Genomes and Genes
George M Anderson
Affiliation: Yale University
- Effects of short- and long-term risperidone treatment on prolactin levels in children with autismGeorge M Anderson
Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 61:545-50. 2007..The effects of short- and long-term risperidone treatment on serum prolactin were assessed in children and adolescents with autism...
- Network approach to autistic traits: group and subgroup analyses of ADOS item scoresGeorge M Anderson
Yale Child Study Center, Yale University School of Medicine, 230 S Frontage Rd, New Haven, CT, 06519, USA
J Autism Dev Disord 45:3115-32. 2015..The approach should be useful in characterizing individuals and groups, in elucidating mechanisms of trait generation and routes to outcome phenotypes, and in suggesting points of intervention. ..
- Autism biomarkers: challenges, pitfalls and possibilitiesGeorge M Anderson
Yale Child Study Center and the Departments of Child Psychiatry and Laboratory Medicine, Yale University School of Medicine, 230 S Frontage Road, New Haven, CT, 06519, USA
J Autism Dev Disord 45:1103-13. 2015..Finally, the serotonin-melatonin-oxidative stress-placental intersection might be an especially fruitful area of biological investigation. ..
- Brief report: Platelet-poor plasma serotonin in autismGeorge M Anderson
Departments of Child Psychiatry and Laboratory Medicine, Yale University School of Medicine, 230 S Frontage Rd, New Haven, CT 06520, USA
J Autism Dev Disord 42:1510-4. 2012....
- Twin studies in autism: what might they say about genetic and environmental influencesGeorge M Anderson
Child Study Center, Yale University School of Medicine, 230 S Frontage Road, New Haven, CT, 06519, USA
J Autism Dev Disord 42:1526-7. 2012..Assuming phenotypic differences between monozygotic twins are due to environmental influences may lead to mistaken conclusions regarding the relative genetic and environmental contribution to autism risk...
- Relationships among body mass, brain size, gut length, and blood tryptophan and serotonin in young wild-type miceRicardo Albay
Department of Psychology, University of California, Santa Barbara, California, USA
BMC Physiol 9:4. 2009....
- Time course of the effects of the serotonin-selective reuptake inhibitor sertraline on central and peripheral serotonin neurochemistry in the rhesus monkeyGeorge M Anderson
Departments of Child Psychiatry and Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA
Psychopharmacology (Berl) 178:339-46. 2005..Fundamental questions remain regarding the actions of the selective serotonin reuptake inhibitors (SSRIs)...
- Peripheral and central neurochemical effects of the selective serotonin reuptake inhibitors (SSRIs) in humans and nonhuman primates: assessing bioeffect and mechanisms of actionGeorge M Anderson
Child Study Center and the Department of Laboratory Medicine, Yale University School of Medicine, 230 S Frontage Road, New Haven, CT 06520, USA
Int J Dev Neurosci 22:397-404. 2004..The implications of the observations in terms of behavioral effects, clinical practice, and underlying mechanisms of action of the SSRIs are discussed...
- Autism clinical trials: biological and medical issues in patient selection and treatment responseGeorge M Anderson
Department of Child Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
CNS Spectr 9:57-64. 2004..The potential utility and desirability of specific measures are considered and the general approach to choosing measures for incorporation is discussed...
- Platelet serotonin in newborns and infants: ontogeny, heritability, and effect of in utero exposure to selective serotonin reuptake inhibitorsGeorge M Anderson
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Pediatr Res 56:418-22. 2004..The observed mother-infant correlation agrees with a previous report of high heritability in a large adult population...
- Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemiaGeorge M Anderson
Dept of Child Psychiatry, Child Study Center, Yale University School of Medicine, 230 S Frontage Road, New Haven, CT 06510, USA
Mol Psychiatry 7:831-6. 2002..In addition, it appears that studies of platelet 5-HT measures in autism and other disorders should take account of the effects of 5-HTTLPR genotype on 5-HT uptake..
- Serotonin in cisternal cerebrospinal fluid of rhesus monkeys: basal levels and effects of sertraline administrationGeorge M Anderson
Department of Child Psychiatry, Yale University School of Medicine, 230 S Frontage Road, New Haven, CT 06510, USA
Psychopharmacology (Berl) 161:95-9. 2002..The measurement of cisternal CSF 5-HT levels in the monkey might offer a method of assessing the effects of agents and actions on central 5-HT functioning in primate brain...
- Adrenomedullary function during cognitive testing in attention-deficit/hyperactivity disorderG M Anderson
Child Study Center, Yale University School of Medicine, New Haven, CT 06510, USA
J Am Acad Child Adolesc Psychiatry 39:635-43. 2000..This hypothesis was tested by examining sympathetic and adrenomedullary functioning during cognitive testing in boys with diagnosed ADHD...
- The potential role for emergence in autismGeorge M Anderson
Child Study Center, Yale University School of Medicine, 230 South Frontage Rd, New Haven, Connecticut, USA
Autism Res 1:18-30. 2008..It is concluded that consideration of the role of emergence in autistic behavior and related phenomena should complement a reductionist approach and might help illuminate the components and complexities of autism...
- The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findingsC Neill Epperson
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
J Psychopharmacol 21:414-20. 2007..While preliminary, the results suggest that serotonin may be less critical to the pathogenesis of depression during the menopause...
- Frequency of recent cocaine and alcohol use affects drug craving and associated responses to stress and drug-related cuesHelen C Fox
Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, New Haven, 06519, USA
Psychoneuroendocrinology 30:880-91. 2005..The current study examined whether frequency of cocaine and alcohol abuse alters drug craving and associated arousal with laboratory exposure to stress and to drug related cues...
- A single nucleotide polymorphism at DBH, possibly associated with attention-deficit/hyperactivity disorder, associates with lower plasma dopamine beta-hydroxylase activity and is in linkage disequilibrium with two putative functional single nucleotide polYilang Tang
Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, New Haven, Connecticut, USA
Biol Psychiatry 60:1034-8. 2006..We tested whether 1) SNP2 associates with pDbetaH; and 2) whether linkage disequilibrium (LD) between SNP2 and the other SNPs explains that association...
- Macrophage migration inhibitory factor and autism spectrum disordersElena L Grigorenko
Child Study Center, Department ofPsychology, Yale University, New Haven, Connecticut 06519, USA
Pediatrics 122:e438-45. 2008....
- Prazosin effects on stress- and cue-induced craving and stress response in alcohol-dependent individuals: preliminary findingsHelen C Fox
The Connecticut Mental Health Center, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Alcohol Clin Exp Res 36:351-60. 2012..Here we report findings from a preliminary efficacy study of the alpha-1 receptor antagonist, prazosin, in modulating these relapse-relevant factors in alcohol-dependent individuals...
- The structure of linkage disequilibrium at the DBH locus strongly influences the magnitude of association between diallelic markers and plasma dopamine beta-hydroxylase activityCyrus P Zabetian
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Am J Hum Genet 72:1389-400. 2003..These results provide a direct example of the potential value of constructing a haplotype map of the human genome prior to embarking on large-scale association studies...
- Ontogeny of brain and blood serotonin levels in 5-HT receptor knockout mice: potential relevance to the neurobiology of autismSkirmantas Janusonis
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA
J Neurochem 99:1019-31. 2006..The results are discussed in relation to the possible role of 5-HT in the ontogeny of autism...
- Weight and leptin changes among risperidone-treated youths with autism: 6-month prospective dataAndres Martin
Yale Child Study Center, Yale University, New Haven, CT 06520, USA
Am J Psychiatry 161:1125-7. 2004..The authors examined the developmental impact and temporal characteristics of risperidone-associated weight change...
- Genotypic and haplotypic associations of the DBH gene with plasma dopamine beta-hydroxylase activity in African AmericansYi lang Tang
Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, New Haven, CT, USA
Eur J Hum Genet 15:878-83. 2007..0025 and 0.0036, respectively). The data support the validity of prior reported associations and underscore the importance of analyzing multiple SNPs across DBH in future association studies examining disease and biochemical phenotypes...
- Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and miceLissandra Castellan Baldan
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
Neuron 81:77-90. 2014..These data confirm histidine decarboxylase deficiency as a rare cause of TS and identify HA-DA interactions in the basal ganglia as an important locus of pathology. ..
- Maternal fluoxetine treatment in the postpartum period: effects on platelet serotonin and plasma drug levels in breastfeeding mother-infant pairsC Neill Epperson
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
Pediatrics 112:e425. 2003..Thus, to extend our previous work in this area, we measured platelet 5-HT levels and plasma drug levels in breastfeeding mother-infant pairs before and during maternal treatment with fluoxetine...
- The measurement of platelet-poor plasma serotonin: a systematic review of prior reports and recommendations for improved analysisTheresa Brand
Child Study Center, Yale University School of Medicine, New Haven, CT, USA
Clin Chem 57:1376-86. 2011..Measurement of the much smaller but potentially critically important pool of human free plasma serotonin in platelet-poor plasma (PPP) has proven much more difficult, with a wide range of reference values reported...
- Blunted vagal reactivity predicts stress-precipitated tobacco smokingRebecca L Ashare
Department of Psychiatry, Yale University School of Medicine, 2 Church St South, Suite 109, New Haven, CT 06519, USA
Psychopharmacology (Berl) 220:259-68. 2012..One index of the inability to adapt to stress may be blunted vagal reactivity. Stress is a primary mechanism involved in relapse to smoking, but mechanisms leading to stress-precipitated relapse are not well understood...
- Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving statesRajita Sinha
Department of Psychiatry, Yale University School of Medicine, S 112 Substance Abuse Center, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
Psychopharmacology (Berl) 170:62-72. 2003..This study examined the response of brain stress circuits to environmental stimuli that are known to increase cocaine craving in cocaine dependent individuals...
- Obstetric and parental psychiatric variables as potential predictors of autism severityAnna E Wallace
Yale School of Public Health, New Haven, CT, USA
J Autism Dev Disord 38:1542-54. 2008..025). The associations between hypertension-related obstetric conditions and autistic severity warrant further investigation and raise intriguing questions regarding potential causal and modifying factors in autism...
- A double-blind, placebo-controlled, crossover trial of an antiandrogen in the treatment of Tourette's syndromeB S Peterson
General Clinical Research Center, Yale Child Study Center, Yale School of Medicine, New Haven, Connecticut 06520, USA
J Clin Psychopharmacol 18:324-31. 1998..The therapeutic and endocrine findings may have implications for understanding the sex differences in TS prevalence and the sex-specific variability in the phenotypic expression of the putative TS vulnerability genes...
- Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairsN Epperson
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
Am J Psychiatry 158:1631-7. 2001..This study determined the degree of transporter blockade in infants exposed to sertraline through maternal breast milk...
- A haplotype at the DBH locus, associated with low plasma dopamine beta-hydroxylase activity, also associates with cocaine-induced paranoiaJ F Cubells
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
Mol Psychiatry 5:56-63. 2000..Molecular Psychiatry (2000) 5, 56-63...
- Imaging extrastriatal dopamine D(2) receptor occupancy by endogenous dopamine in healthy humansM Fujita
Department of Psychiatry, Yale University, VA Connecticut, West Haven, CT 06516, USA
Eur J Pharmacol 387:179-88. 2000..88, P=0.004). These results imply that [123I]epidepride, coupled with acute dopamine depletion might provide estimates of synaptic dopamine concentration...
- Serum and plasma brain-derived neurotrophic factor (BDNF) in abstinent alcoholics and social drinkersCarrol D'Sa
Yale Stress Center, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Alcohol 46:253-9. 2012..Further research is warranted to fully elucidate mechanisms underlying this alteration and determine the utility of serum BDNF as a predictor or surrogate marker of chronic alcohol abuse...
- Low-dose fluvoxamine treatment of children and adolescents with pervasive developmental disorders: a prospective, open-label studyAndres Martin
Child Study Center, Yale University, New Haven, Connecticut 06520 7900, USA
J Autism Dev Disord 33:77-85. 2003..Fluvoxamine can be beneficial in the treatment of select children and adolescents with PDDs. Gender differences in selective serotonin reuptake inhibitor (SSRI) response warrant further investigation...
- Estradiol and tryptophan depletion interact to modulate cognition in menopausal womenZenab Amin
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
Neuropsychopharmacology 31:2489-97. 2006..These data support the interaction of estrogen and 5-HT in nonreproductive behavior in humans as well as highlight the role of ovarian steroids in cognition...
- Effects of age and emotionality on the effectiveness of midazolam administered preoperatively to childrenZeev N Kain
Center for the Advancement of Perioperative Health, Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510, USA
Anesthesiology 107:545-52. 2007..Multiple studies document the beneficial effect of midazolam on preoperative anxiety in children. Many clinicians report, however, that some children may in fact not benefit from the administration of this drug...
- A decrease in the plasma DHEA to cortisol ratio during smoking abstinence may predict relapse: a preliminary studyAnn M Rasmusson
Department of Psychiatry, Yale University School of Medicine, New Haven, and Clinical Neuroscience Division, VA National Center for PTSD, West Haven, CT 06516, USA
Psychopharmacology (Berl) 186:473-80. 2006..Increases in depressive symptoms during smoking cessation have been associated with risk for relapse. Several studies have linked plasma levels of cortisol and dehydroepiandrosterone (DHEA) or DHEA-sulfate (DHEAS) to depressive symptoms...
- Placental trophoblast inclusions in autism spectrum disorderGeorge M Anderson
The Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 61:487-91. 2007..Microscopic examination of placental tissue may provide a route to assessing risk and understanding underlying biology of autism...
- Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in psychotic unipolar major depressionJoseph F Cubells
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
Biol Psychiatry 51:358-64. 2002..Plasma DbetaH is under genetic control by the structural locus encoding DbetaH protein, DBH. This study tested the hypothesis that diagnosis-specific allelic variation at DBH accounts for lower plasma DbetaH in UDPF...
- Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotypeMatthew W State
Child Study Center and Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA
Proc Natl Acad Sci U S A 100:4684-9. 2003....
- Early postnatal astroglial cells produce multilineage precursors and neural stem cells in vivoYosif M Ganat
Child Study Center, Yale University Medical School, New Haven, Connecticut 06520, USA
J Neurosci 26:8609-21. 2006....
- High levels of histidine decarboxylase in the striatum of mice and ratsKuakarun Krusong
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Neurosci Lett 495:110-4. 2011..This discrepancy between HDC protein and histamine levels in the striatum suggests that histamine metabolism and neurotransmission in basal ganglia may have unique characteristics, the details of which remain to be elucidated...
- Serotonin uptake and metabolism by cultured guinea pig airway smooth muscle cellsA M Dodson
John B Pierce Laboratory, 290 Congress Avenue, New Haven, CT 06519, USA
Pulm Pharmacol Ther 17:19-25. 2004..The results of this study suggest that ASM contributes to the uptake and metabolism of serotonin via SERT and MAO, respectively, and may therefore play a role in the inactivation of endogenous serotonin generated within the airway wall...
- A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locusC P Zabetian
Department of Psychiatry, Yale University, New Haven, CT, USA
Am J Hum Genet 68:515-22. 2001..Our findings demonstrate that --1021C-->T is a major genetic marker for plasma-D beta H activity and provide new tools for investigation of the role of both D beta H and the DBH gene in human disease...
- Cerebrospinal fluid corticotropin-releasing hormone in healthy humans: effects of yohimbine and naloxoneM Vythilingam
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
J Clin Endocrinol Metab 85:4138-45. 2000..Although both yohimbine and naloxone stimulated the HPA axis, only yohimbine appeared to have stimulatory effects on central NE and non-HPA CRH...
- Temperament and hypothalamic-pituitary-adrenal axis function in healthy adultsAudrey R Tyrka
Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, 345 Blackstone Road, Providence, RI 02906, USA
Psychoneuroendocrinology 31:1036-45. 2006..A recent study found HPA hyperactivity in adults with high levels of neuroticism. The present study investigated associations of temperament and HPA function in 31 healthy adults...
- Genetics of childhood disorders: XLV. Autism, part 4: serotonin in autismGeorge M Anderson
J Am Acad Child Adolesc Psychiatry 41:1513-6. 2002
- Cortisol levels and hippocampus volumes in healthy preadolescent childrenChristoph P Wiedenmayer
Department of Psychiatry, Columbia University, New York, New York 10032, USA
Biol Psychiatry 60:856-61. 2006..The objective of this study was to examine possible associations of serum cortisol levels with hippocampal volumes and morphology in healthy children...
- Effects of dopamine beta-hydroxylase genotype and disulfiram inhibition on catecholamine homeostasis in miceBrooke N Bourdélat-Parks
Department of Human Genetics, Emory University School of Medicine, Whitehead 301, 615 Michael St, Atlanta, GA 30322, USA
Psychopharmacology (Berl) 183:72-80. 2005..Dopamine beta-hydroxylase (DBH) converts dopamine (DA) to norepinephrine (NE), thus playing a critical role in catecholamine metabolism...
- Automated on-line solid-phase extraction coupled with HPLC for measurement of 5-hydroxyindole-3-acetic acid in urineErik J Mulder
Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Clin Chem 51:1698-703. 2005..We describe an automated method that incorporates on-line solid-phase extraction (SPE) and HPLC to measure urinary 5-HIAA...
- Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorderSylvie Tordjman
Center for Scientific Research, Unité de Recherche Mixte 7593, Vurnérabilité, Adaptation et Psychopathologie, Hopital Pitie Salpetriere, Rennes, France
Biol Psychiatry 57:134-8. 2005..Additionally, melatonin, a pineal gland hormone produced from serotonin, is of special interest in autistic disorder given reported alterations in central and peripheral serotonin neurobiology...
- Reactivity of serotonin in whole bloodErik J Mulder
Biol Psychiatry 51:266-8. 2002
- Serotonin transporter intron 2 polymorphism associated with rigid-compulsive behaviors in Dutch individuals with pervasive developmental disorderErik J Mulder
Child and Adolescent Psychiatry Center, University of Groningen, Groningen, The Netherlands
Am J Med Genet B Neuropsychiatr Genet 133:93-6. 2005..015). These results suggest that intron 2 VNTR alleles or nearby polymorphisms in linkage disequilibrium may play a role in specific aspects of the behavioral phenotype of autism...
- Platelet serotonin levels in pervasive developmental disorders and mental retardation: diagnostic group differences, within-group distribution, and behavioral correlatesErik J Mulder
Child and Adolescent Psychiatry Center, University of Groningen, The Netherlands
J Am Acad Child Adolesc Psychiatry 43:491-9. 2004..To investigate group differences, the within-group distributions, and the clinical correlates of platelet serotonin (5-HT) levels in pervasive developmental disorders (PDD)...
- Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatmentMeena Vythilingam
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892 2670, USA
Biol Psychiatry 56:101-12. 2004..However, the relationships between depression, hippocampal structure and function, and cortisol levels are unclear and the effects of antidepressant treatment on the measures are not well studied...
- Assessing the assessment of brain serotonin turnoverGeorge M Anderson
Arch Gen Psychiatry 65:1223; author reply 1223-4. 2008
- A genotype-controlled analysis of plasma dopamine beta-hydroxylase in healthy and alcoholic subjects: evidence for alcohol-related differences in noradrenergic functionMichael D Köhnke
University Hospital of Psychiatry and Psychotherapy, Tubingen University Hospital, Tubingen, Germany
Biol Psychiatry 52:1151-8. 2002..A recent study demonstrated a strong association between variance in plasma DbetaH activity and a novel polymorphism (DBH-1021C-->T) at the structural locus (DBH) encoding DbetaH protein...
- Childhood parental loss and adult hypothalamic-pituitary-adrenal functionAudrey R Tyrka
Mood Disorders Research Program, Laboratory for Clinical Neuroscience, Butler Hospital, Providence, Rhode Island 02906, USA
Biol Psychiatry 63:1147-54. 2008....
- Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeysMasanori Ichise
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurosci 26:4638-43. 2006....
- Sex differences in emotional and physiological responses to the Trier Social Stress TestMegan M Kelly
Mood Disorders Research Program, Department of Psychiatry and Human Behavior, Butler Hospital, Brown Medical School, 345 Blackstone Blvd, Providence, RI 02906, USA
J Behav Ther Exp Psychiatry 39:87-98. 2008..The broader implications of these results and how they relate to sex differences in the etiology and clinical presentation of anxiety and mood disorders are discussed...
- Cortisol and ACTH responses to the Dex/CRH test: influence of temperamentAudrey R Tyrka
Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906, USA
Horm Behav 53:518-25. 2008..Increased adrenocortical reactivity, which previously has been linked to major depression and anxiety disorders, may contribute to the association between temperament/personality traits and these disorders...
- Measurement of plasma serotonin in autismGeorge M Anderson
Pediatr Neurol 36:138; author reply 138-9. 2007
- Acute changes in cerebrospinal fluid 5-HIAA following oral paroxetine challenge in healthy humansLinda L Carpenter
Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02906, USA
Neuropsychopharmacology 28:339-47. 2003..Our findings stand in contrast to the decreases reported for CSF 5-HIAA after chronic SSRI treatment in humans and the decreases seen in brain extracellular 5-HIAA after acute or chronic administration of SSRIs to animals...
- Effect of vagus nerve stimulation on cerebrospinal fluid monoamine metabolites, norepinephrine, and gamma-aminobutyric acid concentrations in depressed patientsLinda L Carpenter
Laboratory for Clinical Neuroscience, Butler Hospital, Department of Psychiatry and Human Behavior, Brown University School of Medicine, Providence, Rhode Island 02906, USA edu
Biol Psychiatry 56:418-26. 2004..Cerebrospinal fluid (CSF) studies in epilepsy patients show that VNS alters concentrations of monamines and gamma-aminobutyric acid (GABA), neurotransmitter systems possibly involved in the pathogenesis of depression...
- Plasma kynurenine and related measures in tic disorder patientsPieter J Hoekstra
Department of Psychiatry, University Medical Center Groningen, University of Groningen, P O Box 660, 9700 AR, Groningen, The Netherlands
Eur Child Adolesc Psychiatry 16:71-7. 2007..In the present study, we examined plasma levels of kynurenine and related molecules in a group of tic disorder patients...
- A liquid chromatographic-tandem mass spectrometric method for the analysis of serotonin and related indoles in human whole bloodJonathan P Danaceau
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 20 South 2030 East, Room 490, Salt Lake City, Utah 84112, USA
J Anal Toxicol 27:440-4. 2003..A regression analysis of the two data sets resulted in correlation coefficients of 0.981, 0.964, and 0.987 for 5-HT, TRP, and IAA, respectively...
- Ferritin levels and their association with regional brain volumes in Tourette's syndromeDaniel A Gorman
Department of Psychiatry, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada
Am J Psychiatry 163:1264-72. 2006..The authors measured peripheral iron indices in a large group of Tourette's syndrome and comparison subjects and explored associations of ferritin levels with regional brain volumes...
- Behavioral effects of pubertal anabolic androgenic steroid exposure in male rats with low serotoninYonas B Keleta
Department of Biology, University of Texas at San Antonio, San Antonio, 6900 N Loop 1604 West, San Antonio, TX 78249, USA
Brain Res 1132:129-38. 2007..Based on these data, it can be speculated that pubertal AAS users with low central 5-HT may be especially prone to exhibit aggressive behavior...
- Report of altered urinary oxytocin and AVP excretion in neglected orphans should be reconsideredGeorge M Anderson
J Autism Dev Disord 36:829-30. 2006
- Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatmentLinda L Carpenter
Mood Disorders Research Program, Butler Hospital, Brown Medical School, Providence, Rhode Island 02906, USA
Biol Psychiatry 62:1080-7. 2007..Abnormal HPA response to stress challenge has been reported in adult patients with major depressive disorder and posttraumatic stress disorder...