V Bhandari

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Molecular mechanisms of hyperoxia-induced acute lung injury
    Vineet Bhandari
    Division of Perinatal Medicine, Yale University School of Medicine, Department of Pediatrics, 333 Cedar Street, LCI 401B, New Haven, CT 06520 8064, USA
    Front Biosci 13:6653-61. 2008
  2. pmc SNIPPV vs NIPPV: does synchronization matter?
    V Dumpa
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    J Perinatol 32:438-42. 2012
  3. pmc A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung
    Huanxing Sun
    Department of Pediatrics, Yale University, New Haven, Connecticut, United States of America
    PLoS ONE 8:e60560. 2013
  4. pmc Small molecular modulation of macrophage migration inhibitory factor in the hyperoxia-induced mouse model of bronchopulmonary dysplasia
    Huanxing Sun
    Department of Pediatrics, Yale University, New Haven, CT 06520, USA
    Respir Res 14:27. 2013
  5. doi request reprint The potential of non-invasive ventilation to decrease BPD
    Vineet Bhandari
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Semin Perinatol 37:108-14. 2013
  6. ncbi request reprint Noninvasive respiratory support in the preterm infant
    Vineet Bhandari
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, Yale Child Health Research Center, Room 219, PO Box 208081, 464 Congress Avenue, New Haven, CT 06520, USA
    Clin Perinatol 39:497-511. 2012
  7. pmc Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2
    Vineet Bhandari
    Division of Perinatal Medicine, Yale University School of Medicine, Department of Pediatrics, Children s Hospital, 20 York Street, New Haven, CT 06520 8057, USA
    Am J Respir Cell Mol Biol 46:668-76. 2012
  8. ncbi request reprint A randomized controlled trial of synchronized nasal intermittent positive pressure ventilation in RDS
    V Bhandari
    Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, PA, USA
    J Perinatol 27:697-703. 2007
  9. doi request reprint Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker
    Vineet Bhandari
    Department of Pediatrics, Division of Perinatal Medicine, Yale University School of Medicine, LCI 401B, PO Box 208064, New Haven, CT 06520 8064, USA
    Pediatrics 121:129-34. 2008
  10. ncbi request reprint The role of angiopoietin 2 in hyperoxia-induced acute lung injury
    Vineet Bhandari
    Divison of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Cell Cycle 6:1049-52. 2007

Research Grants

Detail Information

Publications78

  1. ncbi request reprint Molecular mechanisms of hyperoxia-induced acute lung injury
    Vineet Bhandari
    Division of Perinatal Medicine, Yale University School of Medicine, Department of Pediatrics, 333 Cedar Street, LCI 401B, New Haven, CT 06520 8064, USA
    Front Biosci 13:6653-61. 2008
    ..Significant differences exist in the response of the mature and developing lung to HALI...
  2. pmc SNIPPV vs NIPPV: does synchronization matter?
    V Dumpa
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    J Perinatol 32:438-42. 2012
    ..Use of NIPPV in the neonatal intensive care unit has shown promise with better clinical outcomes in premature neonates. It is not known if synchronization makes a significant clinical impact when using this technique...
  3. pmc A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung
    Huanxing Sun
    Department of Pediatrics, Yale University, New Haven, Connecticut, United States of America
    PLoS ONE 8:e60560. 2013
    ..The role and mechanism of action of MIF in hyperoxia-induced acute lung injury (HALI) in the newborn lung are not known. We hypothesized that MIF is a critical regulatory molecule in HALI in the developing lung...
  4. pmc Small molecular modulation of macrophage migration inhibitory factor in the hyperoxia-induced mouse model of bronchopulmonary dysplasia
    Huanxing Sun
    Department of Pediatrics, Yale University, New Haven, CT 06520, USA
    Respir Res 14:27. 2013
    ..The role and mechanism of action of MIF in bronchopulmonary dysplasia (BPD) are not known. We hypothesized that increased MIF signaling would ameliorate the pulmonary phenotype of BPD in the mouse lung...
  5. doi request reprint The potential of non-invasive ventilation to decrease BPD
    Vineet Bhandari
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Semin Perinatol 37:108-14. 2013
    ..Research efforts are summarized, and some guidelines are suggested for clinical use of these techniques in neonates...
  6. ncbi request reprint Noninvasive respiratory support in the preterm infant
    Vineet Bhandari
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, Yale Child Health Research Center, Room 219, PO Box 208081, 464 Congress Avenue, New Haven, CT 06520, USA
    Clin Perinatol 39:497-511. 2012
    ..This article summarizes these studies and suggests strategies for the use of nasal intermittent positive pressure ventilation in neonates...
  7. pmc Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2
    Vineet Bhandari
    Division of Perinatal Medicine, Yale University School of Medicine, Department of Pediatrics, Children s Hospital, 20 York Street, New Haven, CT 06520 8057, USA
    Am J Respir Cell Mol Biol 46:668-76. 2012
    ..They also demonstrate that this response is mediated, at least in part, by the ability of NOS2 to inhibit hyperoxia-induced Ang2 production and thereby decrease Ang2-induced tissue injury...
  8. ncbi request reprint A randomized controlled trial of synchronized nasal intermittent positive pressure ventilation in RDS
    V Bhandari
    Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, PA, USA
    J Perinatol 27:697-703. 2007
    ..Comparison of outcomes of infants with respiratory distress syndrome (RDS), post-surfactant, extubated to synchronized nasal intermittent positive pressure ventilation (SNIPPV) or continued on conventional ventilation (CV)...
  9. doi request reprint Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker
    Vineet Bhandari
    Department of Pediatrics, Division of Perinatal Medicine, Yale University School of Medicine, LCI 401B, PO Box 208064, New Haven, CT 06520 8064, USA
    Pediatrics 121:129-34. 2008
    ..The goal was to determine the utility of neutrophil CD64 as a diagnostic marker for sepsis in neonates...
  10. ncbi request reprint The role of angiopoietin 2 in hyperoxia-induced acute lung injury
    Vineet Bhandari
    Divison of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Cell Cycle 6:1049-52. 2007
    ..The clinical significance of our findings was highlighted by the detection of increased Angiopoietin 2 levels in patients with ALI...
  11. ncbi request reprint Making babies breathe better: hopeful signals?
    Vineet Bhandari
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Pediatr Res 64:123-4. 2008
  12. ncbi request reprint The genetics of bronchopulmonary dysplasia
    Vineet Bhandari
    Division of Perinatal Medicine and Yale Child Health Research Center, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Semin Perinatol 30:185-91. 2006
    ..004, 95% CI = 16%-89%) of the variance in liability for BPD. Incremental improvements will likely depend on identification of these genetic components for targeting specific therapies...
  13. pmc Developmental regulation of NO-mediated VEGF-induced effects in the lung
    Vineet Bhandari
    Division of Perinatal Medicine, Yale University School of Medicine, Department of Pediatrics, New Haven, CT 06520 8057, USA
    Am J Respir Cell Mol Biol 39:420-30. 2008
    ..This opens up the possibility of selective manipulation of any VEGF-based intervention using NO inhibitors for maximal potential clinical benefit...
  14. pmc Genetic contribution to patent ductus arteriosus in the premature newborn
    Vineet Bhandari
    Yale University School of Medicine, Department of Pediatrics, 333 Cedar St, PO Box 208064, New Haven, CT 06520 8064, USA
    Pediatrics 123:669-73. 2009
    ..In addition to prematurity and environmental factors, we hypothesized that genetic factors play a significant role in this condition...
  15. pmc Synchronized nasal intermittent positive-pressure ventilation and neonatal outcomes
    Vineet Bhandari
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Pediatrics 124:517-26. 2009
    ..Limited information is available on the outcomes of infants managed with SNIPPV...
  16. pmc Hyperoxia-derived lung damage in preterm infants
    Vineet Bhandari
    Division of Perinatal Medicine, Yale University School of Medicine, Department of Pediatrics, New Haven, CT 06520 8064, USA
    Semin Fetal Neonatal Med 15:223-9. 2010
    ..The focus will be on agents that contribute to hyperoxia-induced lung injury in developmentally appropriate animal models, and those that have been detected in human premature neonates...
  17. pmc Cord blood erythropoietin and interleukin-6 for prediction of intraventricular hemorrhage in the preterm neonate
    Vineet Bhandari
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    J Matern Fetal Neonatal Med 24:673-9. 2011
    ..To evaluate cord blood erythropoietin (EPO) and interleukin-6 (IL-6) levels to predict preterm infants at risk of developing intraventricular hemorrhage (IVH)...
  18. pmc A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung
    Zhang Li
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    BMC Cell Biol 12:54. 2011
    ..We hypothesized that the JNK pathway is an important regulator of hyperoxia-induced pulmonary responses in the developing murine lung...
  19. ncbi request reprint Cytokines in tolerance to hyperoxia-induced injury in the developing and adult lung
    Vineet Bhandari
    Divison of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Free Radic Biol Med 41:4-18. 2006
    ..Designing a therapeutic approach to counteract oxygen toxicity in the adult and immature lung first needs understanding of the unique responses in each scenario...
  20. ncbi request reprint Morphine administration and short-term pulmonary outcomes among ventilated preterm infants
    Vineet Bhandari
    Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA
    Pediatrics 116:352-9. 2005
    ..The use of opioid therapy for sedation and analgesia among ventilated infants varies among care providers. The impact of opioid therapy early in the neonatal course of respiratory distress syndrome (RDS) on pulmonary outcomes is not known...
  21. ncbi request reprint Nasal intermittent positive pressure ventilation in the newborn: review of literature and evidence-based guidelines
    V Bhandari
    Department of Pediatrics, Division of Perinatal Medicine, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    J Perinatol 30:505-12. 2010
    ..This article will critically review the literature and provide some practical guidelines of the use of this technique in neonates...
  22. ncbi request reprint Developmental differences in the role of interleukins in hyperoxic lung injury in animal models
    Vineet Bhandari
    Department of Pediatrics, Children s Hospital, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Front Biosci 7:d1624-33. 2002
    ..Designing a therapeutic approach to counteract oxygen toxicity in the immature lung first needs understanding of the unique responses in the newborn...
  23. ncbi request reprint The role of nitric oxide in hyperoxia-induced injury to the developing lung
    Vineet Bhandari
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, Children s Hospital, New Haven, CT 06520 8064, USA
    Front Biosci 8:e361-9. 2003
    ..In the human newborn, use of iNO in infants< 34 weeks of gestation should be considered experimental, pending results of ongoing trials...
  24. ncbi request reprint Hyperoxia and nitric oxide reduce surfactant components (DSPC and surfactant proteins) and increase apoptosis in adult and fetal rat type II pneumocytes
    V Bhandari
    Department of Pediatrics, Albert Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141, USA
    Lung 180:301-17. 2002
    ..The effect of hyperoxia and NO could be abrogated with catalase and superoxide dismutase. These findings may have significant clinical implications in the use of NO in premature infants...
  25. ncbi request reprint Current incidence of retinopathy of prematurity, 1989-1997
    N Hussain
    Department of Pediatrics, University of Connecticut School of Medicine, John Dempsey Hospital, Farmington, Connecticut 06030 2498, USA
    Pediatrics 104:e26. 1999
    ..To report the current incidence and the need for surgery for retinopathy of prematurity (ROP) in neonates (22-36 weeks' gestational age [GA], July 1, 1989 through June 30, 1997)...
  26. ncbi request reprint Pulmonary hemorrhage in neonates of early and late gestation
    V Bhandari
    Department of Pediatrics, University of Connecticut Health Center, Farmington, USA
    J Perinat Med 27:369-75. 1999
    ..We have identified 2 groups of neonates with distinct factors associated with PH; use of 1:10,000 epinephrine (0.1 ml/kg) and/or 4% cocaine (4 mg/kg) may be useful adjuncts to increases in MAP for management of PH...
  27. ncbi request reprint Site-specific characteristics of infants developing bronchopulmonary dysplasia
    M Akram Khan
    Division of Neonatology, Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, PA, USA
    J Perinatol 26:428-35. 2006
    ..Objectives:To evaluate the demographic, nutrition and growth characteristics of infants at risk for developing BPD at two neonatal intensive care units (NICUs: sites A and O)...
  28. doi request reprint High-mobility group box-1 protein in tracheal aspirates from premature infants: relationship with bronchopulmonary dysplasia and steroid therapy
    Z H Aghai
    Department of Pediatrics, Cooper University Hospital, Camden, NJ, USA
    J Perinatol 30:610-5. 2010
    ..We studied the association between HMGB1 levels in tracheal aspirates (TAs) and adverse outcomes (BPD/death) in ventilated premature infants (VPIs) and modulation of HMGB1 levels with dexamethasone (Dex) use...
  29. doi request reprint Pitfalls, problems, and progress in bronchopulmonary dysplasia
    Anita Bhandari
    Division of Pediatric Pulmonology, Connecticut Children s Medical Center, Hartford, Connecticut, USA
    Pediatrics 123:1562-73. 2009
    ..Finally, recent data on long-term pulmonary and neurodevelopmental outcomes of infants with bronchopulmonary dysplasia will be summarized...
  30. ncbi request reprint Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia
    Rayman Choo-Wing
    Department of Pediatrics, Division of Perinatal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Am J Physiol Lung Cell Mol Physiol 293:L142-50. 2007
    ..In contrast to the protective effects in adults, there was no survival advantage to the NB IL-13 mice in hyperoxia. These findings imply that caution should be exercised in extrapolating results from the adult to the NB...
  31. ncbi request reprint Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Perinatal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Pediatr Res 61:318-24. 2007
    ..To conclude, AF proteomic analysis shows that women with MR scores 3-4 are more likely to have histologic funisitis, and deliver neonates with early-onset sepsis...
  32. pmc Fetal inflammatory response in women with proteomic biomarkers characteristic of intra-amniotic inflammation and preterm birth
    C S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    BJOG 116:257-67. 2009
    ..To determine the relationship between presence of amniotic fluid (AF) biomarkers characteristic of inflammation (defensins 2 and 1 and calgranulins C and A) and fetal inflammatory status at birth...
  33. ncbi request reprint Effect of antioxidants on apoptosis and cytokine release in fetal rat Type II pneumocytes exposed to hyperoxia and nitric oxide
    L Johnson-Varghese
    Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, PA, USA
    Cytokine 28:10-6. 2004
    ..Our data suggest that the use of SOD and/or IL-10 may decrease hyperoxic lung injury by decreasing apoptosis. Further studies are needed to understand the mode of protection from catalase and GSPE...
  34. pmc Fetal heart rate monitoring patterns in women with amniotic fluid proteomic profiles indicative of inflammation
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Perinatol 25:359-72. 2008
    ..An abnormal FHR-MP can thus raise the level of awareness that a fetus with EONS may be born, but it is not a useful clinical indicator of the need for antibiotic treatment of the neonate...
  35. ncbi request reprint Clinical correlations in infants in the neonatal intensive care unit with varying severity of gastroesophageal reflux
    M N Khalaf
    Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141, USA
    J Pediatr Gastroenterol Nutr 32:45-9. 2001
    ..Infants with severe GER also had prolonged hospital stays. Early diagnosis and aggressive management of GER may decrease neonatal morbidity and result in earlier discharge from the NICU...
  36. ncbi request reprint Angiopoietin 2 concentrations in infants developing bronchopulmonary dysplasia: attenuation by dexamethasone
    Z H Aghai
    Department of Pediatrics, Cooper University Hospital Robert Wood Johnson Medical School, UMDNJ Camden, NJ, USA
    J Perinatol 28:149-55. 2008
    ....
  37. ncbi request reprint Early markers of late-onset sepsis in premature neonates: clinical, hematological and cytokine profile
    Blanca E Gonzalez
    Department of Medicine, Division of Neonatology, Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, USA
    J Perinat Med 31:60-8. 2003
    ..Late-onset sepsis in the NICU is a major problem associated with high morbidity and mortality...
  38. ncbi request reprint A prospective randomized, controlled trial comparing synchronized nasal intermittent positive pressure ventilation versus nasal continuous positive airway pressure as modes of extubation
    M N Khalaf
    Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA
    Pediatrics 108:13-7. 2001
    ..1 times higher (95% confidence interval: 3.4, 130.1) than that of the NCPAP group. CONCLUSIONS: SNIPPV is more effective than NCPAP in weaning infants with RDS from the ventilator. PFT may be useful in predicting successful extubation...
  39. ncbi request reprint A prospective controlled trial of albuterol aerosol delivered via metered dose inhaler-spacer device (MDI) versus jet nebulizer in ventilated preterm neonates
    M N Khalaf
    Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141, USA
    Am J Perinatol 18:169-74. 2001
    ..Furthermore, it was also cost-effective as one MDI-spacer treatment costs 2 cents, while a Jet treatment costs 10 cents in our neonatal intensive care unit (NICU)...
  40. ncbi request reprint Release of cytokines and apoptosis in fetal rat Type II pneumocytes exposed to hyperoxia and nitric oxide: modulatory effects of dexamethasone and pentoxifylline
    R Gavino
    Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, PA, USA
    Cytokine 20:247-55. 2002
    ..We speculate that the cytoprotective effects of dexamethasone in the immature lung may, in part, be mediated via IL-10...
  41. ncbi request reprint Morbidity and mortality of preterm twins and higher-order multiple births
    K Suri
    Department of Pediatrics, Division of Neonatology, University of Connecticut School of Medicine, Farmington, CT 06032, USA
    J Perinatol 21:293-9. 2001
    ..CONCLUSION: Although premature infants of HOM had lower birthweight and needed a longer hospital stay, their mortality and morbidity at hospital discharge were not worse than that for preterm twins...
  42. pmc Fetal renal artery impedance as assessed by Doppler ultrasound in pregnancies complicated by intraamniotic inflammation and preterm birth
    Humberto Azpurua
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Obstet Gynecol 200:203.e1-11. 2009
    ..The objective of the study was to evaluate the fetal renal artery impedance in the context of inflammation-associated preterm birth...
  43. pmc Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future
    Catalin S Buhimschi
    Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Curr Opin Infect Dis 22:235-43. 2009
    ..Proteomics offers the opportunity for detecting fetuses at risk of sepsis and neurological injury...
  44. pmc Characterization of RAGE, HMGB1, and S100beta in inflammation-induced preterm birth and fetal tissue injury
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, 333 Cedar Street, New Haven, CT 06520, USA
    Am J Pathol 175:958-75. 2009
    ..Our findings indicate that RAGE and HMGB1 may be important mediators of cellular injury in fetuses delivered in the setting of inflammation-induced preterm birth...
  45. pmc Amniotic fluid angiopoietin-1, angiopoietin-2, and soluble receptor tunica interna endothelial cell kinase-2 levels and regulation in normal pregnancy and intraamniotic inflammation-induced preterm birth
    Catalin S Buhimschi
    Yale University School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, 333 Cedar Street, LLCI 804, New Haven, CT 06520, USA
    J Clin Endocrinol Metab 95:3428-36. 2010
    ..Angiopoietin-1 (Ang-1) and Ang-2 act selectively on endothelial cells by engaging the Tunica interna endothelial cell kinase-2 (Tie2) receptor. A soluble form of Tie2 (sTie2) blocks angiopoietin bioactivity...
  46. pmc Antenatal consent in the SUPPORT trial: challenges, costs, and representative enrollment
    Wade D Rich
    Department of Pediatrics, School of Medicine, University of California, San Diego, California, USA
    Pediatrics 126:e215-21. 2010
    ....
  47. pmc Surfactant protein-A (SP-A) selectively inhibits prostaglandin F2alpha (PGF2alpha) production in term decidua: implications for the onset of labor
    Victoria V Snegovskikh
    Departments of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 96:E624-32. 2011
    ..Labor is characterized by "decidual activation" with production of inflammatory mediators. Recent data suggest that surfactant protein-A (SP-A) may be critical to the onset of labor in mice. Whether this is also true in humans is unclear...
  48. ncbi request reprint Fetal adrenal gland volume and cortisol/dehydroepiandrosterone sulfate ratio in inflammation-associated preterm birth
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Obstet Gynecol 111:715-22. 2008
    ..We sought to estimate the impact of intraamniotic inflammation on fetal adrenal gland volume and cortisol-to-dehydroepiandrosterone sulfate ratio (fetal stress ratio) in pregnancies complicated by preterm birth...
  49. doi request reprint Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis
    Jonathan M Siner
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    Shock 31:348-53. 2009
    ..5-38.0 ng/mL) compared with those who survived (13.5 ng/mL; interquartile range, 8.1-21.6 ng/mL). Elevated circulating serum Ang-2 levels are associated with increased hospital mortality in patients with sepsis...
  50. pmc Proteomic profiling of the amniotic fluid to detect inflammation, infection, and neonatal sepsis
    Catalin S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Med 4:e18. 2007
    ..Proteomic analysis of amniotic fluid shows the presence of biomarkers characteristic of intrauterine inflammation. We sought to validate prospectively the clinical utility of one such proteomic profile, the Mass Restricted (MR) score...
  51. ncbi request reprint Circulating stem cells in extremely preterm neonates
    Matthew J Bizzarro
    Department of Pediatrics, Division of Perinatal Medicine, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Acta Paediatr 96:521-5. 2007
    ..To measure circulating CD34+ cell levels in premature neonates and to correlate the initial CD34+ counts with measures of pulmonary function and neonatal morbidity...
  52. ncbi request reprint Increased hyperoxia-induced mortality and acute lung injury in IL-13 null mice
    Vineet Bhandari
    Division of Perinatal Medicine, Yale University School of Medicine, Department of Pediatrics, Children s Hospital, New Haven, CT 06520, USA
    J Immunol 178:4993-5000. 2007
    ..These studies demonstrate that the expression of the IL-13R is augmented and that the endogenous IL-13-IL-13R pathway contributes to the induction of inflammation and the inhibition of injury in hyperoxic acute lung injury...
  53. ncbi request reprint A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome
    Katharine A Kevill
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 180:601-8. 2008
    ..03). This study demonstrates for the first time a role for MIF in lung maturation, and supports a protective role for MIF in newborn lung disease...
  54. ncbi request reprint Lactate dehydrogenase isoform activity mapping in patients with intra-amniotic infection
    Lissa K Magloire
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, New Haven, CT 06520, USA
    Am J Obstet Gynecol 195:1045-52. 2006
    ..Five distinct lactate dehydrogenase isoenzymes have been described. We sought to illustrate the specific amniotic fluid lactate dehydrogenase isoenzyme activity profiles in women with intra-amniotic infection...
  55. pmc Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis
    Antonette T Dulay
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 198:426.e1-9. 2008
    ..We sought to determine whether fetal inflammation is associated with an elevation in neonatal NRBC count in the setting of inflammation-associated preterm birth...
  56. ncbi request reprint Temporal quantification of oxygen saturation ranges: an effort to reduce hyperoxia in the neonatal intensive care unit
    M J Bizzarro
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    J Perinatol 34:33-8. 2014
    ..To reduce exposure to hyperoxia and its associated morbidities in preterm neonates...
  57. pmc The genetic susceptibility to respiratory distress syndrome
    Orly Levit
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Pediatr Res 66:693-7. 2009
    ..We found 49.7% (p = 0.04) of the variance in liability to RDS was the result of genetic factors alone. We conclude that there is a significant genetic susceptibility to RDS in preterm infants...
  58. pmc Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, 441c TAC, New Haven, Connecticut 06520 8057, USA
    Nat Med 10:1095-103. 2004
    ..Thus, VEGF is a mediator of vascular and extravascular remodeling and inflammation that enhances antigen sensitization and is crucial in adaptive T(H)2 inflammation. VEGF regulation may be therapeutic in asthma and other T(H)2 disorders...
  59. pmc Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung
    Vineet Bhandari
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, LCI 401 B, New Haven, CT 06520 8057, USA
    Proc Natl Acad Sci U S A 103:11021-6. 2006
    ..Furthermore, they demonstrate that eNOS and iNOS both contribute to these responses. NO/NOS-based interventions may be therapeutic in VEGF-driven inflammation and remodeling...
  60. pmc Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death
    Vineet Bhandari
    Division of Perinatal Medicine, Yale University School of Medicine, Department of Pediatrics, 333 Cedar Street, New Haven, Connecticut 06520 8064, USA
    Nat Med 12:1286-93. 2006
    ..Tracheal Ang2 is also increased in neonates that develop bronchopulmonary dysplasia. Ang2 is thus a mediator of epithelial necrosis with an important role in hyperoxic ALI and pulmonary edema...
  61. ncbi request reprint Pulmonary expression of leukemia inhibitory factor induces B cell hyperplasia and confers protection in hyperoxia
    Jingming Wang
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, USA
    J Biol Chem 278:31226-32. 2003
    ..They also demonstrate that LIF induces IL-6 and that the protective effects of LIF are mediated, in part, via this inductive event. LIF may be an important regulator of B cell-mediated responses and oxidant injury in the lung...
  62. ncbi request reprint Effect of introduction of synchronized nasal intermittent positive-pressure ventilation in a neonatal intensive care unit on bronchopulmonary dysplasia and growth in preterm infants
    Ameya Kulkarni
    Division of Perinatal Medicine, Department of Pediatrics, Yale New Haven Children s Hospital, New Haven, Connecticut 06520 8064, USA
    Am J Perinatol 23:233-40. 2006
    ....
  63. ncbi request reprint The future in paediatric respirology
    H Joel Schmidt
    Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    Respirology 15:733-41. 2010
    ..The authors hope that these visionary articles will generate comments, arguments, inspiration, and perhaps even motivate funding agencies...
  64. ncbi request reprint A prospective observational pilot study of synchronized nasal intermittent positive pressure ventilation (SNIPPV) as a primary mode of ventilation in infants > or = 28 weeks with respiratory distress syndrome (RDS)
    Rene Santin
    Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, PA, USA
    J Perinatol 24:487-93. 2004
    ....
  65. ncbi request reprint Pathogenesis, pathology and pathophysiology of pulmonary sequelae of bronchopulmonary dysplasia in premature infants
    Anita Bhandari
    Division of Pulmonary Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    Front Biosci 8:e370-80. 2003
    ..Infants with BPD have significant pulmonary sequelae during childhood and adolescence; whether the pulmonary dysfunction in these patients will predispose them to obstructive lung disease as older adults, remains to be seen...
  66. ncbi request reprint Pulmonary hypoplasia and persistent pulmonary hypertension in the newborn with homozygous alpha-thalassemia: a case report and review of the literature
    M J Bizzarro
    Department of Pediatrics, Yale New Haven Hospital, New Haven, Connecticut, USA
    J Matern Fetal Neonatal Med 14:411-6. 2003
    ..We report the survival of a newborn with homozygous alpha-thalassemia complicated by pulmonary hypoplasia and persistent pulmonary hypertension, an association not previously reported...
  67. ncbi request reprint Familial and genetic susceptibility to major neonatal morbidities in preterm twins
    Vineet Bhandari
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Pediatrics 117:1901-6. 2006
    ..Intraventricular hemorrhage, necrotizing enterocolitis, and bronchopulmonary dysplasia remain significant causes of morbidity and mortality in preterm newborns...
  68. pmc Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice
    Abrahim I Orabi
    Department of Pediatrics, 333 Cedar St, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 299:G196-204. 2010
    ..Blockade of Ca(2+) signals and particularly RYR-Ca(2+) may be useful as prophylactic treatment for this disease in high-risk settings for pancreatitis...
  69. pmc A role for matrix metalloproteinase 9 in IFNγ-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia
    Anantha Harijith
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Am J Respir Cell Mol Biol 44:621-30. 2011
    ..IFNγ and its downstream targets may contribute significantly to the final common pathway of hyperoxia-induced injury in the developing lung and in human BPD...
  70. ncbi request reprint Esophageal perforation in the premature newborn: case report and review of the literature
    Sean T Devine
    Departments of Medicine and Pediatrics, Albert Einstein Medical Center, Philadelphia, PA, USA
    Conn Med 66:131-5. 2002
    ..The child had also received the nonsteroidal anti-inflammatory drug, indomethacin. An exhaustive review of the literature has been done to define the clinical profile and current recommendations for management...
  71. ncbi request reprint Improved outcome of extremely low birth weight infants with Tegaderm application to skin
    Vineet Bhandari
    Division of Neonatology, Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, PA, USA
    J Perinatol 25:276-81. 2005
    ..We investigated the effect of semipermeable polyurethane membrane (Tegaderm) applied to the skin shortly after birth on fluid and electrolyte status and the clinical outcome in these infants...
  72. ncbi request reprint Antenatal steroid use is associated with increased gastroesophageal reflux in neonates
    Song Ok S Chin
    Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA
    Am J Perinatol 20:205-13. 2003
    ..01) still held true among infants who had GER confirmed by a pH-probe study. Use of ANS is associated with a significantly decreased need for surfactant; however, there is an increased incidence of GER...
  73. ncbi request reprint Bronchopulmonary dysplasia: an update
    Anita Bhandari
    Division of Pediatric Pulmonology, Connecticut Children s Medical Center, Hartford, CT, USA
    Indian J Pediatr 74:73-7. 2007
    ..Infants with BPD, however, continue to have significant pulmonary and neurodevelopmental sequelae. Unraveling the genetic contribution to BPD will potentially pave the way to improved preventive and therapeutic approaches...
  74. ncbi request reprint Fetal nucleated red blood cells in a rat model of intrauterine growth restriction induced by hypoxia and nitric oxide synthase inhibition
    Viswanathan Ravishankar
    Department of Obstetrics, Gynecology, and Reproductive Medicine, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
    Am J Obstet Gynecol 196:482.e1-8. 2007
    ..We sought to determine the effects of chronic hypoxia, chronic nitric oxide inhibition with N(G)-nitro-L-arginine methyl ester (L-NAME), or both on NRBC counts, erythropoietin levels, and pathologic changes in an animal model of IUGR...
  75. ncbi request reprint Intrapartum fever at term: serum and histologic markers of inflammation
    John C Smulian
    Division of Maternal Fetal Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School Saint Peter s University Hospital, New Brunswick, NJ, USA
    Am J Obstet Gynecol 188:269-74. 2003
    ..Placentas were examined for histologic chorioamnionitis. Demographic and clinical data were collected and compared between cases and controls...
  76. ncbi request reprint Leptin enhances lung maturity in the fetal rat
    Susan M Kirwin
    Department of Biomedical Research and Pediatrics, Alfred I duPont Hospital for Children Nemours Children s Clinic, Delaware 19803, USA
    Pediatr Res 60:200-4. 2006
    ..Collectively, these results suggest that leptin is a cytokine regulator of rat fetal lung maturity...

Research Grants3

  1. Angiogenic Agents and Alveolar Injury
    Vineet Bhandari; Fiscal Year: 2007
    ..Determine the differences and the degree to which the response to hyperoxia-induced acute lung injury differs in adult, newborn and fetal mice with regard to VEGF, Angiopoietin 1 and Angiopoietin 2. ..
  2. Role of Angiogenic Agents in Alveolar Maturation and Injury
    Vineet Bhandari; Fiscal Year: 2009
    ....
  3. Role of Angiogenic Agents in Alveolar Maturation and Injury
    Vineet Bhandari; Fiscal Year: 2010
    ....