Bret F Bessac

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures
    Bret F Bessac
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8066, USA
    Proc Am Thorac Soc 7:269-77. 2010
  2. pmc Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases
    Bret F Bessac
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    FASEB J 23:1102-14. 2009
  3. pmc TRPA1 mediates the noxious effects of natural sesquiterpene deterrents
    JASMINE ESCALERA
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Biol Chem 283:24136-44. 2008
  4. pmc A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
    Ana I Caceres
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 106:9099-104. 2009
  5. pmc TRPA1 is a major oxidant sensor in murine airway sensory neurons
    Bret F Bessac
    Department of Pharmacology and Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 118:1899-910. 2008
  6. pmc Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control
    Bret F Bessac
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA
    Physiology (Bethesda) 23:360-70. 2008

Collaborators

  • Donato Del Camino
  • Robert J Homer
  • Ana I Caceres
  • Sven Eric Jordt
  • JASMINE ESCALERA
  • Jayhong A Chong
  • Magdalene M Moran
  • Xiaozhu Huang
  • Marc D'Amours
  • JoAnn S Witek
  • Neil J Hayward
  • Lauren Cohn
  • Chistopher M Fanger
  • Maxwell D Elia
  • Marian Brackmann
  • Michael Sivula
  • Christian A von Hehn

Detail Information

Publications6

  1. pmc Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures
    Bret F Bessac
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8066, USA
    Proc Am Thorac Soc 7:269-77. 2010
    ..Sensory channels such as TRPA1 are essential for maintenance of airway inflammation in asthma and may contribute to the progression of airway injury following high-level chemical exposures...
  2. pmc Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases
    Bret F Bessac
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    FASEB J 23:1102-14. 2009
    ..Treatment with TRPA1 antagonists may prevent and alleviate chemical irritation of the eyes, skin, and airways and reduce the adverse health effects of exposures to a wide range of toxic noxious chemicals...
  3. pmc TRPA1 mediates the noxious effects of natural sesquiterpene deterrents
    JASMINE ESCALERA
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Biol Chem 283:24136-44. 2008
    ..Isovelleral and polygodial represent the first fungal and animal small molecule agonists of nociceptive transient receptor potential channels...
  4. pmc A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma
    Ana I Caceres
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 106:9099-104. 2009
    ..TRPA1 may represent a promising pharmacological target for the treatment of asthma and other allergic inflammatory conditions...
  5. pmc TRPA1 is a major oxidant sensor in murine airway sensory neurons
    Bret F Bessac
    Department of Pharmacology and Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 118:1899-910. 2008
    ..Our results indicate that TRPA1 is an oxidant sensor in sensory neurons, initiating neuronal excitation and subsequent physiological responses in vitro and in vivo...
  6. pmc Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control
    Bret F Bessac
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA
    Physiology (Bethesda) 23:360-70. 2008
    ..Together with TRPV1, the capsaicin receptor, TRPA1 may contribute to chemical hypersensitivity, chronic cough, and airway inflammation in asthma, COPD, and reactive airway dysfunction syndrome...