J A Black
Affiliation: Yale University
Black J, Waxman S. Sodium channels and microglial function. Exp Neurol. 2012;234:302-15 pubmed publisher
..These studies also provide strong evidence that Nav1.6 is the predominant sodium channel isoform expressed in microglia and that its activity contributes to the response of microglia to multiple activating signals. ..
Rice F, Albrecht P, Wymer J, Black J, Merkies I, Faber C, et al
. Sodium channel Nav1.7 in vascular myocytes, endothelium, and innervating axons in human skin. Mol Pain. 2015;11:26 pubmed publisher
..These observations suggest that the activity of mutant Nav1.7 channels in smooth muscle cells of skin vasculature and innervating sensory and sympathetic fibers contribute to the skin reddening and/or pain in IEM and PEPD. ..
Black J, Waxman S, Smith K. Remyelination of dorsal column axons by endogenous Schwann cells restores the normal pattern of Nav1.6 and Kv1.2 at nodes of Ranvier. Brain. 2006;129:1319-29 pubmed
..6 the predominant subtype of sodium channel present at such nodes at all stages of their development. ..
Black J, Liu S, Hains B, Saab C, Waxman S. Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE. Brain. 2006;129:3196-208 pubmed
..These observations demonstrate that phenytoin provides long-term protection of CNS axons and improves clinical status in both monophasic and chronic-relapsing models of neuroinflammation. ..
Black J, Waxman S. Phenytoin protects central axons in experimental autoimmune encephalomyelitis. J Neurol Sci. 2008;274:57-63 pubmed publisher
..Our results also, however, indicate that we need to learn more about the long-term effects of sodium-channel blockers, and of their withdrawal, in neuroinflammatory disorders. ..
Black J, Renganathan M, Waxman S. Sodium channel Na(v)1.6 is expressed along nonmyelinated axons and it contributes to conduction. Brain Res Mol Brain Res. 2002;105:19-28 pubmed
..These observations indicate that Na(v)1.6 functions not only in saltatory conduction in myelinated axons but also in continuous conduction in nonmyelinated axons. ..
Black J, Newcombe J, Trapp B, Waxman S. Sodium channel expression within chronic multiple sclerosis plaques. J Neuropathol Exp Neurol. 2007;66:828-37 pubmed
..6 and NCX in acute lesions but independent of coexpression of these 2 molecules in chronic lesions. ..
Black J, Nikolajsen L, Kroner K, Jensen T, Waxman S. Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas. Ann Neurol. 2008;64:644-53 pubmed publisher
..We also examined the expression of two mitogen-activated protein (MAP) kinases, activated p38 and extracellular signal-regulated kinases 1 and 2 (ERK1/2), which are known to contribute to chronic pain, within these human neuromas...
Black J, Liu S, Waxman S. Sodium channel activity modulates multiple functions in microglia. Glia. 2009;57:1072-81 pubmed publisher
..6) indicate that Nav1.6 plays a role in microglial migration. The results demonstrate that the activity of sodium channels contributes to effector roles of activated microglia. ..