W F Boron

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Sodium-coupled bicarbonate transporters
    W F Boron
    Department of Cell and Molecular Physiology, Yale University School of Medicine New Haven, CT 06520 8026, USA
    JOP 2:176-81. 2001
  2. ncbi request reprint Regulation of intracellular pH
    Walter F Boron
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8026, USA
    Adv Physiol Educ 28:160-79. 2004
  3. ncbi request reprint Acid-base transport by the renal proximal tubule
    Walter F Boron
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8026, USA
    J Am Soc Nephrol 17:2368-82. 2006
  4. ncbi request reprint Expression cloning and characterization of a renal electrogenic Na+/HCO3- cotransporter
    M F Romero
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 387:409-13. 1997
  5. ncbi request reprint The electrogenic Na/HCO3 cotransporter
    W F Boron
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Wien Klin Wochenschr 109:445-56. 1997
  6. ncbi request reprint Sodium-hydrogen exchangers and sodium-bicarbonate co-transporters: ontogeny of protein expression in the rat brain
    R M Douglas
    Department of Pediatrics, Section of Respiratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuroscience 102:217-28. 2001
  7. pmc Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity
    Mark D Parker
    Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 283:12777-88. 2008
  8. ncbi request reprint An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel
    I Choi
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 405:571-5. 2000
  9. ncbi request reprint Cloning, characterization, and chromosomal mapping of a human electroneutral Na(+)-driven Cl-HCO3 exchanger
    I I Grichtchenko
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 276:8358-63. 2001
  10. ncbi request reprint Immunolocalization of the electrogenic Na+-HCO-3 cotransporter in mammalian and amphibian kidney
    B M Schmitt
    Department of Cellular and Molecular Physiology, Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol 276:F27-38. 1999

Research Grants

Detail Information

Publications56

  1. ncbi request reprint Sodium-coupled bicarbonate transporters
    W F Boron
    Department of Cell and Molecular Physiology, Yale University School of Medicine New Haven, CT 06520 8026, USA
    JOP 2:176-81. 2001
    ..A characteristic of most, but not all, BT's is that they are inhibited rather effectively by 4,4'-diisothiocyanostilbene-4,4'-disulfonate (DIDS)...
  2. ncbi request reprint Regulation of intracellular pH
    Walter F Boron
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8026, USA
    Adv Physiol Educ 28:160-79. 2004
    ....
  3. ncbi request reprint Acid-base transport by the renal proximal tubule
    Walter F Boron
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8026, USA
    J Am Soc Nephrol 17:2368-82. 2006
    ..Together, these processes ensure that the proximal tubule responds appropriately to acute acid-base disturbances and thereby contributes to the regulation of blood pH...
  4. ncbi request reprint Expression cloning and characterization of a renal electrogenic Na+/HCO3- cotransporter
    M F Romero
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 387:409-13. 1997
    ....
  5. ncbi request reprint The electrogenic Na/HCO3 cotransporter
    W F Boron
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Wien Klin Wochenschr 109:445-56. 1997
    ..Using aNBC to screen a rat-kidney cDNA library, we identified a full-length cDNA clone (rNBC), rNBC encodes a protein of 1035 amino acids, is 86% identical to aNBC, and can be functionally expressed in oocytes...
  6. ncbi request reprint Sodium-hydrogen exchangers and sodium-bicarbonate co-transporters: ontogeny of protein expression in the rat brain
    R M Douglas
    Department of Pediatrics, Section of Respiratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuroscience 102:217-28. 2001
    ..These data indicate that the expression of sodium-hydrogen exchanger and sodium-bicarbonate co-transporter proteins varies as a function of both development and specific brain region...
  7. pmc Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity
    Mark D Parker
    Department of Cellular and Molecular Physiology, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 283:12777-88. 2008
    ..We propose to rename NCBE as the second electroneutral Na/HCO(3) cotransporter, NBCn2...
  8. ncbi request reprint An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel
    I Choi
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 405:571-5. 2000
    ..Oocytes injected with low levels of NBCn1-B complementary RNA exhibit a Na+ conductance that 4,4-diisothiocyanatostilbene-2,2'-disulphonate stimulates slowly and irreversibly...
  9. ncbi request reprint Cloning, characterization, and chromosomal mapping of a human electroneutral Na(+)-driven Cl-HCO3 exchanger
    I I Grichtchenko
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 276:8358-63. 2001
    ..Running in reverse, NDCBE1 requires extracellular Cl(-). Thus, NDCBE1 encodes a human, electroneutral Na(+)-driven Cl-HCO3 exchanger...
  10. ncbi request reprint Immunolocalization of the electrogenic Na+-HCO-3 cotransporter in mammalian and amphibian kidney
    B M Schmitt
    Department of Cellular and Molecular Physiology, Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol 276:F27-38. 1999
    ....
  11. ncbi request reprint Cloning of a Na+-driven Cl/HCO3 exchanger from squid giant fiber lobe
    Leila V Virkki
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Cell Physiol 285:C771-80. 2003
    ..Transport was blocked by 50 microM 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS). The characteristics of our novel clone fit those of a Na+-driven Cl/HCO3 exchanger (NDCBE)...
  12. pmc Expression and localization of Na-driven Cl-HCO(3)(-) exchanger (SLC4A8) in rodent CNS
    L M Chen
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuroscience 153:162-74. 2008
    ..Thus, NDCBE is in a position to contribute substantially to pH(i) regulation in multiple CNS neurons...
  13. ncbi request reprint Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC)
    I Choi
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol 276:C576-84. 1999
    ..We conclude that hhNBC is an electrogenic Na+-HCO-3 cotransporter and that hkNBC is also electrogenic...
  14. ncbi request reprint Cloning and functional expression of an MIP (AQP0) homolog from killifish (Fundulus heteroclitus) lens
    L V Virkki
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, SHM B 133, PO Box 208026, New Haven, CT 06520 8026, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1994-2003. 2001
    ..The mercurials HgCl(2) and p-chloromercuribenzenesulfonate inhibit the water permeability of MIPfun by approximately 25%. MIPfun is not permeable to glycerol, urea, or formic acid but is weakly permeable to CO(2)...
  15. pmc Cloning and characterization of novel human SLC4A8 gene products encoding Na+-driven Cl-/HCO3(-) exchanger variants NDCBE-A, -C, and -D
    Mark D Parker
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, OH 44106, USA
    Physiol Genomics 34:265-76. 2008
    ....
  16. ncbi request reprint Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes
    N L Nakhoul
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol 274:C543-8. 1998
    ..Even if AQP1 should mediate a CO2 flux, it would remain to be determined whether this CO2 movement is quantitatively important...
  17. pmc Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG
    Raif Musa-Aziz
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 106:5406-11. 2009
    ..Thus, each channel exhibits a characteristic ratio for indices of CO(2) vs. NH(3) permeability, demonstrating that, like ion channels, gas channels can exhibit selectivity...
  18. ncbi request reprint Cloning and characterization of an electrogenic Na/HCO3- cotransporter from the squid giant fiber lobe
    Peter M Piermarini
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Physiol Cell Physiol 292:C2032-45. 2007
    ..Extracellular Cl(-) is not necessary for the transporter to operate. Therefore, SF3 is an NBCe, representing the first NBCe characterized from an invertebrate...
  19. pmc Use of a new polyclonal antibody to study the distribution and glycosylation of the sodium-coupled bicarbonate transporter NCBE in rodent brain
    L M Chen
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Neuroscience 151:374-85. 2008
    ..In oocytes, mutating any one of the three consensus N-glycosylation sites reduces glycosylation of the other two, and the triple mutant exhibits negligible functional expression...
  20. ncbi request reprint Effect of isolated removal of either basolateral HCO-3 or basolateral CO2 on HCO-3 reabsorption by rabbit S2 proximal tubule
    Jinhua Zhao
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Renal Physiol 285:F359-69. 2003
    ....
  21. ncbi request reprint Effects of angiotensin II on the CO2 dependence of HCO3- reabsorption by the rabbit S2 renal proximal tubule
    Yuehan Zhou
    Dept of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Am J Physiol Renal Physiol 290:F666-73. 2006
    ....
  22. ncbi request reprint Evidence against a direct interaction between intracellular carbonic anhydrase II and pure C-terminal domains of SLC4 bicarbonate transporters
    Peter M Piermarini
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 282:1409-21. 2007
    ..Thus, although an HCO3 metabolon may exist, CA II cannot bind directly to pure SLC4-Ct peptides and can bind to GST-SLC4-Ct fusion proteins only when the CA II is immobilized and the fusion protein is soluble, and not vice versa...
  23. pmc Sodium kinetics of Na,K-ATPase alpha isoforms in intact transfected HeLa cells
    R Zahler
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Gen Physiol 110:201-13. 1997
    ..We conclude that the apparent Km(Na+) for rat Na-K pump isoforms increases in the sequence alpha1 < alpha2 < alpha3. The alpha3 isoform may be suited for handling large Na+ loads in electrically active cells...
  24. ncbi request reprint Expression of Na+/H+ and HCO3- -dependent transporters in Na+/H+ exchanger isoform 1 null mutant mouse brain
    J Xue
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Neuroscience 122:37-46. 2003
    ..The alteration is region-specific. An increase in acid extruders (e.g. NHE3) and a decrease in acid loaders (e.g. AE3) suggest that there are some compensatory mechanisms that occur in NHE1 null mutant mice...
  25. ncbi request reprint Inhibition of K/HCO(3) cotransport in squid axons by quaternary ammonium ions
    B A Davis
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Membr Biol 183:25-32. 2001
    ..The identification of inhibitors of the K/HCO(3) cotransporter, for which no inhibitors previously existed, will facilitate the study of this transporter...
  26. ncbi request reprint Effect of human carbonic anhydrase II on the activity of the human electrogenic Na/HCO3 cotransporter NBCe1-A in Xenopus oocytes
    Jing Lu
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 281:19241-50. 2006
    ..Thus, fused CA II was functional. Slope conductances of EGFP-e1-CAII versus EGFP-e1 oocytes were indistinguishable, and EZA had no effect. Thus, even when fused to NBCe1-A, CA II does not enhance NBCe1-A activity...
  27. ncbi request reprint Colony-stimulating factor-1 increases osteoclast intracellular pH and promotes survival via the electroneutral Na/HCO3 cotransporter NBCn1
    Patrice Bouyer
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, POB 208026, New Haven, Connecticut 06520 8026, USA
    Endocrinology 148:831-40. 2007
    ..This study provides the first evidence that osteoclasts express a CSF-1-regulated Na/HCO(3) cotransporter, which may play a role in cell survival...
  28. ncbi request reprint Reversible and irreversible interactions of DIDS with the human electrogenic Na/HCO3 cotransporter NBCe1-A: role of lysines in the KKMIK motif of TM5
    Jing Lu
    Department Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8026, USA
    Am J Physiol Cell Physiol 292:C1787-98. 2007
    ..The fitted maximal inhibitions were 80-91% for the first five constructs, and 66% for NNMIN. Thus DIDS probably reversibly binds before irreversibly reacting with NBCe1-A. Finally, tenidap blocks not only KKMIK, but also NNMIN and EEMIE...
  29. pmc A conductive pathway generated from fragments of the human red cell anion exchanger AE1
    Mark D Parker
    Department of Biochemistry, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    J Physiol 581:33-50. 2007
    ..Although this conductive pathway is not a usual feature of intact mammalian AE1, it shares many properties with the anion-conductive pathways intrinsic to two other Cl-HCO3- exchangers, trout AE1 and mammalian SLC26A7...
  30. ncbi request reprint Role of the AT1A receptor in the CO2-induced stimulation of HCO3- reabsorption by renal proximal tubules
    Yuehan Zhou
    Dept of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Am J Physiol Renal Physiol 293:F110-20. 2007
    ..Neither apical AT(2) receptors nor basolateral ANG II receptors are involved in these processes...
  31. pmc Effects of acute hypoxia on intracellular-pH regulation in astrocytes cultured from rat hippocampus
    Mark O Bevensee
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Brain Res 1193:143-52. 2008
    ....
  32. pmc ATP dependence of Na+-driven Cl-HCO3 exchange in squid axons
    Bruce A Davis
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Membr Biol 222:107-13. 2008
    ..0 pmol cm(-2 )s(-1)) but increased modestly by 1 mM ADP beta S (J (H) = 16.0 pmol cm(-2 )s(-1)). We suggest that ATP gamma S leads to stable phosphorylation of the transporter or an essential activator...
  33. ncbi request reprint Expression and purification of the cytoplasmic N-terminal domain of the Na/HCO3 cotransporter NBCe1-A: structural insights from a generalized approach
    Harindarpal S Gill
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Protein Expr Purif 49:228-34. 2006
    ..A comparison of Nt-NBCe1 to SLC4 member Nt-AE1, based on purification properties and predicted secondary-structure sequence alignments, suggests a similar mechanism for dimer stabilization...
  34. pmc Preliminary X-ray diffraction analysis of the cytoplasmic N-terminal domain of the Na/HCO3 cotransporter NBCe1-A
    Harindarpal S Gill
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:534-7. 2006
    ..9 A3 Da(-1), with two monomers of molecular weight approximately 83 kDa in the asymmetric unit. The molecular- replacement packing solution shows that the molecules form dimers by a domain-swapping mechanism...
  35. ncbi request reprint Role of glycosylation in the renal electrogenic Na+-HCO3- cotransporter (NBCe1)
    Inyeong Choi
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Renal Physiol 284:F1199-206. 2003
    ..The triple mutant (N592Q/N597Q/N617Q) is completely unglycosylated but, based on microelectrode measurements of membrane potential and pH(i) in oocytes, preserves the Na(+) and HCO(3)(-) dependence and electrogenicity of wild-type NBCe1...
  36. ncbi request reprint Functional characterization of human NBC4 as an electrogenic Na+-HCO cotransporter (NBCe2)
    Leila V Virkki
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520 8026, USA
    Am J Physiol Cell Physiol 282:C1278-89. 2002
    ..This observation, as well as the absolute E(rev) values, are consistent with a 2:1 stoichiometry. In conclusion, the behavior of NBC4c, which we propose to call NBCe2-c, is similar to that of NBCe1, the first electrogenic NBC...
  37. ncbi request reprint Cloning and functional characterization of a novel aquaporin from Xenopus laevis oocytes
    Leila V Virkki
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, PO Box 108026, 333 Cedar Street, New Haven, CT 06520, USA
    J Biol Chem 277:40610-6. 2002
    ..Remarkably, low HgCl(2) concentrations (0.3-10 microm) reduced P(f) and urea uptake, whereas high concentrations (300-1000 microm) reversed the inhibition. We propose that AQPxlo is a new AQP paralogue unknown in mammals...
  38. ncbi request reprint Role of endogenously secreted angiotensin II in the CO2-induced stimulation of HCO3 reabsorption by renal proximal tubules
    Yuehan Zhou
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Physiol Renal Physiol 294:F245-52. 2008
    ..We conclude that the isolated PT predominantly secretes preformed ANG II, rather than angiotensinogen or ANG I...
  39. ncbi request reprint An increase in intracellular calcium concentration that is induced by basolateral CO2 in rabbit renal proximal tubule
    Patrice Bouyer
    Department of Cellular and Molecular Physiology, Yale University, School of Medicine, 333 Cedar St, PO Box 208026, New Haven, CT 06520 8026, USA
    Am J Physiol Renal Physiol 285:F674-87. 2003
    ..Adding 10 mM caffeine (ryanodine-receptor agonist) had no effect on [Ca2+]i. Thus basolateral CO2, presumably via a basolateral sensor, triggers the release of Ca2+ from a nonconventional intracellular pool...
  40. pmc Effect of extracellular acid-base disturbances on the intracellular pH of neurones cultured from rat medullary raphe or hippocampus
    Patrice Bouyer
    Department of Cellular and Molecular Physiology, SHM B 133, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Physiol 559:85-101. 2004
    ..Moreover, regardless of whether neurones were cultured from the chemosensitive or the non-chemosensitive region, pH(i) did not recover during any of the acid-base stresses...
  41. pmc Evidence from renal proximal tubules that HCO3- and solute reabsorption are acutely regulated not by pH but by basolateral HCO3- and CO2
    Yuehan Zhou
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 102:3875-80. 2005
    ..Because the cells cannot respond acutely to pH changes, we propose that the responses of J(HCO(3)) and the reabsorption of other solutes to changes in [HCO(3)(-)](BL) or [CO(2)](BL) involve sensors for basolateral HCO(3)(-) and CO(2)...
  42. ncbi request reprint Role of a tyrosine kinase in the CO2-induced stimulation of HCO3- reabsorption by rabbit S2 proximal tubules
    Yuehan Zhou
    Dept of Cellular and Molecular Physiology, Yale Univ School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Am J Physiol Renal Physiol 291:F358-67. 2006
    ....
  43. pmc Concentration-dependent effects on intracellular and surface pH of exposing Xenopus oocytes to solutions containing NH3/NH4(+)
    Raif Musa-Aziz
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Membr Biol 228:15-31. 2009
    ....
  44. ncbi request reprint Arginine vasopressin enhances pHi regulation in the presence of HCO3- by stimulating three acid-base transport systems
    M B Ganz
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06511
    Nature 337:648-51. 1989
    ..The stimulation of three acid-base transporters by the growth factor AVP greatly enhances the ability of the cell to regulate pHi...
  45. ncbi request reprint Cloning and functional expression of rNBC, an electrogenic Na(+)-HCO3- cotransporter from rat kidney
    M F Romero
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol 274:F425-32. 1998
    ..Subsequent removal of Na+ in the presence of CO2/HCO3- causes a depolarization of > 50 mV and a concomitant decrease of pHi. Thus rNBC is in the same newly identified family of Na(+)-linked HCO3- transporters as is aNBC...
  46. ncbi request reprint Specificity of anion exchange mediated by mouse Slc26a6
    Zhirong Jiang
    Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8029, USA
    J Biol Chem 277:33963-7. 2002
    ..In the presence of high oxalate concentrations as found in renal tubular fluid and urine, Slc26a6 may largely function as an electrogenic Cl(-)-oxalate exchanger...
  47. pmc Transport of volatile solutes through AQP1
    Gordon J Cooper
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520 8026, USA
    J Physiol 542:17-29. 2002
    ....
  48. ncbi request reprint Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain
    Li Ming Chen
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Physiol Regul Integr Comp Physiol 293:R2412-20. 2007
    ..We hypothesize that these decreases, which are out of proportion to the expected overall decreases in brain protein levels, may especially be important for reducing energy consumption...
  49. ncbi request reprint The human NBCe1-A mutant R881C, associated with proximal renal tubular acidosis, retains function but is mistargeted in polarized renal epithelia
    Ashley M Toye
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    Am J Physiol Cell Physiol 291:C788-801. 2006
    ..In summary, the pathophysiology of pRTA caused by the R881C mutation is likely due to a deficit of NBCe1-A at the proximal tubule basolateral membrane, rather than a defect in the transport activity of individual molecules...
  50. pmc The electrogenicity of the rat sodium-bicarbonate cotransporter NBCe1 requires interactions among transmembrane segments of the transporter
    Inyeong Choi
    Department of Physiology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    J Physiol 578:131-42. 2007
    ..Thus, these chimeras were electroneutral, as were two others consisting of NBCe1(Nt-L)/NBCn1(TM6-Ct) and NBCn1(Nt-L)/NBCe1(TM6-Ct). We propose that the electrogenicity of NBCe1 requires interactions between TM1-5 and TM6-13...
  51. ncbi request reprint Na+-dependent HCO3- uptake into the rat choroid plexus epithelium is partially DIDS sensitive
    Elena V Bouzinova
    Institute for Physiology and Biophysics, Univ of Aarhus, Ole Worms Alle, Bldg 1160, DK 8000 Aarhus C, Denmark
    Am J Physiol Cell Physiol 289:C1448-56. 2005
    ..This is consistent with the localization of the three base transporters NBCn1, Na+-driven Cl- bicarbonate exchanger, and NBCe2 in this tissue...
  52. ncbi request reprint The SLC4 family of HCO 3 - transporters
    Michael F Romero
    Departments of Physiology and Biophysics and Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4970, USA
    Pflugers Arch 447:495-509. 2004
    ..SLC4 gene products play important roles in the carriage of CO(2) by erythrocytes, the absorption or secretion of H(+) or HCO(3)(-) by several epithelia, as well as the regulation of cell volume and intracellular pH...
  53. ncbi request reprint Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse
    Amjad Kanaan
    Department of Pediatrics, Section of Respiratory Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1294-302. 2007
    ....
  54. doi request reprint Physiology and the Olympics ... on our fourth anniversary
    Walter F Boron
    Physiology (Bethesda) 23:182. 2008
  55. ncbi request reprint Exploring gas permeability of cellular membranes and membrane channels with molecular dynamics
    Yi Wang
    Theoretical and Computational Biophysics Group, Beckman Institute, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Struct Biol 157:534-44. 2007
    ..As such, gas conduction through AQP1 may only be physiologically relevant either in membranes of low gas permeability, or in cells where a major fraction of the cellular membrane is occupied by AQPs...

Research Grants2

  1. Physiology of Electrogenic Na/HCO3 Cotransporters
    Walter Boron; Fiscal Year: 2007
    ..The results could have important implications for understanding the normal control of acid-base balance and renal-tubule acidosis. ..