S Aksoy

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Wolbachia, Sodalis and trypanosome co-infections in natural populations of Glossina austeni and Glossina pallidipes
    Florence N Wamwiri
    KARI Trypanosomiasis Research Centre, Kikuyu, Kenya
    Parasit Vectors 6:232. 2013
  2. pmc The population structure of Glossina fuscipes fuscipes in the Lake Victoria basin in Uganda: implications for vector control
    Chaz Hyseni
    Department of Ecology and Evolutionary Biology, Yale University, 21 Sachem Street, New Haven, CT, USA
    Parasit Vectors 5:222. 2012
  3. pmc Wolbachia association with the tsetse fly, Glossina fuscipes fuscipes, reveals high levels of genetic diversity and complex evolutionary dynamics
    Rebecca E Symula
    Department of Ecology and Evolutionary Biology, Yale University, 21 Sachem St, New Haven, CT, USA
    BMC Evol Biol 13:31. 2013
  4. pmc Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda
    Serap Aksoy
    Yale School of Public Health, Department of Epidemiology of Microbial Diseases, Yale University, 60 College Street, New Haven, CT, USA
    Trends Parasitol 29:394-406. 2013
  5. pmc Implications of microfauna-host interactions for trypanosome transmission dynamics in Glossina fuscipes fuscipes in Uganda
    Uzma Alam
    Yale University School of Public Health, New Haven, Connecticut, USA
    Appl Environ Microbiol 78:4627-37. 2012
  6. pmc Genetic diversity and population structure of Glossina pallidipes in Uganda and western Kenya
    Johnson O Ouma
    Trypanosomiasis Research Centre, Kenya Agricultural Research Institute, Kikuyu, Kenya
    Parasit Vectors 4:122. 2011
  7. pmc Temporal stability of Glossina fuscipes fuscipes populations in Uganda
    Richard Echodu
    Faculty of Science, Gulu University, Uganda
    Parasit Vectors 4:19. 2011
  8. pmc Transcriptome analysis of reproductive tissue and intrauterine developmental stages of the tsetse fly (Glossina morsitans morsitans)
    Geoffrey M Attardo
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    BMC Genomics 11:160. 2010
  9. pmc An insight into the sialome of Glossina morsitans morsitans
    Juliana Alves-Silva
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
    BMC Genomics 11:213. 2010
  10. doi request reprint Paratransgenesis applied for control of tsetse transmitted sleeping sickness
    Serap Aksoy
    Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, CT 06520, USA
    Adv Exp Med Biol 627:35-48. 2008

Collaborators

Detail Information

Publications51

  1. pmc Wolbachia, Sodalis and trypanosome co-infections in natural populations of Glossina austeni and Glossina pallidipes
    Florence N Wamwiri
    KARI Trypanosomiasis Research Centre, Kikuyu, Kenya
    Parasit Vectors 6:232. 2013
    ..This study was conducted to determine the prevalence of these endosymbionts in natural populations of G. austeni and G. pallidipes and to assess the degree of concurrent infections with trypanosomes...
  2. pmc The population structure of Glossina fuscipes fuscipes in the Lake Victoria basin in Uganda: implications for vector control
    Chaz Hyseni
    Department of Ecology and Evolutionary Biology, Yale University, 21 Sachem Street, New Haven, CT, USA
    Parasit Vectors 5:222. 2012
    ..We screened tsetse flies from the three Ugandan PATTEC blocks for genetic diversity at 15 microsatellite loci from continental and offshore populations to provide empirical data to support this initiative...
  3. pmc Wolbachia association with the tsetse fly, Glossina fuscipes fuscipes, reveals high levels of genetic diversity and complex evolutionary dynamics
    Rebecca E Symula
    Department of Ecology and Evolutionary Biology, Yale University, 21 Sachem St, New Haven, CT, USA
    BMC Evol Biol 13:31. 2013
    ....
  4. pmc Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda
    Serap Aksoy
    Yale School of Public Health, Department of Epidemiology of Microbial Diseases, Yale University, 60 College Street, New Haven, CT, USA
    Trends Parasitol 29:394-406. 2013
    ..We discuss the implications of these findings for large-scale tsetse control programs, including suppression or eradication, being undertaken in Uganda, and potential future genetic applications. ..
  5. pmc Implications of microfauna-host interactions for trypanosome transmission dynamics in Glossina fuscipes fuscipes in Uganda
    Uzma Alam
    Yale University School of Public Health, New Haven, Connecticut, USA
    Appl Environ Microbiol 78:4627-37. 2012
    ..It is imperative to note that these novel findings would have been missed if we had employed the standard univariate analysis used in previous studies. Our results are discussed in the context of disease epidemiology and vector control...
  6. pmc Genetic diversity and population structure of Glossina pallidipes in Uganda and western Kenya
    Johnson O Ouma
    Trypanosomiasis Research Centre, Kenya Agricultural Research Institute, Kikuyu, Kenya
    Parasit Vectors 4:122. 2011
    ..It is unknown whether the G. pallidipes belt in southeastern Uganda extends into western Kenya. We investigated the genetic diversity and population structure of G. pallidipes in Uganda and western Kenya...
  7. pmc Temporal stability of Glossina fuscipes fuscipes populations in Uganda
    Richard Echodu
    Faculty of Science, Gulu University, Uganda
    Parasit Vectors 4:19. 2011
    ..f. fuscipes distributed across southeastern Uganda, including a zone of contact between two historically isolated lineages. A total of 667 tsetse flies were genotyped at 16 microsatellite loci and at one mitochondrial locus...
  8. pmc Transcriptome analysis of reproductive tissue and intrauterine developmental stages of the tsetse fly (Glossina morsitans morsitans)
    Geoffrey M Attardo
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    BMC Genomics 11:160. 2010
    ..3438 expressed sequence tags were sequenced and analyzed...
  9. pmc An insight into the sialome of Glossina morsitans morsitans
    Juliana Alves-Silva
    Vector Group, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
    BMC Genomics 11:213. 2010
    ..Adult tsetse flies feed exclusively on vertebrate blood and are important vectors of human and animal diseases. Thus far, only limited information exists regarding the Glossina sialome, or any other fly belonging to the Hippoboscidae...
  10. doi request reprint Paratransgenesis applied for control of tsetse transmitted sleeping sickness
    Serap Aksoy
    Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, CT 06520, USA
    Adv Exp Med Biol 627:35-48. 2008
    ....
  11. ncbi request reprint A case for a Glossina genome project
    Serap Aksoy
    Yale University School of Medicine, 60 College Street, 606 LEPH, New Haven, CT 06520, USA
    Trends Parasitol 21:107-11. 2005
    ..An international consortium is now in place to further efforts to lead to a full genome project...
  12. ncbi request reprint Interactions among multiple genomes: tsetse, its symbionts and trypanosomes
    Serap Aksoy
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, 606 LEPH, New Haven, CT 06510, USA
    Insect Biochem Mol Biol 35:691-8. 2005
    ....
  13. ncbi request reprint Control of tsetse flies and trypanosomes using molecular genetics
    Serap Aksoy
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Vet Parasitol 115:125-45. 2003
    ..A strategy is outlined where the replacement of susceptible insect phenotypes with their engineered refractory counterparts can result in decreased disease transmission...
  14. ncbi request reprint Tsetse--A haven for microorganisms
    S Aksoy
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, 60 College St, 606 LEPH, New Haven, CT 06510, USA
    Parasitol Today 16:114-8. 2000
    ....
  15. ncbi request reprint Prospects for control of African trypanosomiasis by tsetse vector manipulation
    S Aksoy
    Dept Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, 60 College St, 606 LEPH, New Haven, CT 06510, USA
    Trends Parasitol 17:29-35. 2001
    ..Here, Serap Aksoy and colleagues discuss molecular genetic approaches to modulate tsetse vector competence...
  16. ncbi request reprint Molecular characterization of two serine proteases expressed in gut tissue of the African trypanosome vector, Glossina morsitans morsitans
    J Yan
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, 60 College St, New Haven, CT 06510, USA
    Insect Mol Biol 10:47-56. 2001
    ..Both the coding sequences and patterns of expression of Gsp1 and Gsp2 genes are similar to the serine proteases that have been reported from the bloodfeeding insect Stomoxys calcitrans...
  17. pmc Genome size determination and coding capacity of Sodalis glossinidius, an enteric symbiont of tsetse flies, as revealed by hybridization to Escherichia coli gene arrays
    L Akman
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, 60 College St, New Haven, Connecticut 06510, USA
    J Bacteriol 183:4517-25. 2001
    ..We present gene arrays as a rapid tool for comparative genomics in the absence of whole genome sequence to advance our understanding of closely related bacteria...
  18. ncbi request reprint Characterization of genes expressed in the salivary glands of the tsetse fly, Glossina morsitans morsitans
    S Li
    Yale University School of Medicine, Department of Epidemiology and Public Health, Section of Vector Biology, 60 College St, New Haven, CT 06510, USA
    Insect Mol Biol 10:69-76. 2001
    ..The expression of these cDNAs in different tsetse species (G. m. morsitans, Glossina austeni and Glossina fuscipes) shows wide variations...
  19. ncbi request reprint Microsatellite polymorphism in tsetse flies (Diptera: Glossinidae)
    C Luna
    Yale University School of Medicine, Epidemiology and Public Health, New Haven, CT 06520, USA
    J Med Entomol 38:376-81. 2001
    ..austeni Newstead. Genetic variability was estimated in one field population of G. p. gambiensis. These results confirmed that microsatellite markers may be used to examine the subpopulation structure of tsetse flies...
  20. pmc Molecular characterization of two novel milk proteins in the tsetse fly (Glossina morsitans morsitans)
    G Yang
    Yale School of Public Health, Division of Epidemiology of Microbial Diseases, New Haven, CT 06510, USA
    Insect Mol Biol 19:253-62. 2010
    ..To understand milk protein function and regulation during viviparous reproduction, milk proteins need to be identified and characterized...
  21. ncbi request reprint Analysis of fat body transcriptome from the adult tsetse fly, Glossina morsitans morsitans
    G M Attardo
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Insect Mol Biol 15:411-24. 2006
    ..Milk gland protein, apparently important for larval nutrition, however, is primarily synthesized by accessory milk gland tissue...
  22. pmc Tsetse immune responses and trypanosome transmission: implications for the development of tsetse-based strategies to reduce trypanosomiasis
    Z Hao
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 98:12648-53. 2001
    ..The results are discussed in relation to transgenic approaches proposed for modulating vector competence in tsetse...
  23. ncbi request reprint Interactions between tsetse and trypanosomes with implications for the control of trypanosomiasis
    Serap Aksoy
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Adv Parasitol 53:1-83. 2003
    ..This article reviews the known biology of trypanosome development in the fly in the context of the physiology of the digestive system and interactions of the immune defences and symbiotic flora...
  24. ncbi request reprint Phylogenetically distant symbiotic microorganisms reside in Glossina midgut and ovary tissues
    S L O'Neill
    Department of Epidemiology, Yale University School of Medicine, New Haven, Connecticut 06525
    Med Vet Entomol 7:377-83. 1993
    ..The presence of Wolbachia-like Rickettsia in the ovaries of G.morsitans subspecies may help to explain the maternally inherited incompatibility of some crosses within this species...
  25. pmc Dynamics of multiple symbiont density regulation during host development: tsetse fly and its microbial flora
    Rita V M Rio
    Department of Epidemiology and Public Health, Yale University School of Medicine, 606 LEPH, New Haven CT 06510, USA
    Proc Biol Sci 273:805-14. 2006
    ..The regulation of symbiont density, arising from coadaptive processes, may be an important mechanism driving inter-specific relations to ensure their competitive survival and to promote specialization of beneficial associations...
  26. pmc Interspecific transfer of bacterial endosymbionts between tsetse fly species: infection establishment and effect on host fitness
    Brian L Weiss
    Department of Epidemiology and Public Health, Yale University School of Medicine, LEPH 606, 60 College Street, New Haven, CT 06510, USA
    Appl Environ Microbiol 72:7013-21. 2006
    ..Our ability to transinfect tsetse flies is indicative of Sodalis ' recent evolutionary history with its tsetse fly host and demonstrates that this procedure may be used as a means of streamlining future paratransgenesis experiments...
  27. pmc Characterization of the antimicrobial peptide attacin loci from Glossina morsitans
    J Wang
    Yale University School of Medicine, Department of Epidemiology and Public Health, 60 College Street, New Haven, CT 06510, USA
    Insect Mol Biol 17:293-302. 2008
    ..Transcription of AttD is significantly less relative to the other two genes, and is preferentially induced in the fat body of parasitized flies. These results indicate that the different attacin genes may be differentially regulated...
  28. ncbi request reprint Strategies of the home-team: symbioses exploited for vector-borne disease control
    Rita V M Rio
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA
    Trends Microbiol 12:325-36. 2004
    ..Replacing susceptible insect genotypes with modified counterparts with reduced pathogen transmission ability, might provide a new set of armaments in the battle for vector-borne disease reduction...
  29. pmc Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission
    Jingwen Wang
    Department of Epidemiology of Microbial Diseases, Yale School of Public Heath, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 106:12133-8. 2009
    ..A dynamic interplay between Wigglesworthia and host immunity apparently is influential in tsetse's ability to transmit trypanosomes...
  30. ncbi request reprint Cloning and functional expression of a fat body-specific chitinase cDNA from the tsetse fly, Glossina morsitans morsitans
    J Yan
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Insect Biochem Mol Biol 32:979-89. 2002
    ..The intrauterine larva of tsetse may receive the protein from its mother via the milk gland route. The molecular characteristics of GChit and its product and the potential role of this chitinase in tsetse biology are discussed...
  31. ncbi request reprint Refractoriness in tsetse flies (Diptera: Glossinidae) may be a matter of timing
    Dana Nayduch
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA
    J Med Entomol 44:660-5. 2007
    ..pallidipes. The role of early, uninduced attacin expression, and its role in relative refractoriness in tsetse, is discussed...
  32. pmc Comparative genomics of insect-symbiotic bacteria: influence of host environment on microbial genome composition
    Rita V M Rio
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Appl Environ Microbiol 69:6825-32. 2003
    ..It is possible that these adaptations, streamlining genomes, act to make a free-living state no longer feasible for the harnessed microbe...
  33. ncbi request reprint Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia
    Leyla Akman
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, 60 College Street, 606 LEPH, New Haven, Connecticut 06510, USA
    Nat Genet 32:402-7. 2002
    ..Unexpectedly, this obligate's genome bears hallmarks of both parasitic and free-living microbes, and the gene encoding the important regulatory protein DnaA is absent...
  34. pmc Molecular aspects of transferrin expression in the tsetse fly (Glossina morsitans morsitans)
    Nurper Guz
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, 606 LEPH, New Haven, CT 06510, USA
    J Insect Physiol 53:715-23. 2007
    ..Analysis of tsetse that have cured the parasite challenge shows normal levels of GmmTsf. This observation suggests that the parasite in competing for the availability of limited dietary iron may manipulate host gene expression...
  35. pmc A novel application of gene arrays: Escherichia coli array provides insight into the biology of the obligate endosymbiont of tsetse flies
    L Akman
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 98:7546-51. 2001
    ..We present an application of E. coli gene arrays to obtain broad genome information for a closely related organism in the absence of complete genome sequence data...
  36. pmc An insect symbiosis is influenced by bacterium-specific polymorphisms in outer-membrane protein A
    Brian L Weiss
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, LEPH 606, 60 College Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 105:15088-93. 2008
    ..coli K12. Our results show that polymorphisms in the exposed loop domains of OmpA represent a microbial adaptation that mediates host tolerance of endogenous symbiotic bacteria...
  37. ncbi request reprint Proventriculus-specific cDNAs characterized from the tsetse, Glossina morsitans morsitans
    Zhengrong Hao
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, 60 College St, 606 LEPH, New Haven, Connecticut 06510, USA
    Insect Biochem Mol Biol 32:1663-71. 2002
    ..We discuss the molecular characteristics of these proventriculus specific cDNAs and their products as well as their potential role for vector control studies...
  38. pmc Analysis of milk gland structure and function in Glossina morsitans: milk protein production, symbiont populations and fecundity
    Geoffrey M Attardo
    Yale School of Public Health, Department of Epidemiology and Microbial Diseases, 60 College Street, 606 LEPH New Haven, CT 06510, USA
    J Insect Physiol 54:1236-42. 2008
    ..We discuss the significance of the milk gland in larval nutrition and in transmission of symbiotic bacteria to developing offspring...
  39. pmc The obligate mutualist Wigglesworthia glossinidia influences reproduction, digestion, and immunity processes of its host, the tsetse fly
    Roshan Pais
    Yale School of Public Heath, Department of Epidemiology of Microbial Diseases, New Haven, CT 06520, USA
    Appl Environ Microbiol 74:5965-74. 2008
    ..The ability to rear adult tsetse that lack the obligate Wigglesworthia endosymbionts will now enable functional investigations into this ancient symbiosis...
  40. pmc Molecular characterization of iron binding proteins from Glossina morsitans morsitans (Diptera: Glossinidae)
    Patricia M Strickler-Dinglasan
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA
    Insect Biochem Mol Biol 36:921-33. 2006
    ..On the other hand, GmmFer1HCH maintains both the conserved ferroxidase center and the 5'UTR IRE; however, transcript variants suggest a more extensive regulatory mechanism for this subunit...
  41. ncbi request reprint An antimicrobial peptide with trypanocidal activity characterized from Glossina morsitans morsitans
    Youjia Hu
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University, School of Medicine, 60 College St, 606 LEPH, New Haven, CT 06510, USA
    Insect Biochem Mol Biol 35:105-15. 2005
    ..We discuss a paratransgenic strategy, which involves the expression of trypanocidal molecules such as recGmAttA1 in the midgut symbiont Sodalis in vivo to reduce trypanosome transmission...
  42. pmc Molecular aspects of viviparous reproductive biology of the tsetse fly (Glossina morsitans morsitans): regulation of yolk and milk gland protein synthesis
    Geoffrey M Attardo
    Department of Epidemiology and Public Health, Yale University School of Medicine, 606 LEPH New Haven, CT 06510, USA
    J Insect Physiol 52:1128-36. 2006
    ..These results demonstrate that both GmmYP1 and GmmMGP are involved in tsetse reproductive biology, the former associated with the process of oogenesis and the latter with larvigenesis...
  43. ncbi request reprint Innate immune responses regulate trypanosome parasite infection of the tsetse fly Glossina morsitans morsitans
    Changyun Hu
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, 606 LEPH, New Haven, CT 06510, USA
    Mol Microbiol 60:1194-204. 2006
    ..Our results provide the first direct evidence for the involvement of antimicrobial peptides in trypanosome transmission in tsetse...
  44. ncbi request reprint Proventriculus (cardia) plays a crucial role in immunity in tsetse fly (Diptera: Glossinidiae)
    Zhengrong Hao
    Department of Epidemiology and Public Health, Section of Vector Biology, Yale University School of Medicine, New Haven, CT 06510, USA
    Insect Biochem Mol Biol 33:1155-64. 2003
    ..We discuss the putative role of the proventriculus in invertebrate immunity and specifically speculate on its significance for trypanosome transmission in tsetse...
  45. pmc Infections with immunogenic trypanosomes reduce tsetse reproductive fitness: potential impact of different parasite strains on vector population structure
    Changyun Hu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    PLoS Negl Trop Dis 2:e192. 2008
    ..Potential repercussions for vector population growth, parasite-host coevolution, and disease prevalence are discussed...
  46. ncbi request reprint Comparative genomics to uncover the secrets of tsetse and livestock-infective trypanosomes
    Alberto M R Dávila
    Departamento de Bioquimica e Biologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ, Av Brasil 4365, Rio de Janeiro, RJ 21045 900, Brazil
    Trends Parasitol 19:436-9. 2003
  47. ncbi request reprint Immune responses and parasite transmission in blood-feeding insects
    Michael J Lehane
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Trends Parasitol 20:433-9. 2004
    ..An outline of insect immunity is given here based on the Drosophila studies, which is used as a framework to discuss recent work on Plasmodium-mosquito and Trypanosoma-tsetse interactions...
  48. ncbi request reprint Replication of flock house virus in three genera of medically important insects
    Ranjit Dasgupta
    Department of Animal Health and Biomedical Sciences University of Wisconsin, Madison 53706, USA
    J Med Entomol 44:102-10. 2007
    ..Our results indicate that FHV has uniquely broad insect host range and that the virus can be used to study virus host interactions in a variety of medically important insects...
  49. ncbi request reprint Abdominal pericardial sinus: a neurohemal site in the tsetse and other cyclorraphan flies
    Shirlee Meola
    Areawide Pest Management Research Unit, United States Department of Agriculture Agricultural Research Service, College Station, TX 77845, USA
    J Med Entomol 40:755-65. 2003
    ..In the tsetse fly, some of the neurosecretory fibers also extend between the muscle fibers of the myocardium, and release their material into the lumen of the heart...
  50. pmc Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host
    Hidehiro Toh
    Kitasato Institute for Life Sciences, Kitasato University, Sagamihara, Kanagawa 228 0829, Japan
    Genome Res 16:149-56. 2006
    ..The data suggest that Sodalis represents an evolutionary intermediate transitioning from a free-living to a mutualistic lifestyle...
  51. ncbi request reprint Transgenesis and the management of vector-borne disease. Preface
    Serap Aksoy
    Adv Exp Med Biol 627:vii-viii. 2008

Research Grants26

  1. Adaptive evolution of pathogenesis towards symbiosis
    Serap Aksoy; Fiscal Year: 2007
    ..The role of functions typically associated with pathogenic microorganisms will be pursued in these beneficial microbes. ..
  2. Evolutionary genetics of tsetse and its symbionts
    Serap Aksoy; Fiscal Year: 2009
    ..This interdisciplinary application will combine epidemiology, population genetics and modeling with model parameterization and verification from laboratory and field research. ..
  3. Evolutionary genetics of tsetse and its symbionts
    Serap Aksoy; Fiscal Year: 2010
    ..This interdisciplinary application will combine epidemiology, population genetics and modeling with model parameterization and verification from laboratory and field research. ..
  4. Tsetse Fecundity Reduction for Trypanosomiasis Control
    Serap Aksoy; Fiscal Year: 2010
    ..Disruption of tsetse reproduction would be an effective way to reduce or eliminate fly populations resulting in the prevention of trypanosome transmission to humans and livestock. ..
  5. Adaptive evolution of pathogenesis towards symbiosis
    Serap Aksoy; Fiscal Year: 2009
    ..The role of functions typically associated with pathogenic microorganisms will be pursued in these beneficial microbes. ..
  6. Molecular Aspects of Tsetse and Trypanosome Transmission
    Serap Aksoy; Fiscal Year: 2010
    ..The ultimate goal is to be able to interfere with parasite transmission in the fly. ..
  7. Tsetse Fecundity Reduction for Trypanosomiasis Control
    Serap Aksoy; Fiscal Year: 2010
    ..Disruption of tsetse reproduction would be an effective way to reduce or eliminate fly populations resulting in the prevention of trypanosome transmission to humans and livestock. ..
  8. Molecular Aspects of Tsetse and Trypanosome Transmission
    Serap Aksoy; Fiscal Year: 2007
    ..Immunity genes are strong =candidates which this study may help to identify. These genes may also play a role in differentiation of trypanosomes and again, this project will identify potential candidates. ..
  9. INTERACTION OF TSETSE--ITS SYMBIONTS AND TRYPANOSOMES
    Serap Aksoy; Fiscal Year: 2001
    ..The basic knowledge obtained will strengthen our understanding of tsetse biology and will also provide information relevant to other important disease vectors which harbor similar symbionts (e.g., ticks, fleas, reduviid bugs etc.). ..
  10. Molecular Aspects of Tsetse and Trypanosome Transmission
    Serap Aksoy; Fiscal Year: 2003
    ..Immunity genes are strong candidates, which this study may help to identify. These genes may also play a role in differentiation of trypanosomes and again, this project will identify potential candidates. ..
  11. Molecular Aspects of Tsetse and Trypanosome Transmission
    Serap Aksoy; Fiscal Year: 2006
    ..Immunity genes are strong candidates, which this study may help to identify. These genes may also play a role in differentiation of trypanosomes and again, this project will identify potential candidates. ..
  12. Trypanosome gene expression in tsetse
    Serap Aksoy; Fiscal Year: 2006
    ....
  13. Evolutionary genetics of tsetse and its symbionts
    Serap Aksoy; Fiscal Year: 2010
    ..This interdisciplinary proposal will combine epidemiology, population genetics and modeling with model parameterization and verification from laboratory and field research. ..