Dan Arin-Silasi

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody
    Rhoda Raji
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    J Exp Clin Cancer Res 30:106. 2011
  2. ncbi Expression of tissue factor in adenocarcinoma and squamous cell carcinoma of the uterine cervix: implications for immunotherapy with hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor
    Emiliano Cocco
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA
    BMC Cancer 11:263. 2011
  3. ncbi Carcinosarcoma of the ovary
    D A Silasi
    Division of Gynecology Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Int J Gynecol Cancer 18:22-9. 2008
  4. ncbi Phenoxodiol: pharmacology and clinical experience in cancer monotherapy and in combination with chemotherapeutic drugs
    Dan Arin Silasi
    Yale University School of Medicine, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, CT 06520, USA
    Expert Opin Pharmacother 10:1059-67. 2009
  5. ncbi Generation of CA125-specific cytotoxic T lymphocytes in human leukocyte antigen-A2.1-positive healthy donors and patients with advanced ovarian cancer
    Stefania Bellone
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Am J Obstet Gynecol 200:75.e1-10. 2009
  6. ncbi High-grade, chemotherapy-resistant ovarian carcinomas overexpress epithelial cell adhesion molecule (EpCAM) and are highly sensitive to immunotherapy with MT201, a fully human monoclonal anti-EpCAM antibody
    Christine E Richter
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 203:582.e1-7. 2010
  7. ncbi Primary cervical carcinoma cell lines overexpress epithelial cell adhesion molecule (EpCAM) and are highly sensitive to immunotherapy with MT201, a fully human monoclonal anti-EpCAM antibody
    Christine E Richter
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Int J Gynecol Cancer 20:1440-7. 2010
  8. ncbi Cervical carcinomas overexpress human trophoblast cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized monoclonal anti-Trop-2 antibody
    Joyce Varughese
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 205:567.e1-7. 2011
  9. ncbi Overexpression of EpCAM in uterine serous papillary carcinoma: implications for EpCAM-specific immunotherapy with human monoclonal antibody adecatumumab (MT201)
    Karim El-Sahwi
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Mol Cancer Ther 9:57-66. 2010
  10. ncbi Induction of human tumor-associated differentially expressed gene-12 (TADG-12/TMPRSS3)-specific cytotoxic T lymphocytes in human lymphocyte antigen-A2.1-positive healthy donors and patients with advanced ovarian cancer
    Stefania Bellone
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Cancer 115:800-11. 2009

Collaborators

Detail Information

Publications24

  1. ncbi Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody
    Rhoda Raji
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    J Exp Clin Cancer Res 30:106. 2011
    ....
  2. ncbi Expression of tissue factor in adenocarcinoma and squamous cell carcinoma of the uterine cervix: implications for immunotherapy with hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor
    Emiliano Cocco
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06519, USA
    BMC Cancer 11:263. 2011
    ....
  3. ncbi Carcinosarcoma of the ovary
    D A Silasi
    Division of Gynecology Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Int J Gynecol Cancer 18:22-9. 2008
    ..The most effective cytotoxic regimen remains to be determined. First-line cisplatin and ifosfamide or carboplatin and taxol can achieve survival rates observed in epithelial ovarian cancer...
  4. ncbi Phenoxodiol: pharmacology and clinical experience in cancer monotherapy and in combination with chemotherapeutic drugs
    Dan Arin Silasi
    Yale University School of Medicine, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, CT 06520, USA
    Expert Opin Pharmacother 10:1059-67. 2009
    ..The US Food and Drug Administration has granted 'fast track' status to the development of phenoxodiol as chemosensitizer for platinum and taxane drugs used in the treatment of recurrent ovarian cancer...
  5. ncbi Generation of CA125-specific cytotoxic T lymphocytes in human leukocyte antigen-A2.1-positive healthy donors and patients with advanced ovarian cancer
    Stefania Bellone
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Am J Obstet Gynecol 200:75.e1-10. 2009
    ..To identify potential immunogenic peptides derived from CA125...
  6. ncbi High-grade, chemotherapy-resistant ovarian carcinomas overexpress epithelial cell adhesion molecule (EpCAM) and are highly sensitive to immunotherapy with MT201, a fully human monoclonal anti-EpCAM antibody
    Christine E Richter
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 203:582.e1-7. 2010
    ..We evaluated the expression of epithelial cell adhesion molecule (EpCAM) and the potential of MT201 (adecatumumab), a human-monoclonal-antibody that targets EpCAM against chemotherapy-resistant ovarian disease...
  7. ncbi Primary cervical carcinoma cell lines overexpress epithelial cell adhesion molecule (EpCAM) and are highly sensitive to immunotherapy with MT201, a fully human monoclonal anti-EpCAM antibody
    Christine E Richter
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Int J Gynecol Cancer 20:1440-7. 2010
    ..The goal of this study was to evaluate the expression of EpCAM and the potential of MT201 (adecatumumab), a human monoclonal antibody targeting EpCAM, against multiple primary cervical carcinoma cell lines...
  8. ncbi Cervical carcinomas overexpress human trophoblast cell-surface marker (Trop-2) and are highly sensitive to immunotherapy with hRS7, a humanized monoclonal anti-Trop-2 antibody
    Joyce Varughese
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Obstet Gynecol 205:567.e1-7. 2011
    ..We evaluated the expression of human trophoblast cell-surface marker (Trop-2) and the potential of hRS7, a humanized monoclonal anti-Trop-2 antibody, against treatment-refractory cervical cancer...
  9. ncbi Overexpression of EpCAM in uterine serous papillary carcinoma: implications for EpCAM-specific immunotherapy with human monoclonal antibody adecatumumab (MT201)
    Karim El-Sahwi
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Mol Cancer Ther 9:57-66. 2010
    ..MT201 might represent a novel therapeutic strategy in patients harboring advanced/recurrent or metastatic USPC refractory to standard treatment modalities...
  10. ncbi Induction of human tumor-associated differentially expressed gene-12 (TADG-12/TMPRSS3)-specific cytotoxic T lymphocytes in human lymphocyte antigen-A2.1-positive healthy donors and patients with advanced ovarian cancer
    Stefania Bellone
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Cancer 115:800-11. 2009
    ..The goal of this study was to identify potential immunogenic peptides derived from TADG-12 for immunotherapy of ovarian carcinoma...
  11. ncbi Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGF(c) chimeric protein targeting tissue factor
    Emiliano Cocco
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Clin Exp Metastasis 28:689-700. 2011
    ....
  12. ncbi Eradication of chemotherapy-resistant CD44+ human ovarian cancer stem cells in mice by intraperitoneal administration of Clostridium perfringens enterotoxin
    Francesca Casagrande
    Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut 06520 8063, USA
    Cancer 117:5519-28. 2011
    ..Because this tight junction protein is the natural high-affinity receptor for Clostridium perfringens enterotoxin (CPE), we have extensively investigated the sensitivity of ovarian cancer stem cells to CPE treatment in vitro and in vivo...
  13. ncbi Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance
    Ayesha B Alvero
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Cell Cycle 8:158-66. 2009
    ..The identification and cloning of human OCSCs can aid in the development of better therapeutic approaches for ovarian cancer patients...
  14. ncbi The significance of perineural invasion in early-stage cervical cancer
    Karim S Elsahwi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, CT, USA
    Gynecol Oncol 123:561-4. 2011
    ..Cervical cancer spreads directly and through lymphatic and vascular channels. Perineural invasion is an alternative method of spread. Several risk factors portend poor prognosis and inform management decisions regarding adjuvant therapy...
  15. ncbi Detection of cancer-related proteins in fresh-frozen ovarian cancer samples using laser capture microdissection
    Dan Arin Silasi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Biol 414:35-45. 2008
    ..Using this technique, we can detect proteins such as X-linked inhibitor of apoptosis protein (XIAP) and Fas ligand (FasL) with as little as 1000 cells...
  16. ncbi Inflammation, cancer and chemoresistance: taking advantage of the toll-like receptor signaling pathway
    Rui Chen
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Am J Reprod Immunol 57:93-107. 2007
    ....
  17. ncbi Regulation of inflammation by the NF-κB pathway in ovarian cancer stem cells
    Aliza L Leizer
    Department of Obstetrics Gynecology and Reproductive Sciences, Yale University, New Haven, CT 06520, USA
    Am J Reprod Immunol 65:438-47. 2011
    ..The aim of this study is to determine whether the inhibition of NFκB by Eriocalyxin B (EriB) in the OCSCs may induce cell death in otherwise chemoresistant cells...
  18. ncbi Stem-like ovarian cancer cells can serve as tumor vascular progenitors
    Ayesha B Alvero
    Department of Obstetrics and Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Stem Cells 27:2405-13. 2009
    ..Our findings suggest that anti-angiogenic therapies should take into consideration the inherent capacity of these cells to serve as vascular progenitors...
  19. ncbi HER-2/NEU overexpression in vulvar Paget disease: the Yale experience
    Christine E Richter
    Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Clin Pathol 63:544-7. 2010
    ..To determine the level of HER-2/neu overexpression in vulvar Paget disease (PD) in order to assess the possibility of using HER-2/neu as a target for the treatment of Paget disease...
  20. ncbi MyD88 predicts chemoresistance to paclitaxel in epithelial ovarian cancer
    Dan Arin Silasi
    Department of Obstetrics, Gynecology, and Reproductive Services, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Yale J Biol Med 79:153-63. 2006
    ..The objective of this study was to determine the correlation of MyD88 expression in primary and recurrent epithelial ovarian cancers with the response to carboplatin and paclitaxel combination chemotherapy...
  21. ncbi Overexpression of epithelial cell adhesion molecule in primary, metastatic, and recurrent/chemotherapy-resistant epithelial ovarian cancer: implications for epithelial cell adhesion molecule-specific immunotherapy
    Stefania Bellone
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Int J Gynecol Cancer 19:860-6. 2009
    ....
  22. ncbi Human papillomavirus type 16 (HPV-16) virus-like particle L1-specific CD8+ cytotoxic T lymphocytes (CTLs) are equally effective as E7-specific CD8+ CTLs in killing autologous HPV-16-positive tumor cells in cervical cancer patients: implications for L1 den
    Stefania Bellone
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    J Virol 83:6779-89. 2009
    ..These results may have important implications for the treatment of patients harboring established HPV-infected lesions with L1 VLPs or combined E7/L1 DC-based vaccinations...
  23. ncbi Clostridium perfringens enterotoxin carboxy-terminal fragment is a novel tumor-homing peptide for human ovarian cancer
    Emiliano Cocco
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    BMC Cancer 10:349. 2010
    ..Using high-throughput technologies to analyze genetic fingerprints of ovarian cancer, we have discovered extremely high expression of the genes encoding the proteins claudin-3 and claudin-4...
  24. ncbi Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells
    R Chen
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA
    Oncogene 27:225-33. 2008
    ..TLRs serve as cell surface sensors that can initiate pathways leading to proliferation and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression...