AMY FT ARNSTEN

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Adrenergic pharmacology and cognition: focus on the prefrontal cortex
    Brian P Ramos
    Department Neurobiology, Yale Medical School, New Haven, CT 06520 8001, USA
    Pharmacol Ther 113:523-36. 2007
  2. pmc Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress
    Avis Brennan Hains
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street SHM C 303, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 106:17957-62. 2009
  3. pmc The neurobiology of thought: the groundbreaking discoveries of Patricia Goldman-Rakic 1937-2003
    Amy F T Arnsten
    Department of Neurobiology, Yale Medical School, New Haven, CT 06510, USA
    Cereb Cortex 23:2269-81. 2013
  4. pmc Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses
    Amy F T Arnsten
    Department of Neurobiology, Yale Medical School, New Haven, CT 06510, USA
    Neuron 76:223-39. 2012
  5. pmc Guanfacine for the treatment of cognitive disorders: a century of discoveries at Yale
    Amy F T Arnsten
    Department of Neurobiology, Yale School of Medicine, New Haven, CT 06510, USA
    Yale J Biol Med 85:45-58. 2012
  6. doi request reprint Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatric disorders
    Amy F T Arnsten
    Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, CT 06510, USA
    J Am Acad Child Adolesc Psychiatry 51:356-67. 2012
  7. ncbi request reprint Fundamentals of attention-deficit/hyperactivity disorder: circuits and pathways
    Amy F T Arnsten
    Department of Neurobiology, Yale University School of Medicine, New Haven, Conn 06510, USA
    J Clin Psychiatry 67:7-12. 2006
  8. pmc The use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorder
    Amy F T Arnsten
    Department of Neurobiology, Yale Medical School, 333 Cedar St, New Haven, CT 06510, USA
    Expert Rev Neurother 10:1595-605. 2010
  9. pmc Dynamic Network Connectivity: A new form of neuroplasticity
    Amy F T Arnsten
    Department Neurobiology, Yale Medical School, 333 Cedar St, New Haven, CT 06510, USA
    Trends Cogn Sci 14:365-75. 2010
  10. ncbi request reprint Adolescence: vulnerable period for stress-induced prefrontal cortical function? Introduction to part IV
    Amy F T Arnsten
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Ann N Y Acad Sci 1021:143-7. 2004

Research Grants

Collaborators

Detail Information

Publications42

  1. pmc Adrenergic pharmacology and cognition: focus on the prefrontal cortex
    Brian P Ramos
    Department Neurobiology, Yale Medical School, New Haven, CT 06520 8001, USA
    Pharmacol Ther 113:523-36. 2007
    ..Understanding these receptor mechanisms has led to new intelligent treatments for neuropsychiatric disorders associated with PFC dysfunction...
  2. pmc Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress
    Avis Brennan Hains
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street SHM C 303, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 106:17957-62. 2009
    ....
  3. pmc The neurobiology of thought: the groundbreaking discoveries of Patricia Goldman-Rakic 1937-2003
    Amy F T Arnsten
    Department of Neurobiology, Yale Medical School, New Haven, CT 06510, USA
    Cereb Cortex 23:2269-81. 2013
    ..Ten years following her death, we look back to see how she inspired an entire field, fundamentally changing our view of cognition and cognitive disorders. ..
  4. pmc Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses
    Amy F T Arnsten
    Department of Neurobiology, Yale Medical School, New Haven, CT 06510, USA
    Neuron 76:223-39. 2012
    ..Impaired DNC regulation contributes to age-related cognitive decline, while genetic insults to DNC proteins are commonly linked to schizophrenia...
  5. pmc Guanfacine for the treatment of cognitive disorders: a century of discoveries at Yale
    Amy F T Arnsten
    Department of Neurobiology, Yale School of Medicine, New Haven, CT 06510, USA
    Yale J Biol Med 85:45-58. 2012
    ..This article reviews the history of Yale discoveries on the neurobiology of PFC working memory function and the identification of guanfacine for treating cognitive disorders...
  6. doi request reprint Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatric disorders
    Amy F T Arnsten
    Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, CT 06510, USA
    J Am Acad Child Adolesc Psychiatry 51:356-67. 2012
    ....
  7. ncbi request reprint Fundamentals of attention-deficit/hyperactivity disorder: circuits and pathways
    Amy F T Arnsten
    Department of Neurobiology, Yale University School of Medicine, New Haven, Conn 06510, USA
    J Clin Psychiatry 67:7-12. 2006
    ..Stimulant medications may have some of their therapeutic effects by increasing endogenous stimulation of alpha2A-adrenoceptors and dopamine D1-receptors in the PFC, optimizing PFC regulation of behavior and attention...
  8. pmc The use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorder
    Amy F T Arnsten
    Department of Neurobiology, Yale Medical School, 333 Cedar St, New Haven, CT 06510, USA
    Expert Rev Neurother 10:1595-605. 2010
    ..Stimulation of these receptors inhibits cAMP signaling, thus closing potassium channels and strengthening physiological connections. These actions may benefit patients with weak PFC function...
  9. pmc Dynamic Network Connectivity: A new form of neuroplasticity
    Amy F T Arnsten
    Department Neurobiology, Yale Medical School, 333 Cedar St, New Haven, CT 06510, USA
    Trends Cogn Sci 14:365-75. 2010
    ..These insults can dysregulate network connections and erode higher cognitive abilities, leading to symptoms such as forgetfulness, susceptibility to interference, and disorganized thought and behavior...
  10. ncbi request reprint Adolescence: vulnerable period for stress-induced prefrontal cortical function? Introduction to part IV
    Amy F T Arnsten
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Ann N Y Acad Sci 1021:143-7. 2004
    ..These neurobiological factors may increase susceptibility to impaired judgment, drug addiction, and neuropsychiatric disorders during adolescence...
  11. ncbi request reprint Catecholamine and second messenger influences on prefrontal cortical networks of "representational knowledge": a rational bridge between genetics and the symptoms of mental illness
    Amy F T Arnsten
    Department of Neurobiology, Kavli Institute of Neuroscience, Yale Medical School, New Haven, CT 06510, USA
    Cereb Cortex 17:i6-15. 2007
    ..Loss of function in these genes may render patients vulnerable to profound stress-induced PFC dysfunction including symptoms of thought disorder...
  12. ncbi request reprint alpha2-Adrenergic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: emerging concepts from new data
    AMY F ARNSTEN
    Director of Graduate Studies, Deparment of Neurobiology, Yale Medical School, New Haven, Connecticut 06520 8001, USA
    J Child Adolesc Psychopharmacol 17:393-406. 2007
    ..Knowledge of these basic mechanisms may inform our medication choices and facilitate treatment of ADHD and related disorders...
  13. pmc Stress signalling pathways that impair prefrontal cortex structure and function
    Amy F T Arnsten
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Neurosci 10:410-22. 2009
    ..This research has provided clues as to why genetic or environmental insults that disinhibit stress signalling pathways can lead to symptoms of profound prefrontal cortical dysfunction in mental illness...
  14. ncbi request reprint Stimulants: Therapeutic actions in ADHD
    Amy F T Arnsten
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510 8001, USA
    Neuropsychopharmacology 31:2376-83. 2006
    ..The low dose improvement is hiocked by either an alpha2-adrenoceptor or Dl receptor antagonist, suggesting that both norepinephrine and dopamine contribute to the beneficial actions of stimulant medications...
  15. pmc Catecholamine influences on prefrontal cortical function: relevance to treatment of attention deficit/hyperactivity disorder and related disorders
    Amy F T Arnsten
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Pharmacol Biochem Behav 99:211-6. 2011
    ..Stronger PFC regulation of attention, behavior, and emotion likely contributes to the therapeutic effects of these medications for the treatment of ADHD...
  16. ncbi request reprint Adrenergic targets for the treatment of cognitive deficits in schizophrenia
    Amy F T Arnsten
    Department of Neurobiology, Yale University School of Medicine, PO Box 208001, New Haven, CT 06520 8001, USA
    Psychopharmacology (Berl) 174:25-31. 2004
    ..Although dopamine has been the major focus of schizophrenia research, norepinephrine (NE) also has marked influences on PFC cognitive functioning...
  17. pmc Prefrontal cortical network connections: key site of vulnerability in stress and schizophrenia
    Amy F T Arnsten
    Department of Neurobiology, Yale Medical School, 333 Cedar St, New Haven, CT 06510, USA
    Int J Dev Neurosci 29:215-23. 2011
    ....
  18. ncbi request reprint Protein kinase A as a therapeutic target for memory disorders: rationale and challenges
    Amy F T Arnsten
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Trends Mol Med 11:121-8. 2005
    ..PKA might be most practical as a therapeutic target in disorders with global alterations in cAMP-PKA activity due to genetic or environmental factors...
  19. ncbi request reprint Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions
    Amy F T Arnsten
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Biol Psychiatry 57:1377-84. 2005
    ..Most effective treatments for attention-deficit/hyperactivity disorder facilitate catecholamine transmission and likely have their therapeutic actions by optimizing catecholamine actions in prefrontal cortex...
  20. pmc Catecholamine influences on dorsolateral prefrontal cortical networks
    Amy F T Arnsten
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Biol Psychiatry 69:e89-99. 2011
    ..Stronger PFC regulation of attention, behavior, and emotion likely contributes to the therapeutic effects of these medications for the treatment of ADHD...
  21. pmc Ameliorating prefrontal cortical dysfunction in mental illness: inhibition of phosphotidyl inositol-protein kinase C signaling
    A F T Arnsten
    Department of Neurobiology, Yale Medical School, 333 Cedar St, New Haven, CT 06510, USA
    Psychopharmacology (Berl) 202:445-55. 2009
    ....
  22. ncbi request reprint Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline
    Brian P Ramos
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 40:835-45. 2003
    ..These data demonstrate that PKA inhibition, rather than activation, is the appropriate strategy for restoring prefrontal cortical cognitive abilities in the elderly...
  23. ncbi request reprint Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex
    Min Wang
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510 USA
    Cell 129:397-410. 2007
    ..In behavioral studies, either blockade or knockdown of HCN1 channels in PFC improved WM performance. These data reveal a powerful mechanism for rapidly altering the strength of WM networks in PFC...
  24. pmc Alpha2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals
    Brian P Ramos
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Learn Mem 13:770-6. 2006
    ..These results are consistent with alpha2A-adrenoceptor stimulation enhancing PFC working-memory function via inhibition of cAMP-mediated signaling...
  25. doi request reprint Toward a new understanding of attention-deficit hyperactivity disorder pathophysiology: an important role for prefrontal cortex dysfunction
    Amy F T Arnsten
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    CNS Drugs 23:33-41. 2009
    ..Further understanding of the neurobiology of attention and impulse control will allow us to better tailor treatments for specific patient needs...
  26. ncbi request reprint Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
    Susheel Vijayraghavan
    Department of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, Connecticut 06520 8001, USA
    Nat Neurosci 10:376-84. 2007
    ..The evidence for an inverted U at the cellular level in behaving animals promises to bridge in vitro molecular analyses with human cognitive experience...
  27. pmc Neuronal mechanisms underlying attention deficit hyperactivity disorder: the influence of arousal on prefrontal cortical function
    Avis R Brennan
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Ann N Y Acad Sci 1129:236-45. 2008
    ..Medications may have many of their therapeutic effects by optimizing stimulation of alpha2A adrenoceptors and D1 receptors in the PFC, thus strengthening PFC regulation of behavior and attention...
  28. ncbi request reprint The beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeys
    Brian P Ramos
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8001, USA
    Biol Psychiatry 58:894-900. 2005
    ..The current study examined the effects of the selective beta-1 antagonist, betaxolol, on working memory in rats and monkeys...
  29. pmc Striatal dopamine transporters correlate with simple reaction time in elderly subjects
    Christopher H van Dyck
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, United States
    Neurobiol Aging 29:1237-46. 2008
    ..These results demonstrate that a loss of nigrostriatal dopaminergic function likely contributes to slowing of reaction speed with advancing age...
  30. pmc Primate models of schizophrenia: future possibilities
    Arthur A Simen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Prog Brain Res 179:117-25. 2009
    ..Adeno-associated virus technology appears particularly promising for studying the impact of genetic insults on the structure and function of the primate association cortex...
  31. pmc Protein kinase C activity is associated with prefrontal cortical decline in aging
    Avis R Brennan
    Yale University School of Medicine, Department of Neurobiology, 333 Cedar Street, New Haven, CT 06511, USA
    Neurobiol Aging 30:782-92. 2009
    ..Together these findings indicate that PKC is dysregulated in aged animals and that PKC inhibitors may be useful in the treatment of cognitive deficits in the elderly...
  32. ncbi request reprint Actions of alpha-2 noradrenergic agonists on spatial working memory and blood pressure in rhesus monkeys appear to be mediated by the same receptor subtype
    Jenna S Franowicz
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8001, USA
    Psychopharmacology (Berl) 162:304-12. 2002
    ..alpha-2 Agonists are also known to decrease blood pressure significantly. Recent evidence using genetically altered mice indicates that the alpha-2A receptor subtype mediates this decrease in blood pressure...
  33. ncbi request reprint Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine
    Jenna S Franowicz
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:8771-7. 2002
    ..These data demonstrate the importance of alpha2A-AR subtype stimulation for the cognitive functions of the prefrontal cortex and identify the molecular substrate for guanfacine and novel therapeutic interventions...
  34. pmc Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth
    Stephane Budel
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Neurosci 28:13161-72. 2008
    ..For a restricted subset of individuals diagnosed with schizophrenia, the expression of dysfunctional NGR variants may contribute to increased disease risk...
  35. pmc Beta2 adrenergic agonist, clenbuterol, enhances working memory performance in aging animals
    Brian P Ramos
    Yale University School of Medicine, Department of Neurobiology, SHM C 300, 333 Cedar Street, New Haven, CT 06510, USA
    Neurobiol Aging 29:1060-9. 2008
    ..The effects of clenbuterol were not universal and depended on the cognitive status of the animal: the drug moderately improved only a subset of animals with working memory impairment...
  36. ncbi request reprint Molecular mechanisms of stress-induced prefrontal cortical impairment: implications for mental illness
    Avis B Hains
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Learn Mem 15:551-64. 2008
    ..This review highlights the signaling pathways onto which genetic vulnerability and stress converge to impair PFC function and induce debilitating symptoms such as thought disorder, disinhibition, and impaired working memory...
  37. pmc Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory
    Avis R Brennan
    Yale University School of Medicine, Department of Neurobiology, New Haven, Connecticut 06511, USA
    Learn Mem 15:93-6. 2008
    ..The present findings demonstrate that blockade of IP3R or SK channels in the prefrontal cortex enhances WM performance in rats, suggesting that both arms of the PI cascade influence prefrontal cognitive function...
  38. ncbi request reprint Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function
    Craig W Berridge
    Psychology Department, University of Wisconsin, Madison, WI 53706, USA
    Biol Psychiatry 60:1111-20. 2006
    ..Moreover, dopamine (DA) and norepinephrine (NE) are important modulators of PFC-dependent cognition. To date, the actions of low-dose psychostimulants on PFC DA and NE neurotransmission are unknown...
  39. ncbi request reprint New developments in the treatment of ADHD
    Joseph Biederman
    Dept of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 67:148-59. 2006
  40. ncbi request reprint Locomotor hyperactivity induced by blockade of prefrontal cortical alpha2-adrenoceptors in monkeys
    Chao Lin Ma
    Institute of Neurobiology, Fudan University, Shanghai, The People s Republic of China
    Biol Psychiatry 57:192-5. 2005
    ..However, it is unknown if alpha(2)-ARs in the PFC are involved in the neural mechanisms underlying regulation of locomotor activity...
  41. ncbi request reprint D1 dopamine receptors in the mouse prefrontal cortex: Immunocytochemical and cognitive neuropharmacological analyses
    Michael S Lidow
    Department of Oral and Craniofacial Biological Sciences and Program of Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    Synapse 47:101-8. 2003
    ..Results indicate that mice are generally similar to monkeys and rats, expressing both D1A and D1B receptors in the prefrontal cortex and exhibiting an inverted "U" dose/response curve when administered SKF81297...

Research Grants7

  1. Neurobiology of cortical Systems.
    Amy Arnsten; Fiscal Year: 2007
    ..D.s and M.D.s. with NINDS grants and/or NINDS related research foci. Training includes coursework, intensive research apprentice-ship, structured seminar programs, and laboratory and departmental presentations of research progress. ..
  2. Estrogen, Stress and Dysfunction of Prefrontal Cortex
    Amy Arnsten; Fiscal Year: 2005
    ..This research will begin to reveal how estrogen amplifies the neurochemical cascades that lead to activation of CREB and dysfunction of the PFC during stress ..
  3. COGNITIVE LOSS WITH AGE--ROLE OF CORTICAL CATECHOLAMINES
    Amy Arnsten; Fiscal Year: 2007
    ..abstract_text> ..