Philip Askenase

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of contact sensitivity
    Atsuko Itakura
    Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8013, USA
    J Immunol 175:7170-8. 2005
  2. ncbi request reprint Invariant NKT cells rapidly activated via immunization with diverse contact antigens collaborate in vitro with B-1 cells to initiate contact sensitivity
    Regis A Campos
    Immunology Service of Professor Edgar Santos, Federal University of Bahia, Salvador BA, Brazil
    J Immunol 177:3686-94. 2006
  3. pmc Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity
    Regis A Campos
    Department of Medicine, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8013, USA
    J Exp Med 198:1785-96. 2003
  4. pmc B cell-dependent T cell responses: IgM antibodies are required to elicit contact sensitivity
    Ryohei F Tsuji
    Noda Institute for Scientific Research, Chiba ken 278, Japan
    J Exp Med 196:1277-90. 2002
  5. pmc Yes T cells, but three different T cells (alphabeta, gammadelta and NK T cells), and also B-1 cells mediate contact sensitivity
    P W Askenase
    Section of Allergy and Clinical Immunology, Yale University School of Medicine, New Haven, CT 06510, USA
    Clin Exp Immunol 125:345-50. 2001
  6. ncbi request reprint Extravascular T-cell recruitment requires initiation begun by Valpha14+ NKT cells and B-1 B cells
    Philip W Askenase
    Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8013, USA
    Trends Immunol 25:441-9. 2004
  7. ncbi request reprint TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo
    Philip W Askenase
    Sections of Allergy and Clinical Immunology and Cardiology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 175:6390-401. 2005
  8. ncbi request reprint Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1
    Fayyaz S Sutterwala
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 24:317-27. 2006
  9. pmc Interleukin-4-dependent innate collaboration between iNKT cells and B-1 B cells controls adaptative contact sensitivity
    Regis A Campos
    Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8013, USA
    Immunology 117:536-47. 2006
  10. ncbi request reprint Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cells
    Atsuko Itakura
    Division of Immunology, Department of Immunology and Microbiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Int Arch Allergy Immunol 140:8-16. 2006

Research Grants

  1. Initiation of Contact and Asthmatic Hypersensitivity
    Philip Askenase; Fiscal Year: 2004
  2. Initiation of Contact and Asthmatic Hypersensitivity
    Philip Askenase; Fiscal Year: 2005
  3. Initiation of Contact and Asthmatic Hypersensitivity
    Philip Askenase; Fiscal Year: 2006
  4. Initiation of Contact and Asthmatic Hypersensitivity
    Philip Askenase; Fiscal Year: 2007
  5. ALLERGY AND IMMUNOLOGY TRAINING GRANT
    Philip Askenase; Fiscal Year: 2007

Collaborators

Detail Information

Publications21

  1. ncbi request reprint An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of contact sensitivity
    Atsuko Itakura
    Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8013, USA
    J Immunol 175:7170-8. 2005
    ....
  2. ncbi request reprint Invariant NKT cells rapidly activated via immunization with diverse contact antigens collaborate in vitro with B-1 cells to initiate contact sensitivity
    Regis A Campos
    Immunology Service of Professor Edgar Santos, Federal University of Bahia, Salvador BA, Brazil
    J Immunol 177:3686-94. 2006
    ..These findings have relevance to allergic and autoimmune diseases in which infections can trigger exacerbation of T cell responses to allergens or to autoantigens...
  3. pmc Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity
    Regis A Campos
    Department of Medicine, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8013, USA
    J Exp Med 198:1785-96. 2003
    ....
  4. pmc B cell-dependent T cell responses: IgM antibodies are required to elicit contact sensitivity
    Ryohei F Tsuji
    Noda Institute for Scientific Research, Chiba ken 278, Japan
    J Exp Med 196:1277-90. 2002
    ..The IgM and challenge antigen likely form local complexes that activate complement, generating C5a, leading to local vascular activation to recruit the antigen-primed effector T cells that mediate the CS response...
  5. pmc Yes T cells, but three different T cells (alphabeta, gammadelta and NK T cells), and also B-1 cells mediate contact sensitivity
    P W Askenase
    Section of Allergy and Clinical Immunology, Yale University School of Medicine, New Haven, CT 06510, USA
    Clin Exp Immunol 125:345-50. 2001
    ..Three of these four cell types are present in the immune lymphoid cell population that adoptively transfers CS: B-1 cells, gammadelta-T cells, and the alphabeta-T cells...
  6. ncbi request reprint Extravascular T-cell recruitment requires initiation begun by Valpha14+ NKT cells and B-1 B cells
    Philip W Askenase
    Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8013, USA
    Trends Immunol 25:441-9. 2004
  7. ncbi request reprint TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo
    Philip W Askenase
    Sections of Allergy and Clinical Immunology and Cardiology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 175:6390-401. 2005
    ..The result is polyclonal IgM Ab responses capable of recruiting Ag-specific T cells into tissues. This may be involved in the promotion of autoimmunity by infectious agents...
  8. ncbi request reprint Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1
    Fayyaz S Sutterwala
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 24:317-27. 2006
    ..These data suggest that NALP3 plays a specific role in the caspase-1 activation pathway...
  9. pmc Interleukin-4-dependent innate collaboration between iNKT cells and B-1 B cells controls adaptative contact sensitivity
    Regis A Campos
    Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8013, USA
    Immunology 117:536-47. 2006
    ....
  10. ncbi request reprint Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cells
    Atsuko Itakura
    Division of Immunology, Department of Immunology and Microbiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Int Arch Allergy Immunol 140:8-16. 2006
    ..In this study, we investigated the role of interleukin (IL)-5, which has broad effects on both eosinophils and B-1 cells, in elicitation of CS...
  11. ncbi request reprint Alpha-galactosylceramide-induced iNKT cells suppress experimental allergic asthma in sensitized mice: role of IFN-gamma
    Patricia Hachem
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147, Paris V, Hopital Necker, Paris, France
    Eur J Immunol 35:2793-802. 2005
    ..Our findings demonstrate for the first time that alpha-GalCer administered locally inhibits asthma symptoms, even in predisposed asthmatic mice, through an iNKT cell- and IFN-gamma-dependent pathway...
  12. pmc Epicutaneous immunization induces alphabeta T-cell receptor CD4 CD8 double-positive non-specific suppressor T cells that inhibit contact sensitivity via transforming growth factor-beta
    Marian Szczepanik
    Department of Human Developmental Biology, Jagellonian University College of Medicine, Krakow, Poland
    Immunology 115:42-54. 2005
    ....
  13. pmc Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma
    Ivana Kawikova
    Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Immunology 113:234-45. 2004
    ....
  14. pmc Early delayed-type hypersensitivity eosinophil infiltrates depend on T helper 2 cytokines and interferon-gamma via CXCR3 chemokines
    Moe Akahira-Azuma
    Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 0813, USA
    Immunology 111:306-17. 2004
    ..These results suggest that both a Th2-like (IL-5, IL-4 and STAT-6) and a Th1-like (IFN-gamma, IP-10, CXCR3) pathway contribute to eosinophil recruitment in early delayed-type hypersensitivity...
  15. ncbi request reprint B-1 B cells mediate required early T cell recruitment to elicit protein-induced delayed-type hypersensitivity
    Marian Szczepanik
    Department of Human Developmental Biology, Jagiellonian University College of Medicine, Krakow, Poland
    J Immunol 171:6225-35. 2003
    ..This stimulates C5a receptors on mast cells to release vasoactive substances, leading to endothelial activation for the 2-h DTH-initiating response, allowing local recruitment of DTH-effector T cells...
  16. ncbi request reprint Subunits of IgM reconstitute defective contact sensitivity in B-1 cell-deficient xid mice: kappa light chains recruit T cells independent of complement
    Vipin Paliwal
    Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Immunol 169:4113-23. 2002
    ..Thus, B-1 cell-mediated CS initiation required for T cell recruitment is due to activation of C by specific IgM pentamer, and also subunits of IgM, while kappa L chains act via another C-independent but mast cell-dependent pathway...
  17. ncbi request reprint CD8 T cells inhibit IgE via dendritic cell IL-12 induction that promotes Th1 T cell counter-regulation
    Matthew J Thomas
    Department of Immunology, Guy s, King s, and St Thomas s School of Medicine, Kings College, Rayne Institute, 123 Coldharbour Lane, London, SE5 9NU, United Kingdom
    J Immunol 168:216-23. 2002
    ..Th1 cell IFN-gamma is the final step that inhibits B cell IgE class switching. This demonstrates a novel regulatory network through which CD8 T cells inhibit allergic sensitization...
  18. ncbi request reprint Identification of initiator B cells, a novel subset of activation-induced deaminase-dependent B-1-like cells that mediate initiation of contact sensitivity
    Steven M Kerfoot
    Department of Internal Medicine, Section of Allergy and Clinical Immunology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 181:1717-27. 2008
    ....
  19. ncbi request reprint Mast cells and the mediation of T-cell recruitment in arthritis
    Philip W Askenase
    N Engl J Med 349:1294. 2003
  20. ncbi request reprint Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation
    Juan Anguita
    Sections of Rheumatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 16:849-59. 2002
    ..Salp15 provides a molecular basis for understanding the immunosuppressive activity of I. scapularis saliva and vector-host interactions...
  21. pmc c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 76:308-16. 2008
    ..Collectively, these findings provide strong evidence that JNK2 is an important regulatory protein for IFN-gamma secretion upon challenge with A. phagocytophilum...

Research Grants7

  1. Initiation of Contact and Asthmatic Hypersensitivity
    Philip Askenase; Fiscal Year: 2004
    ..abstract_text> ..
  2. Initiation of Contact and Asthmatic Hypersensitivity
    Philip Askenase; Fiscal Year: 2005
    ..abstract_text> ..
  3. Initiation of Contact and Asthmatic Hypersensitivity
    Philip Askenase; Fiscal Year: 2006
    ..abstract_text> ..
  4. Initiation of Contact and Asthmatic Hypersensitivity
    Philip Askenase; Fiscal Year: 2007
    ..abstract_text> ..
  5. ALLERGY AND IMMUNOLOGY TRAINING GRANT
    Philip Askenase; Fiscal Year: 2007
    ..In summary, the program offers unique and high quality superb training of outstanding candidates for future positions in academic medicine and pediatrics, and has been quite successful over more than 25 years of continuous funding. ..