A Arici

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Regulation of interleukin-8 expression in human endometrial endothelial cells: a potential mechanism for the pathogenesis of endometriosis
    Janelle Luk
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 806, USA
    J Clin Endocrinol Metab 90:1805-11. 2005
  2. ncbi Altered expression of interleukin-18 in the peritoneal fluid of women with endometriosis
    Aydin Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 80:889-94. 2003
  3. ncbi Phyto-oestrogens and the endometrium
    Aydin Arici
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Lancet 364:2081-2. 2004
  4. ncbi Endometrial cancer and fertility
    Beth W Rackow
    Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Curr Opin Obstet Gynecol 18:245-52. 2006
  5. ncbi Estrogen-mediated regulation of p38 mitogen-activated protein kinase in human endometrium
    Yasemin Seval
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    J Clin Endocrinol Metab 91:2349-57. 2006
  6. ncbi Increased levels of interleukin-15 in the peritoneal fluid of women with endometriosis: inverse correlation with stage and depth of invasion
    Aydin Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520 8063, USA
    Hum Reprod 18:429-32. 2003
  7. ncbi Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor-beta1 in human myometrium and leiomyoma
    Aydin Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Obstet Gynecol 188:76-83. 2003
  8. ncbi Diagnostic role of inhibin B in resistant ovary syndrome associated with secondary amenorrhea
    Aydin Arici
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 78:1324-6. 2002
  9. ncbi Increased pregnancy-associated plasma protein-A (PAPP-A) concentrations in peritoneal fluid of women with endometriosis
    Aydin Arici
    Yale University School of Medicine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, New Haven, CT 06520 8063, USA
    Am J Reprod Immunol 49:70-4. 2003
  10. ncbi Local cytokines in endometrial tissue: the role of interleukin-8 in the pathogenesis of endometriosis
    Aydin Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Ann N Y Acad Sci 955:101-9; discussion 118, 396-406. 2002

Collaborators

Detail Information

Publications86

  1. ncbi Regulation of interleukin-8 expression in human endometrial endothelial cells: a potential mechanism for the pathogenesis of endometriosis
    Janelle Luk
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 806, USA
    J Clin Endocrinol Metab 90:1805-11. 2005
    ..We postulate that the stimulation of chemokine expression by sex steroids in HEEC of women with endometriosis may play a role in the inflammatory aspect of this disease...
  2. ncbi Altered expression of interleukin-18 in the peritoneal fluid of women with endometriosis
    Aydin Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 80:889-94. 2003
    ..Peritoneal fluid (PF) inflammatory factors may participate in the pathogenesis of endometriosis. The aim of this study was to investigate PF interleukin (IL)-18 levels in women with and without endometriosis...
  3. ncbi Phyto-oestrogens and the endometrium
    Aydin Arici
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA
    Lancet 364:2081-2. 2004
  4. ncbi Endometrial cancer and fertility
    Beth W Rackow
    Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Curr Opin Obstet Gynecol 18:245-52. 2006
    ..Endometrial cancer can affect reproductive-age women who may desire fertility preservation. This article discusses the current, available data about conservative management of endometrial cancer in young women...
  5. ncbi Estrogen-mediated regulation of p38 mitogen-activated protein kinase in human endometrium
    Yasemin Seval
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    J Clin Endocrinol Metab 91:2349-57. 2006
    ..p38 MAPK plays key roles in mediating apoptosis, proliferation, and inflammation, which all take place in the endometrium during cyclical changes under the influence of estrogen...
  6. ncbi Increased levels of interleukin-15 in the peritoneal fluid of women with endometriosis: inverse correlation with stage and depth of invasion
    Aydin Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520 8063, USA
    Hum Reprod 18:429-32. 2003
    ..Interleukin (IL)-15 is a novel cytokine with immunoregulatory and angiogenic properties. We compared IL-15 levels in the peritoneal fluid (PF) of women with and without endometriosis...
  7. ncbi Expression, menstrual cycle-dependent activation, and bimodal mitogenic effect of transforming growth factor-beta1 in human myometrium and leiomyoma
    Aydin Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Obstet Gynecol 188:76-83. 2003
    ..We also studied the mitogenic effects of transforming growth factor-beta1 and platelet derived growth factor on myometrial and leiomyoma cells in culture...
  8. ncbi Diagnostic role of inhibin B in resistant ovary syndrome associated with secondary amenorrhea
    Aydin Arici
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 78:1324-6. 2002
    ..Inhibin B has a diagnostic role in women with gonadotropin-resistant ovary syndrome associated with secondary amenorrhea. A review of the literature confirms the uniqueness of the diagnostic role of inhibin B in these cases...
  9. ncbi Increased pregnancy-associated plasma protein-A (PAPP-A) concentrations in peritoneal fluid of women with endometriosis
    Aydin Arici
    Yale University School of Medicine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, New Haven, CT 06520 8063, USA
    Am J Reprod Immunol 49:70-4. 2003
    ..We hypothesized that PAPP-A levels might also be elevated in the peritoneal fluid (PF) of women with endometriosis, and examined variations in PF PAPP-A during the menstrual cycle and with the severity of the disease...
  10. ncbi Local cytokines in endometrial tissue: the role of interleukin-8 in the pathogenesis of endometriosis
    Aydin Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Ann N Y Acad Sci 955:101-9; discussion 118, 396-406. 2002
    ....
  11. ncbi Transforming growth factor-beta3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation
    A Arici
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA
    Fertil Steril 73:1006-11. 2000
    ..CONCLUSION(s): These findings suggest that TGF-beta3 may be mediating the growth-promoting effects of sex steroids on leiomyomas by playing a role in the fibrogenic process and cell proliferation that characterize these tumors...
  12. ncbi Interleukin-8 expression and modulation in human preovulatory follicles and ovarian cells
    A Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Endocrinology 137:3762-9. 1996
    ..The modulation of IL-8 in these cell cultures by steroid and trophic hormones suggests that IL-8 may play an important role in the physiology of ovulation, such as timely follicular rupture and neovascularization of the corpus luteum...
  13. ncbi Monocyte chemotactic protein-1 expression in human preovulatory follicles and ovarian cells
    A Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    J Reprod Immunol 32:201-19. 1997
    ..We propose that regulation of MCP-1 in ovarian stromal and granulosa-lutein cells by cytokines may play a role in the physiology of periovulatory events...
  14. ncbi Interleukin-8 induces proliferation of endometrial stromal cells: a potential autocrine growth factor
    A Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 83:1201-5. 1998
    ..We propose that IL-8 may act as an autocrine growth factor in the endometrium, and suggest that it may also play a role in the pathogenesis of endometriosis...
  15. ncbi Interleukin-8 in the human endometrium
    A Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 83:1783-7. 1998
    ..We speculate that IL-8 may modulate the timely recruitment of neutrophils and lymphocytes into the endometrium...
  16. ncbi Interleukin 8 production and interleukin 8 receptor expression in human myometrium and leiomyoma
    L M Senturk
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA
    Am J Obstet Gynecol 184:559-66. 2001
    ..This study could lead to a better understanding of potential involvement of cytokines in leiomyoma growth and in gonadatropin-releasing hormone agonist-induced regression...
  17. ncbi Regulation of Fas ligand expression by estradiol and progesterone in human endometrium
    B Selam
    Yale University School of Medicine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, New Haven, Connecticut 06520-8063, USA
    Biol Reprod 65:979-85. 2001
    ..We speculate that increased FasL expression may mediate the apoptosis of endometrial cells and thus may play a role in trophoblast invasion...
  18. ncbi Regulation of monocyte chemotactic protein-1 expression in human endometrial stromal cells by estrogen and progesterone
    A Arici
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Biol Reprod 61:85-90. 1999
    ..In summary, we found that E2 inhibits MCP-1 expression in endometrial stromal cells, and we speculate that E2 may control endometrial macrophage migration by regulating MCP-1 expression...
  19. ncbi Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen
    E Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 75:1172-6. 2001
    ..To determine whether aminopeptidase N (APN) regulates the cycle-dependent bioavailability of interleukin-8 (IL-8) in the endometrium...
  20. ncbi Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium
    H S Taylor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 84:1129-35. 1999
    ..Steroids are novel regulators HOX gene expression. The spatial and temporal pattern of HOXA11 expression in the human endometrium suggests a role in endometrial development, implantation, and maintenance of pregnancy...
  21. ncbi Estradiol regulates monocyte chemotactic protein-1 in human coronary artery smooth muscle cells: a mechanism for its antiatherogenic effect
    E Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 6520-8063, USA
    Menopause 8:296-301. 2001
    ..CONCLUSION: Our findings suggest that one of the mechanisms by which estrogen prevents atherosclerosis is by down-regulating MCP-1 expression, thus decreasing macrophage recruitment to the arterial wall...
  22. ncbi Growth-regulated alpha expression in the peritoneal environment with endometriosis
    E Oral
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA
    Obstet Gynecol 88:1050-6. 1996
    ..To investigate the presence and modulation of growth-regulated alpha, a member of the chemokine family with neutrophil chemotactic activity, in the peritoneal fluid of women with or without endometriosis...
  23. ncbi Regulation and activation of ezrin protein in endometriosis
    T Ornek
    Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Hum Reprod 23:2104-12. 2008
    ..In this study, we hypothesized that these proteins play a role in the pathogenesis of endometriosis by promoting adhesion and invasion of endometrial stromal cells (ESCs) in ectopic sites...
  24. ncbi Association of endometriosis with family history of non-Hodgkin's lymphoma: presentation of 10 cases
    I Matalliotakis
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA
    J BUON 14:699-701. 2009
    ..The purpose of this article was to investigate the familial risk of NHL in women with endometriosis. We report on 10 cases with endometriosis and positive family history of NHL...
  25. ncbi Effect of gonadotropin-releasing hormone agonists on monocyte chemotactic protein-1 production and macrophage infiltration in leiomyomatous uterus
    I Sozen
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA
    Fertil Steril 76:792-6. 2001
    ....
  26. ncbi Regulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro
    M Berkkanoglu
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Hum Reprod 10:393-8. 2004
    ..Our results show that FasL in endometrial stromal cells in culture has a cyclic expression model, suggesting that there may be a regulation at the translation level...
  27. ncbi Endocrine-immune interactions in human endometrium
    U A Kayisli
    Yale University School of Medicine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, 333 Cedar Street, New Haven, CT 06520-8063, USA
    Ann N Y Acad Sci 1034:50-63. 2004
    ....
  28. ncbi HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium
    H S Taylor
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 101:1379-84. 1998
    ..HOXA10 may have an important function in regulating endometrial development during the menstrual cycle and in establishing conditions necessary for implantation in the human...
  29. ncbi High rate of allergies among women with endometriosis
    I Matalliotakis
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    J Obstet Gynaecol 32:291-3. 2012
    ..Overall, our study indicated a link between endometriosis and increased risk of allergic autoimmune disorders that should further be explored...
  30. ncbi Interleukin-8 in the human fallopian tube
    S F Palter
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 86:2660-7. 2001
    ..The IL-8 system seems to be an active component of tubal physiology...
  31. ncbi Proliferation and differentiation of rat theca-interstitial cells: comparison of effects induced by platelet-derived growth factor and insulin-like growth factor-I
    A J Duleba
    Department of Obstetrics, Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Biol Reprod 60:546-50. 1999
    ....
  32. ncbi Endometriosis and assisted reproductive technologies: are outcomes affected?
    N G Mahutte
    Department of Obstetrics and Gynecology, Yale University, New Haven, Connecticut 06520 8063, USA
    Curr Opin Obstet Gynecol 13:275-9. 2001
    ....
  33. ncbi Diagnosis and laparoscopic management of a fallopian tube torsion following Irving tubal sterilization: a case report
    I Sozen
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520 8063, USA
    Surg Endosc 16:217. 2002
    ..A right salipingectomy was done laparoscopically. Combination of PID and tubal sterilization in the medical history of a patient presenting with acute or intermittent pelvic pain may suggest tubal torsion...
  34. ncbi Epidemiological factors influencing IVF outcome: Evidence from the Yale IVF program
    I Matalliotakis
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, CT, USA
    J Obstet Gynaecol 28:204-8. 2008
    ..As expected, we also confirmed the inverse association between the age of women and IVF outcome. Overall, body attributes, lifestyle, family history, menstrual and reproductive factors were not related to IVF-ET outcome...
  35. ncbi Anatomic factors in recurrent pregnancy loss
    Anne S Devi Wold
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA
    Semin Reprod Med 24:25-32. 2006
    ..In this article, we review the common congenital and acquired uterine anomalies associated with recurrent pregnancy losses, and discuss contemporary diagnosis and treatment options...
  36. ncbi Expression of interleukin-8 receptors in patients with adenomyosis
    Murat Ulukus
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 85:714-20. 2006
    ..To investigate the expression of interleukin-8 (IL-8) receptors CXCR1 and CXCR2 in adenomyosis...
  37. ncbi Natural killer cells and reproductive failure
    Anne S Devi Wold
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Curr Opin Obstet Gynecol 17:237-41. 2005
    ..The purpose of this review is to provide an update of what is known about the role of natural killer cells in reproduction...
  38. ncbi Fibroids and in-vitro fertilization: which comes first?
    Beth W Rackow
    Section of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Curr Opin Obstet Gynecol 17:225-31. 2005
    ..We discuss the importance of proper evaluation of the uterus and endometrial cavity, and current options for optimal fibroid management in patients desiring fertility...
  39. ncbi Expression of interleukin-8 receptors in endometriosis
    Murat Ulukus
    Yale University School of Medicine, Department of Obstetrics and Gynecology, New Haven, CT 06511, USA
    Hum Reprod 20:794-801. 2005
    ....
  40. ncbi Endometriosis associated with Stage IA clear cell ovarian carcinoma in a woman with IVF-ET treatments in the Yale Series
    Ioannis Matalliotakis
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Have, CT, USA
    Arch Gynecol Obstet 274:184-6. 2006
    ..Our unusual case serves as a reminder that clear cell adenocarcinoma may coexist with endometriosis, and that parity does not necessarily protect infertility patients against the development of ovarian cancer...
  41. ncbi Expression of interleukin-8 and monocyte chemotactic protein-1 in adenomyosis
    E Cagnur Ulukus
    Yale University School of Medicine, Department of Pathology, New Haven, CT 06520, USA
    Hum Reprod 20:2958-63. 2005
    ....
  42. ncbi The role of endometrium in endometriosis
    Murat Ulukus
    Yale University School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, Connecticut 06520-8063, USA
    J Soc Gynecol Investig 13:467-76. 2006
    ..Furthermore, significant biochemical differences exist even between ectopic and autologous eutopic endometrium. These differences can be explained by the direct effects of an inflammatory peritoneal environment...
  43. ncbi Extracellularly signal-regulated kinase activity in the human endometrium: possible roles in the pathogenesis of endometriosis
    William Murk
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520 8063, USA
    J Clin Endocrinol Metab 93:3532-40. 2008
    ..It is unclear why ectopic endometrium remains viable in only a subset of women. ERK1/2 plays key intracellular roles in activating cellular survival and differentiation processes...
  44. ncbi Fragile X and reproduction
    J Ryan Martin
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Curr Opin Obstet Gynecol 20:216-20. 2008
    ..To review the recent literature on fragile X and the genotypic and phenotypic implications on human reproduction...
  45. ncbi Endometriosis and infertility: epidemiology and evidence-based treatments
    Sebiha Ozkan
    Department of Obstetrics and Gynecology, Kocaeli University School of Mediine, Kocaeli, Turkey
    Ann N Y Acad Sci 1127:92-100. 2008
    ..Further randomized clinical trials focusing on diverse etiopathogenic mechanisms and therapeutic innovation are necessary to find more conclusive, evidence-based answers regarding this enigmatic disease...
  46. ncbi Expression of proliferative and preapoptotic molecules in human myometrium and leiomyoma throughout the menstrual cycle
    Umit A Kayisli
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Reprod Sci 14:678-86. 2007
    ....
  47. ncbi Tenascin is highly expressed in endometriosis and its expression is upregulated by estrogen
    Orkun Tan
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 89:1082-9. 2008
    ..To investigate the localization of tenascin expression in the endometrium of women without endometriosis and in endometriotic implants, and to determine the in vitro regulation of tenascin by E(2) in these tissues...
  48. ncbi Reproductive performance of women with müllerian anomalies
    Beth W Rackow
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Curr Opin Obstet Gynecol 19:229-37. 2007
    ..This review discusses current diagnostic techniques for müllerian anomalies, reproductive outcome data, and management options in reproductive-age women...
  49. ncbi Intra-uterine adhesions and fertility outcome: how to optimize success?
    Pinar H Kodaman
    Yale University School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Section of Reproductive Endocrinology and Infertility, New Haven, Connecticut 06520, USA
    Curr Opin Obstet Gynecol 19:207-14. 2007
    ..To review the etiology, diagnosis, and clinical manifestations of intra-uterine adhesions and to address treatment with a specific focus on fertility outcome...
  50. ncbi Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility
    Ioannis M Matalliotakis
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Fertil Steril 88:1568-72. 2007
    ..To investigate the response to controlled ovarian hyperstimulation and ART outcomes in women with advanced-stage endometriosis and previous surgeries at the Yale IVF program between 1996 and 2002...
  51. ncbi Role of gonadotropin-releasing hormone antagonists in poor responders
    Neal G Mahutte
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Fertil Steril 87:241-9. 2007
    ..To evaluate the role of GnRH antagonists in poor-responder protocols...
  52. ncbi Myomas and assisted reproductive technologies: when and how to act?
    Aytug Kolankaya
    Infertility and IVF Unit, Department of Obstetrics and Gynecology, Anadolu Health Center, Affiliated with Johns Hopkins Medicine, Anadolu Saglik Merkezi, Anadolu CAD No 1, Cayirova, Gebze, 41400 Kocaeli, Turkey
    Obstet Gynecol Clin North Am 33:145-52. 2006
    ..Other alternative treatment modalities, such as CUV, laparoscopic myolysis, or MRI-guided focused ultrasound, are to be monitored and evaluated thoroughly before they are applied as routine procedures...
  53. ncbi Luteal phase defect: myth or reality
    Orhan Bukulmez
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9032, USA
    Obstet Gynecol Clin North Am 31:727-44, ix. 2004
    ..Once diagnosed, the treatment options are empiric and include those that are recommended for unexplained infertility. The efforts to diagnose LPD in patients who have infertility or recurrent abortion are not justified...
  54. ncbi Regulation of fas ligand expression by IL-8 in human endometrium
    Belgin Selam
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    J Clin Endocrinol Metab 87:3921-7. 2002
    ..We speculate that increased FasL expression by IL-8 may induce apoptosis of T lymphocytes and thus produce a local immunotolerant environment for the development of ectopic implants...
  55. ncbi Regulation of PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression by estradiol and progesterone in human endometrium
    Ozlem Guzeloglu-Kayisli
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    J Clin Endocrinol Metab 88:5017-26. 2003
    ..We propose that PTEN might be one of the signaling proteins that estrogen and progesterone are acting to affect endometrial cell proliferation and/or apoptosis...
  56. ncbi Elevated soluble Fas ligand levels may suggest a role for apoptosis in women with endometriosis
    Juan A Garcia-Velasco
    IVI Madrid, Madrid, Spain
    Fertil Steril 78:855-9. 2002
    ....
  57. ncbi Coordinated regulation of HOX gene expression in myometrium and uterine leiomyoma
    Dilek Cermik
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA
    Fertil Steril 78:979-84. 2002
    ..The identification of this developmental control gene in myometrium and leiomyoma may lead to a better understanding of the molecular mechanisms responsible for growth and differentiation of these tissues...
  58. ncbi Immune testing in fertility practice: truth or deception?
    Caleb B Kallen
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Curr Opin Obstet Gynecol 15:225-31. 2003
    ....
  59. ncbi Inverse correlation between peritoneal fluid leptin concentrations and the extent of endometriosis
    Neal G Mahutte
    Yale University School of Medicine, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, New Haven, CT 06520 8063, USA
    Hum Reprod 18:1205-9. 2003
    ..Because leptin has intrinsic angiogenic properties, may be induced by inflammatory cytokines and induces matrix metalloproteinases, we examined peritoneal fluid (PF) leptin concentrations in women with endometriosis...
  60. ncbi Twenty-year history of endometriosis-associated pelvic pain: too much surgery or not enough?
    Ioannis M Matalliotakis
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Conn, USA
    Am J Obstet Gynecol 188:1103-4. 2003
    ..Multiple recurrences of endometriosis were documented. Although clearly an unusual case, our patient highlights the importance of using even the most advanced surgical techniques judiciously...
  61. ncbi Chemokine receptor expression in human endometrium
    Naciye Mulayim
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Reprod 68:1491-5. 2003
    ..Expression of interleukin-8 and RANTES in endometrium, together with the presence of their receptors, suggests that autocrine and paracrine interactions involving these chemokines may participate in endometrial physiology...
  62. ncbi Pulmonary endometriosis in a patient with unicornuate uterus and noncommunicating rudimentary horn
    Ioannis M Matalliotakis
    Department of Obstetrics and Gynecology, University of Crete, Heraklion, Greece
    Fertil Steril 78:183-5. 2002
    ..To our knowledge, this is the first case of catamenial hemoptysis with a congenital müllerian anomaly. We describe successful management using a combination of GnRH agonist and surgical resection of the rudimentary uterine horn...
  63. ncbi Medical management of endometriosis-associated pain
    Neal G Mahutte
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Obstet Gynecol Clin North Am 30:133-50. 2003
    ..The surgery may have analgesic value and serves to reconfirm the diagnosis. Finally, if endometriosis is identified at the time of surgery, then consideration should be given to prescribing medical therapy postoperatively...
  64. ncbi In vivo and in vitro regulation of Akt activation in human endometrial cells is estrogen dependent
    Ozlem Guzeloglu Kayisli
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Biol Reprod 71:714-21. 2004
    ..Thus, estradiol may exert part of its proliferative and antiapoptotic effects by a nongenomic manner through the Akt signaling pathway...
  65. ncbi Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells
    Emre Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA
    Fertil Steril 77:542-7. 2002
    ..CONCLUSION(S): Our findings suggest that one of the mechanisms by which estrogen down-regulates atherosclerosis is by suppressing vascular MCP-1 expression, resulting in decreased macrophage recruitment...
  66. ncbi Effects of oxidants and antioxidants on proliferation of endometrial stromal cells
    Nastaran Foyouzi
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Fertil Steril 82:1019-22. 2004
    ..Under pathologic conditions such as endometriosis, increased oxidative stress and depletion of antioxidants may contribute to excessive growth of endometrial stromal cells...
  67. ncbi Elevations in peritoneal fluid macrophage migration inhibitory factor are independent of the depth of invasion or stage of endometriosis
    Neal G Mahutte
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA
    Fertil Steril 82:97-101. 2004
    ..CONCLUSION(S): Peritoneal fluid migration inhibitory factor levels are markedly elevated in women with endometriosis but are independent of the extent of disease...
  68. ncbi Poor responders: does the protocol make a difference?
    Neal G Mahutte
    Department of Obstetrics and Gynecology, Yale University, New Haven, Connecticut 06520 8063, USA
    Curr Opin Obstet Gynecol 14:275-81. 2002
    ..Aside from oocyte donation, greater hope for poor responders may rest in aneuploidy screening, in-vitro oocyte maturation and cytoplasm/nuclear transfer...
  69. ncbi New advances in the understanding of endometriosis related infertility
    Neal G Mahutte
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, PO Box 208063, New Haven, CT 06520-8063, USA
    J Reprod Immunol 55:73-83. 2002
    ..The potential impact of each of these is critically examined. The role of endometriomas, prior surgeries and donor oocytes is also discussed...
  70. ncbi Comparison of the effects of leuprorelin acetate and danazol treatments on serum CA-125 levels in women with endometriosis
    Ioannis M Matalliotakis
    Department of Obstetrics and Gynecology, University Hospital of Heraklion, Crete, Greece
    Int J Fertil Womens Med 49:75-8. 2004
    ..b) Moreover, the results support the view that the determination of CA-125 levels may assist in evaluating progress of endometriosis treatment...
  71. ncbi Removal of endometriomas before in vitro fertilization does not improve fertility outcomes: a matched, case-control study
    Juan A Garcia-Velasco
    Instituto Valenciano de Infertilidad, Madrid, Spain
    Fertil Steril 81:1194-7. 2004
    ..To investigate whether conservative surgery on ovarian endometriomas before an IVF cycle improves fertility outcomes...
  72. ncbi Uterine chemokines in reproductive physiology and pathology
    Umit A Kayisli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520-8063, USA
    Am J Reprod Immunol 47:213-21. 2002
    ..Moreover, unbalanced chemokine expression contributes to pathologic conditions typified by uncontrolled cellular proliferation, migration and invasion...
  73. ncbi Estrogenicity of isoflavones on human endometrial stromal and glandular cells
    Umit A Kayisli
    Section of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 87:5539-44. 2002
    ..05). We conclude that, although isoflavones alone have weak estrogenic effects on endometrial stromal and glandular cells, in the presence of E(2) they act as antiestrogens...
  74. ncbi Epidemiological characteristics in women with and without endometriosis in the Yale series
    Ioannis M Matalliotakis
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT, USA
    Arch Gynecol Obstet 277:389-93. 2008
    ..The association between demographic factors, menstrual and reproductive characteristics, and clinical profile for women with endometriosis was analyzed in a retrospective case-control study...
  75. ncbi The broad-spectrum chemokine inhibitor NR58-3.14.3 suppresses the implantation and survival of human endometrial implants in the nude mice endometriosis model
    Umit A Kayisli
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Reprod Sci 14:825-35. 2007
    ..NR58-3.14.3, by possibly regulating cell survival, can reduce the number and size of ectopic implants in vivo, supporting the potential use of chemokine inhibitors in novel therapies for endometriosis...
  76. ncbi Apoptosis and the pathogenesis of endometriosis
    Juan A Garcia-Velasco
    Instituto Valenciano de Infertilidad-Madrid, Madrid, Spain
    Semin Reprod Med 21:165-72. 2003
    ..Special emphasis is placed on sex steroid modulation and cell adhesion regulation, both relevant in early events of endometriosis...
  77. ncbi Regulation of angiogenic activity of human endometrial endothelial cells in culture by ovarian steroids
    Umit A Kayisli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA
    J Clin Endocrinol Metab 89:5794-802. 2004
    ..01). In conclusion, our results suggest that there are direct effects of E(2) and P(4) on HEEC and provide a new understanding of the physiological role of sex steroids in the regulation of endometrial events such as angiogenesis...
  78. ncbi Initial endometriosis showing direct morphologic evidence of metaplasia in the pathogenesis of ovarian endometriosis
    Wenxin Zheng
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520-8070, USA
    Int J Gynecol Pathol 24:164-72. 2005
    ..Local production of estrogen, probably in high-levels, may be related to the initial process of endometriosis, although detailed mechanisms remain to be clarified...
  79. ncbi Apoptosis and differential expression of apoptosis-related proteins in endometriotic glandular and stromal cells
    Anastasia G Goumenou
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8063, USA
    J Soc Gynecol Investig 11:318-22. 2004
    ..The apoptotic rate as well as Bcl-2 and Bax expression in ovarian endometriotic cells were not affected by the stage of endometriosis or the phase of the menstrual cycle...
  80. ncbi Impact of endometrioma resection prior to IVF/ICSI cycles
    Juan A Garcia-Velasco
    Am J Obstet Gynecol 193:594-5; author reply 595-6. 2005
  81. ncbi Cellular biology of myomas: interaction of sex steroids with cytokines and growth factors
    Ibrahim Sozen
    Department of Obstetrics and Gynecology, Anadolu Health Center, Anadolu CAD No 1, Cay rova mevkii, Gebze, 41400 Kocaeli, Turkey
    Obstet Gynecol Clin North Am 33:41-58. 2006
    ..quot;..
  82. ncbi Options for medical treatment of myomas
    Beth W Rackow
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, P.O. Box 208063, New Haven, CT 06520-8063, USA
    Obstet Gynecol Clin North Am 33:97-113. 2006
    ..If one medical therapy does not work, several other effective therapies are available...
  83. ncbi Regulation of endometrial stromal cell matrix metalloproteinase activity and invasiveness by interleukin-8
    Naciye Mulayim
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8063, USA
    Fertil Steril 81:904-11. 2004
    ..CONCLUSION(S): IL-8 increases MMP activity and invasive capability of endometrial stromal cells in culture; IL-8 may be involved in the pathogenesis of endometriosis and menstrual physiology...
  84. ncbi Human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating Fas-Fas ligand system
    Umit A Kayisli
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Immunol 171:2305-13. 2003
    ..These results suggest that hCG may be a link in the development of peritrophoblastic immune tolerance and may facilitate the trophoblast invasion by regulating proapoptotic molecules such as FasL in endometrial cells...
  85. ncbi Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability
    Piotr C Piotrowski
    Department of OB/GYN, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Reprod 75:107-11. 2006
    ..The present observations may be relevant to potential therapeutic use of statins in conditions such as endometriosis...
  86. ncbi Extracellular matrix-dependent regulation of Fas ligand expression in human endometrial stromal cells
    Belgin Selam
    Yale University School of Medicine, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, New Haven, Connecticut 06520, USA
    Biol Reprod 66:1-5. 2002
    ....