Hal Blumenfeld

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint What is a seizure network? Long-range network consequences of focal seizures
    Hal Blumenfeld
    Department of Neurology, Neurobiology and Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520, USA
    Adv Exp Med Biol 813:63-70. 2014
  2. pmc Should consciousness be included in the classification of focal (partial) seizures?
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    Epilepsia 54:1125-30. 2013
  3. pmc Impaired consciousness in epilepsy
    Hal Blumenfeld
    Departments of Neurology, Neurobiology, and Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Lancet Neurol 11:814-26. 2012
  4. ncbi request reprint Corticothalamic inputs control the pattern of activity generated in thalamocortical networks
    H Blumenfeld
    Section of Neurobiology and Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 20:5153-62. 2000
  5. pmc Early treatment suppresses the development of spike-wave epilepsy in a rat model
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Epilepsia 49:400-9. 2008
  6. ncbi request reprint Positive and negative network correlations in temporal lobe epilepsy
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8018, USA
    Cereb Cortex 14:892-902. 2004
  7. ncbi request reprint Functional MRI studies of animal models in epilepsy
    Hal Blumenfeld
    Department of Neurology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Epilepsia 48:18-26. 2007
  8. ncbi request reprint Neocortical and thalamic spread of amygdala kindled seizures
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Epilepsia 48:254-62. 2007
  9. ncbi request reprint Ictal neocortical slowing in temporal lobe epilepsy
    H Blumenfeld
    Department of Neurology and Neurobiology, Yale University School of Medicine, New Haven, CT, USA
    Neurology 63:1015-21. 2004
  10. pmc Consciousness and epilepsy: why are patients with absence seizures absent?
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Prog Brain Res 150:271-86. 2005

Collaborators

Detail Information

Publications72

  1. ncbi request reprint What is a seizure network? Long-range network consequences of focal seizures
    Hal Blumenfeld
    Department of Neurology, Neurobiology and Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520, USA
    Adv Exp Med Biol 813:63-70. 2014
    ....
  2. pmc Should consciousness be included in the classification of focal (partial) seizures?
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    Epilepsia 54:1125-30. 2013
    ..We hope that this discussion will bring impaired consciousness off the back roads of epilepsy classification, and provide useful names for these two very common seizure types...
  3. pmc Impaired consciousness in epilepsy
    Hal Blumenfeld
    Departments of Neurology, Neurobiology, and Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Lancet Neurol 11:814-26. 2012
    ..Understanding of these mechanisms could lead to improved treatment strategies to prevent impairment of consciousness and improve the quality of life of people with epilepsy...
  4. ncbi request reprint Corticothalamic inputs control the pattern of activity generated in thalamocortical networks
    H Blumenfeld
    Section of Neurobiology and Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 20:5153-62. 2000
    ..We suggest that differential activation of thalamic GABA(A) and GABA(B) receptors in response to varying corticothalamic input patterns may be critical in setting the oscillation frequency of thalamocortical network interactions...
  5. pmc Early treatment suppresses the development of spike-wave epilepsy in a rat model
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Epilepsia 49:400-9. 2008
    ..We sought to determine whether early treatment in a model of genetic epilepsy would reduce the severity of the epilepsy phenotype in adulthood...
  6. ncbi request reprint Positive and negative network correlations in temporal lobe epilepsy
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8018, USA
    Cereb Cortex 14:892-902. 2004
    ..These results suggest that impaired consciousness in temporal lobe seizures may result from focal abnormal activity in temporal and subcortical networks linked to widespread impaired function of the association cortex...
  7. ncbi request reprint Functional MRI studies of animal models in epilepsy
    Hal Blumenfeld
    Department of Neurology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Epilepsia 48:18-26. 2007
    ..fMRI studies in animal models of epilepsy can enable us to correctly interpret fMRI signal increases and decreases in human studies, ultimately elucidating specific networks that will be targeted for improved treatment of epilepsy...
  8. ncbi request reprint Neocortical and thalamic spread of amygdala kindled seizures
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Epilepsia 48:254-62. 2007
    ..The mechanisms for worsening behavioral seizures, and the possible role of enhanced connectivity between the amygdala and other structures have not been thoroughly investigated...
  9. ncbi request reprint Ictal neocortical slowing in temporal lobe epilepsy
    H Blumenfeld
    Department of Neurology and Neurobiology, Yale University School of Medicine, New Haven, CT, USA
    Neurology 63:1015-21. 2004
    ..Temporal lobe epilepsy (TLE) may affect brain regions outside the temporal lobe, causing impaired neocortical function during seizures...
  10. pmc Consciousness and epilepsy: why are patients with absence seizures absent?
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Prog Brain Res 150:271-86. 2005
    ..Further investigations of the relationship between behavior and altered network function in absence seizures may improve our understanding of both normal and impaired consciousness...
  11. pmc Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    Epilepsia 50:44-55. 2009
    ..6 is crucial for action potential generation. The goal of the present study was to investigate the possible role of changes in Nav1.6 expression in abnormal, activity-dependent plasticity of hippocampal circuits...
  12. pmc Cortical and subcortical networks in human secondarily generalized tonic-clonic seizures
    H Blumenfeld
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8018, USA
    Brain 132:999-1012. 2009
    ..Understanding the networks involved in generalized tonic-clonic seizures can provide insights into mechanisms of behavioural changes, and may elucidate targets for improved therapies...
  13. ncbi request reprint The thalamus and seizures
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Arch Neurol 59:135-7. 2002
  14. pmc Epilepsy and the consciousness system: transient vegetative state?
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Neurol Clin 29:801-23. 2011
    ....
  15. ncbi request reprint Why do seizures cause loss of consciousness?
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Neuroscientist 9:301-10. 2003
    ..Information flow during normal conscious processing may require a dynamic balance between these two extremes of excitation and inhibition...
  16. ncbi request reprint From molecules to networks: cortical/subcortical interactions in the pathophysiology of idiopathic generalized epilepsy
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, U S A
    Epilepsia 44:7-15. 2003
    ..A greater understanding of these molecular and network mechanisms will ultimately lead to improved targeted therapies for generalized epilepsy...
  17. ncbi request reprint Targeted prefrontal cortical activation with bifrontal ECT
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Psychiatry Res 123:165-70. 2003
    ..In bifrontal ECT, a greater increase in prefrontal activation, while sparing the temporal lobes, may result in a better therapeutic response and fewer adverse effects on memory than bitemporal ECT...
  18. ncbi request reprint Selective frontal, parietal, and temporal networks in generalized seizures
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Neuroimage 19:1556-66. 2003
    ..Relative sparing of many brain regions during both spontaneous and induced seizures suggests that specific networks may be more important than others in so-called generalized seizures...
  19. ncbi request reprint Cellular and network mechanisms of spike-wave seizures
    Hal Blumenfeld
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Epilepsia 46:21-33. 2005
    ..It is hoped that improved understanding of the heterogeneous defects and selective brain regions involved will ultimately lead to more effective treatments for spike-wave seizures...
  20. pmc Impaired consciousness in temporal lobe seizures: role of cortical slow activity
    Dario J Englot
    Department of Neurosurgery, University of California, San Francisco, CA 94122, USA
    Brain 133:3764-77. 2010
    ..Further investigations will be needed to fully determine the role of cortical-subcortical networks in ictal neocortical dysfunction and may reveal treatments to prevent this important negative consequence of temporal lobe epilepsy...
  21. pmc Cortical deactivation induced by subcortical network dysfunction in limbic seizures
    Dario J Englot
    Departments of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 29:13006-18. 2009
    ..If confirmed, subcortical networks may represent a target for therapies aimed at preserving consciousness in human temporal lobe seizures...
  22. pmc Where fMRI and electrophysiology agree to disagree: corticothalamic and striatal activity patterns in the WAG/Rij rat
    Asht Mangal Mishra
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 31:15053-64. 2011
    ..These opposite changes in vascular and electrical activity indicate that caution should be applied when interpreting fMRI signals in both health and disease from the caudate-putamen, as well as possibly from other subcortical structures...
  23. ncbi request reprint Imaging onset and propagation of ECT-induced seizures
    Miro Enev
    Departments of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Epilepsia 48:238-44. 2007
    ....
  24. pmc Simultaneous EEG, fMRI, and behavior in typical childhood absence seizures
    Rachel Berman
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Epilepsia 51:2011-22. 2010
    ..However, fMRI during typical childhood absence seizures with confirmed impaired consciousness has not been previously investigated...
  25. pmc Dynamic time course of typical childhood absence seizures: EEG, behavior, and functional magnetic resonance imaging
    Xiaoxiao Bai
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 30:5884-93. 2010
    ..These results may be important mechanistically for seizure initiation and termination and may also contribute to changes in EEG and behavior...
  26. ncbi request reprint Localizing value of ictal-interictal SPECT analyzed by SPM (ISAS)
    Kelly A McNally
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Epilepsia 46:1450-64. 2005
    ..A widely available and objective method is needed to interpret ambiguous ictal and postictal scans, with changes in multiple brain regions...
  27. doi request reprint Background intracranial EEG spectral changes with anti-epileptic drug taper
    Hitten P Zaveri
    Department of Neurology, Yale University, New Haven, CT 06520, USA
    Clin Neurophysiol 121:311-7. 2010
    ..Here, we expand the measures evaluated to icEEG power and frequency band power...
  28. ncbi request reprint Dynamic fMRI and EEG recordings during spike-wave seizures and generalized tonic-clonic seizures in WAG/Rij rats
    Hrachya Nersesyan
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 24:589-99. 2004
    ....
  29. pmc Increased resting functional connectivity in spike-wave epilepsy in WAG/Rij rats
    Asht M Mishra
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 6520 8018, USA
    Epilepsia 54:1214-22. 2013
    ..An animal model of this phenomenon would be valuable for investigating fundamental mechanisms and testing therapeutic interventions...
  30. ncbi request reprint Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy
    Joshua P Klein
    Department of Neurology, Yale University School of Medicine, New Haven, and Rehabilitation Research Center, VA Connecticut Healthcare System, West Haven, CT, USA
    Brain Res 1000:102-9. 2004
    ..This region of cortex approximately matches the electrophysiologically determined region of seizure onset. Changes in the expression of Nav1.1 and Nav1.6 parallel age-dependent increases in seizure frequency and duration...
  31. pmc Focal BOLD fMRI changes in bicuculline-induced tonic-clonic seizures in the rat
    Matthew N DeSalvo
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuroimage 50:902-9. 2010
    ....
  32. pmc Remote effects of focal hippocampal seizures on the rat neocortex
    Dario J Englot
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 28:9066-81. 2008
    ..This remote effect of partial seizures may cause impaired cerebral functions, including loss of consciousness...
  33. ncbi request reprint Relative changes in cerebral blood flow and neuronal activity in local microdomains during generalized seizures
    Hrachya Nersesyan
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Cereb Blood Flow Metab 24:1057-68. 2004
    ..The normal response to somatosensory stimulation appears to be poised between two abnormal responses produced by two physiologically different types of seizures...
  34. pmc Cerebral oxygen demand for short-lived and steady-state events
    Peter Herman
    Magnetic Resonance Research Center MRRC, Yale University, New Haven, Connecticut 06520, USA
    J Neurochem 109:73-9. 2009
    ..We discuss the importance of minimizing residual signal, represented by the difference between modeled and raw signals, in convolution analysis of multi-modal signals...
  35. pmc Seizure localization using three-dimensional surface projections of intracranial EEG power
    Hyang Woon Lee
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA Department of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, 1071, Anyangcheon ro, Yangcheon Gu, Seoul 158 710, South Korea
    Neuroimage 83:616-26. 2013
    ..These findings suggest that 3D-SPIER could be an improved diagnostic method for presurgical seizure localization in patients with intractable epilepsy and may also be useful for mapping normal brain function. ..
  36. pmc Ictal spread of medial temporal lobe seizures with and without secondary generalization: an intracranial electroencephalography analysis
    Ji Yeoun Yoo
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, U S A
    Epilepsia 55:289-95. 2014
    ....
  37. pmc Negative BOLD with large increases in neuronal activity
    Ulrich Schridde
    Department of Neurology, Yale University, New Haven, CT 06510, USA
    Cereb Cortex 18:1814-27. 2008
    ..Caution should be used in interpreting fMRI signals because the relationship between neuronal activity and BOLD signals may depend on brain region and state and can be different during normal and pathological conditions...
  38. pmc Consciousness and epilepsy: why are complex-partial seizures complex?
    Dario J Englot
    Department of Neurology, Yale University School of Medicine, New Haven, CT, USA
    Prog Brain Res 177:147-70. 2009
    ....
  39. pmc Quantitative basis for neuroimaging of cortical laminae with calibrated functional MRI
    Peter Herman
    Magnetic Resonance Research Center and Departments of Diagnostic Radiology, Biomedical Engineering, Neurology, and Neurobiology, Yale University, New Haven, CT 06520
    Proc Natl Acad Sci U S A 110:15115-20. 2013
    ..These results lay the framework for quantitative neuroimaging across cortical laminae with calibrated fMRI methods...
  40. doi request reprint Intracranial EEG surface renderings: new insights into normal and abnormal brain function
    Mark W Youngblood
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Neuroscientist 19:238-47. 2013
    ..As new technologies lead to a dramatic increase in the rate of data acquisition, these novel visualization and analysis techniques will play an important role in processing the valuable information obtained through icEEG...
  41. pmc Analysis of time and space invariance of BOLD responses in the rat visual system
    Christopher J Bailey
    Magnetic Resonance Research Center, Yale University, New Haven, CT 06520, USA
    Cereb Cortex 23:210-22. 2013
    ..These results illustrate the importance of measured neural signals for interpretation of fMRI by showing that GLM of BOLD responses may lead to misinterpretation of neural activity in some cases...
  42. pmc Role of ongoing, intrinsic activity of neuronal populations for quantitative neuroimaging of functional magnetic resonance imaging-based networks
    Fahmeed Hyder
    Magnetic Resonance Research Center MRRC, Yale University, New Haven, Connecticut, USA
    Brain Connect 1:185-93. 2011
    ....
  43. pmc Development of spike-wave seizures in C3H/HeJ mice
    Damien J Ellens
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Epilepsy Res 85:53-9. 2009
    ....
  44. ncbi request reprint Focal network involvement in generalized seizures: new insights from electroconvulsive therapy
    Kelly A McNally
    Department of Neurology and Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Epilepsy Behav 5:3-12. 2004
    ..Further studies of this kind may elucidate specific networks in generalized tonic-clonic seizures, providing targets for new therapeutic interventions in epilepsy...
  45. pmc Oxidative neuroenergetics in event-related paradigms
    Basavaraju G Sanganahalli
    Magnetic Resonance Research Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 29:1707-18. 2009
    ..The results identified a component of the BOLD signal that can be attributed to significant changes in CMR(O(2)), even for temporal events separated by <200 ms...
  46. pmc Energetics of neuronal signaling and fMRI activity
    Natasja J G Maandag
    Magnetic Resonance Research Center, Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 104:20546-51. 2007
    ..We discuss implications for interpreting fMRI data where stimulus-specific DeltaCMR(O2) is generally small compared with baseline CMR(O2)...
  47. pmc Functional MRI and neural responses in a rat model of Alzheimer's disease
    Basavaraju G Sanganahalli
    Magnetic Resonance Research Center, Yale University, New Haven, CT 06520, USA
    Neuroimage 79:404-11. 2013
    ....
  48. pmc Prospective assessment of ictal behavior using the revised Responsiveness in Epilepsy Scale (RES-II)
    Andrew Bauerschmidt
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Epilepsy Behav 26:25-8. 2013
    ..We conclude that RES-II has improved accuracy and testing efficiency compared with the original RES. Prospective objective testing will ultimately lead to a better understanding of the mechanisms of impaired consciousness in epilepsy...
  49. pmc New open-source ictal SPECT analysis method implemented in BioImage Suite
    Dustin Scheinost
    Department of Diagnostic Radiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8018, USA
    Epilepsia 51:703-7. 2010
    ..These findings establish a simple, validated and objective method for analyzing ictal-interictal SPECT difference images for use in the care of patients with epilepsy...
  50. ncbi request reprint Lamotrigine suppresses neurophysiological responses to somatosensory stimulation in the rodent
    Ikuhiro Kida
    Magnetic Resonance Research Center MRRC, Yale University, New Haven, CT 06510, USA
    Neuroimage 29:216-24. 2006
    ....
  51. pmc Testing for minimal consciousness in complex partial and generalized tonic-clonic seizures
    Alison McPherson
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Epilepsia 53:e180-3. 2012
    ..Further work may elucidate the specific brain networks underlying relatively spared functions in CPS, ultimately leading to improved treatments aimed at preventing impaired consciousness...
  52. doi request reprint Theories of impaired consciousness in epilepsy
    Lissa Yu
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Ann N Y Acad Sci 1157:48-60. 2009
    ..This review of the major prior theories of impaired consciousness in epilepsy allows us to put more recent data into context and to reach a better understanding of the mechanisms important for normal consciousness...
  53. pmc The default mode network and altered consciousness in epilepsy
    Nathan B Danielson
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8018, USA
    Behav Neurol 24:55-65. 2011
    ..This may represent a push-pull mechanism similar to that seen operating between cortical networks under normal conditions...
  54. ncbi request reprint Comparison of statistical parametric mapping and SPECT difference imaging in patients with temporal lobe epilepsy
    David J Chang
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06501, USA
    Epilepsia 43:68-74. 2002
    ....
  55. pmc A prospective study of loss of consciousness in epilepsy using virtual reality driving simulation and other video games
    Li Yang
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Epilepsy Behav 18:238-46. 2010
    ..This methodology may be applied to further describe differential driving impairment in specific types of seizures and to gain data on anatomical networks disrupted in seizures that impair consciousness and driving safety...
  56. pmc Decreased resting functional connectivity after traumatic brain injury in the rat
    Asht Mangal Mishra
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America Core Center for Quantitative Neuroscience with Magnetic Resonance, Yale University, New Haven, Connecticut, United States of America
    PLoS ONE 9:e95280. 2014
    ..Our data provide the first evidence on abnormal functional connectivity after experimental TBI assessed with resting state BOLD-fMRI. ..
  57. pmc LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology
    Katherine Owuor
    Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Cell Neurosci 42:448-57. 2009
    ..Thus, LGI1 binding to ADAM23 is necessary to correctly pattern neuronal morphology and altered anatomical patterning contributes to ADPEAF...
  58. pmc Symptoms of anxiety and depression in childhood absence epilepsy
    Clemente Vega
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA
    Epilepsia 52:e70-4. 2011
    ..Screening of patients with CAE for comorbid psychiatric disorders early by focusing on specific symptom profiles unique to this population may enhance overall treatment and developmental outcomes...
  59. ncbi request reprint Levetiracetam efficacy in refractory partial-onset seizures, especially after failed epilepsy surgery
    Mahmood Motamedi
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, U S A
    Epilepsia 44:211-4. 2003
    ..We conducted a retrospective study to evaluate the efficacy of levetiracetam as adjunctive therapy in patients with localization-related epilepsy, and specifically in the subset of patients for whom epilepsy surgery failed...
  60. pmc Differentiation of attention-related problems in childhood absence epilepsy
    Clemente Vega
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510, USA
    Epilepsy Behav 19:82-5. 2010
    ..Children with CAE are at risk for certain inattentive and hyperactive problems, which can differ depending on duration of illness and active seizure status...
  61. ncbi request reprint Consciousness of seizures and consciousness during seizures: are they related?
    Kamil Detyniecki
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA Electronic address
    Epilepsy Behav 30:6-9. 2014
    ..Better methods to alert caregivers about unrecognized seizures and to improve seizure documentation are under investigation...
  62. pmc Cerebral energetics and spiking frequency: the neurophysiological basis of fMRI
    Arien J Smith
    Magnetic Resonance Research Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 99:10765-70. 2002
    ..Because DeltaCMR(O2)/CMR(O2) had the same high spatial and temporal resolutions of the fMRI signal, these results show how BOLD imaging, when converted to DeltaCMR(O2)/CMR(O2), responds to localized changes in neuronal spike frequency...
  63. pmc Impaired consciousness in epilepsy investigated by a prospective responsiveness in epilepsy scale (RES)
    Li Yang
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Epilepsia 53:437-47. 2012
    ..Prior work on epileptic unconsciousness has mainly used retrospective and nonstandardized methods. Our goal was to validate and to obtain initial data using a standardized prospective testing battery...
  64. ncbi request reprint Frontal lobe tumoral epilepsy: clinical, neurophysiologic features and predictors of surgical outcome
    Megdad M Zaatreh
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Epilepsia 43:727-33. 2002
    ..To review the clinical, neurophysiologic features and surgical outcomes in patients with frontal lobe tumors and chronic intractable seizures...
  65. pmc Visual memory in patients after anterior right temporal lobectomy and adult normative data for the Brown Location Test
    Franklin C Brown
    Department of Neurosurgery, Yale University, School of Medicine, New Haven, CT, USA
    Epilepsy Behav 17:215-20. 2010
    ..The present findings support a role for the right anterior mesial temporal lobe in dot location learning and memory...
  66. pmc Is epilepsy a preventable disorder? New evidence from animal models
    Kathryn A Giblin
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Neuroscientist 16:253-75. 2010
    ..Hopefully, further investigation of antiepileptogenesis in animal models will soon enable human therapeutic trials to be initiated, leading to long-term epilepsy prevention and improved patient quality of life...
  67. pmc Clinical use of ictal SPECT in secondarily generalized tonic-clonic seizures
    G I Varghese
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    Brain 132:2102-13. 2009
    ..These findings suggest that, with appropriate cautious interpretation, ictal SPECT in secondarily generalized seizures can help localize the region of seizure onset...
  68. pmc Functional neuroimaging of spike-wave seizures
    Joshua E Motelow
    Department of Neurology, Yale University, School of Medicine, New Haven, CT, USA
    Methods Mol Biol 489:189-209. 2009
    ....
  69. pmc Neuroimaging biomarkers of epileptogenesis
    Asht Mangal Mishra
    Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Neurosci Lett 497:194-204. 2011
    ..This review provides a brief summary of the major human and animal studies in both partial and generalized epilepsies that demonstrate the potential of these imaging modalities to serve as biomarkers of epileptogenesis...
  70. ncbi request reprint Going deep to cut the link: cortical disconnection syndrome caused by a thalamic lesion
    D Weisman
    Yale University School of Medicine, Department of Neurology, New Haven, CT 06520, USA
    Neurology 60:1865-6. 2003
  71. pmc Resting functional connectivity between the hemispheres in childhood absence epilepsy
    X Bai
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Neurology 76:1960-7. 2011
    ..Our aim was to investigate whether this abnormal bisynchrony may extend to the interictal period, using a blood oxygen level-dependent (BOLD) resting functional connectivity approach...
  72. ncbi request reprint Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT
    Tamara G Fong
    Department of Neurlogy, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    J Gerontol A Biol Sci Med Sci 61:1294-9. 2006
    ..Prior studies describe variable cerebral blood flow changes in delirium. This study aims to investigate cerebral blood flow changes in older hospitalized patients with delirium, the population in which most cases of delirium occur...

Research Grants12

  1. HIGH FREQUENCY BURST FIRING IN VISUAL CORTEX
    Hal Blumenfeld; Fiscal Year: 2002
    ..The information provided by these studies may yield insights into the mechanisms of normal cortical rhythmic oscillations, and suggest new therapies for the therapeutic management of epileptic seizures. ..
  2. Preventing spike-wave epileptogenesis: critical periods & neuroimaging biomarkers
    Hal Blumenfeld; Fiscal Year: 2009
    ..untreated animals. We will also investigate the anatomical basis of white matter DTI abnormalities through electron microscopy to determine changes in axons and myelin in affected regions. 2. ..
  3. Functional Neuroimaging in Childhood Absence Epilepsy
    Hal Blumenfeld; Fiscal Year: 2009
    ..Understanding mechanisms of impaired attention in this form of epilepsy may have implications for treating other types of epilepsy as well. ..
  4. Functional Neuroimaging in Childhood Absence Epilepsy
    Hal Blumenfeld; Fiscal Year: 2007
    ..Understanding mechanisms of impaired attention in this form of epilepsy may have implications for treating other types of epilepsy as well. ..
  5. Neuronal firing and neuroimaging in spike-wave seizures
    Hal Blumenfeld; Fiscal Year: 2006
    ..The approach used in this well-characterized model may also enhance the ability to interpret noninvasive epilepsy neuroimaging studies in humans. ..
  6. Neuronal firing and neuroimaging in spike-wave seizures
    Hal Blumenfeld; Fiscal Year: 2007
    ..The approach used in this well-characterized model may also enhance the ability to interpret noninvasive epilepsy neuroimaging studies in humans. ..
  7. Functional Neuroimaging in Childhood Absence Epilepsy
    Hal Blumenfeld; Fiscal Year: 2006
    ..Understanding mechanisms of impaired attention in this form of epilepsy may have implications for treating other types of epilepsy as well. ..
  8. Neuronal firing and neuroimaging in spike-wave seizures
    Hal Blumenfeld; Fiscal Year: 2006
    ..The approach used in this well-characterized model may also enhance the ability to interpret noninvasive epilepsy neuroimaging studies in humans. ..
  9. Neuronal firing and neuroimaging in spike-wave seizures
    Hal Blumenfeld; Fiscal Year: 2005
    ..The approach used in this well-characterized model may also enhance the ability to interpret noninvasive epilepsy neuroimaging studies in humans. ..
  10. Neuronal firing and neuroimaging in spike-wave seizures
    Hal Blumenfeld; Fiscal Year: 2004
    ..The approach used in this well-characterized model may also enhance the ability to interpret noninvasive epilepsy neuroimaging studies in humans. ..
  11. Preventing spike-wave epileptogenesis: critical periods & neuroimaging biomarkers
    Hal Blumenfeld; Fiscal Year: 2010
    ..untreated animals. We will also investigate the anatomical basis of white matter DTI abnormalities through electron microscopy to determine changes in axons and myelin in affected regions. 2. ..