N N Boutros

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Electrophysiological assessment of neuropsychiatric disorders
    Nashaat N Boutros
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, CT, USA
    Semin Clin Neuropsychiatry 7:30-41. 2002
  2. ncbi request reprint Sensory gating deficits during the mid-latency phase of information processing in medicated schizophrenia patients
    Nashaat N Boutros
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Psychiatry Res 126:203-15. 2004
  3. ncbi request reprint Electrophysiological aberrations in borderline personality disorder: state of the evidence
    Nashaat N Boutros
    Department of Psychiatry at Yale University School of Medicine, New Haven, USA
    J Neuropsychiatry Clin Neurosci 15:145-54. 2003
  4. ncbi request reprint Morphological and latency abnormalities of the mid-latency auditory evoked responses in schizophrenia: a preliminary report
    Nashaat N Boutros
    Yale University School of Medicine and VA Connecticut Healthcare System, 950 Campbell Ave 116A, West Haven, CT, USA
    Schizophr Res 70:303-13. 2004
  5. ncbi request reprint Lack of a therapeutic effect of a 2-week sub-threshold transcranial magnetic stimulation course for treatment-resistant depression
    Nashaat N Boutros
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Psychiatry Res 113:245-54. 2002
  6. ncbi request reprint Auditory evoked responses in a comparison between schizophrenia patients with and without premorbid history of drug abuse: report of pilot results
    Nash N Boutros
    Psychiatry, Yale University School of Medicine, West Haven, Connecticut 06516, USA
    Clin EEG Neurosci 35:193-7. 2004
  7. ncbi request reprint Cortical excitability in cocaine-dependent patients: a replication and extension of TMS findings
    Nashaat N Boutros
    Department of Psychiatry, c o VA Connecticut Healthcare System, Yale University School of Medicine, 950 Campbell Avenue, 116A West Haven, CT 06516, USA
    J Psychiatr Res 39:295-302. 2005
  8. ncbi request reprint Normative data for the unquantified EEG: examination of adequacy for neuropsychiatric research
    Nashaat Boutros
    Yale University School of Medicine, Department of Psychiatry, 950 Campbell Ave 116A West Haven, CT 06516, USA
    J Neuropsychiatry Clin Neurosci 17:84-90. 2005
  9. ncbi request reprint EEG monitoring in depressed patients undergoing repetitive transcranial magnetic stimulation
    N N Boutros
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    J Neuropsychiatry Clin Neurosci 13:197-205. 2001
  10. ncbi request reprint Similarities in the disturbances in cortical information processing in alcoholism and aging: a pilot evoked potential study
    N N Boutros
    Yale University School of Medicine, New Haven, Connecticut, USA
    Int Psychogeriatr 12:513-25. 2000

Detail Information

Publications32

  1. ncbi request reprint Electrophysiological assessment of neuropsychiatric disorders
    Nashaat N Boutros
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, CT, USA
    Semin Clin Neuropsychiatry 7:30-41. 2002
    ..Finally, the limitations of the routine EEG are discussed. The article concludes with a brief mention of the future promise of other electrophysiological testing modalities such as quantified EEG, evoked potentials, and sleep studies...
  2. ncbi request reprint Sensory gating deficits during the mid-latency phase of information processing in medicated schizophrenia patients
    Nashaat N Boutros
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Psychiatry Res 126:203-15. 2004
    ..Furthermore, the data suggest that N100 and P200 gating indices may influence subsequent information processing...
  3. ncbi request reprint Electrophysiological aberrations in borderline personality disorder: state of the evidence
    Nashaat N Boutros
    Department of Psychiatry at Yale University School of Medicine, New Haven, USA
    J Neuropsychiatry Clin Neurosci 15:145-54. 2003
    ..We conclude that although the existing literature reflects a preliminary stage of the field, it suggests that electrophysiological investigations may be useful in investigating BPD...
  4. ncbi request reprint Morphological and latency abnormalities of the mid-latency auditory evoked responses in schizophrenia: a preliminary report
    Nashaat N Boutros
    Yale University School of Medicine and VA Connecticut Healthcare System, 950 Campbell Ave 116A, West Haven, CT, USA
    Schizophr Res 70:303-13. 2004
    ..Morphological abnormalities of the mid-latency auditory evoked responses (MLAERs; P50, N100, P200), on the other hand, received very little attention...
  5. ncbi request reprint Lack of a therapeutic effect of a 2-week sub-threshold transcranial magnetic stimulation course for treatment-resistant depression
    Nashaat N Boutros
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Psychiatry Res 113:245-54. 2002
    ..The duration of the therapeutic effects of rTMS delivered to the left prefrontal cortex using the above-described parameters is highly variable...
  6. ncbi request reprint Auditory evoked responses in a comparison between schizophrenia patients with and without premorbid history of drug abuse: report of pilot results
    Nash N Boutros
    Psychiatry, Yale University School of Medicine, West Haven, Connecticut 06516, USA
    Clin EEG Neurosci 35:193-7. 2004
    ..The data suggest that significant clinical and electrophysiological differences between these groups can be identified. Further research to better define these differences seems warranted...
  7. ncbi request reprint Cortical excitability in cocaine-dependent patients: a replication and extension of TMS findings
    Nashaat N Boutros
    Department of Psychiatry, c o VA Connecticut Healthcare System, Yale University School of Medicine, 950 Campbell Avenue, 116A West Haven, CT 06516, USA
    J Psychiatr Res 39:295-302. 2005
    ..These data support our initial finding of decreased cortical excitability in abstinent cocaine-dependent subjects. We interpret this finding as a compensatory mechanism against the stimulating and epileptogenic effects of cocaine...
  8. ncbi request reprint Normative data for the unquantified EEG: examination of adequacy for neuropsychiatric research
    Nashaat Boutros
    Yale University School of Medicine, Department of Psychiatry, 950 Campbell Ave 116A West Haven, CT 06516, USA
    J Neuropsychiatry Clin Neurosci 17:84-90. 2005
    ..The majority of studies met no criteria, one criterion or two criteria. We conclude that the boundaries for normal unquantified EEG are poorly defined...
  9. ncbi request reprint EEG monitoring in depressed patients undergoing repetitive transcranial magnetic stimulation
    N N Boutros
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    J Neuropsychiatry Clin Neurosci 13:197-205. 2001
    ..Two patients with progressive EEG changes in association with sham rTMS in one and active rTMS in the other are also discussed...
  10. ncbi request reprint Similarities in the disturbances in cortical information processing in alcoholism and aging: a pilot evoked potential study
    N N Boutros
    Yale University School of Medicine, New Haven, Connecticut, USA
    Int Psychogeriatr 12:513-25. 2000
    ..To examine the hypothesis that chronic alcohol use causes accelerated aging of the brain...
  11. ncbi request reprint Electroencephalogram and repetitive transcranial magnetic stimulation
    N N Boutros
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Depress Anxiety 12:166-9. 2000
    ..Our data support the practice of using continuous EEG monitoring when the stimulation parameters fall outside established safety guidelines...
  12. ncbi request reprint Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary report
    N N Boutros
    Yale University School of Medicine and VA Connecticut Healthcare System, Department of Psychiatry, West Haven 06516, USA
    Psychiatry Res 88:119-30. 1999
    ..The data also suggest that similar abnormalities can be demonstrated at a slightly later phase of information processing (i.e. early-attentive phase) using the N100 EP...
  13. ncbi request reprint Elevated motor threshold in drug-free, cocaine-dependent patients assessed with transcranial magnetic stimulation
    N N Boutros
    Yale University School of Medicine and VA-Connecticut Healthcare System, West Haven, Connecticut, USA
    Biol Psychiatry 49:369-73. 2001
    ..We hypothesize that this observation reflects adaptation to those effects of cocaine intoxication that promote cortical excitability and seizures...
  14. ncbi request reprint Test-retest reliability of the rat N40 auditory evoked response: preliminary data
    N N Boutros
    Department of Psychiatry, Yale University School of Medicine, Yale University, New Haven, CT, USA
    Psychiatry Res 81:269-76. 1998
    ..47 for the S2/S1 ratio measure. These results suggest that the N40 can be used to study sensory gating, but caution has to be exercised in interpreting the data particularly in a repeated measures design...
  15. ncbi request reprint Effect of tryptophan depletion on alcohol cue-induced craving in abstinent alcoholic patients
    I L Petrakis
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 25:1151-5. 2001
    ..This study evaluated whether attenuation of serotonin synthesis via depletion of its precursor tryptophan reduces the magnitude of cue-induced craving for alcohol in recently abstinent alcoholic individuals...
  16. ncbi request reprint gamma-Aminobutyric acid-serotonin interactions in healthy men: implications for network models of psychosis and dissociation
    DEEPAK CYRIL D'SOUZA
    Schizophrenia Biological Research Center, West Haven Veterans Affairs Medical Center, West Haven, Connecticut, USA
    Biol Psychiatry 59:128-37. 2006
    ....
  17. ncbi request reprint Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism
    Ismene L Petrakis
    West Haven VA Medical Center 116 A, 950 Campbell Ave, West Haven, CT 06516, USA
    Am J Psychiatry 161:1776-82. 2004
    ....
  18. ncbi request reprint Altered NMDA glutamate receptor antagonist response in recovering ethanol-dependent patients
    John H Krystal
    Department of Veterans Affairs Alcohol Research Center, VA Connecticut Healthcare System 116 A, West Haven, CT, USA
    Neuropsychopharmacology 28:2020-8. 2003
    ..The alterations in NMDA receptor function observed in recovering ethanol-dependent patients may have important implications for ethanol tolerance, ethanol dependence, and the treatment of alcoholism...
  19. ncbi request reprint The health-related effects of alcohol use in older persons: a systematic review
    M Carrington Reid
    Clinical Epidemiology Unit, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Subst Abus 23:149-64. 2002
    ..Prospective studies are needed to better define the health-related effects of alcohol use in older populations...
  20. ncbi request reprint The effect of tryptophan depletion on alcohol self-administration in non-treatment-seeking alcoholic individuals
    Ismene L Petrakis
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 26:969-75. 2002
    ....
  21. ncbi request reprint Sensory gating and psychosis vulnerability in cocaine-dependent individuals: preliminary data
    Nashaat N Boutros
    VA Connecticut Healthcare System West Haven Campus, Yale University School of Medicine, 950 Campbell Avenue 116A, West Haven, CT 06516, USA
    Biol Psychiatry 51:683-6. 2002
    ..Deficits in sensory gating and attention, such as those occurring in idiopathic psychosis, might represent experimentally tractable factors contributing to vulnerability to cocaine-induced paranoia...
  22. ncbi request reprint Auditory verbal hallucinations and dysfunction of the neural substrates of speech
    M Stephane
    Department of Psychiatry, Johns Hopkins Medical Institutions, JHOC Research Room # 3245, 601 North Caroline Street, Baltimore, MD 21287, USA
    Schizophr Res 50:61-78. 2001
    ..Direct stimulation or disease of Wernicke's area produces AVH without SVS...
  23. ncbi request reprint Genetic and environmental influences on sensory gating of mid-latency auditory evoked responses: a twin study
    Andrey P Anokhin
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Schizophr Res 89:312-9. 2007
    ..These results suggest that gating measures derived from the N1/P2 wave complex may be useful endophenotypes for population-based genetic studies of the sensory gating function and its impairments in psychopathology...
  24. pmc Generators of the intracranial P50 response in auditory sensory gating
    Oleg Korzyukov
    Department of Psychiatry, Wayne State University, 2751 E Jefferson, Suite 304, Detroit, MI 48207, USA
    Neuroimage 35:814-26. 2007
    ..Present findings suggest that while the temporal lobe is the main generator of the P50 component, the frontal lobe seems to be a substantial contributor to the process of sensory gating as observed from scalp recordings...
  25. ncbi request reprint Short-term habituation of the intracranially recorded auditory evoked potentials P50 and N100
    Timm Rosburg
    Department of Epileptology, University of Bonn, Sigmund Freud Street 25, D 53105 Bonn, Germany
    Neurosci Lett 372:245-9. 2004
    ..Current results indicate that the P50 suppression as investigated in sensory gating experiments seems to be completed after the 2nd stimulus...
  26. ncbi request reprint Contribution of different EEG frequencies to auditory evoked potential abnormalities in schizophrenia
    Ben H Jansen
    Department of Electrical and Computer Engineering, University of Houston, Houston, TX 77204 4005, USA
    Clin Neurophysiol 115:523-33. 2004
    ..In the present study, we investigate whether schizophrenia patients suffer from phase synchronization deficits as compared to normal subjects...
  27. ncbi request reprint Habituation of auditory evoked potentials in intracranial and extracranial recordings
    Timm Rosburg
    Department of Epileptology, University of Bonn, D 53105 Bonn, Germany
    Psychophysiology 43:137-44. 2006
    ..This dissociation between the intracranial and scalp recordings might be explained by a different sensitivity of the two measurements for N100 generators...
  28. ncbi request reprint Risk factors for experiencing psychosis during cocaine use: a preliminary report
    Alicia G Floyd
    School of Medicine and VA Connecticut Healthcare System, Yale University, New York, NY 10032, USA
    J Psychiatr Res 40:178-82. 2006
    ..This study tests the hypothesis that earlier age of initiation of regular use may increase the likelihood of developing CIP, or the severity of CIP symptoms...
  29. ncbi request reprint Subdural recordings of the mismatch negativity (MMN) in patients with focal epilepsy
    Timm Rosburg
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Brain 128:819-28. 2005
    ..Current findings have, however, to be interpreted with caution owing to the placement and limited extension of the used electrode arrays...
  30. ncbi request reprint Phase synchronization of the ongoing EEG and auditory EP generation
    Ben H Jansen
    Department of Electrical and Computer Engineering, University of Houston, Houston, TX, USA
    Clin Neurophysiol 114:79-85. 2003
    ..We investigated the role of phase synchronization of the spontaneous electroencephalogram (EEG) in auditory evoked potential (EP) generation in a sample of healthy individuals...
  31. ncbi request reprint Neuronal substrates of sensory gating within the human brain
    Thomas Grunwald
    Department of Epileptology, University of Bonn, Germany
    Biol Psychiatry 53:511-9. 2003
    ..To identify its neural correlates, we recorded electrical traces of sensory gating directly from the human hippocampus and neocortex...
  32. ncbi request reprint Target probability affects the likelihood that a P300 will be generated in response to a target stimulus, but not its amplitude
    Bharat Bonala
    Department of Electrical and Computer Engineering, University of Houston, Houston, Texas 77204 4005, USA
    Psychophysiology 45:93-9. 2008
    ..This suggests that local target probability affects the consistency with which a subject responds to target stimuli, but not the P300 amplitude...