Bret F Bessac
Affiliation: Yale University
- Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasuresBret F Bessac
Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8066, USA
Proc Am Thorac Soc 7:269-77. 2010..Sensory channels such as TRPA1 are essential for maintenance of airway inflammation in asthma and may contribute to the progression of airway injury following high-level chemical exposures...
- Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gasesBret F Bessac
Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
FASEB J 23:1102-14. 2009..Treatment with TRPA1 antagonists may prevent and alleviate chemical irritation of the eyes, skin, and airways and reduce the adverse health effects of exposures to a wide range of toxic noxious chemicals...
- TRPA1 mediates the noxious effects of natural sesquiterpene deterrentsJASMINE ESCALERA
Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
J Biol Chem 283:24136-44. 2008..Isovelleral and polygodial represent the first fungal and animal small molecule agonists of nociceptive transient receptor potential channels...
- A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthmaAna I Caceres
Department of Pharmacology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 106:9099-104. 2009..TRPA1 may represent a promising pharmacological target for the treatment of asthma and other allergic inflammatory conditions...
- TRPA1 is a major oxidant sensor in murine airway sensory neuronsBret F Bessac
Department of Pharmacology and Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Clin Invest 118:1899-910. 2008..Our results indicate that TRPA1 is an oxidant sensor in sensory neurons, initiating neuronal excitation and subsequent physiological responses in vitro and in vivo...
- Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex controlBret F Bessac
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA
Physiology (Bethesda) 23:360-70. 2008..Together with TRPV1, the capsaicin receptor, TRPA1 may contribute to chemical hypersensitivity, chronic cough, and airway inflammation in asthma, COPD, and reactive airway dysfunction syndrome...