Zubin Bhagwagar

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Neural correlates of impulse control during stop signal inhibition in cocaine-dependent men
    Chiang Shan Ray Li
    Connecticut Mental Health Center, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 33:1798-806. 2008
  2. ncbi request reprint Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C]MDL 100,907
    Zubin Bhagwagar
    Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, 34 Park St, New Haven, CT 06519 1187, USA
    Am J Psychiatry 163:1580-7. 2006
  3. pmc Abnormal corpus callosum integrity in bipolar disorder: a diffusion tensor imaging study
    Fei Wang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Biol Psychiatry 64:730-3. 2008
  4. pmc Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 34:1198-208. 2009
  5. pmc Enhanced visual motion perception in major depressive disorder
    Julie D Golomb
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 29:9072-7. 2009
  6. pmc Citalopram reduces endotoxin-induced fatigue
    Jonas Hannestad
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Brain Behav Immun 25:256-9. 2011
  7. pmc Increased peripheral blood expression of electron transport chain genes in bipolar depression
    Robert D Beech
    Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA
    Bipolar Disord 12:813-24. 2010
  8. pmc Assessing the sensitivity of [¹¹C]p943, a novel 5-HT1B radioligand, to endogenous serotonin release
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Synapse 65:1113-7. 2011
  9. pmc Time course of regional brain activity accompanying auditory verbal hallucinations in schizophrenia
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Br J Psychiatry 198:277-83. 2011
  10. pmc The impact of NMDA receptor blockade on human working memory-related prefrontal function and connectivity
    Naomi R Driesen
    1 Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT, USA 2 Department of Neurology, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 38:2613-22. 2013

Collaborators

Detail Information

Publications29

  1. pmc Neural correlates of impulse control during stop signal inhibition in cocaine-dependent men
    Chiang Shan Ray Li
    Connecticut Mental Health Center, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 33:1798-806. 2008
    ..Relative hypoactivation of the rACC during response inhibition may represent a useful neural marker of difficulties in impulse control in abstinent cocaine-dependent men who are at risk of relapse...
  2. ncbi request reprint Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: a positron emission study with [(11)C]MDL 100,907
    Zubin Bhagwagar
    Clinical Neuroscience Research Unit, Abraham Ribicoff Research Facilities, 34 Park St, New Haven, CT 06519 1187, USA
    Am J Psychiatry 163:1580-7. 2006
    ....
  3. pmc Abnormal corpus callosum integrity in bipolar disorder: a diffusion tensor imaging study
    Fei Wang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Biol Psychiatry 64:730-3. 2008
    ..In this study, we used complementary diffusion tensor imaging methods to study the structural integrity of the CC and localization of potential abnormalities in BD...
  4. pmc Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuropsychopharmacology 34:1198-208. 2009
    ....
  5. pmc Enhanced visual motion perception in major depressive disorder
    Julie D Golomb
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 29:9072-7. 2009
    ..This finding raises the possibility that spatial suppression may represent a sensitive endophenotypic marker of trait vulnerability in MDD...
  6. pmc Citalopram reduces endotoxin-induced fatigue
    Jonas Hannestad
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Brain Behav Immun 25:256-9. 2011
    ..9). These results suggest that subchronic pre-treatment with the serotonin-reuptake inhibitor citalopram blunts mood symptoms induced by acute immune system activation with endotoxin without inhibiting the peripheral immune response...
  7. pmc Increased peripheral blood expression of electron transport chain genes in bipolar depression
    Robert D Beech
    Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA
    Bipolar Disord 12:813-24. 2010
    ..To identify specific genetic pathways showing altered expression in peripheral blood of depressed subjects with bipolar disorder (BPD)...
  8. pmc Assessing the sensitivity of [¹¹C]p943, a novel 5-HT1B radioligand, to endogenous serotonin release
    Kelly P Cosgrove
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Synapse 65:1113-7. 2011
    ..Receptor occupancy by P943 (0.2 mg/kg) was 68 and 86% in the baboons. PET imaging of 5-HT(1B) receptors with [¹¹C]P943 may be a useful approach for measuring changes in endogenous 5-HT in the living human brain...
  9. pmc Time course of regional brain activity accompanying auditory verbal hallucinations in schizophrenia
    Ralph E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Br J Psychiatry 198:277-83. 2011
    ..The pathophysiology of auditory verbal hallucinations remains poorly understood...
  10. pmc The impact of NMDA receptor blockade on human working memory-related prefrontal function and connectivity
    Naomi R Driesen
    1 Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT, USA 2 Department of Neurology, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 38:2613-22. 2013
    ..These results support the hypothesis that NMDA-Rs are critical for WM. The knowledge gained may be helpful in understanding disorders that might involve glutamatergic deficits such as schizophrenia and developing better treatments. ..
  11. ncbi request reprint Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients
    Zubin Bhagwagar
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Int J Neuropsychopharmacol 11:255-60. 2008
    ..These changes could represent part of the neurobiological vulnerability to recurrent depressive episodes...
  12. pmc Effects of ketamine in treatment-refractory obsessive-compulsive disorder
    Michael H Bloch
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 72:964-70. 2012
    ..Ketamine is a potent noncompetitive antagonist of the N-methyl-D-aspartate glutamate receptor. Trials have reported rapid antidepressant effects after low-dose ketamine infusion...
  13. pmc Age effects on serotonin receptor 1B as assessed by PET
    David Matuskey
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Nucl Med 53:1411-4. 2012
    ..This paper addresses whether the availability of 5-hydroxytryptamine receptor 1B (5-HT(1B)) is seen to decrease with aging via PET imaging...
  14. pmc A sequencing-based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controls
    Zenab Amin
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 153:332-5. 2010
    ..In addition, the E777K and N782T variants were found at low frequencies both in patients and population controls, suggesting that these variants have limited impact on risk for MDD...
  15. doi request reprint Lamotrigine-associated rash: to rechallenge or not to rechallenge?
    Boris Lorberg
    Department of Psychiatry, Yale University School of Medicine, CT 06519 1187, USA
    Int J Neuropsychopharmacol 12:257-65. 2009
    ..We believe that lamotrigine rechallenge in bipolar depression is an under-utilized option in our clinical armamentarium, and further studies are needed to guide us in this area...
  16. ncbi request reprint Inflammation, glutamate, and glia in depression: a literature review
    Leah McNally
    Yale University School of Medicine, New Haven, CT 06519, USA
    CNS Spectr 13:501-10. 2008
    ....
  17. doi request reprint Rechallenging with clozapine following neutropenia: treatment options for refractory schizophrenia
    Sharmin Ghaznavi
    Department of Psychiatry, Yale University, 34 Park St, New Haven, CT 06519, USA
    Am J Psychiatry 165:813-8. 2008
  18. ncbi request reprint Risperidone augmentation decreases rapid eye movement sleep and decreases wake in treatment-resistant depressed patients
    Ann L Sharpley
    University Department of Psychiatry, Warneford Hospital, Oxford, Oxfordshire, UK
    J Clin Psychiatry 64:192-6. 2003
    ..This study aimed to assess whether risperidone produced typical antidepressant-like effects in the polysomnogram of healthy subjects and in depressed patients unresponsive to antidepressant medication...
  19. ncbi request reprint Validation of a tracer kinetic model for the quantification of 5-HT(2A) receptors in human brain with [(11)C]MDL 100,907
    Rainer Hinz
    Hammersmith Imanet Ltd, London, UK
    J Cereb Blood Flow Metab 27:161-72. 2007
    ..This study confirmed the use of an arterial input kinetic model for the quantification of 5-HT(2A) receptor binding with [(11)C]MDL 100,907 and the use of the cerebellum as a reference region for the free and nonspecific binding...
  20. doi request reprint Effects of citalopram infusion on the serotonin transporter binding of [11C]DASB in healthy controls
    Rainer Hinz
    Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK
    J Cereb Blood Flow Metab 28:1478-90. 2008
    ..The SERT occupancy for six target regions with moderate to high binding was 60% derived from BP(ND) and 69% derived from BP(P)...
  21. ncbi request reprint Cortisol modulation of 5-HT-mediated growth hormone release in recovered depressed patients
    Zubin Bhagwagar
    University Department of Psychiatry, Warneford Hospital, OX3 7JX, Oxford, UK
    J Affect Disord 72:249-55. 2002
    ..We therefore assessed the effect of a single dose of hydrocortisone on 5-HT-mediated growth hormone (GH) release in healthy volunteers and euthymic subjects recovered from at least two episodes of major depression...
  22. ncbi request reprint Increase in concentration of waking salivary cortisol in recovered patients with depression
    Zubin Bhagwagar
    University Department of Psyhiatry, Warneford Hospital, Oxford, UK
    Am J Psychiatry 160:1890-1. 2003
    ..An increase in salivary cortisol levels after waking provides a simple, dynamic measure of HPA axis activity. The authors measured this increase in recovered depressed patients and in a healthy comparison group...
  23. ncbi request reprint Lack of effect of a single dose of hydrocortisone on serotonin(1A) receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635
    Zubin Bhagwagar
    Clinical Sciences Centre Medical Research Council, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Biol Psychiatry 54:890-5. 2003
    ..We tested this hypothesis by studying the effect of acute administration of hydrocortisone on 5-HT(1A) receptor binding potential (BP) in subjects recovered from depression...
  24. ncbi request reprint Preferential 5-HT1A autoreceptor occupancy by pindolol is attenuated in depressed patients: effect of treatment or an endophenotype of depression?
    Eugenii A Rabiner
    PET Psychiatry, Translational Medicine and Technologies, GlaxoSmithKline, Cambridge, UK
    Neuropsychopharmacology 29:1688-98. 2004
    ..Speculatively, the degree of preferential occupancy may serve as a surrogate marker for depression, or the pharmacological effects of antidepressants...
  25. ncbi request reprint The effects of low doses of delta-9 tetrahydrocannabinol on reinforcement processing in the risky decision-making of young healthy adults
    Robert D Rogers
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Neuropsychopharmacology 32:417-28. 2007
    ..These results suggest that THC mediates specific motivational processes and the processing of reinforcement cues during risky choice, perhaps reflecting altered CB1 receptor or catecholamine activity within corticolimbic pathways...
  26. pmc Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysis
    Matthew J Taylor
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, England
    Arch Gen Psychiatry 63:1217-23. 2006
    ..Selective serotonin reuptake inhibitors (SSRIs) are often described as having a delayed onset of effect in the treatment of depression. However, some trials have reported clinical improvement as early as the first week of treatment...
  27. ncbi request reprint Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects
    Zubin Bhagwagar
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 61:806-12. 2007
    ..The aim of this study was to use MRS to determine whether changes in GABA and Glu levels were present in patients with mood disorders who had recovered and were no longer taking medication...
  28. ncbi request reprint 5-HTT binding in recovered depressed patients and healthy volunteers: a positron emission tomography study with [11C]DASB
    Zubin Bhagwagar
    PET Psychiatry, Cyclotron Building, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, UK
    Am J Psychiatry 164:1858-65. 2007
    ..The purpose of this study was to determine whether abnormalities in 5-HTT might be present in recovered depressed patients...
  29. ncbi request reprint State and trait abnormalities in serotonin function in major depression
    Zubin Bhagwagar
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Br J Psychiatry 180:24-8. 2002
    ..Neuroendocrine studies of brain serotonin (5-HT) function in depression generally show evidence of impaired 5-HT function but it is disputed whether or not this impairment resolves with clinical recovery...

Research Grants2

  1. A study of GABA and 5-HT interactions to test a molecular model of vulnerability
    Zubin Bhagwagar; Fiscal Year: 2007
    ..Using sophisticated brain imaging techniques and genetic analysis, this project will study the interaction of two main brain chemicals implicated in the causation of depression. ..