Research Topics
| AMY FT ARNSTENSummaryAffiliation: Yale University Country: USA Publications
Research Grants
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Detail Information
Publications
Adrenergic pharmacology and cognition: focus on the prefrontal cortexBrian P Ramos
Department Neurobiology, Yale Medical School, New Haven, CT 06520 8001, USA
Pharmacol Ther 113:523-36. 2007..Understanding these receptor mechanisms has led to new intelligent treatments for neuropsychiatric disorders associated with PFC dysfunction...- Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stressAvis Brennan Hains
Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street SHM C 303, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 106:17957-62. 2009.... - Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapsesAmy F T Arnsten
Department of Neurobiology, Yale Medical School, New Haven, CT 06510, USA
Neuron 76:223-39. 2012..Impaired DNC regulation contributes to age-related cognitive decline, while genetic insults to DNC proteins are commonly linked to schizophrenia... - Guanfacine for the treatment of cognitive disorders: a century of discoveries at YaleAmy F T Arnsten
Department of Neurobiology, Yale School of Medicine, New Haven, CT 06510, USA
Yale J Biol Med 85:45-58. 2012..This article reviews the history of Yale discoveries on the neurobiology of PFC working memory function and the identification of guanfacine for treating cognitive disorders... 
Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatric disordersAmy F T Arnsten
Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, CT 06510, USA
J Am Acad Child Adolesc Psychiatry 51:356-67. 2012....
Stimulants: Therapeutic actions in ADHDAmy F T Arnsten
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510 8001, USA
Neuropsychopharmacology 31:2376-83. 2006..The low dose improvement is hiocked by either an alpha2-adrenoceptor or Dl receptor antagonist, suggesting that both norepinephrine and dopamine contribute to the beneficial actions of stimulant medications...- Fundamentals of attention-deficit/hyperactivity disorder: circuits and pathwaysAmy F T Arnsten
Department of Neurobiology, Yale University School of Medicine, New Haven, Conn 06510, USA
J Clin Psychiatry 67:7-12. 2006..Stimulant medications may have some of their therapeutic effects by increasing endogenous stimulation of alpha2A-adrenoceptors and dopamine D1-receptors in the PFC, optimizing PFC regulation of behavior and attention... - Dynamic Network Connectivity: A new form of neuroplasticityAmy F T Arnsten
Department Neurobiology, Yale Medical School, 333 Cedar St, New Haven, CT 06510, USA
Trends Cogn Sci 14:365-75. 2010..These insults can dysregulate network connections and erode higher cognitive abilities, leading to symptoms such as forgetfulness, susceptibility to interference, and disorganized thought and behavior... - Stress signalling pathways that impair prefrontal cortex structure and functionAmy F T Arnsten
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Nat Rev Neurosci 10:410-22. 2009..This research has provided clues as to why genetic or environmental insults that disinhibit stress signalling pathways can lead to symptoms of profound prefrontal cortical dysfunction in mental illness... - Ameliorating prefrontal cortical dysfunction in mental illness: inhibition of phosphotidyl inositol-protein kinase C signalingA F T Arnsten
Department of Neurobiology, Yale Medical School, 333 Cedar St, New Haven, CT 06510, USA
Psychopharmacology (Berl) 202:445-55. 2009..Recent data suggest that lithium and valproate can protect gray matter in patients with bipolar disorder. These findings encourage the development of protein kinase C inhibitors for the treatment of mental illness... - alpha2-Adrenergic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: emerging concepts from new dataAMY F ARNSTEN
Director of Graduate Studies, Deparment of Neurobiology, Yale Medical School, New Haven, Connecticut 06520 8001, USA
J Child Adolesc Psychopharmacol 17:393-406. 2007..Knowledge of these basic mechanisms may inform our medication choices and facilitate treatment of ADHD and related disorders... - The use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorderAmy F T Arnsten
Department of Neurobiology, Yale Medical School, 333 Cedar St, New Haven, CT 06510, USA
Expert Rev Neurother 10:1595-605. 2010..Stimulation of these receptors inhibits cAMP signaling, thus closing potassium channels and strengthening physiological connections. These actions may benefit patients with weak PFC function... - Catecholamine influences on prefrontal cortical function: relevance to treatment of attention deficit/hyperactivity disorder and related disordersAmy F T Arnsten
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Pharmacol Biochem Behav 99:211-6. 2011..Stronger PFC regulation of attention, behavior, and emotion likely contributes to the therapeutic effects of these medications for the treatment of ADHD... - Prefrontal cortical network connections: key site of vulnerability in stress and schizophreniaAmy F T Arnsten
Department of Neurobiology, Yale Medical School, 333 Cedar St, New Haven, CT 06510, USA
Int J Dev Neurosci 29:215-23. 2011.... - Neurobiology of executive functions: catecholamine influences on prefrontal cortical functionsAmy F T Arnsten
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Biol Psychiatry 57:1377-84. 2005..Most effective treatments for attention-deficit/hyperactivity disorder facilitate catecholamine transmission and likely have their therapeutic actions by optimizing catecholamine actions in prefrontal cortex... - Protein kinase A as a therapeutic target for memory disorders: rationale and challengesAmy F T Arnsten
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Trends Mol Med 11:121-8. 2005..PKA might be most practical as a therapeutic target in disorders with global alterations in cAMP-PKA activity due to genetic or environmental factors... - Catecholamine influences on dorsolateral prefrontal cortical networksAmy F T Arnsten
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Biol Psychiatry 69:e89-99. 2011..Stronger PFC regulation of attention, behavior, and emotion likely contributes to the therapeutic effects of these medications for the treatment of ADHD... - Adolescence: vulnerable period for stress-induced prefrontal cortical function? Introduction to part IVAmy F T Arnsten
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Ann N Y Acad Sci 1021:143-7. 2004..These neurobiological factors may increase susceptibility to impaired judgment, drug addiction, and neuropsychiatric disorders during adolescence... - Adrenergic targets for the treatment of cognitive deficits in schizophreniaAmy F T Arnsten
Department of Neurobiology, Yale University School of Medicine, PO Box 208001, New Haven, CT 06520 8001, USA
Psychopharmacology (Berl) 174:25-31. 2004..Although dopamine has been the major focus of schizophrenia research, norepinephrine (NE) also has marked influences on PFC cognitive functioning... - Catecholamine and second messenger influences on prefrontal cortical networks of "representational knowledge": a rational bridge between genetics and the symptoms of mental illnessAmy F T Arnsten
Department of Neurobiology, Kavli Institute of Neuroscience, Yale Medical School, New Haven, CT 06510, USA
Cereb Cortex 17:i6-15. 2007..Loss of function in these genes may render patients vulnerable to profound stress-induced PFC dysfunction including symptoms of thought disorder... - Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive declineBrian P Ramos
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Neuron 40:835-45. 2003..These data demonstrate that PKA inhibition, rather than activation, is the appropriate strategy for restoring prefrontal cortical cognitive abilities in the elderly... - Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortexMin Wang
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510 USA
Cell 129:397-410. 2007..In behavioral studies, either blockade or knockdown of HCN1 channels in PFC improved WM performance. These data reveal a powerful mechanism for rapidly altering the strength of WM networks in PFC... - Alpha2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animalsBrian P Ramos
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Learn Mem 13:770-6. 2006..These results are consistent with alpha2A-adrenoceptor stimulation enhancing PFC working-memory function via inhibition of cAMP-mediated signaling... - Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memorySusheel Vijayraghavan
Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, Connecticut 06520 8001, USA
Nat Neurosci 10:376-84. 2007..The evidence for an inverted U at the cellular level in behaving animals promises to bridge in vitro molecular analyses with human cognitive experience... - Toward a new understanding of attention-deficit hyperactivity disorder pathophysiology: an important role for prefrontal cortex dysfunctionAmy F T Arnsten
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
CNS Drugs 23:33-41. 2009..Further understanding of the neurobiology of attention and impulse control will allow us to better tailor treatments for specific patient needs... - Protein kinase C activity is associated with prefrontal cortical decline in agingAvis R Brennan
Yale University School of Medicine, Department of Neurobiology, 333 Cedar Street, New Haven, CT 06511, USA
Neurobiol Aging 30:782-92. 2009..Together these findings indicate that PKC is dysregulated in aged animals and that PKC inhibitors may be useful in the treatment of cognitive deficits in the elderly... - Neuronal mechanisms underlying attention deficit hyperactivity disorder: the influence of arousal on prefrontal cortical functionAvis R Brennan
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Ann N Y Acad Sci 1129:236-45. 2008..Medications may have many of their therapeutic effects by optimizing stimulation of alpha2A adrenoceptors and D1 receptors in the PFC, thus strengthening PFC regulation of behavior and attention... - The beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeysBrian P Ramos
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8001, USA
Biol Psychiatry 58:894-900. 2005..Pancreatic side effects in aged subjects taking betaxolol warrants further investigation... - Striatal dopamine transporters correlate with simple reaction time in elderly subjectsChristopher H van Dyck
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, United States
Neurobiol Aging 29:1237-46. 2008..These results demonstrate that a loss of nigrostriatal dopaminergic function likely contributes to slowing of reaction speed with advancing age... - Primate models of schizophrenia: future possibilitiesArthur A Simen
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Prog Brain Res 179:117-25. 2009..Adeno-associated virus technology appears particularly promising for studying the impact of genetic insults on the structure and function of the primate association cortex... - Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacineJenna S Franowicz
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 22:8771-7. 2002..These data demonstrate the importance of alpha2A-AR subtype stimulation for the cognitive functions of the prefrontal cortex and identify the molecular substrate for guanfacine and novel therapeutic interventions... - Actions of alpha-2 noradrenergic agonists on spatial working memory and blood pressure in rhesus monkeys appear to be mediated by the same receptor subtypeJenna S Franowicz
Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8001, USA
Psychopharmacology (Berl) 162:304-12. 2002..Previous evidence suggests that the most likely candidate is the alpha-2A receptor subtype... - Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growthStephane Budel
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06536, USA
J Neurosci 28:13161-72. 2008..For a restricted subset of individuals diagnosed with schizophrenia, the expression of dysfunctional NGR variants may contribute to increased disease risk... - Molecular mechanisms of stress-induced prefrontal cortical impairment: implications for mental illnessAvis B Hains
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06511, USA
Learn Mem 15:551-64. 2008..This review highlights the signaling pathways onto which genetic vulnerability and stress converge to impair PFC function and induce debilitating symptoms such as thought disorder, disinhibition, and impaired working memory... - Beta2 adrenergic agonist, clenbuterol, enhances working memory performance in aging animalsBrian P Ramos
Yale University School of Medicine, Department of Neurobiology, SHM C 300, 333 Cedar Street, New Haven, CT 06510, USA
Neurobiol Aging 29:1060-9. 2008..The effects of clenbuterol were not universal and depended on the cognitive status of the animal: the drug moderately improved only a subset of animals with working memory impairment... - Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memoryAvis R Brennan
Yale University School of Medicine, Department of Neurobiology, New Haven, Connecticut 06511, USA
Learn Mem 15:93-6. 2008..The present findings demonstrate that blockade of IP3R or SK channels in the prefrontal cortex enhances WM performance in rats, suggesting that both arms of the PI cascade influence prefrontal cognitive function... - Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive functionCraig W Berridge
Psychology Department, University of Wisconsin, Madison, WI 53706, USA
Biol Psychiatry 60:1111-20. 2006..Moreover, dopamine (DA) and norepinephrine (NE) are important modulators of PFC-dependent cognition. To date, the actions of low-dose psychostimulants on PFC DA and NE neurotransmission are unknown... - New developments in the treatment of ADHDJoseph Biederman
Dept. of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
J Clin Psychiatry 67:148-59. 2006 - Locomotor hyperactivity induced by blockade of prefrontal cortical alpha2-adrenoceptors in monkeysChao-Lin Ma
Institute of Neurobiology, Fudan University, Shanghai, The People's Republic of China
Biol Psychiatry 57:192-5. 2005..CONCLUSIONS: The present study suggests that alpha(2)-ARs in the dlPFC are involved in inhibitory control of locomotor activity... - D1 dopamine receptors in the mouse prefrontal cortex: Immunocytochemical and cognitive neuropharmacological analysesMichael S Lidow
Department of Oral and Craniofacial Biological Sciences and Program of Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
Synapse 47:101-8. 2003..Results indicate that mice are generally similar to monkeys and rats, expressing both D1A and D1B receptors in the prefrontal cortex and exhibiting an inverted "U" dose/response curve when administered SKF81297...
Research Grants
- Estrogen, Stress and Dysfunction of Prefrontal CortexAmy Arnsten; Fiscal Year: 2005..This research will begin to reveal how estrogen amplifies the neurochemical cascades that lead to activation of CREB and dysfunction of the PFC during stress ..
- Neurobiology of cortical Systems.Amy Arnsten; Fiscal Year: 2007..D.s and M.D.s. with NINDS grants and/or NINDS related research foci. Training includes coursework, intensive research apprentice-ship, structured seminar programs, and laboratory and departmental presentations of research progress. ..
- COGNITIVE LOSS WITH AGE--ROLE OF CORTICAL CATECHOLAMINESAmy Arnsten; Fiscal Year: 2007..abstract_text> ..