Michael H Bloch

Summary

Affiliation: Yale University
Country: USA

Publications

  1. doi request reprint Clinical course of Tourette syndrome
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Psychosom Res 67:497-501. 2009
  2. doi request reprint Long-term outcome in adults with obsessive-compulsive disorder
    Michael H Bloch
    Child Study Center, Yale University, New Haven, CT, USA
    Depress Anxiety 30:716-22. 2013
  3. pmc N-acetylcysteine in the treatment of pediatric trichotillomania: a randomized, double-blind, placebo-controlled add-on trial
    Michael H Bloch
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 52:231-40. 2013
  4. pmc Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis
    M H Bloch
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Psychiatry 17:1272-82. 2012
  5. pmc Meta-analysis of LCPUFA supplementation of infant formula and visual acuity
    Ahmad Qawasmi
    Child Study Center and cDepartment of Psychiatry, Yale University, New Haven, Connecticut 06520, USA
    Pediatrics 131:e262-72. 2013
  6. pmc Effects of ketamine in treatment-refractory obsessive-compulsive disorder
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 72:964-70. 2012
  7. ncbi request reprint Paraneoplastic limbic encephalitis: ovarian cancer presenting as an amnesic syndrome
    Michael H Bloch
    Department of Neurology and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA
    Obstet Gynecol 104:1174-7. 2004
  8. doi request reprint Meta-analysis of the symptom structure of obsessive-compulsive disorder
    Michael H Bloch
    Yale Child Study Center, 230 South Frontage Rd, New Haven, CT 06520, USA
    Am J Psychiatry 165:1532-42. 2008
  9. pmc Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder
    M H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Psychiatry 15:850-5. 2010
  10. doi request reprint Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 48:884-93. 2009

Collaborators

Detail Information

Publications46

  1. doi request reprint Clinical course of Tourette syndrome
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Psychosom Res 67:497-501. 2009
    ..The goal of this article was to review the long-term clinical course of tics and comorbid conditions in children with TS...
  2. doi request reprint Long-term outcome in adults with obsessive-compulsive disorder
    Michael H Bloch
    Child Study Center, Yale University, New Haven, CT, USA
    Depress Anxiety 30:716-22. 2013
    ..However, these studies were conducted before validated OCD rating scales were established and the development of evidence-based treatments for OCD...
  3. pmc N-acetylcysteine in the treatment of pediatric trichotillomania: a randomized, double-blind, placebo-controlled add-on trial
    Michael H Bloch
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 52:231-40. 2013
    ..To examine the efficacy of N-acetylcysteine (NAC) for the treatment of pediatric trichotillomania (TTM) in a double-blind, placebo-controlled, add-on study...
  4. pmc Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis
    M H Bloch
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Psychiatry 17:1272-82. 2012
    ..Current published trials suggest a small, non-significant benefit of omega-3 FAs for major depression. Nearly all of the treatment efficacy observed in the published literature may be attributable to publication bias...
  5. pmc Meta-analysis of LCPUFA supplementation of infant formula and visual acuity
    Ahmad Qawasmi
    Child Study Center and cDepartment of Psychiatry, Yale University, New Haven, Connecticut 06520, USA
    Pediatrics 131:e262-72. 2013
    ..This meta-analysis was conducted to evaluate whether LCPUFA supplementation of infant formulas improves infants' visual acuity...
  6. pmc Effects of ketamine in treatment-refractory obsessive-compulsive disorder
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 72:964-70. 2012
    ..Ketamine is a potent noncompetitive antagonist of the N-methyl-D-aspartate glutamate receptor. Trials have reported rapid antidepressant effects after low-dose ketamine infusion...
  7. ncbi request reprint Paraneoplastic limbic encephalitis: ovarian cancer presenting as an amnesic syndrome
    Michael H Bloch
    Department of Neurology and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA
    Obstet Gynecol 104:1174-7. 2004
    ..Paraneoplastic limbic encephalitis typically presents with short-term memory loss, seizures, or other limbic system abnormalities. The majority of PLE cases are associated with lung and testicular cancer...
  8. doi request reprint Meta-analysis of the symptom structure of obsessive-compulsive disorder
    Michael H Bloch
    Yale Child Study Center, 230 South Frontage Rd, New Haven, CT 06520, USA
    Am J Psychiatry 165:1532-42. 2008
    ..The authors conducted a meta-analysis to determine the factor structure of the Yale-Brown Obsessive Compulsive Scale Symptom Checklist...
  9. pmc Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder
    M H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Psychiatry 15:850-5. 2010
    ..This greater treatment efficacy is somewhat counterbalanced by the greater side-effect burden with higher doses of SSRIs. At present, there are insufficient data to generalize these findings to children or adolescents with OCD...
  10. doi request reprint Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 48:884-93. 2009
    ..We sought to determine the relative efficacy of different medications in treating ADHD and tic symptoms in children with both Tourette's syndrome and ADHD...
  11. doi request reprint Predictors of early adult outcomes in pediatric-onset obsessive-compulsive disorder
    Michael H Bloch
    Child Study Center, Yale University School of Medicine, PO Box 2070900, New Haven, CT 06520, USA
    Pediatrics 124:1085-93. 2009
    ....
  12. ncbi request reprint Emerging treatments for Tourette's disorder
    Michael H Bloch
    Yale Child Study Center, 230 South Frontage Road, New Haven, CT 06520, USA
    Curr Psychiatry Rep 10:323-30. 2008
    ..This article examines the evidence base for current treatments for Tourette's disorder. Emerging treatments such as deep brain stimulation, habit reversal therapy, and repetitive trans-cranial magnetic stimulation are also discussed...
  13. pmc Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 50:991-1000. 2011
    ..Cell membrane fluidity can alter serotonin and dopamine neurotransmission. The goal of this meta-analysis was to examine the efficacy of omega-3 fatty acid supplementation in children with ADHD...
  14. doi request reprint Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med Genet B Neuropsychiatr Genet 147:850-8. 2008
    ..Further meta-analyses based on individual patient data would be helpful in determining whether age of OCD onset, gender and the presence of comorbid illness (e.g., tics) moderates the relationship between 5-HTTLPR and OCD...
  15. ncbi request reprint Systematic review: pharmacological and behavioral treatment for trichotillomania
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Psychiatry 62:839-46. 2007
    ..Future therapy and pharmacotherapy studies in trichotillomania should employ larger sample sizes and intention-to-treat analysis and seek to validate clinical rating scales of trichotillomania severity...
  16. pmc Poor fine-motor and visuospatial skills predict persistence of pediatric-onset obsessive-compulsive disorder into adulthood
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine 06520, USA
    J Child Psychol Psychiatry 52:974-83. 2011
    ..Our goal was to examine the association between childhood performance on neuropsychological testing and persistence of OCD into adulthood...
  17. ncbi request reprint A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder
    M H Bloch
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Psychiatry 11:622-32. 2006
    ..Patients with comorbid tics are likely to have a differential benefit to antipsychotic augmentation...
  18. doi request reprint Dimensional predictors of response to SRI pharmacotherapy in obsessive-compulsive disorder
    Angeli Landeros-Weisenberger
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    J Affect Disord 121:175-9. 2010
    ..Our objective was to replicate these results in OCD patients who participated in one of four randomized, placebo-controlled, clinical trials (RCT)...
  19. pmc Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome
    Michael H Bloch
    Yale Child Study Center, and General Clinical Research Center, Yale University School of Medicine, New Haven, CT 06520 7900, USA
    Arch Pediatr Adolesc Med 160:65-9. 2006
    ..One half to two thirds of children with TS experience a reduction or complete resolution of tic symptoms during adolescence. At least one third of adults with TS have comorbid obsessive-compulsive disorder (OCD)...
  20. ncbi request reprint Fine-motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome
    Michael H Bloch
    Yale Child Study Center, CT 06510, USA
    J Child Psychol Psychiatry 47:551-9. 2006
    ..Patients with TS have deficits on neuropsychological tests involving fine-motor coordination and visual-motor integration. We seek to determine if these neuropsychological tests are useful in predicting future symptom severity...
  21. pmc Symptom dimensions and subtypes of obsessive-compulsive disorder: a developmental perspective
    James F Leckman
    Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520 7900, USA
    Dialogues Clin Neurosci 11:21-33. 2009
    ....
  22. pmc Predictors of early adulthood quality of life in children with obsessive-compulsive disorder
    Sean D Palermo
    Yale Child Study Center, Yale University School of Medicine, PO Box 2070900, New Haven, CT 06520, USA
    Soc Psychiatry Psychiatr Epidemiol 46:291-7. 2011
    ..The goal of this study was to determine childhood clinical predictors of quality of life (QoL) in early adulthood in children with obsessive-compulsive disorder (OCD)...
  23. ncbi request reprint Tourette syndrome: the self under siege
    James F Leckman
    Yale Child Study Center, New Haven, CT 06510, USA
    J Child Neurol 21:642-9. 2006
    ....
  24. pmc Systematic review: pharmacological treatment of tic disorders--efficacy of antipsychotic and alpha-2 adrenergic agonist agents
    Hannah Weisman
    Yale Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Neurosci Biobehav Rev 37:1162-71. 2013
    ..15 (95%CI: -0.06 to 0.36). Our findings demonstrated significant benefit of both antipsychotics and alpha-2 agonists in treating tics but suggest alpha-2 agonists may have minimal benefit in tic patients without ADHD...
  25. pmc NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
    Alan Anticevic
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 109:16720-5. 2012
    ..Together, the present findings establish links between glutamate's role in the organization of large-scale anticorrelated neural systems, cognition, and symptoms associated with schizophrenia in humans...
  26. pmc Meta-analysis of long-chain polyunsaturated fatty acid supplementation of formula and infant cognition
    Ahmad Qawasmi
    Yale Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    Pediatrics 129:1141-9. 2012
    ..We conducted this meta-analysis to examine the efficacy of LCPUFA supplementation of infant formula on early cognitive development...
  27. pmc Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome
    Michael H Bloch
    Child Study Center, Yale University School of Medicine, New Haven, CT, USA
    Neurology 65:1253-8. 2005
    ..Currently no clinical measures can predict whose tic symptoms will persist into adulthood. Previous cross-sectional imaging studies have identified reduced caudate nucleus volumes in subjects with TS...
  28. doi request reprint Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder
    Alan Anticevic
    Department of Psychiatry, Yale University Abraham Ribicoff Research Facilities, Yale University NIAAA Center for the Translational Neuroscience of Alcoholism, Yale University
    Biol Psychiatry 75:595-605. 2014
    ..A hypothesis-neutral, data-driven approach to the analysis of connectivity is vital...
  29. pmc Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder
    Stephen A Kichuk
    Department of Psychiatry, Yale University, United States
    Prog Neuropsychopharmacol Biol Psychiatry 44:233-9. 2013
    ..Subjects with primary OCD symptoms in the forbidden thoughts dimension were more likely to report a waxing-and-waning course, whereas symmetry symptoms were less likely to be associated with a waxing-and-waning course...
  30. ncbi request reprint Phenomenology of tics and natural history of tic disorders
    James F Leckman
    Child Study Center, Sterling Hall of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Adv Neurol 99:1-16. 2006
  31. doi request reprint Family accommodation in obsessive-compulsive disorder
    Eli R Lebowitz
    Yale Child Study Center, 230 S Frontage Rd, New Haven, CT 06520, USA
    Expert Rev Neurother 12:229-38. 2012
    ..Family accommodation represents important clinical data that is worth measuring, monitoring and tracking in clinical care. Therapies targeting family accommodation may be successful in improving treatment outcomes in OCD...
  32. pmc Cognitive-behavioral therapy for anxiety in children with high-functioning autism: a meta-analysis
    Denis G Sukhodolsky
    Yale Child Study Center, 230 South Frontage Road, New Haven, CT 06520
    Pediatrics 132:e1341-50. 2013
    ..Anxiety is a common and impairing problem in children and adolescents with autism spectrum disorder (ASD). There is emerging evidence that cognitive-behavioral therapy (CBT) could reduce anxiety in children with high-functioning ASD...
  33. pmc Clinical assessment of Tourette syndrome and tic disorders
    Stephanie C Cohen
    Yale University School of Medicine, New Haven, CT 06520, USA
    Neurosci Biobehav Rev 37:997-1007. 2013
    ..Proper diagnosis and treatment of TS involves appropriate evaluation and recognition, not only of tics, but also of these associated conditions...
  34. pmc Time-lag bias in trials of pediatric antidepressants: a systematic review and meta-analysis
    Magdalena M Reyes
    Yale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 50:63-72. 2011
    ..To determine whether there is evidence of a time-lag bias in the publication of pediatric antidepressant trials...
  35. pmc D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders: a meta-analysis
    Allyson Bontempo
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Psychiatry 73:533-7. 2012
    ..To determine the efficacy of D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders...
  36. doi request reprint Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: initial findings
    Nazlee Zebardast
    Yale School of Medicine, New Haven, CT, USA
    Psychiatry Res 214:33-41. 2013
    ....
  37. pmc The impact of NMDA receptor blockade on human working memory-related prefrontal function and connectivity
    Naomi R Driesen
    1 Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT, USA 2 Department of Neurology, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 38:2613-22. 2013
    ..These results support the hypothesis that NMDA-Rs are critical for WM. The knowledge gained may be helpful in understanding disorders that might involve glutamatergic deficits such as schizophrenia and developing better treatments. ..
  38. doi request reprint Two cases of delayed-onset suicidal ideation, dysphoria and anxiety after ketamine infusion in patients with obsessive-compulsive disorder and a history of major depressive disorder
    Mark J Niciu
    Yale University, Department of Psychiatry Connecticut Mental Health Center CMHC, Clinical Neuroscience Research Unit CNRU, New Haven, Connecticut, USA
    J Psychopharmacol 27:651-4. 2013
    ..We conclude that there remains insufficient data on therapeutic ketamine in the presence of comorbid psychiatric disorders to promote its off-label use in a non-research milieu. ..
  39. pmc Age and gender correlates of pulling in pediatric trichotillomania
    Kaitlyn E Panza
    Child Study Center, Yale University, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 52:241-9. 2013
    ..Our goals were to examine clinical characteristics and age and gender correlates in pediatric trichotillomania...
  40. pmc Systematic review of proinflammatory cytokines in obsessive-compulsive disorder
    Simon M Gray
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Curr Psychiatry Rep 14:220-8. 2012
    ..Future studies examining immune function in OCD should adjust for potential confounding due to medication use and comorbid depression. Further studies assessing cerebrospinal fluid cytokine levels in OCD are also needed...
  41. pmc Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment
    Christopher Pittenger
    Department of Psychiatry, Yale University School of Medicine, USA
    Pharmacol Ther 132:314-32. 2011
    ....
  42. pmc Neurobiological substrates of Tourette's disorder
    James F Leckman
    Child Study Center, Yale University, New Haven, Connecticut 06520 7900, USA
    J Child Adolesc Psychopharmacol 20:237-47. 2010
    ..This article reviews the available scientific literature concerning the neurobiological substrates of Tourette's disorder (TD)...
  43. doi request reprint Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice
    Lissandra Castellan Baldan
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuron 81:77-90. 2014
    ..These data confirm histidine decarboxylase deficiency as a rare cause of TS and identify HA-DA interactions in the basal ganglia as an important locus of pathology. ..
  44. doi request reprint Riluzole augmentation in treatment-refractory obsessive-compulsive disorder: a series of 13 cases, with long-term follow-up
    Christopher Pittenger
    J Clin Psychopharmacol 28:363-7. 2008
  45. ncbi request reprint Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with trichotillomania
    Vladimir Coric
    J Clin Psychiatry 68:170-1. 2007
  46. ncbi request reprint A developmental and evolutionary perspective on obsessive-compulsive disorder: whence and whither compulsive hoarding?
    James F Leckman
    Am J Psychiatry 165:1229-33. 2008