Linda Bockenstedt

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Detection of attenuated, noninfectious spirochetes in Borrelia burgdorferi-infected mice after antibiotic treatment
    Linda K Bockenstedt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8031, USA
    J Infect Dis 186:1430-7. 2002
  2. pmc What ticks do under your skin: two-photon intravital imaging of Ixodes scapularis feeding in the presence of the lyme disease spirochete
    Linda K Bockenstedt
    Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut
    Yale J Biol Med 87:3-13. 2014
  3. pmc Modulation of murine Lyme borreliosis by interruption of the B7/CD28 T-cell costimulatory pathway
    M C Shanafelt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Infect Immun 66:266-71. 1998
  4. pmc MyD88 deficiency enhances acquisition and transmission of Borrelia burgdorferi by Ixodes scapularis ticks
    Linda K Bockenstedt
    S 525C TAC, Section of Rheumatology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520 8031, USA
    Infect Immun 74:2154-60. 2006
  5. pmc CD4+ T helper 1 cells facilitate regression of murine Lyme carditis
    L K Bockenstedt
    Department of Internal Medicine, Yale University School of Medicine, Yale University, New Haven, Connecticut 06520 8031, USA
    Infect Immun 69:5264-9. 2001
  6. pmc Myeloid differentiation antigen 88 deficiency impairs pathogen clearance but does not alter inflammation in Borrelia burgdorferi-infected mice
    Nengyin Liu
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Infect Immun 72:3195-203. 2004
  7. pmc Humoral immunity reflects altered T helper cell bias in Borrelia burgdorferi-infected gamma delta T-cell-deficient mice
    Linda K Bockenstedt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Infect Immun 71:2938-40. 2003
  8. pmc OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands
    Utpal Pal
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 113:220-30. 2004
  9. pmc Increased TLR4 expression and downstream cytokine production in immunosuppressed adults compared to non-immunosuppressed adults
    Dana W Dunne
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 5:e11343. 2010
  10. pmc Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi
    Curry L Koening
    Division of Rheumatology, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Blood 114:1913-8. 2009

Research Grants

  1. Real-time Imaging Analysis of Vector-borne Lyme Borreliosis Pathogenesis & Persis
    Linda K Bockenstedt; Fiscal Year: 2010
  2. CD1-Mediated Immunity Of Lyme Disease
    Linda Bockenstedt; Fiscal Year: 2001
  3. CD1-Mediated Immunity Of Lyme Disease
    Linda Bockenstedt; Fiscal Year: 2003
  4. Genesis & Control of Lyme Disease by Innate Immunity
    Linda Bockenstedt; Fiscal Year: 2007
  5. Genesis & Conrol of Lyme Disease by Innate Immunity
    Linda Bockenstedt; Fiscal Year: 2005
  6. Genesis & Conrol of Lyme Disease by Innate Immunity
    Linda Bockenstedt; Fiscal Year: 2006
  7. CD1-Mediated Immunity Of Lyme Disease
    Linda Bockenstedt; Fiscal Year: 2005
  8. Genesis & Control of Lyme Disease by Innate Immunity
    Linda Bockenstedt; Fiscal Year: 2004
  9. CD1-Mediated Immunity Of Lyme Disease
    Linda Bockenstedt; Fiscal Year: 2004
  10. CD1-Mediated Immunity Of Lyme Disease
    Linda Bockenstedt; Fiscal Year: 2002

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Detection of attenuated, noninfectious spirochetes in Borrelia burgdorferi-infected mice after antibiotic treatment
    Linda K Bockenstedt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8031, USA
    J Infect Dis 186:1430-7. 2002
    ..These results provide evidence that noninfectious spirochetes can persist for a limited duration after antibiotics but are not associated with disease in mice...
  2. pmc What ticks do under your skin: two-photon intravital imaging of Ixodes scapularis feeding in the presence of the lyme disease spirochete
    Linda K Bockenstedt
    Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut
    Yale J Biol Med 87:3-13. 2014
    ....
  3. pmc Modulation of murine Lyme borreliosis by interruption of the B7/CD28 T-cell costimulatory pathway
    M C Shanafelt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Infect Immun 66:266-71. 1998
    ..These studies may provide insight into the role of the B7/CD28 pathway in other infectious and autoimmune diseases in which deviation of Th cell immune responses occurs and antigen is persistently present...
  4. pmc MyD88 deficiency enhances acquisition and transmission of Borrelia burgdorferi by Ixodes scapularis ticks
    Linda K Bockenstedt
    S 525C TAC, Section of Rheumatology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520 8031, USA
    Infect Immun 74:2154-60. 2006
    ..These results show that the absence of MyD88 facilitates passage of both low- and high-infectivity B. burgdorferi strains between the tick vector and the mammal and enhances the infectivity of a low-infectivity B. burgdorferi strain...
  5. pmc CD4+ T helper 1 cells facilitate regression of murine Lyme carditis
    L K Bockenstedt
    Department of Internal Medicine, Yale University School of Medicine, Yale University, New Haven, Connecticut 06520 8031, USA
    Infect Immun 69:5264-9. 2001
    ..These results show that alphabeta T cells can promote resolution of murine Lyme carditis and are the first demonstration of a beneficial role for CD4+ T helper 1 cells in this disease...
  6. pmc Myeloid differentiation antigen 88 deficiency impairs pathogen clearance but does not alter inflammation in Borrelia burgdorferi-infected mice
    Nengyin Liu
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Infect Immun 72:3195-203. 2004
    ..Our results show that MyD88-dependent signaling pathways are not required for B. burgdorferi-induced inflammation but are necessary for the efficient control of the pathogen burden by phagocytes...
  7. pmc Humoral immunity reflects altered T helper cell bias in Borrelia burgdorferi-infected gamma delta T-cell-deficient mice
    Linda K Bockenstedt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Infect Immun 71:2938-40. 2003
    ..Arthropod transmission of Borrelia burgdorferi spirochetes results in similar antibody isotypes when gamma delta T cells are present, suggesting that vector effects can negate gamma delta T-cell functions in vivo...
  8. pmc OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands
    Utpal Pal
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 113:220-30. 2004
    ..These studies conclusively demonstrate the importance of OspC in the invasion of tick salivary glands by B. burgdorferi, a critical step in the transmission of spirochetes from the arthropod vector to the mammalian host...
  9. pmc Increased TLR4 expression and downstream cytokine production in immunosuppressed adults compared to non-immunosuppressed adults
    Dana W Dunne
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 5:e11343. 2010
    ..We studied monocyte Toll-like receptor (TLR) expression and cytokine production in 137 patients with autoimmune diseases who were maintained on immunosuppressive medications and 419 non-immunosuppressed individuals...
  10. pmc Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi
    Curry L Koening
    Division of Rheumatology, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Blood 114:1913-8. 2009
    ..Hepcidin expression induced by B burgdorferi was mediated primarily by activation of Toll-like receptor 2...
  11. pmc The caspase 1 inflammasome is not required for control of murine Lyme borreliosis
    Nengyin Liu
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 77:3320-7. 2009
    ..These findings reveal that the caspase 1 inflammasome is not critical to host defense against the extracellular pathogen Borrelia burgdorferi...
  12. pmc Marginal zone B-cell depletion impairs murine host defense against Borrelia burgdorferi infection
    Alexia A Belperron
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 75:3354-60. 2007
    ....
  13. ncbi request reprint Infection-induced marginal zone B cell production of Borrelia hermsii-specific antibody is impaired in the absence of CD1d
    Alexia A Belperron
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 174:5681-6. 2005
    ..hermsii from the MZB cells. These results demonstrate that blood-borne spirochetes activate MZB cells to produce pathogen-specific IgM and reveal a role for CD1d in this process...
  14. pmc Langerhans cell deficiency impairs Ixodes scapularis suppression of Th1 responses in mice
    Diana L Vesely
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, TAC S 520, 300 Cedar Street, New Haven, CT 06520, USA
    Infect Immun 77:1881-7. 2009
    ....
  15. doi request reprint Anti-tumor necrosis factor-alpha activation of Borrelia burgdorferi spirochetes in antibiotic-treated murine Lyme borreliosis: an unproven conclusion
    Gary P Wormser
    J Infect Dis 196:1865-6; author reply 1866-7. 2007
  16. ncbi request reprint IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis
    Joao H F Pedra
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    FEMS Immunol Med Microbiol 50:401-10. 2007
    ..The IL-12/23p40 subunit drives the CD4(+) Th1 immune response in the early phase of infection and IL-12/23p40-independent mechanisms ultimately contribute to pathogen elimination from the host...

Research Grants12

  1. Real-time Imaging Analysis of Vector-borne Lyme Borreliosis Pathogenesis & Persis
    Linda K Bockenstedt; Fiscal Year: 2010
    ....
  2. CD1-Mediated Immunity Of Lyme Disease
    Linda Bockenstedt; Fiscal Year: 2001
    ..For the field of Lyme disease, defining the key molecules expressed by tick-borne spirochetes will move us one step closer toward understanding how this pathogen invades, disseminates and persists in the mammalian host. ..
  3. CD1-Mediated Immunity Of Lyme Disease
    Linda Bockenstedt; Fiscal Year: 2003
    ..For the field of Lyme disease, defining the key molecules expressed by tick-borne spirochetes will move us one step closer toward understanding how this pathogen invades, disseminates and persists in the mammalian host. ..
  4. Genesis & Control of Lyme Disease by Innate Immunity
    Linda Bockenstedt; Fiscal Year: 2007
    ..For the field of Lyme disease, defining the key molecules expressed by host-adapted spirochetes will move us one step closer toward understanding how this pathogen persists in an immunologically responsive host. ..
  5. Genesis & Conrol of Lyme Disease by Innate Immunity
    Linda Bockenstedt; Fiscal Year: 2005
    ..For the field of Lyme disease, defining the key molecules expressed by host-adapted spirochetes will move us one step closer toward understanding how this pathogen persists in an immunologically responsive host. ..
  6. Genesis & Conrol of Lyme Disease by Innate Immunity
    Linda Bockenstedt; Fiscal Year: 2006
    ..For the field of Lyme disease, defining the key molecules expressed by host-adapted spirochetes will move us one step closer toward understanding how this pathogen persists in an immunologically responsive host. ..
  7. CD1-Mediated Immunity Of Lyme Disease
    Linda Bockenstedt; Fiscal Year: 2005
    ..For the field of Lyme disease, defining the key molecules expressed by tick-borne spirochetes will move us one step closer toward understanding how this pathogen invades, disseminates and persists in the mammalian host. ..
  8. Genesis & Control of Lyme Disease by Innate Immunity
    Linda Bockenstedt; Fiscal Year: 2004
    ..For the field of Lyme disease, defining the key molecules expressed by host-adapted spirochetes will move us one step closer toward understanding how this pathogen persists in an immunologically responsive host. ..
  9. CD1-Mediated Immunity Of Lyme Disease
    Linda Bockenstedt; Fiscal Year: 2004
    ..For the field of Lyme disease, defining the key molecules expressed by tick-borne spirochetes will move us one step closer toward understanding how this pathogen invades, disseminates and persists in the mammalian host. ..
  10. CD1-Mediated Immunity Of Lyme Disease
    Linda Bockenstedt; Fiscal Year: 2002
    ..For the field of Lyme disease, defining the key molecules expressed by tick-borne spirochetes will move us one step closer toward understanding how this pathogen invades, disseminates and persists in the mammalian host. ..
  11. Genesis & Control of Lyme Disease by Innate Immunity
    Linda Bockenstedt; Fiscal Year: 2009
    ..For the field of Lyme disease, defining the key molecules expressed by host-adapted spirochetes will move us one step closer toward understanding how this pathogen persists in an immunologically responsive host. ..