Irina A Buhimschi

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Advances in medical diagnosis of intra-amniotic infection
    Irina A Buhimschi
    Yale University, Department of Obstetrics, Gynecology and Reprod Science, New Haven, CT 06520, USA
    Expert Opin Med Diagn 7:5-16. 2013
  2. pmc Long-term progestin contraceptives (LTPOC) induce aberrant angiogenesis, oxidative stress and apoptosis in the guinea pig uterus: A model for abnormal uterine bleeding in humans
    Graciela Krikun
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, 06510, USA
    J Angiogenes Res 2:8. 2010
  3. pmc Proteomics/diagnosis of chorioamnionitis and of relationships with the fetal exposome
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA
    Semin Fetal Neonatal Med 17:36-45. 2012
  4. ncbi request reprint The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Obstet Gynecol 196:181.e1-13. 2007
  5. pmc Proteomics of the amniotic fluid in assessment of the placenta. Relevance for preterm birth
    I A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA
    Placenta 29:S95-101. 2008
  6. doi request reprint Using proteomic analysis of the human amniotic fluid to identify histologic chorioamnionitis
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Obstet Gynecol 111:403-12. 2008
  7. pmc Multidimensional proteomics analysis of amniotic fluid to provide insight into the mechanisms of idiopathic preterm birth
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 3:e2049. 2008
  8. pmc Proteomic profiling of urine identifies specific fragments of SERPINA1 and albumin as biomarkers of preeclampsia
    Irina A Buhimschi
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 199:551.e1-16. 2008
  9. pmc The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA
    Clin Perinatol 37:355-74. 2010
  10. pmc Using SELDI-TOF mass spectrometry on amniotic fluid and for clinical proteomics and theranostics in disorders of pregnancy
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Biol 818:171-97. 2012

Collaborators

Detail Information

Publications74

  1. pmc Advances in medical diagnosis of intra-amniotic infection
    Irina A Buhimschi
    Yale University, Department of Obstetrics, Gynecology and Reprod Science, New Haven, CT 06520, USA
    Expert Opin Med Diagn 7:5-16. 2013
    ..Prompt and accurate diagnosis of intra-amniotic infection in the asymptomatic stage of the disease is critical for improved maternal and neonatal outcomes...
  2. pmc Long-term progestin contraceptives (LTPOC) induce aberrant angiogenesis, oxidative stress and apoptosis in the guinea pig uterus: A model for abnormal uterine bleeding in humans
    Graciela Krikun
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, 06510, USA
    J Angiogenes Res 2:8. 2010
    ..However, obtaining sufficient, good quality tissues have precluded elucidation of the mechanisms underlying these morphological and functional vascular changes...
  3. pmc Proteomics/diagnosis of chorioamnionitis and of relationships with the fetal exposome
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA
    Semin Fetal Neonatal Med 17:36-45. 2012
    ..This review summarizes the results of proteomics studies that have aimed or reached these goals...
  4. ncbi request reprint The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Obstet Gynecol 196:181.e1-13. 2007
    ..sRAGE, a competitive soluble RAGE receptor, inhibits RAGE ligands. Here we aimed to investigate the presence and changes in components of the RAGE system in women with intra-amniotic infection and inflammation...
  5. pmc Proteomics of the amniotic fluid in assessment of the placenta. Relevance for preterm birth
    I A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA
    Placenta 29:S95-101. 2008
    ....
  6. doi request reprint Using proteomic analysis of the human amniotic fluid to identify histologic chorioamnionitis
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Obstet Gynecol 111:403-12. 2008
    ..To estimate the relationship between histologic chorioamnionitis and four amniotic fluid proteomic biomarkers characteristic of inflammation (defensins 2 and 1, calgranulins C and A)...
  7. pmc Multidimensional proteomics analysis of amniotic fluid to provide insight into the mechanisms of idiopathic preterm birth
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 3:e2049. 2008
    ..We conducted a multidimensional proteomic analysis of the amniotic fluid to identify pathways related to preterm birth in the absence of inflammation or bleeding...
  8. pmc Proteomic profiling of urine identifies specific fragments of SERPINA1 and albumin as biomarkers of preeclampsia
    Irina A Buhimschi
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 199:551.e1-16. 2008
    ..The cause of preeclampsia remains unknown and the diagnosis can be uncertain. We used proteomic-based analysis of urine to improve disease classification and extend the pathophysiologic understanding of preeclampsia...
  9. pmc The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA
    Clin Perinatol 37:355-74. 2010
    ..Discovery of clinically and biologically relevant biomarkers able to reveal key pathogenic pathways and predict pregnancies at risk for antenatal fetal damage is a priority. Proteomics provides a unique opportunity to fill this gap...
  10. pmc Using SELDI-TOF mass spectrometry on amniotic fluid and for clinical proteomics and theranostics in disorders of pregnancy
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Biol 818:171-97. 2012
    ..Many of the principles described herein for amniotic fluid could be generalized to studies involving other types of biological samples and other clinical questions...
  11. pmc Proteomic but not enzyme-linked immunosorbent assay technology detects amniotic fluid monomeric calgranulins from their complexed calprotectin form
    Irina A Buhimschi
    Department of Obstetrics, Gynecology, and Reproductive Science, Yale University School of Medicine, 333 Cedar Street LCI 804, P O Box 208063, New Haven, CT 06520 8063, USA
    Clin Diagn Lab Immunol 12:837-44. 2005
    ..Monomeric Cal-A is not reliably estimated by specific ELISA as it binds to Cal-B to form the calprotectin complex. Cal-C was reliably measured by SELDI-TOF mass spectrometry or specific ELISA...
  12. ncbi request reprint Physical and biomechanical characteristics of rat cervical ripening are not consistent with increased collagenase activity
    Irina A Buhimschi
    Department of Obstetrics, Gynecology, and Reproductive Science, Yale University School of Medicine, New Haven, Conn, USA
    Am J Obstet Gynecol 191:1695-704. 2004
    ....
  13. pmc Proteomic profiling of the amniotic fluid to detect inflammation, infection, and neonatal sepsis
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Med 4:e18. 2007
    ..Proteomic analysis of amniotic fluid shows the presence of biomarkers characteristic of intrauterine inflammation. We sought to validate prospectively the clinical utility of one such proteomic profile, the Mass Restricted (MR) score...
  14. pmc Activation of the receptor for advanced glycation end products system in women with severe preeclampsia
    Emily A Oliver
    Yale University School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, 333 Cedar Street, LLCI 804, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 96:689-98. 2011
    ..Soluble forms of RAGE [soluble RAGE (sRAGE), endogenous secretory (esRAGE)] bind RAGE ligands, thereby preventing downstream signaling and damage...
  15. pmc Amniotic fluid angiopoietin-1, angiopoietin-2, and soluble receptor tunica interna endothelial cell kinase-2 levels and regulation in normal pregnancy and intraamniotic inflammation-induced preterm birth
    Catalin S Buhimschi
    Yale University School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA
    J Clin Endocrinol Metab 95:3428-36. 2010
    ..Ang-2/Ang-1 ratio may play a role in modulating the fetal inflammatory response to IAI. Placental sTie2 shedding likely involves a Golgi-mediated mechanism...
  16. pmc Fetal heart rate monitoring patterns in women with amniotic fluid proteomic profiles indicative of inflammation
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Perinatol 25:359-72. 2008
    ..An abnormal FHR-MP can thus raise the level of awareness that a fetus with EONS may be born, but it is not a useful clinical indicator of the need for antibiotic treatment of the neonate...
  17. doi request reprint Fetal adrenal gland volume and cortisol/dehydroepiandrosterone sulfate ratio in inflammation-associated preterm birth
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Obstet Gynecol 111:715-22. 2008
    ..We sought to estimate the impact of intraamniotic inflammation on fetal adrenal gland volume and cortisol-to-dehydroepiandrosterone sulfate ratio (fetal stress ratio) in pregnancies complicated by preterm birth...
  18. pmc Proteomics mapping of cord blood identifies haptoglobin "switch-on" pattern as biomarker of early-onset neonatal sepsis in preterm newborns
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e26111. 2011
    ..A prompt and accurate diagnosis of EONS is critical for improved neonatal outcomes. We sought to explore the cord blood proteome and identify biomarkers and functional protein networks characterizing EONS in preterm newborns...
  19. pmc Cord blood erythropoietin and interleukin-6 for prediction of intraventricular hemorrhage in the preterm neonate
    Vineet Bhandari
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    J Matern Fetal Neonatal Med 24:673-9. 2011
    ..To evaluate cord blood erythropoietin (EPO) and interleukin-6 (IL-6) levels to predict preterm infants at risk of developing intraventricular hemorrhage (IVH)...
  20. pmc Fetal renal artery impedance as assessed by Doppler ultrasound in pregnancies complicated by intraamniotic inflammation and preterm birth
    Humberto Azpurua
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Obstet Gynecol 200:203.e1-11. 2009
    ..The objective of the study was to evaluate the fetal renal artery impedance in the context of inflammation-associated preterm birth...
  21. doi request reprint Ultrasonographic evaluation of myometrial thickness in twin pregnancies
    Anna K Sfakianaki
    Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Obstet Gynecol 198:530.e1-10. 2008
    ..The objective of the study was to evaluate longitudinally the in vivo changes in myometrial thickness (MT) during gestation in patients carrying twin gestations in relation to pregnancy outcome...
  22. doi request reprint Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis
    Antonette T Dulay
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 198:426.e1-9. 2008
    ..We sought to determine whether fetal inflammation is associated with an elevation in neonatal NRBC count in the setting of inflammation-associated preterm birth...
  23. pmc Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future
    Catalin S Buhimschi
    Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Curr Opin Infect Dis 22:235-43. 2009
    ..Proteomics offers the opportunity for detecting fetuses at risk of sepsis and neurological injury...
  24. doi request reprint Multidimensional system biology: genetic markers and proteomic biomarkers of adverse pregnancy outcome in preterm birth
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Perinatol 25:175-87. 2008
    ..Genomics and proteomics have emerged to provide a better comprehension of the pathophysiological conditions leading to preterm birth, thereby providing a perspective for improving neonatal outcome...
  25. ncbi request reprint A low vaginal "pool" amniotic fluid glucose measurement is a predictive but not a sensitive marker for infection in women with preterm premature rupture of membranes
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology, and Reproductive Science, Yale University, New Haven, CT 06520, USA
    Am J Obstet Gynecol 194:309-16. 2006
    ....
  26. pmc Comparative analysis of 2-D versus 3-D ultrasound estimation of the fetal adrenal gland volume and prediction of preterm birth
    Ozhan M Turan
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Perinatol 29:673-80. 2012
    ..We aim to test the hypothesis that two-dimensional (2-D) fetal adrenal gland volume (AGV) measurements offer similar volume estimates as volume calculations based on 3-D technique...
  27. pmc Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia
    Seth Guller
    Department of Obstetrics Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Lab Invest 88:1057-67. 2008
    ....
  28. ncbi request reprint Value of placental microbial evaluation in diagnosing intra-amniotic infection
    Christian M Pettker
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Obstet Gynecol 109:739-49. 2007
    ..To evaluate the ability of microbiologic and pathologic examination of the placenta to accurately diagnose intraamniotic infection and inflammation...
  29. ncbi request reprint Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Perinatal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Pediatr Res 61:318-24. 2007
    ..To conclude, AF proteomic analysis shows that women with MR scores 3-4 are more likely to have histologic funisitis, and deliver neonates with early-onset sepsis...
  30. pmc IL-6 trans-signaling system in intra-amniotic inflammation, preterm birth, and preterm premature rupture of the membranes
    Sarah Y Lee
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 186:3226-36. 2011
    ..We conclude that IL-6 trans-signaling molecules are physiologic constituents of the AF regulated by gestational age and inflammation. PPROM likely involves functional loss of sgp130...
  31. ncbi request reprint Serum and urine inhibin A but not free activin A are endocrine biomarkers of severe pre-eclampsia
    Benjamin D Hamar
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 195:1636-45. 2006
    ..We sought to evaluate serum and urine levels of inhibin A and free activin A in normal and hypertensive pregnancies...
  32. ncbi request reprint Fractional excretion of angiogenic factors in women with severe preeclampsia
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University, New Haven, Connecticut 06520, USA
    Obstet Gynecol 107:1103-13. 2006
    ..We estimated the fractional excretions of soluble fms-like tyrosine kinase 1 (sFlt-1), vascular endothelial growth factor, and placental growth factor of severely preeclamptic women at the time of disease clinical manifestation...
  33. doi request reprint Ultrasonographic evaluation of myometrial thickness and prediction of a successful external cephalic version
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, CT, USA
    Obstet Gynecol 118:913-20. 2011
    ..To test the hypothesis that myometrial thickness predicts the success of external cephalic version...
  34. ncbi request reprint Biomechanical properties of the lower uterine segment above and below the reflection of the urinary bladder flap
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, New Haven, Connecticut 06520, USA
    Obstet Gynecol 109:691-700. 2007
    ..To test the hypothesis that differences in the matrix arrangement of the lower uterine segment (above and below the reflection of the bladder flap) translate to differences in biomechanical or structural properties of the uterine wall...
  35. doi request reprint Interpretation of amniotic fluid white blood cell count in "bloody tap" amniocenteses in women with symptoms of preterm labor
    Sonya S Abdel-Razeq
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Obstet Gynecol 116:344-54. 2010
    ..To estimate whether blood-contaminated amniotic fluid affects the performance of white blood cell (WBC) count in diagnosing intraamniotic inflammation and infection...
  36. pmc Fractional excretion of tumor necrosis factor-alpha in women with severe preeclampsia
    Michael Cackovic
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Obstet Gynecol 112:93-100. 2008
    ..We sought to estimate the fractional excretion of tumor necrosis factor (TNF)-alpha in relationship to proteinuria in women with severe preeclampsia...
  37. pmc Myometrial wound healing post-Cesarean delivery in the MRL/MpJ mouse model of uterine scarring
    Catalin S Buhimschi
    Director Perinatal Research, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, LLCI 804, New Haven, CT 06520, USA
    Am J Pathol 177:197-207. 2010
    ..Our findings indicate that differences in regenerative ability translate in histological, mitotic, and functional differences in biomechanical properties of the scarred myometrium after CD...
  38. ncbi request reprint Proteomics technology for the accurate diagnosis of inflammation in twin pregnancies
    Irina A Buhimschi
    Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    BJOG 112:250-5. 2005
  39. doi request reprint Soluble TLR2 is present in human amniotic fluid and modulates the intraamniotic inflammatory response to infection
    Antonette T Dulay
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 182:7244-53. 2009
    ..We conclude that sTLR2 is part of the amniotic fluid innate immune system and participates in regulating the inflammatory response to microbial pathogens...
  40. ncbi request reprint Fetal nucleated red blood cells in a rat model of intrauterine growth restriction induced by hypoxia and nitric oxide synthase inhibition
    Viswanathan Ravishankar
    Department of Obstetrics, Gynecology, and Reproductive Medicine, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
    Am J Obstet Gynecol 196:482.e1-8. 2007
    ..We sought to determine the effects of chronic hypoxia, chronic nitric oxide inhibition with N(G)-nitro-L-arginine methyl ester (L-NAME), or both on NRBC counts, erythropoietin levels, and pathologic changes in an animal model of IUGR...
  41. pmc Decreased levels of folate receptor-β and reduced numbers of fetal macrophages (Hofbauer cells) in placentas from pregnancies with severe pre-eclampsia
    Zhonghua Tang
    Department of Obstetrics Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Am J Reprod Immunol 70:104-15. 2013
    ..Previous studies have described placental genes that are up-regulated in expression in PE, but few studies have addressed placental gene suppression in this syndrome...
  42. pmc Modulation of amniotic fluid activin-a and inhibin-a in women with preterm premature rupture of the membranes and infection-induced preterm birth
    Victor A Rosenberg
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Reprod Immunol 67:122-31. 2012
    ..We explored activation of amniotic fluid (AF) activin-A and inhibin-A system in women with intra-amniotic infection and preterm premature rupture of the membranes (PPROM)...
  43. doi request reprint Heparin elevates circulating soluble fms-like tyrosine kinase-1 immunoreactivity in pregnant women receiving anticoagulation therapy
    Victor A Rosenberg
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, 333 Cedar Street, New Haven, CT 06520, USA
    Circulation 124:2543-53. 2011
    ..Alterations in circulating levels of pro- and antiangiogenic factors have been associated with adverse pregnancy outcomes. Heparin is routinely administered to pregnant women, but without clear knowledge of its impact on these factors...
  44. doi request reprint Ultrasound measurement of fetal adrenal gland enlargement: an accurate predictor of preterm birth
    Ozhan M Turan
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Obstet Gynecol 204:311.e1-10. 2011
    ..The objective of the study was to test whether ultrasound-measured fetal adrenal gland volume (AGV) and fetal zone enlargement (FZE) predicts preterm birth (PTB) better than cervical length (CL)...
  45. pmc Characterization of RAGE, HMGB1, and S100beta in inflammation-induced preterm birth and fetal tissue injury
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, 333 Cedar Street, New Haven, CT 06520, USA
    Am J Pathol 175:958-75. 2009
    ..Our findings indicate that RAGE and HMGB1 may be important mediators of cellular injury in fetuses delivered in the setting of inflammation-induced preterm birth...
  46. doi request reprint Relationships of maternal serum levels of vascular endothelial growth factor and tensile strength properties of the cervix in a rat model of chronic hypoxia
    Anna K Sfakianaki
    Department of Obstetrics, Gynecology, and Reproductive Science, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Obstet Gynecol 198:223.e1-7. 2008
    ..In this study, we sought to test the hypothesis that chronic hypoxia increases maternal serum levels of VEGF, which in turn cause measurable changes in the viscoelastic properties of the rat uterine cervix...
  47. ncbi request reprint Intrauterine pressure during the second stage of labor in obese women
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Obstet Gynecol 103:225-30. 2004
    ..We tested the hypothesis that obese women generate inadequate intrauterine pressure during the second stage of labor...
  48. ncbi request reprint Ultrasound evaluation of the uterine scar after cesarean delivery: a randomized controlled trial of one- and two-layer closure
    Benjamin D Hamar
    Yale School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Biology, New Haven, Connecticut, USA
    Obstet Gynecol 110:808-13. 2007
    ..To survey the uterine scar thickness by ultrasonography in women randomly assigned to one- or two-layer hysterotomy closure after primary cesarean delivery...
  49. ncbi request reprint The effect of fundal pressure manoeuvre on intrauterine pressure in the second stage of labour
    Catalin S Buhimschi
    Department of Obstetrics, Gynaecology and Reproductive Sciences, The University of Maryland School of Medicine, Baltimore, USA
    BJOG 109:520-6. 2002
    ..To investigate the relationship between intrauterine pressure and the application of a standardised fundal pressure manoeuvre, and to determine the maternal, fetal and labour characteristics that modulate the relationship...
  50. ncbi request reprint Proteomics, part II: the emerging role of proteomics over genomics in spontaneous preterm labor/birth
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Obstet Gynecol Surv 61:543-53. 2006
    ..Thus, it provides the ability to identify patients who may benefit from interventions in utero in a modern diagnostic-therapeutic framework...
  51. pmc Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast
    Mark J Wehrum
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Am J Obstet Gynecol 204:411.e1-411.e11. 2011
    ....
  52. ncbi request reprint Advantages of vaginal delivery
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Clin Obstet Gynecol 49:167-83. 2006
  53. ncbi request reprint Progestin inhibits and thrombin stimulates the plasminogen activator/inhibitor system in term decidual stromal cells: implications for parturition
    Errol R Norwitz
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 196:382.e1-8. 2007
    ..This study investigates the separate and interactive effects of steroid hormones and thrombin on PAI-1, uPA, and tPA expression by term decidual cells (DCs)...
  54. ncbi request reprint Proteomic biomarker analysis of amniotic fluid for identification of intra-amniotic inflammation
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, Connecticut 06520 8063, USA
    BJOG 112:173-81. 2005
    ..We applied proteomic technology (SELDI: surface-enhanced laser desorption ionisation) to identify the proteomic profile of intra-amniotic inflammation...
  55. ncbi request reprint Sonographic myometrial thickness predicts the latency interval of women with preterm premature rupture of the membranes and oligohydramnios
    Catalin S Buhimschi
    Yale University, New Haven, CT, USA
    Am J Obstet Gynecol 193:762-70. 2005
    ..We hypothesized that a thickened myometrium at the time of preterm premature rupture of membranes (PPROM) predicts less myometrial wall stress and, consequently, a longer latency interval...
  56. ncbi request reprint Uterine contractility in women whose fetus is delivered in the occipitoposterior position
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Wayne State University, Detroit, Mich 48201, USA
    Am J Obstet Gynecol 188:734-9. 2003
    ..We sought to test the hypothesis that women with a persistent occipitoposterior fetal position have inadequate intrauterine pressure...
  57. ncbi request reprint Proteomic biomarkers that predict the clinical success of rescue cerclage
    Carl P Weiner
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD 21201 1559, USA
    Am J Obstet Gynecol 192:710-8. 2005
    ..We tested amniotic fluid from women who were preparing to undergo rescue cerclage for proteomic biomarkers and correlated their presence with clinical outcome...
  58. ncbi request reprint The effect of dystocia and previous cesarean uterine scar on the tensile properties of the lower uterine segment
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, New Haven, CT 06520, USA
    Am J Obstet Gynecol 194:873-83. 2006
    ..We hypothesized that the stretching of the lower uterine segment in laboring women with dystocia changes the viscoelastic properties of the uterine wall...
  59. ncbi request reprint Myometrial thickness during human labor and immediately post partum
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Wayne State University, Detroit, MI 48201, USA
    Am J Obstet Gynecol 188:553-9. 2003
    ..This growth is most marked at the fundus. Our objective was to evaluate sonographically the in vivo changes in myometrial thickness during active labor, second-stage labor, and after delivery...
  60. ncbi request reprint Fetal adrenal gland volume: a novel method to identify women at risk for impending preterm birth
    Ozhan M Turan
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Obstet Gynecol 109:855-62. 2007
    ....
  61. ncbi request reprint Proteomics: a novel methodology to complement prenatal diagnosis of chromosomal abnormalities and inherited human diseases
    Mert Ozan Bahtiyar
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Am J Perinatol 24:167-81. 2007
    ..This article summarizes current technology and reviews the application of proteomics in diagnosis of genetic disorders during human pregnancy...
  62. ncbi request reprint Lactate dehydrogenase isoform activity mapping in patients with intra-amniotic infection
    Lissa K Magloire
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, New Haven, CT 06520, USA
    Am J Obstet Gynecol 195:1045-52. 2006
    ..Five distinct lactate dehydrogenase isoenzymes have been described. We sought to illustrate the specific amniotic fluid lactate dehydrogenase isoenzyme activity profiles in women with intra-amniotic infection...
  63. ncbi request reprint Beneficial impact of term labor: nonenzymatic antioxidant reserve in the human fetus
    Irina A Buhimschi
    Departments of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Obstet Gynecol 189:181-8. 2003
    ..We tested aspects of this hypothesis by investigating whether the presence of labor or gestational age at delivery (term vs preterm) alters the maternal/fetal nonenzymatic antioxidant reserve peripartum...
  64. ncbi request reprint Discriminatory proteomic biomarker analysis identifies free hemoglobin in the cerebrospinal fluid of women with severe preeclampsia
    Errol R Norwitz
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Am J Obstet Gynecol 193:957-64. 2005
    ..Preeclampsia is an idiopathic multisystem disorder specific to human pregnancy. This study used proteomic analysis of cerebrospinal fluid (CSF) to identify protein biomarkers characteristic of preeclampsia and related to its severity...
  65. ncbi request reprint Pushing in labor: performance and not endurance
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, The University of Maryland School of Medicine, Baltimore, USA
    Am J Obstet Gynecol 186:1339-44. 2002
    ....
  66. doi request reprint Genetic background affects the biomechanical behavior of the postpartum mouse cervix
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology, and Reproductive Science, Yale University School of Medicine, New Haven, CT, USA
    Am J Obstet Gynecol 200:434.e1-7. 2009
    ....
  67. ncbi request reprint Effects of sublingual nitroglycerin on human uterine contractility during the active phase of labor
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, USA
    Am J Obstet Gynecol 187:235-8. 2002
    ..If a clinical option, sublingual nitroglycerin will require a higher dose, which would place mother and fetus at risk for complication...
  68. ncbi request reprint Clinical proteomics: a novel diagnostic tool for the new biology of preterm labor, part I: proteomics tools
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Obstet Gynecol Surv 61:481-6. 2006
    ..Interest in mass spectrometry and its use as a new clinical diagnostic tool has grown rapidly and is poised to become an important medical field for the next century...
  69. ncbi request reprint Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University, New Haven, CT 06520, USA
    Am J Obstet Gynecol 192:734-41. 2005
    ..We sought to identify whether similar alterations in urinary levels of these proteins cluster hypertensive disorders in pregnancy, and identify women with severe preeclampsia (sPE)...
  70. ncbi request reprint Protective effect of N-acetylcysteine against fetal death and preterm labor induced by maternal inflammation
    Irina A Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Obstet Gynecol 188:203-8. 2003
    ..We tested aspects of this hypothesis in an animal model of preterm labor and fetal damage (death)...
  71. ncbi request reprint Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction
    Mert Ozan Bahtiyar
    Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 196:72.e1-6. 2007
    ..We tested our hypothesis in a rodent model of intrauterine growth restriction induced by chronic hypoxia and NO inhibition with N(G)-nitro-L-arginine methyl ester (L-NAME)...
  72. doi request reprint Novel insights into molecular mechanisms of abruption-induced preterm birth
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Expert Rev Mol Med 12:e35. 2010
    ..Here, we provide novel insights into the molecular mechanisms and pathways leading to PTB in the setting of placental abruption...
  73. ncbi request reprint The presence and function of phosphodiesterase type 5 in the rat myometrium
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, New Haven, CT 06520, USA
    Am J Obstet Gynecol 190:268-74. 2004
    ..The type 5 isoform (PDE-5, cGMP specific) is the target of specific antagonists (ie, sildenafil, Viagra). We tested the hypothesis that PDE-5 is present in rat myometrium and modulates myometrial activity...
  74. ncbi request reprint Alterations in syncytiotrophoblast cytokine expression following treatment with lipopolysaccharide
    Yuehong Ma
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Reprod Immunol 55:12-8. 2006
    ..Responsiveness of this cell type to inflammatory compounds remains largely unelucidated...