, PO Box 208064, New Haven, CT 06520 8064, USA
    J Bone Miner Metab 30:1-9. 2012
  7. pmc A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls
    Thomas O Carpenter
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    J Clin Endocrinol Metab 91:4866-72. 2006
  8. ncbi request reprint Evaluation of bone and mineral disorders
    Laleh Ardeshirpour
    Department of Pediatrics Endocrinology, Yale University School of Medicine, New Haven, CT, USA
    Pediatr Endocrinol Rev 5:584-98. 2007
  9. pmc Increased bone volume and correction of HYP mouse hypophosphatemia in the Klotho/HYP mouse
    Catherine A Brownstein
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, SHM I 308, New Haven, Connecticut 06510, USA
    Endocrinology 151:492-501. 2010
  10. doi request reprint Hypercalcemia in children receiving pharmacologic doses of vitamin D
    Michelle B Vanstone
    Department of Pediatrics Endocrinology, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Pediatrics 129:e1060-3. 2012

Research Grants

  1. DISORDERS OF MINERAL METABOLISM IN CHILDREN
    Thomas Carpenter; Fiscal Year: 2003

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors
    Thomas O Carpenter
    Endocrine Sections of the Department of Pediatrics, Yale University School of Medicine, P O Box 208064, New Haven, Connecticut 06520 8064, USA
    J Clin Endocrinol Metab 90:1012-20. 2005
    ..Finally, FGF7 message was confirmed in PCR products of mRNA extracted from fragments of each tumor. Members of the FGF family (other than FGF23) are expressed by OO-associated tumors and may play a role in mediating this syndrome...
  2. pmc Vitamin D binding protein is a key determinant of 25-hydroxyvitamin D levels in infants and toddlers
    Thomas O Carpenter
    Department of Pediatrics Endocrinology, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    J Bone Miner Res 28:213-21. 2013
    ..These findings provide data that may be important in the interpretation of vitamin D status in children of varying ancestral backgrounds...
  3. pmc Demographic, dietary, and biochemical determinants of vitamin D status in inner-city children
    Thomas O Carpenter
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Am J Clin Nutr 95:137-46. 2012
    ..Reports of clinical rickets are particularly evident in minority infants and children, but only limited analyses of vitamin D are available in this demographic group...
  4. pmc A clinician's guide to X-linked hypophosphatemia
    Thomas O Carpenter
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    J Bone Miner Res 26:1381-8. 2011
    ..We briefly review the clinical and pathophysiologic features of the disorder and offer this guide in response to the conference recommendation, based on our collective accumulated experience in the management of this complex disorder...
  5. pmc Circulating levels of soluble klotho and FGF23 in X-linked hypophosphatemia: circadian variance, effects of treatment, and relationship to parathyroid status
    Thomas O Carpenter
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    J Clin Endocrinol Metab 95:E352-7. 2010
    ....
  6. ncbi request reprint The expanding family of hypophosphatemic syndromes
    Thomas O Carpenter
    Department of Pediatrics Endocrinology, Yale University School of Medicine, 333 Cedar Street, PO Box 208064, New Haven, CT 06520 8064, USA
    J Bone Miner Metab 30:1-9. 2012
    ..Secretion of excess FGF23 (as in tumor-induced osteomalacia), and mutations preventing proteolytic cleavage of FGF23 result in similar clinical features. Other hypophosphatemic disorders are discussed...
  7. pmc A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls
    Thomas O Carpenter
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    J Clin Endocrinol Metab 91:4866-72. 2006
    ..Limited studies suggest that dietary Mg intake and bone mineral density are correlated in adults, but no data from interventional studies in children and adolescents are available...
  8. ncbi request reprint Evaluation of bone and mineral disorders
    Laleh Ardeshirpour
    Department of Pediatrics Endocrinology, Yale University School of Medicine, New Haven, CT, USA
    Pediatr Endocrinol Rev 5:584-98. 2007
    ..Thus, our mission is to discuss the strengths and shortcomings of these diagnostic modalities and to provide a concise review of nuances involved in interpretation of data when using these techniques...
  9. pmc Increased bone volume and correction of HYP mouse hypophosphatemia in the Klotho/HYP mouse
    Catherine A Brownstein
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, SHM I 308, New Haven, Connecticut 06510, USA
    Endocrinology 151:492-501. 2010
    ....
  10. doi request reprint Hypercalcemia in children receiving pharmacologic doses of vitamin D
    Michelle B Vanstone
    Department of Pediatrics Endocrinology, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Pediatrics 129:e1060-3. 2012
    ..Dosage recommendations may need to be reassessed, in particular, where follow-up and monitoring may be compromised...
  11. pmc Effect of vitamin D-binding protein genotype on the development of asthma in children
    Aledie Navas-Nazario
    Section of Respiratory Medicine, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut
    Ann Allergy Asthma Immunol 112:519-24. 2014
    ..Single nucleotide polymorphisms in the GC gene encoding vitamin D-binding protein are associated with circulating vitamin D metabolite levels in healthy infants and toddlers...
  12. pmc A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism
    Catherine A Brownstein
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 105:3455-60. 2008
    ....
  13. pmc Effects of ethnicity and vitamin D supplementation on vitamin D status and changes in bone mineral content in infants
    Steven A Abrams
    Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Houston, Texas 77030, USA
    BMC Pediatr 12:6. 2012
    ..To evaluate the effects on serum 25(OH)D and bone mineralization of supplementation of breast-fed Hispanic and non-Hispanic Caucasian infants with vitamin D in infants in Houston, Texas...
  14. pmc Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content
    Arijeet K Gattu
    1Section of Digestive Diseases, Department of Medicine, Yale University School of Medicine, 1080 LMP, New Haven, CT, USA
    FASEB J 27:4384-94. 2013
    ..Bones from KO mice demonstrated a reduction in mineral content recapitulating the OI type VI phenotype. These results demonstrate that the human diseases associated with PEDF reflect its ability to modulate MSC differentiation...
  15. doi request reprint Rapid correction of bone mass after parathyroidectomy in an adolescent with primary hyperparathyroidism
    Michelle B Vanstone
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    J Clin Endocrinol Metab 96:E347-50. 2011
    ..Primary hyperparathyroidism is rare in children. Absence of specific symptoms and limited biochemical evaluation in children has led to lengthy delays in diagnosis with the potential for damage to the kidneys and skeleton...
  16. ncbi request reprint Nutritional rickets with normal circulating 25-hydroxyvitamin D: a call for reexamining the role of dietary calcium intake in North American infants
    Maria C DeLucia
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    J Clin Endocrinol Metab 88:3539-45. 2003
    ....
  17. pmc Survey of the enthesopathy of X-linked hypophosphatemia and its characterization in Hyp mice
    Guoying Liang
    Department of Internal Medicine Endocrinology, Yale University, P O Box 208020, New Haven, CT 06520 8020, USA
    Calcif Tissue Int 85:235-46. 2009
    ....
  18. ncbi request reprint Multisystem study of 20 older adults with Williams syndrome
    Elizabeth M Cherniske
    Child Study Center, Yale School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet A 131:255-64. 2004
    ..We provide monitoring guidelines to assist in the comprehensive care of adults with WS...
  19. ncbi request reprint Bone health in children and adolescents: a symposium at the annual meeting of the Pediatric Academic Societies/Lawson Wilkins Pediatric Endocrine Society, May 2003
    Catherine M Gordon
    Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Curr Probl Pediatr Adolesc Health Care 34:226-42. 2004
  20. ncbi request reprint Dual energy X-ray absorptiometry interpretation and reporting in children and adolescents: the 2007 ISCD Pediatric Official Positions
    Catherine M Gordon
    Division of Endocrinology, Children s Hospital Boston, Boston, MA 02115, USA
    J Clin Densitom 11:43-58. 2008
    ..The rationale and evidence for development of the Official Positions are provided. Given the sparse data currently available in many of these areas, it is likely that these positions will change over time as new data become available...
  21. ncbi request reprint The state of pediatric bone: summary of the ASBMR pediatric bone initiative
    Gordon L Klein
    University of Texas Medical Branch, Galveston, USA
    J Bone Miner Res 20:2075-81. 2005
  22. pmc Relationships among vitamin D levels, parathyroid hormone, and calcium absorption in young adolescents
    Steven A Abrams
    United States Department of Agriculture Agricultural Research Service, Children s Nutrition Research Center, 1100 Bates Street, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 90:5576-81. 2005
    ..Evidence suggests that vitamin D status in adults, as assessed by serum 25-hydroxyvitamin D (25-OHD), is positively associated with calcium absorption fraction and inversely associated with serum PTH. Few comparable pediatric data exist...
  23. ncbi request reprint Oncogenic osteomalacia--a complex dance of factors
    Thomas O Carpenter
    N Engl J Med 348:1705-8. 2003

Research Grants5

  1. DISORDERS OF MINERAL METABOLISM IN CHILDREN
    Thomas Carpenter; Fiscal Year: 2003
    ..Furthermore, the long-standing collaborations with the Departments of Internal Medicine and Orthopaedics provide for a rich intellectual environment, and critical mass of interest. ..