Margaret S Bynoe
Affiliation: Yale University
- Epicutaneous immunization with autoantigenic peptides induces T suppressor cells that prevent experimental allergic encephalomyelitisMargaret S Bynoe
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Immunity 19:317-28. 2003..There was no CD4 T cell infiltration in the brain of protected mice. Finally, ECi with autoantigenic peptides protected two nontransgenic models from relapsing-remitting EAE in an antigen-specific and antigen dose-dependent manner...
- T cells from epicutaneously immunized mice are prone to T cell receptor revisionMargaret S Bynoe
Section of Immunobiology, Howard Hughes Medical Institute and Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 102:2898-903. 2005..The emergence of these cells did not depend on the thymic compartment. We conclude that in mice epicutaneously immunized with an autoantigen, peripheral specific T cells are susceptible to multiple mechanisms of tolerance...
- Antigen-induced suppressor T cells from the skin point of view: suppressor T cells induced through epicutaneous immunizationMargaret S Bynoe
Section of Immunobiology, Yale University School of Medicine, and Howard Hughes Medical Institute, 300 Cedar St, New Haven, CT 06520 8011, USA
J Neuroimmunol 167:4-12. 2005..We discuss the skin environment as a privileged anatomical site for therapeutic intervention against pro-inflammatory auto-immune disorders using non-invasive approaches for antigen delivery...
- Semaphorin 7A is a negative regulator of T cell responsesAgnieszka K Czopik
Section of Immunobiology, Yale University, New Haven, Connecticut 06520, USA
Immunity 24:591-600. 2006..These results demonstrate an important role of Sema7A in limiting autoimmune responses and add to growing evidence of shared signaling pathways used by the immune and nervous systems...
- Control of experimental autoimmune encephalomyelitis by CD4+ suppressor T cells: peripheral versus in situ immunoregulationMargaret S Bynoe
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14850, USA
J Neuroimmunol 191:61-9. 2007..Finally, we give an overview of genes recently discovered to be important in regulation of the immune system that may also prove to be key players in the modulation of EAE and MS...
- Foxp3+CD4+ T cell-mediated immunosuppression involves extracellular nucleotide catabolismMargaret S Bynoe
College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Trends Immunol 29:99-102. 2008..Novel studies now establish that, through the generation of the immunosuppressive factor adenosine, the ectoenzymes CD39 and CD73 are important contributors to the regulatory activity of Foxp3(+)CD4(+) T cells...
- CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitisJeffrey H Mills
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Proc Natl Acad Sci U S A 105:9325-30. 2008....