Research Topics
| Kelly A BordnerSummaryAffiliation: Yale University Country: USA Publications
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Detail Information
Publications
Parallel declines in cognition, motivation, and locomotion in aging mice: association with immune gene upregulation in the medial prefrontal cortexKelly A Bordner
Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06511, USA
Exp Gerontol 46:643-59. 2011..These data suggest that, as in humans, cognition, motivation, and motoric performance in the mouse change together with age and are strongly associated with CNS immune gene upregulation...
Maternal separation with early weaning: a rodent model providing novel insights into neglect associated developmental deficitsBecky C Carlyle
Yale University School of Medicine, CT, USA
Dev Psychopathol 24:1401-16. 2012..Finally, we summarize the molecular characterization of these animals, including RNA profiling and label-free proteomics, which highlight protein translation and myelination as novel pathways of interest...
Neuroanatomical changes in a mouse model of early life neglectAlvaro Duque
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06511 6624, USA
Brain Struct Funct 217:459-72. 2012..Moreover, our current knowledge of the mouse genome makes this model particularly suited for targeted anatomical, molecular, and pharmacological experimentation not yet possible in other species...
Functional genomic and proteomic analysis reveals disruption of myelin-related genes and translation in a mouse model of early life neglectKelly A Bordner
Department of Psychiatry, Yale University School of Medicine New Haven, CT, USA
Front Psychiatry 2:18. 2011..These findings are likely to prove useful in understanding the mechanism by which early life neglect affects brain structure, cognition, and behavior...
Maternal separation with early weaning: a novel mouse model of early life neglectElizabeth D George
Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06511, USA
BMC Neurosci 11:123. 2010..Maternal separation is a commonly used model of early life neglect, but has led to inconsistent results in the mouse...
Cognitive dysfunction with aging and the role of inflammationArthur A Simen
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Ther Adv Chronic Dis 2:175-95. 2011..New insights from preclinical and clinical research may give rise to novel therapeutics which may have efficacy in slowing or preventing cognitive decline with advancing age...
