PETER ARONSON

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Sat1 is dispensable for active oxalate secretion in mouse duodenum
    Narae Ko
    Section of Nephrology, Dept of Internal Medicine, Yale School of Medicine, New Haven, CT 06520 8029, USA
    Am J Physiol Cell Physiol 303:C52-7. 2012
  2. pmc Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion
    Felix Knauf
    Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, P O Box 208029, One Gilbert Street, TAC S 255, New Haven, Connecticut 06520 8029, USA
    J Am Soc Nephrol 22:2247-55. 2011
  3. pmc Effects of pH on potassium: new explanations for old observations
    Peter S Aronson
    Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    J Am Soc Nephrol 22:1981-9. 2011
  4. ncbi request reprint Role of SLC26A6-mediated Cl⁻-oxalate exchange in renal physiology and pathophysiology
    Peter S Aronson
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    J Nephrol 23:S158-64. 2010
  5. ncbi request reprint Essential roles of CFEX-mediated Cl(-)-oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasis
    P S Aronson
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    Kidney Int 70:1207-13. 2006
  6. ncbi request reprint Role of ion exchangers in mediating NaCl transport in the proximal tubule
    P S Aronson
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Kidney Int 49:1665-70. 1996
  7. ncbi request reprint Ion exchangers mediating NaCl transport in the renal proximal tubule
    Peter S Aronson
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Cell Biochem Biophys 36:147-53. 2002
  8. ncbi request reprint Role of NHE3 in mediating renal brush border Na+-H+ exchange. Adaptation to metabolic acidosis
    M S Wu
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    J Biol Chem 271:32749-52. 1996
  9. ncbi request reprint Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+/H+ exchanger NHE3 at PKA consensus sites
    Hetal S Kocinsky
    Department of Pediatrics, Yale School of Medicine, New Haven, CT 06520 8029, USA
    Am J Physiol Renal Physiol 289:F249-58. 2005
  10. ncbi request reprint Role of SLC26-mediated Cl-/base exchange in proximal tubule NaCl transport
    Peter S Aronson
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Novartis Found Symp 273:148-58; discussion 158-63, 261-4. 2006

Collaborators

Detail Information

Publications34

  1. pmc Sat1 is dispensable for active oxalate secretion in mouse duodenum
    Narae Ko
    Section of Nephrology, Dept of Internal Medicine, Yale School of Medicine, New Haven, CT 06520 8029, USA
    Am J Physiol Cell Physiol 303:C52-7. 2012
    ..We conclude that a DIDS-sensitive basolateral transporter is involved in mediating oxalate secretion across mouse duodenum, but Sat1 itself is dispensable for this process...
  2. pmc Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion
    Felix Knauf
    Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, P O Box 208029, One Gilbert Street, TAC S 255, New Haven, Connecticut 06520 8029, USA
    J Am Soc Nephrol 22:2247-55. 2011
    ..In conclusion, absorptive oxalate flux occurs through the paracellular "leak" pathway, and net absorption of dietary oxalate depends on the relative balance between absorption and SLC26A6-dependent transcellular secretion...
  3. pmc Effects of pH on potassium: new explanations for old observations
    Peter S Aronson
    Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    J Am Soc Nephrol 22:1981-9. 2011
    ..Here we apply these advances in molecular physiology to understand how acid-base disturbances affect serum potassium...
  4. ncbi request reprint Role of SLC26A6-mediated Cl⁻-oxalate exchange in renal physiology and pathophysiology
    Peter S Aronson
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    J Nephrol 23:S158-64. 2010
    ....
  5. ncbi request reprint Essential roles of CFEX-mediated Cl(-)-oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasis
    P S Aronson
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    Kidney Int 70:1207-13. 2006
    ..Thus, by virtue of its function as a Cl(-)-oxalate exchanger, CFEX plays essential roles both in proximal tubule NaCl transport and in the prevention of hyperoxaluria and calcium oxalate nephrolithiasis...
  6. ncbi request reprint Role of ion exchangers in mediating NaCl transport in the proximal tubule
    P S Aronson
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Kidney Int 49:1665-70. 1996
    ....
  7. ncbi request reprint Ion exchangers mediating NaCl transport in the renal proximal tubule
    Peter S Aronson
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Cell Biochem Biophys 36:147-53. 2002
    ..Finally, we cloned and functionally expressed CFEX, an anion transporter expressed on the apical surface of proximal tubule cells and capable of mediating Cl(-)-formate exchange...
  8. ncbi request reprint Role of NHE3 in mediating renal brush border Na+-H+ exchange. Adaptation to metabolic acidosis
    M S Wu
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    J Biol Chem 271:32749-52. 1996
    ..We conclude that virtually all measured Na+-H+ exchange activity in brush border membranes from control and acidotic rats is mediated by NHE3 and that metabolic acidosis causes increased expression of renal brush border NHE3 protein...
  9. ncbi request reprint Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+/H+ exchanger NHE3 at PKA consensus sites
    Hetal S Kocinsky
    Department of Pediatrics, Yale School of Medicine, New Haven, CT 06520 8029, USA
    Am J Physiol Renal Physiol 289:F249-58. 2005
    ..In conclusion, we successfully generated phosphospecific antibodies that should be useful to assess the phosphorylation of endogenous NHE3 at its two PKA consensus sites under a variety of physiological conditions in vitro and in vivo...
  10. ncbi request reprint Role of SLC26-mediated Cl-/base exchange in proximal tubule NaCl transport
    Peter S Aronson
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Novartis Found Symp 273:148-58; discussion 158-63, 261-4. 2006
    ..Expression of SLC26A7 was also detected on the brush border membrane of proximal tubule cells. Finally, we demonstrated an essential role for the scaffolding protein PDZK1 in apical membrane expression of SLC26A6...
  11. ncbi request reprint NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity
    Hetal S Kocinsky
    Dept of Pediatrics, Yale University, New Haven, CT 06520 8064, USA
    Am J Physiol Renal Physiol 293:F212-8. 2007
    ..We conclude that although phosphorylation of NHE3 at serines 552 and 605 is regulated by PKA both in vivo and in vitro, phosphorylation of these sites does not directly alter Na(+)/H(+) exchange activity...
  12. ncbi request reprint Immunolocalization of NHE8 in rat kidney
    Sunita Goyal
    Dept of Internal Medicine, Yale School of Medicine, 1 Gilbert St, TAC S 255, PO Box 208029, New Haven, CT 06520 8029, USA
    Am J Physiol Renal Physiol 288:F530-8. 2005
    ..We conclude that NHE8 is expressed on the apical brush-border membrane of proximal tubule cells, where it may play a role in mediating or regulating ion transport in this nephron segment...
  13. ncbi request reprint Use of transgenic animals to study renal acid-base transport
    Tong Wang
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520 8026, USA
    J Nephrol 15:S151-60. 2002
    ....
  14. ncbi request reprint Role of dipeptidyl peptidase IV in regulating activity of Na+/H+ exchanger isoform NHE3 in proximal tubule cells
    Adriana C C Girardi
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    Am J Physiol Cell Physiol 287:C1238-45. 2004
    ..We conclude that DPPIV plays an unexpected role in modulating Na+/H+ exchange mediated by NHE3 in proximal tubule cells...
  15. ncbi request reprint Regulation of anion exchanger Slc26a6 by protein kinase C
    Hatim A Hassan
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Cell Physiol 292:C1485-92. 2007
    ..We conclude that multiple modes of anion exchange mediated by Slc26a6 are negatively regulated by PKC-delta activation...
  16. ncbi request reprint Immunolocalization of anion transporter Slc26a7 in mouse kidney
    Paul L Dudas
    Department of Internal Medicine, Yale University School of Medicine, 1 Gilbert St, TAC S 255, P O Box 208029, New Haven, CT 06520 8029, USA
    Am J Physiol Renal Physiol 290:F937-45. 2006
    ..We conclude that Slc26a7 is expressed in the proximal tubule and thick ascending limb of the loop of Henle, and it may therefore contribute to anion transport in these nephron segments...
  17. ncbi request reprint Renal expression of novel Na+/H+ exchanger isoform NHE8
    Sunita Goyal
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    Am J Physiol Renal Physiol 284:F467-73. 2003
    ..In the medulla, NHE8 message was most highly expressed in the proximal tubules (S3) of the outer stripe of the outer medulla. Thus NHE8 is expressed in the proximal tubule, where it may contribute to apical membrane ion transport...
  18. pmc Role of PDZK1 in membrane expression of renal brush border ion exchangers
    R Brent Thomson
    Department of Internal Medicine and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Proc Natl Acad Sci U S A 102:13331-6. 2005
    ..In conclusion, the scaffolding protein PDZK1 is essential for the normal expression and function of Cl-anion exchanger CFEX in the proximal tubule of the mammalian kidney...
  19. ncbi request reprint Specificity of anion exchange mediated by mouse Slc26a6
    Zhirong Jiang
    Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8029, USA
    J Biol Chem 277:33963-7. 2002
    ..In the presence of high oxalate concentrations as found in renal tubular fluid and urine, Slc26a6 may largely function as an electrogenic Cl(-)-oxalate exchanger...
  20. pmc Prestin's anion transport and voltage-sensing capabilities are independent
    Jun Ping Bai
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    Biophys J 96:3179-86. 2009
    ..Finally, we distinguish 12 charged residues out of 22, residing within prestin's transmembrane regions, that contribute to unitary charge movement, i.e., voltage sensing. These data redefine our mechanistic concept of prestin...
  21. pmc WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia
    Kristopher T Kahle
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 101:2064-9. 2004
    ..Moreover, they reveal that WNK4 regulates the activities of a diverse group of structurally unrelated ion channels, cotransporters, and exchangers...
  22. pmc Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy
    Felix Knauf
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 99:14315-9. 2002
    ..The life-extending effect of mutations in Indy is likely caused by an alteration in energy balance caused by a decrease in INDY transport function...
  23. ncbi request reprint Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6
    Zhirong Jiang
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Genet 38:474-8. 2006
    ..We conclude that the anion exchanger SLC26A6 has a major constitutive role in limiting net intestinal absorption of oxalate, thereby preventing hyperoxaluria and calcium oxalate urolithiasis...
  24. ncbi request reprint Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status
    Carsten A Wagner
    Department of Cellular and Molecular Physiology, Yale University, School of Medicine, New Haven, Connecticut, USA
    Kidney Int 62:2109-17. 2002
    ..To investigate a possible role of pendrin in modulating acid-base transport in the cortical collecting duct, we examined the regulation of expression of pendrin by acid-base status in mouse kidney...
  25. ncbi request reprint Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD
    R Brent Thomson
    Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Am J Physiol Renal Physiol 285:F870-80. 2003
    ....
  26. pmc NHE2-mediated bicarbonate reabsorption in the distal tubule of NHE3 null mice
    Matthew A Bailey
    Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Physiol 561:765-75. 2004
    ....
  27. ncbi request reprint Pendrin regulation in mouse kidney primarily is chloride-dependent
    Marion Vallet
    INSERM U652, IFR58, Institut des Cordeliers, Paris, France
    J Am Soc Nephrol 17:2153-63. 2006
    ..These results suggest that factors that are associated with changes in distal chloride delivery govern pendrin expression in the connecting tubule and cortical collecting duct...
  28. ncbi request reprint The Cl-/HCO3- exchanger pendrin in the rat kidney is regulated in response to chronic alterations in chloride balance
    Fabienne Quentin
    Institut National de la Santé et de la Recherche Médicale Unité 356, Institut Fédératif de Recherche 58, Universite Rene Descartes, Paris, France
    Am J Physiol Renal Physiol 287:F1179-88. 2004
    ..Conversely, NaCl depletion induced by furosemide was associated with increased Pds expression. We conclude that Pds expression is specifically regulated in response to changes in chloride balance...
  29. ncbi request reprint Renal and intestinal transport defects in Slc26a6-null mice
    Zhaohui Wang
    Department of Internal Medicine, Division of Nephrology and Hypertension, Univ of Cincinnati, 231 Albert Sabin Way, MSB 259G, Cincinnati OH 45267 0585, USA
    Am J Physiol Cell Physiol 288:C957-65. 2005
    ..We conclude that Slc26a6 mediates oxalate-stimulated NaCl absorption, contributes to apical membrane Cl-/base exchange in the kidney proximal tubule, and also plays an important role in HCO3- secretion in the duodenum...
  30. ncbi request reprint Ontogeny of NHE8 in the rat proximal tubule
    Amy M Becker
    Dept of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9063, USA
    Am J Physiol Renal Physiol 293:F255-61. 2007
    ..These data demonstrate that NHE8 does undergo maturational changes on the apical membrane of the rat proximal tubule and may account for the Na(+)-dependent proton flux in neonatal proximal tubules...
  31. ncbi request reprint Formate-stimulated NaCl absorption in the proximal tubule is independent of the pendrin protein
    Lawrence P Karniski
    Department of Internal Medicine, Veterans Affairs Medical Center and University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Renal Physiol 283:F952-6. 2002
    ..These studies demonstrate that pendrin is not responsible for formate-dependent NaCl reabsorption in the proximal tubule...
  32. pmc The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates
    Felix Knauf
    Franz Volhard Clinic at the Max Delbruck Center, HELIOS Kliniken Berlin, Medical Faculty of the Charite, Humboldt University, D 13125 Berlin, Germany
    Biochem J 397:25-9. 2006
    ..The effect of decreasing INDY activity, as in the long-lived Indy mutants, may be to alter energy metabolism in a manner that favours lifespan extension...
  33. pmc Characterization of Na+/H+ exchanger NHE8 in cultured renal epithelial cells
    Jianning Zhang
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 293:F761-6. 2007
    ..NHE8 activity is Na+ dependent, displaying a cooperative sigmoidal relationship, and is highly sensitive to 5-(N-ethyl-n-isopropyl)-amiloride (EIPA). NRK cells provide a useful system where NHE8 can be studied in its native environment...
  34. ncbi request reprint Membrane curvature alters the activation kinetics of the epithelial Na+/H+ exchanger, NHE3
    R Todd Alexander
    Department of Pediatrics, Program in Cell Biology, and Program in Computational Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 282:7376-84. 2007
    ..We conclude that NHE3 exists in multiple states and that different physiological parameters control the transitions between them...

Research Grants19

  1. Roles of SLC26A6 in Renal NaCI Transport and Prevention of Oxalate Urolithiasis
    PETER ARONSON; Fiscal Year: 2007
    ..The proposed studies are also relevant to clinical disorders of NaCI homeostasis such as hypertension and congestive heart failure. ..
  2. METHODS IN NEPHROLOGIC AND UROLOGIC RESEARCH
    PETER ARONSON; Fiscal Year: 2007
    ..Starting in July, 1995, one stipend per year was added to the program to support the research training of individuals in urology. We request continued funding of one stipend per year for use by urologic trainees. ..
  3. MOLECULAR MECHANISMS OF PROXIMAL TUBULE ION TRANSPORT
    PETER ARONSON; Fiscal Year: 2006
    ..nephrolithiasis, osteoporosis) and NaC1 transport (eg. hypertension, congestive heart failure). ..
  4. MOLECULAR MECHANISMS OF PROXIMAL TUBULAR ION TRANSPORT
    PETER ARONSON; Fiscal Year: 1993
    ....