ANGELIQUE F BORDEY
Affiliation: Yale University
Nguyen L, Mahadeo T, Bordey A. mTOR Hyperactivity Levels Influence the Severity of Epilepsy and Associated Neuropathology in an Experimental Model of Tuberous Sclerosis Complex and Focal Cortical Dysplasia. J Neurosci. 2019;39:2762-2773 pubmed publisher
Huang T, Nguyen L, Lin T, Gong X, Zhang L, Kim G, et al
. In utero electroporation-based translating ribosome affinity purification identifies age-dependent mRNA expression in cortical pyramidal neurons. Neurosci Res. 2018;: pubmed publisher
Zhang L, Feliciano D, Huang T, Zhang S, Bordey A. Hypoxia-inducible factor-1a contributes to dendritic overgrowth in tuberous sclerosis. Neurosci Lett. 2016;612:43-47 pubmed publisher
..These data highlight that an increase in HIF1a levels contributes to abnormal dendritic patterning in developing neurons under normal conditions and hyperactive mTORC1 conditions as in TSC. ..
Mahoney C, Feliciano D, Bordey A, Hartman N. Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice. Neurosci Lett. 2016;614:112-8 pubmed publisher
..Taken together these data suggest that hyperactivity of mTORC1 could lead to the progressive loss of NSCs over time. ..
Zhang L, Huang T, Bordey A. Tsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels. Neurosci Lett. 2016;629:15-18 pubmed publisher
Hsieh L, Wen J, Miyares L, Lombroso P, Bordey A. Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks. Neurosci Lett. 2017;637:142-147 pubmed publisher
..Thus, outbred CD1 mice are as appropriate as inbred C57 mice for studying social behavior using either the single or the three-chamber test using a specific acclimation paradigm. ..
Zhang L, Bartley C, Gong X, Hsieh L, Lin T, Feliciano D, et al
. MEK-ERK1/2-dependent FLNA overexpression promotes abnormal dendritic patterning in tuberous sclerosis independent of mTOR. Neuron. 2014;84:78-91 pubmed publisher
..These data demonstrate that altered FLNA expression increases dendritic complexity and contributes to pathologic dendritic patterning in TSC in an mTOR-independent, ERK1/2-dependent manner. ..
Gong X, Zhang L, Huang T, Lin T, Miyares L, Wen J, et al
. Activating the translational repressor 4E-BP or reducing S6K-GSK3β activity prevents accelerated axon growth induced by hyperactive mTOR in vivo. Hum Mol Genet. 2015;24:5746-58 pubmed publisher
Lin T, Hsieh L, Kimura T, Malone T, Bordey A. Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration. Proc Natl Acad Sci U S A. 2016;113:11330-11335 pubmed
..These data show that many aspects of abnormal brain cytoarchitecture can be prevented by manipulating a single intracellular process downstream of mTORC1, cap-dependent translation. ..