ROLAND E BARON

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton
    Roland Baron
    Yale University School of Medicine, 333 Cedar Street, P O Box 208044, New Haven, CT 06520 8044, USA
    Endocrinology 148:2635-43. 2007
  2. pmc Regulation of cytochrome c oxidase activity by c-Src in osteoclasts
    Tsuyoshi Miyazaki
    Department of Cell Biology, Yale University School of Medicine, PO Box 208044, New Haven, CT 06520 8044, USA
    J Cell Biol 160:709-18. 2003
  3. pmc Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility
    A Sanjay
    Department of Cell Biology and Orthopedics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cell Biol 152:181-95. 2001
  4. ncbi Wnt signaling and the regulation of bone mass
    Roland Baron
    Yale University School of Medicine, New Haven, CT 06520 8044, USA
    Curr Osteoporos Rep 5:73-80. 2007
  5. ncbi Src kinase activity is essential for osteoclast function
    Tsuyoshi Miyazaki
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 279:17660-6. 2004
  6. ncbi Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen
    M Page Haynes
    Section of Cardiovascular Medicine, Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 278:2118-23. 2003
  7. ncbi Molecular regulation of osteoclast activity
    Angela Bruzzaniti
    Department of Orthopaedics, Yale University School of Medicine, New Haven, CT 06510, USA
    Rev Endocr Metab Disord 7:123-39. 2006
  8. ncbi The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function
    William C Horne
    Department of Orthopaedics and Rehabilitation and Cell Biology, Yale University School of Medicine, New Haven, CT 06520 8044, USA
    Immunol Rev 208:106-25. 2005
  9. pmc Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity
    Angela Bruzzaniti
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Biol Cell 16:3301-13. 2005
  10. pmc Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia
    Arata Nakajima
    Department of Orthopedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA
    J Bone Miner Res 24:1162-72. 2009

Collaborators

Detail Information

Publications28

  1. ncbi Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton
    Roland Baron
    Yale University School of Medicine, 333 Cedar Street, P O Box 208044, New Haven, CT 06520 8044, USA
    Endocrinology 148:2635-43. 2007
    ..Multiple genetic and pharmacological manipulations of Wnt signaling in mice have since then confirmed the central role of this pathway in regulating bone formation...
  2. pmc Regulation of cytochrome c oxidase activity by c-Src in osteoclasts
    Tsuyoshi Miyazaki
    Department of Cell Biology, Yale University School of Medicine, PO Box 208044, New Haven, CT 06520 8044, USA
    J Cell Biol 160:709-18. 2003
    ..These results suggest that c-Src plays a previously unrecognized role in maintaining cellular energy stores by activating Cox in mitochondria...
  3. pmc Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility
    A Sanjay
    Department of Cell Biology and Orthopedics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cell Biol 152:181-95. 2001
    ..These findings may explain the osteopetrotic phenotype in the Src(-/-) mice...
  4. ncbi Wnt signaling and the regulation of bone mass
    Roland Baron
    Yale University School of Medicine, New Haven, CT 06520 8044, USA
    Curr Osteoporos Rep 5:73-80. 2007
    ....
  5. ncbi Src kinase activity is essential for osteoclast function
    Tsuyoshi Miyazaki
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 279:17660-6. 2004
    ....
  6. ncbi Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen
    M Page Haynes
    Section of Cardiovascular Medicine, Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 278:2118-23. 2003
    ..This complex formation results in the successive activation of PI3-kinase, Akt, and eNOS with consequent enhanced NO release, implicating c-Src as a critical upstream regulator of the estrogen-stimulated PI3-kinase/Akt/eNOS pathway...
  7. ncbi Molecular regulation of osteoclast activity
    Angela Bruzzaniti
    Department of Orthopaedics, Yale University School of Medicine, New Haven, CT 06510, USA
    Rev Endocr Metab Disord 7:123-39. 2006
    ..In this review, several of the key functional players involved in the regulation of osteoclast activity will be discussed...
  8. ncbi The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function
    William C Horne
    Department of Orthopaedics and Rehabilitation and Cell Biology, Yale University School of Medicine, New Haven, CT 06520 8044, USA
    Immunol Rev 208:106-25. 2005
    ....
  9. pmc Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity
    Angela Bruzzaniti
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Biol Cell 16:3301-13. 2005
    ....
  10. pmc Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia
    Arata Nakajima
    Department of Orthopedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA
    J Bone Miner Res 24:1162-72. 2009
    ..e., functions that cannot be compensated by the other homolog). One of Cbl-b's unique functions in osteoclasts is to downregulate bone resorption...
  11. ncbi Deletion of the gene encoding c-Cbl alters the ability of osteoclasts to migrate, delaying resorption and ossification of cartilage during the development of long bones
    Riccardo Chiusaroli
    Department of Orthopaedics, Yale University School of Medicine, New Haven, CT 06520, USA
    Dev Biol 261:537-47. 2003
    ..These results confirm that c-Cbl plays an important role in osteoclast motility and resorbing activity...
  12. pmc Tyrosine phosphatase epsilon is a positive regulator of osteoclast function in vitro and in vivo
    Riccardo Chiusaroli
    Departments of Cell Biology and Orthopedics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Mol Biol Cell 15:234-44. 2004
    ..These results establish PTPepsilon as a phosphatase required for optimal structure, subcellular organization, and function of osteoclasts in vivo and in vitro...
  13. pmc Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice
    Hava Gil-Henn
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06511, USA
    J Cell Biol 178:1053-64. 2007
    ..These experiments underscore an important role of Pyk2 in microtubule-dependent podosome organization, bone resorption, and other osteoclast functions...
  14. ncbi Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl
    Archana Sanjay
    Departments of Orthopedics and Rehabilitation and Cell Biology, Yale University School of Medicine, New Haven, CT, USA
    FEBS J 273:5442-56. 2006
    ..These data indicate that the Cbl RDLPPPP(540-546) sequence is a functionally important binding site for Src...
  15. pmc Calpain is required for normal osteoclast function and is down-regulated by calcitonin
    Marilena Marzia
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut 06520 8044, USA
    J Biol Chem 281:9745-54. 2006
    ..These results indicate that calpain activity is required for normal osteoclast activity and suggest that calcitonin inhibits osteoclast bone resorbing activity in part by down-regulating calpain activity...
  16. pmc The delta e13 isoform of the calcitonin receptor forms a six-transmembrane domain receptor with dominant-negative effects on receptor surface expression and signaling
    Thomas Seck
    Yale University School of Medicine, Department of Orthopaedics, New Haven, Connecticut 06520, USA
    Mol Endocrinol 19:2132-44. 2005
    ....
  17. pmc Zfp521 antagonizes Runx2, delays osteoblast differentiation in vitro, and promotes bone formation in vivo
    Meilin Wu
    Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Bone 44:528-36. 2009
    ..We propose that Zfp521 regulates the rate of osteoblast differentiation and bone formation during development and in the mature skeleton, in part by antagonizing Runx2...
  18. pmc The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts
    Olivier Destaing
    Department of Orthopaedics, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Biol Cell 19:394-404. 2008
    ..Thus, Src is an essential regulator of podosome structure, dynamics and organization...
  19. ncbi The alternatively spliced deltae13 transcript of the rabbit calcitonin receptor dimerizes with the C1a isoform and inhibits its surface expression
    Thomas Seck
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 278:23085-93. 2003
    ..We therefore suggest that the deltae13 variant of the rabbit calcitonin receptor acts to regulate the surface expression of the C1a isoform...
  20. ncbi In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation
    Roland Baron
    Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, IE 55 SHM, New Haven, CT 06510, USA
    Eur J Pharmacol 450:11-7. 2002
    ..05). The inhibition of bone resorption obtained specifically with S12911-2 is related to an inhibition of the differentiation and resorbing activity of the osteoclasts...
  21. ncbi Binding of filamin to the C-terminal tail of the calcitonin receptor controls recycling
    Thomas Seck
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 278:10408-16. 2003
    ....
  22. pmc A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss
    Kazuhiro Aoki
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520 8044, USA
    J Clin Invest 116:1525-34. 2006
    ..These results suggest that a peptide that mimics a TNFR ligand contact site blocks bone resorption by interfering with recruitment and activation of osteoclasts by both RANKL and TNF...
  23. ncbi FSH versus estrogen: who's guilty of breaking bones?
    Roland Baron
    Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Metab 3:302-5. 2006
    ..In conjunction with genetic studies, these data raise the possibility that FSH, independent of estrogen, causes hypogonadal bone loss...
  24. pmc A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice
    Natalie A Sims
    Department of Orthopaedics, Yale University School of Medicine, New Haven, Connecticut 06520 8044, USA
    J Clin Invest 111:1319-27. 2003
    ..We conclude that ERalpha is the main effector of estradiol's protective function in bone in both male and female mice, and that, in its absence, AR is not sufficient to mediate this response...
  25. pmc Bone protection by estrens occurs through non-tissue-selective activation of the androgen receptor
    Sara H Windahl
    Department of Orthopaedics, Yale University School of Medicine, New Haven, Connecticut 06520 8044, USA
    J Clin Invest 116:2500-9. 2006
    ..We conclude that the estrens act mostly through the AR and, in mice, do not fulfill the preclinical efficacy or safety criteria required for the treatment or prevention of osteoporosis...
  26. pmc Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity
    George Sabatakos
    Department of Orthopaedics, Yale University School of Medicine, New Haven, Connecticut, USA
    J Bone Miner Res 23:584-95. 2008
    ..Translation of Deltafosb mRNA produces both DeltaFosB and a further truncated isoform (Delta2DeltaFosB) that lacks known transactivation domains but, like DeltaFosB, induces increased expression of osteoblast marker genes...
  27. pmc Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice
    Glenn C Rowe
    Department of Orthopaedics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Endocrinology 150:135-43. 2009
    ..These findings provide evidence that signaling downstream of DeltaFosB is a potential target for not only osteoporosis but also obesity and diabetes...
  28. ncbi Molecular complexes that contain both c-Cbl and c-Src associate with Golgi membranes
    Frederic Bard
    Department of Orthopaedics, Yale University School of Medicine, New Haven, CT 06520 8044, USA
    Eur J Cell Biol 81:26-35. 2002
    ..The localization and interaction of Src and Cbl at the Golgi and the regulation of the interaction of Cbl with Golgi membrane suggest that this complex may contribute to the regulation of Golgi function...

Research Grants4

  1. Regulation of Osteoclastic Bone Resorption:Role of Cb1b
    Roland Baron; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  2. From Adhesion to Bone Resorption: The role of Dynamin in Osteoclasts
    Roland Baron; Fiscal Year: 2007
    ..This project proposes to explore a novel concept, based on strong (and partially published) preliminary data, which we believe will help further understand the mechanisms that regulate bone resorption. ..
  3. OSTEOBLAST AND ADIPOCYTE DIFFERENTIATION BY FOSB
    Roland Baron; Fiscal Year: 2006
    ..abstract_text> ..
  4. ROLE OF THE C-SRC PROTO-ONCOGENE IN OSTEOCLASTS
    Roland Baron; Fiscal Year: 2007
    ..abstract_text> ..